It is widely acknowledged that a strong relationship exists between physical environments and human health and wellbeing. More specifically, various dimensions of person environment (PE) relationships have been studied relating to the psychological, physical and social aspects of human interactions and transactions. However, health aspects relating to human psychological and physiological relationships and such factors acting upon PE relationships are not well investigated. This paper emerges from a larger study and presents the approach undertaken to investigate the complexities of PE relationships to health and wellbeing for the purpose of reviewing literature. The study attempts to understand how outcomes of health and wellbeing are interrelated to PE relationships when influences of the various systems of the human body are considered. Central to this study is the psychoneuroimmunology (PNI) model that proposes that the person's psychological health is internally related to the neurological and immunological systems. the PNI model was used as a basis to look at the various interrelationships of human environment interactions and transactions to health and wellbeing. This provided the study with an integrative inquiry method for exploring literature which looked at such relationships singularly or collectively.