Physical Activity Promotion Research Articles

Assessment of Park Paths and Trails for Physical Activity Promotion among Older Adults in Saudi Arabia: Feasibility and Future Directions.

A descriptive study design was used to assess five public parks in Riyadh, Saudi Arabia, from April to June 2022. Additionally, process, resource, and management assessments were also conducted. The PEAT was easy to use, but additions are recommended to increase relevance to older adults with chronic disease. Descriptive analyses revealed positive features, such as adequate lighting, but other features such as path slope were more variable. Study findings can guide the future use of the PEAT for older adult participants and inform environmental modifications.

Promotion of Physical Activity by Health Professionals (PROMOTE-PA): protocol for effectiveness outcomes in a hybrid type I effectiveness-implementation cluster randomised controlled trial

Promotion of physical activity by health professionals can increase physical activity participation among patients, however, implementing physical activity promotion within hospital systems is lacking. The Promotion of Physical Activity by...

Effect of physical activity in lymphocytes senescence burden in patients with COPD.

Chronic obstructive pulmonary disease (COPD) is regarded as an accelerated-age disease in which chronic inflammation, maladaptive immune responses, and senescence cell burden coexist. Accordingly, cellular senescence has emerged as a potential mechanism involved in COPD pathophysiology. In this study, 25 stable patients with COPD underwent a daily physical activity promotion program for 6 mo. We reported that increase of physical activity was related to a reduction of the senescent cell burden in circulating lymphocytes of patients with COPD. Senescent T-lymphocyte population, characterized by absence of surface expression of CD28, was reduced after physical activity intervention, and the reduction was associated to the increase of physical activity level. In addition, the mRNA expression of cyclin-dependent kinase inhibitors, a hallmark of cell senescence, was reduced and, in accordance, the proliferative capacity of lymphocytes was improved postintervention. Moreover, we observed an increase in functionality in T cells from patients after intervention, including improved markers of activation, enhanced cytotoxicity, and altered cytokine secretions in response to viral challenge. Lastly, physical activity intervention reduced the potential of lymphocytes' secretome to induce senescence in human primary fibroblasts. In conclusion, our study provides, for the first time, evidence of the potential of physical activity intervention in patients with COPD to reduce the senescent burden in circulating immune cells.NEW & NOTEWORTHY For the first time, we identified in patients with COPD a relation between physical activity intervention with respiratory function improvement and cellular senescence burden in lymphocytes that improved the T cell functionality and proliferative capacity of patients. In addition, our experiments highlight the possible impact of T-cell senescence in other cell types which could be related to some of the clinical lung complications observed in COPD.

Energy Cost of Selected Physical Activities of Older Persons Living in Taguig City, the Philippines

The promotion of physical activity is important for fostering healthy aging. However, a substantial proportion of older adults remain sedentary. Current metrics assessing the energy cost of physical activity are primarily designed for the general adult population and inadequately account for distinct physiological changes in older individuals – encompassing variations in muscle mass, bone density, metabolism, and overall functional capacity. This study aimed to determine the energy cost of selected physical activities of Filipino older persons. This cross- sectional study conducted in Taguig City involved 19 older adults aged 60–79 yr using the COSMED Fitmate indirect calorimeter for resting metabolic rate determination, as well as the portable COSMED K5 indirect calorimeter for measuring energy cost of different physical activities – including treadmill walking, self-paced walking, a routine based on the DOST-FNRI manual, and multi-gym equipment. The outcomes of the study were presented in percentages and averages. Participants in the study were categorized based on their muscle strength and mass. Analysis revealed a consistent trend where older adults with lower appendicular skeletal muscle mass index and handgrip strength values demonstrated lower metabolic equivalent values across the different exercise routines. Notably, Routine 2 displayed an exception, with individuals above the 50th percentile of ASMI and HGS exhibiting lower METs than those below the 50th percentile. This study contributes insights into the energy cost of specific activities among older adults emphasizing the importance of physical activity in healthy aging and providing valuable information for tailored interventions and a nuanced understanding of energy expenditure in this age group.

Physical Activity Engagement among Black Immigrants and African American Adults in the 2010 to 2018 NHIS Study.

High rates of physical inactivity persist in the United States, with higher rates among non-Hispanic Black adults than among their White peers. However, a comparison of physical activity engagement across nativity among Black adults in the United States has yet to be fully documented. The purpose of this cross-sectional study was to examine physical activity engagement rates among African immigrant and Afro-Caribbean immigrant adults compared with native-born African American adults using data from the 2010 to 2018 National Health Interview Survey. Using data from the 2010 to 2018 National Health Interview Survey, we used generalized linear models to compare levels of physical activity (meeting the moderate-to-vigorous physical activity [MVPA] recommendations) by ethnic subgroups of Black adults, sequentially adjusting for sociodemographic and health-related risk factors. Data from 38,037 adults (58.8% female, 21% college/graduate degree, and 41.4% with obesity) were included. Only 41.9% of all participants met the MVPA recommendations. In the fully adjusted models across the 9 years, higher levels of MVPA were seen among African Americans (42%) than among African immigrants (38%) and Afro-Caribbean immigrants (41%). Compared with African Americans, African immigrants were less likely to engage in physical activity that met the MVPA guidelines (prevalence ratio: 0.90; 95% confidence interval: 0.85, 0.96), whereas there were no differences in meeting the guidelines between Afro-Caribbean immigrants (prevalence ratio: 0.96; 95% confidence interval:0.90, 1.02) and African Americans. Culturally tailored interventions addressing socioenvironmental barriers and facilitators of physical activity may have important impacts on physical activity promotion and long-term disease burden among Black adults across nativity.

Actual and Virtual Parks Benefit Quality of Life and Physical Activity: A Cluster Trial.

Urban parks provide connectedness to nature as a health resilience environment for promoting health. Virtual reality can provide opportunities for urban citizens to be exposed to natural elements with health benefits. The purpose was to explore the effects of actual and virtual parks on the quality of life and physical activity of urban residents. The study design was a cluster trial. Participants were healthy adults aged 20-50years, recruited from three college campuses, and randomly assigned to two experimental groups (n = 30, 32) and one control group (n = 30). The intervention with virtual or actual parks was conducted for 30min a session once a week for 12weeks. Outcomes were measured using self-reported questionnaires, including the World Health Organization Quality-of-Life Scale-BREF and International Physical Activity Questionnaire-Short Form. In total, 84 participants completed the interventions and post-intervention measures. Results showed that participants who experienced actual parks had significant increases in the social quality of life and light-intensity physical activity and had decreased body weight. Participants who experienced the virtual parks experienced a significant increase in their mental quality of life. Participants in the experimental groups of both kinds of parks had significant improvements in their self-rated health, physical and environmental quality of life, and sedentary time after the intervention. Urban parks are an important natural resource for citizens' health and physical activity promotion. Virtual parks can simulate actual parks and have similar health benefits and are thus are recommended for citizens who lack opportunities and motivation to go to actual parks.

Whole-of-School Physical Activity Promotion: Findings From Elementary Schools in the United States

IntroductionSchools can support students’ participation in physical activity by offering opportunities consistent with a Whole-of-School (WOS) approach; however, the extent to which physical activity opportunities are provided and how school-level characteristics associate with their use remains unclear. This study examined how elementary schools’ use a WOS approach to promote physical activity, as well as associations between school-level characteristics and physical activity opportunities provided. MethodsSurvey data was collected from 162 elementary schools participating in the NFL PLAY 60 FitnessGram Project during the 2022–23 school year. A WOS index (ranging from 0–12) was created from responses by school staff on questions about six physical activity practices (physical education, recess, before- and after-school programs, classroom-based approaches, active transport). Multivariable regression models examined associations between school characteristics and WOS index scores. Analyses were completed in Spring 2024. ResultsFully adjusted models indicated a statistically significant difference between the percentage of economically disadvantaged students served and WOS index score. Schools serving between 20–39% (p<0.001), 40–59% (p<0.01), 60–79% (p<0.01) and ≥80% (p<0.001) economically disadvantaged students scored significantly lower on the WOS index compared to schools with 0–19% economically disadvantaged students. ConclusionStudies are needed to examine disparities in physical activity practices consistent with a WOS approach to understand the implications on health, academic performance, and other key outcomes. This information can inform the development of strategies to address disparities and ensure youth have equitable access to school-based physical activity opportunities.

Strengthening Whole-of-School Physical Activity Models to Promote Physical Literacy: Moving Beyond a Component Approach

Whole-of-school approaches to physical activity and health promotion have the potential to promote physical literacy. However, for a variety of reasons there has not been widespread adoption of component whole-of-school frameworks to guide schools, such as the Comprehensive School Physical Activity Program. We argue that component frameworks have shortcomings and do not necessarily assist or support schools to take an approach that is consistent with how successful whole-of-school models or programs are created and built over time. In this paper, we argue that we need to apply guidance that resonates with stakeholders and stimulates schools to design their own unique whole-of-school physical activity model to provide equitable programming opportunities. We also present an argument on the need to incorporate improvement science and the use of social–ecological models to investigate the efficacy of this guidance model.

A Golden Perspective: The Evolution of an Exercise Is Medicine On Campus Program

This narrative review will explore the evolution of the Exercise is Medicine on Campus (EIM-OC) initiative, in general, while focusing specifically on the EIM-OC program at a gold-level recognized university through three main research questions. Established in 2016, this referral-based program offers a physical activity assessment and promotion element that incorporates yearly EIM-OC-supported events aimed at positively affecting academics, retention, and other related markers of individual participants. Interdisciplinary and cross-campus partnerships support this program with referral pathways, wellness event collaborations, participant interventions, and financial support. This EIM-OC program seeks to expand beyond student health services and other entry areas toward a self-referral model supported by trained mentors. The EIM-OC program supports the educational and professional development of individuals training to be health professionals while inspiring participants to consider a positive view of aging through movement as a healthy, normal part of life.

Lower physical activity levels in youth with Cystic Fibrosis compared to healthy controls: A multicentre comparative study

BackgroundRegular physical activity (PA) offers significant health benefits on both short (i.e., emotional well-being) and long term (i.e., fewer hospitalizations) in Youth with Cystic Fibrosis (YwCF). Regardless, evidence on PA levels in YwCF compared to healthy controls (HC) is inconsistent. Additionally, PA is a multidimensional outcome influenced by several factors such as Quadriceps strength and functional performance. Therefore, we aimed to assess whether PA, Quadriceps strength and functional performance differ between YwCF and HC across different age groups (i.e., children and adolescents). MethodsYwCF aged 6–17 from two Belgian CF centres and age- and sex-matched HC were recruited. PA was measured with an ActiGraph GT3X + BT during 7 consecutive days. Isometric Quadriceps strength was assessed with a Hand Held Dynamometer and functional performance with a sit-to stand test (STS) and standing long jump (SLJ). ResultsA total of 49 YwCF (44 % male; 11.3 ± 3.3 years) and 49 HC (48 % male; 11.9 ± 3.5 years) were included. On average days, YwCF performed 4 ± 6.4 min less light PA and 7.5 ± 6.7 min less moderate-to-vigorous PA compared to HC (p = 0.04; p = 0.01). The differences in moderate-to-vigorous PA seem more pronounced in children (6–11 years)(p = 0.04). Furthermore, YwCF had similar Quadriceps strength to HC but had lower scores on the STS and SLJ (p = 0.50, p = 0.08; p = 0.02). ConclusionsThis study shows lower PA levels and functional performance for YwCF, indicating that there is an urgent need for interventions promoting PA in YwCF. PA promotion will become increasingly important in the post modulator area to prevent health risks associated with low PA.

Physical Activity, Body Composition, and Fitness Variables in Adolescents After Periods of Mandatory, Promoted or Nonmandatory, Nonpromoted Use of Step Tracker Mobile Apps: Randomized Controlled Trial.

It is not known whether an intervention made mandatory as a physical education (PE) class assignment and aimed at promoting physical activity (PA) in adolescents can create a healthy walking habit, which would allow further improvements to be achieved after the mandatory and promoted intervention has been completed. The aims of this study were to (1) investigate whether, after a period of using a step tracker mobile app made mandatory and promoted as a PE class assignment, adolescents continue to use it when its use is no longer mandatory and promoted; (2) determine whether there are changes in the PA level, body composition, and fitness of adolescents when the use of the app is mandatory and promoted and when it is neither mandatory nor promoted; and (3) analyze whether the covariates maturity status, gender, and specific app used can have an influence. A total of 357 students in compulsory secondary education (age: mean 13.92, SD 1.91 y) participated in the study. A randomized controlled trial was conducted consisting of 2 consecutive 10-week interventions. Participants' PA level, body composition, and fitness were measured at baseline (T1), after 10 weeks of mandatory and promoted app use (T2), and after 10 weeks of nonmandatory and nonpromoted app use (T3). Each participant in the experimental group (EG) used 1 of 4 selected step tracker mobile apps after school hours. The results showed that when the use of the apps was neither mandatory nor promoted as a PE class assignment, only a few adolescents (18/216, 8.3%) continued the walking practice. After the mandatory and promoted intervention period (T1 vs T2), a decrease in the sum of 3 skinfolds (mean difference [MD] 1.679; P=.02) as well as improvements in the PA level (MD -0.170; P<.001), maximal oxygen uptake (MD -1.006; P<.001), countermovement jump test (MD -1.337; P=.04), curl-up test (MD -3.791; P<.001), and push-up test (MD -1.920; P<.001) in the EG were recorded. However, the changes between T1 and T2 were significantly greater in the EG than in the control group only in the PA level and curl-up test. Thus, when comparing the measurements taken between T1 and T3, no significant changes in body composition (P=.07) or fitness (P=.84) were observed between the EG and the control group. The covariates maturity status, gender, and specific app used showed a significant effect in most of the analyses performed. A period of mandatory and promoted use of step tracker mobile apps benefited the variables of body composition and fitness in adolescents but did not create a healthy walking habit in this population; therefore, when the use of these apps ceased to be mandatory and promoted, the effects obtained disappeared. ClinicalTrials.gov NCT06164041; https://clinicaltrials.gov/study/NCT06164041.

Representations of a physically active lifestyle in an aging population: an exploratory study

Institutional ageism remains a significant barrier for older adults seeking to adopt or maintain physical activity. This study explored how organizations promoting active living on a large scale, represent and communicate it to the aging population. Through semi-structured interviews with 11 Quebec non-governmental organizations, findings from an inductive thematic analysis revealed conflicting perceptions about age, aging and active living. Participants lacked sufficient knowledge and resources to adress the needs of this heterogenous population. While they acknowledge the diverse realities and requirements within the aging population, their discourse predominantly centered on fragility and declining capacities. Additionnally, these organizations offered a limited range of activities and promoted an idealized image to conteract sedentary behavior. The findings highlight persistent institutional ageism in physical activity promotion and underscore the necessity for organizations to reflect on their capacity and the services they offer to better support a physically active lifestyle for older adults.

Physical Inactivity Increases Impairment of Daily Activities Due to Pain in Workers: An Ordinal Regression Logistic and Correspondence Analysis.

Background: The evidence for the health benefits of physical activity is growing; however, the prevalence of unhealthy lifestyles continues to contribute to the increase in chronic non-communicable diseases. We know that occupational-time physical activity does not provide the same benefits as leisure-time physical activity, which has been shown to reduce mortality and pain. We also know that multiple factors influence pain; however, there are no studies that specifically analyze the impact of type of working time and occupational-time physical activity on the impairment of daily activities due to pain. We aimed to study the influence of both personal and occupational factors on the impairment of daily activities due to pain, assessing whether leisure-time physical activity acts as a protective factor. Methods: A cross-sectional, population-based design was used based on the 2017 National Health Survey in Spain (ENSE). Sociodemographic, leisure-time physical activity, and work-related variables were collected. The outcome variable was the impairment of daily activities due to pain. Ordinal logistic regression was applied, and the analysis was complemented with simple correspondence analysis. Results: A total of 1,441 workers between 18 and 65 years of age were studied. Significant differences were found between sexes for all variables except age and leisure-time physical activity. Logistic regression revealed significant associations between sex, primary and secondary education levels, no leisure-time physical activity, and overweight with impairment of daily activities due to pain. Simple correspondence analysis showed that the categories doing leisure-time physical activity several times a week as well as several times a month are closer to the categories of little or no pain. Conclusion: Female gender, low educational level, overweight, and lack of leisure-time physical activity were associated with increases in impairment of daily activities due to pain. Occupational-time physical activity and work shift were not related to impairment of daily activities due to pain. Implications for Occupational Health Practice: Occupational Health Nursing interventions through education and counseling on the importance of leisure-time physical activity promotion programs potentially can reduce the impairment of daily activities due to pain in working populations.

GPs' use of video and telephone consultation - implications for physical activity promotion for older adults.

To understand how VC/TC have impacted on the routine promotion of PA to older adults in GPs consultations. A mixed method, cross-sectional study of GPs practice was conducted in Ireland and Northern Ireland in 2020. An online survey and interviews with GPs, explored awareness of PA guidelines, PA promotion during consultations to older adults (65+ years) and the impact on routine practice of moving to VC/TC during the pandemic. GPs from across the Island of Ireland agreed that PA promotion is part of routine practice. Analysis of interviews with GPs highlighted a need to develop practitioners' knowledge of the guidelines and themes emerged around the use of VC/TC In routine practice. Positive themes highlighted that VC/TC enabled GPs to consult with a greater number of patients, thus prioritising face-to-face (FTFCs) consultations where needed. Barriers to using VC/TC included decreased visual assessments of patients FTF. GPs are continuing to use VC/TC at the initial consultation stage, however the broader and longer-term implications on PA promotion with older adults are unknown.

How to Promote Walking in Women with Fibromyalgia: A Look at Catastrophizing, Goal Conflict, and Avoidance from a Self-Emotional Regulatory Perspective.

The aim of this study was twofold: to explore the concordance between two measures of physical activity (accelerometer and IPAQ) among female fibromyalgia (FM) patients, as well as to examine the impact of psychosocial variables (catastrophism, activity avoidance) on walking among these patients. Helplessness, activity avoidance, and commitment to physical activity were evaluated in 132 FM women. After the first assessment, an accelerometer was placed by a psychologist on each participant for seven consecutive days. Eight days later, accelerometers were collected, and participants were evaluated again using the IPAQ. Two models were tested to analyze mediation and a moderated mediation effect. The mediating role of activity avoidance between helplessness and minutes walked was corroborated regarding the objective measure of walking. The effect of helplessness on minutes walked during a week was mediated by activity avoidance and assessed by accelerometers. Cognitive variables played a contextual role when trying to promote exercise. Activity avoidance must be understood as a key variable in physical activity promotion, specifically in the promotion of walking with the aim to do exercise in individuals with FM.

Efficacy of digital interventions on physical activity promotion in individuals with noncommunicable diseases: an overview of systematic reviews

BackgroundPhysical inactivity is considered one of the main modifiable risk factors for noncommunicable diseases. It has been proven that an active lifestyle is an efficient means of preventing and managing noncommunicable diseases. Multiple barriers have been identified that hinder engagement in conventional physical activity programs and the achievement of physical activity recommendations. Digital interventions may expand opportunities to resolve these barriers and empower people with noncommunicable diseases to be physically active. This overview of systematic reviews aims to evaluate the efficacy of digital interventions on physical activity promotion among individuals with major noncommunicable diseases.MethodA protocol was registered in the PROSPERO database (CRD42022364350). A qualitative synthesis method was applied to summarize the efficacy data. The assessment of methodological quality using AMSTAR-2 for each systematic review was performed by two independent reviewers.ResultsSearches in nine databases resulted in seven systematic reviews for inclusion. Most of the primary studies included in these seven reviews were conducted in high-income countries. The reviews addressed five populations: participants with cancers, cardiovascular diseases, chronic obstructive pulmonary disease, type 2 diabetes, and osteoarthritis. Digital interventions were classified into two categories: interventions based on digital activity trackers and remote interventions via digital facilities. Additional components were identified in both categories of interventions such as motivational content, counseling, goal setting, tailored feedback/reminders, and other behavioral change techniques. The overall quality of the reviews ranged from critically low to low. The findings provided some evidence that both categories of interventions were effective in promoting physical activity.ConclusionThe findings of this overview suggest that some types of digital interventions, such as self-monitoring with digital activity trackers and remote interventions via digital facilities, may be effective means of promoting physical activity across major noncommunicable diseases. The findings should be interpreted cautiously since the methodological quality of the included reviews ranged from critically low to low, and there was no consistent assessment of the certainty of evidence. Further systematic reviews are required on efficacy of digital interventions with more rigorous conducting and reporting of systematic review methodologies.

Association of cardiovascular health with anthropometric markers, cardiorespiratory fitness and quality of life of university workers

Objective: To evaluate cardiovascular health (CVH) in university workers at a higher education institution in relation to other health-related factors. Methods: Cross-sectional study consisting of 121 workers. CVH was assessed by seven measures [food consumption, physical activity level (PAL), smoking, total cholesterol, blood glucose, systemic blood pressure (BP), and body mass index (BMI)]. The independent variables waist circumference (WC), waist-hip ratio (WHR), HDL-c, LDL-c, triglycerides, maximal oxygen consumption (VO2max), workload, and health related quality of life (HRQoL) were assessed. Results: Overall, 25% of the sample had poor CVH. The ideal CVH group had lower WC (p&lt;0.001) and WHR (p&lt;0.001), and higher VO2max (p=0.041). The physical component score was higher in the groups with intermediate (p=0.036) and ideal (p=0.002) CVH. Daily workload was higher in the poor CVH group (p=0.05). CVH score was directly related to VO2max (p=0.001) and physical component (p=0.020), and inversely related to WC (p&lt;0.001), WHR (p&lt;0.001), LDL-c (p&lt;0.001), and triglycerides (p&lt; 0.001). Conclusion: Implementation of educational practices, and promotion of physical activity, adequate dietary intake, and other lifestyle habits can help to improve CVH and the physical component of HRQoL.

Altered Body Composition and Cytokine Production in Patients with Elevated HOMA-IR after SARS-CoV-2 Infection: A 12-Month Longitudinal Study.

Altered body composition and cytokine production due to SARS-CoV-2 antigens may affect homeostasis model assessment for insulin resistance (HOMA-IR) after SARS-CoV-2 infection. To elucidate this phenomenon, we conducted a longitudinal study involving 47 COVID-19 patients, who were followed up for 12 months. During recruitment, body composition and glucose indices were measured, and heparin blood samples were collected for measuring cytokine production. HOMA-IR was considered an elevated or non-elevated group based on the ratio between HOMA-IR at 12 months and 1 month of convalescence. Those with elevated HOMA-IR had a significantly higher body mass index, body fat percentage, and visceral fat rating and had a lower lean mass and lean/fat mass ratio than their counterparts. During the convalescent period, the elevated HOMA-IR group had lower TNFα, IFNγ, IL-2, IL-10, and granzyme B expression levels but had higher TNFα/IL-10, IFNγ/IL-10, IL-2/IL-10, and granzyme B/IL-10 ratios than the other group. The reduced cytokine production and pro-/anti-inflammatory imbalance in patients with elevated HOMA-IR may suggest immune cell dysfunction toward SARS-CoV-2. Patients with elevated HOMA-IR after SARS-CoV-2 infection may experience an increase in BMI and body fat percentage, leading to increased immune dysfunction and chronic inflammatory condition. A nutritional approach and promotion of physical activity may help reduce HOMA-IR and ameliorate glucose indices in these patients.

Investigating the Impact of Nutrition, Physical Activity, and Mental Health Interventions on Childhood Obesity

Childhood obesity is a multifaceted public health issue influenced by various factors, including nutrition, physical activity, and mental health. This study employs a qualitative approach to investigate the impact of interventions targeting these factors on childhood obesity. Through in-depth interviews, focus group discussions, and document analysis, the study examines the effectiveness of nutrition education programs, physical activity promotion initiatives, and mental health support services in addressing childhood obesity. The research explores how these interventions are implemented in diverse settings, such as schools, communities, and healthcare facilities, and assesses their outcomes in terms of changes in dietary behaviors, physical activity levels, and psychological well-being among children. Additionally, the study investigates the barriers and facilitators encountered during the implementation of these interventions, including socio-cultural factors, policy environments, and resource availability. The findings highlight the complex interplay between nutrition, physical activity, and mental health in shaping childhood obesity outcomes. Effective interventions often involve a comprehensive, multi-sectoral approach that addresses the underlying determinants of unhealthy behaviors and promotes holistic well-being. Key themes identified include the importance of community engagement, the need for culturally sensitive programming, and the integration of mental health support into obesity prevention efforts. By elucidating the impact of nutrition, physical activity, and mental health interventions on childhood obesity, this study contributes to the evidence base for designing and implementing effective strategies to combat this growing public health challenge.

Feasibility and preliminary effects of the Fit2ThriveMB pilot physical activity promotion intervention on physical activity and patient reported outcomes in individuals with metastatic breast cancer.

Physical activity research among patients with metastatic breast cancer (MBC) is limited. This study examined the feasibility and potential benefits of Fit2ThriveMB, a tailored mHealth intervention. Insufficiently active individuals with MBC (n = 49) were randomized 1:1 to Fit2ThriveMB (Fit2ThriveMB app, Fitbit, and weekly coaching calls) or Healthy Lifestyle attention control (Cancer.Net app and weekly calls) for 12weeks. Fit2ThriveMB aimed to increase daily steps via an algorithm tailored to daily symptom rating and step goal attainment. The primary outcome was feasibility defined as ≥ 80% completion rate. Secondary feasibility metrics included meeting daily step goal and wearing the Fitbit ≥ 70% of study days, fidelity, adherence to intervention features and safety. Secondary outcomes included physical activity, sedentary time, patient reported outcomes (PROs), health-related quality of life (QOL) and social cognitive theory constructs. A subsample (n = 25) completed functional performance tests via video conferencing. The completion rate was 98% (n = 1 died). No related adverse events were reported. Fit2ThriveMB participants (n = 24) wore the Fitbit 92.7%, met their step goal 53.1%, set a step goal 84.6% and used the app 94.1% of 84 study days. Intent-to-treat analyses indicated trends toward improvements in activity, QOL, and some PROs, social cognitive theory constructs, and functional performance tests favoring the Fit2ThriveMB group. Significant effects favoring Fit2ThriveMB were observed for self-efficacy and goal-setting. However, some PROs and functional performance improvements favored the control group (p-values > 0.05). Fit2ThriveMB is feasible and safe for patients with MBC and warrants further evaluation in randomized controlled trials with larger sample sizes. Registration Clinicaltrials.gov NCT04129346, https://clinicaltrials.gov/ct2/show/NCT04129346.