BackgroundEczema is a common inflammatory skin disease with a significant global health burden. Eczema has a significant impact on quality of life. ObjectiveWe aimed to estimate the prevalence, severity, and risk factors associated with eczema among schoolchildren in Saudi Arabia. MethodsUsing the standardized Global Asthma Network questionnaires and methodology, a nationwide cross-sectional study was carried out across 20 regions in Saudi Arabia between March and April 2019. Data were collected from 137 primary schools and 140 intermediate schools using a multistage stratified cluster sampling method. ResultsThe study included 3614 young children aged 6-7 years and 4068 adolescents aged 13-14 years. Current eczema was prevalent among 4.5% of children and 5.1% of adolescents. Severe eczema was reported in 0.8% and 0.9% of young children and adolescents, respectively. Several factors showed significant association with eczema. Among children, eczema was linked positively to having a history of chest infections and wheezing in early life as well as ever attending day care and current exposure to cats. Among adolescents, the main potential risk factors included paracetamol use in the previous year, adherence to a lifestyle of vigorous physical activity, and current exposure to cats. Conversely, high consumption of nuts was found to be negatively associated with eczema. ConclusionThe prevalence of eczema in schoolchildren in Saudi Arabia is lower than the global average but within the average range for the Eastern Mediterranean region. Further studies should be conducted in Saudi Arabia to identify variation among different regions.