Photostress Recovery Research Articles

An Arduino-Powered Device for the Study of White Perception beyond the Visual Chromatic Critical Flicker Fusion Frequency.

Arduino microcontrollers are used for a wide range of technological and biomedical applications, such as image classification, computer vision, brain-computer interaction and vision experiments. Here, we present a new cost-effective mini-device based on RGB LED flicker stimulation for the assessment of the chromatic temporal resolution of the visual function based on the concept of critical flicker fusion frequency (CFF). The assembly of the device and its testing in thirty young subjects demonstrate the steady white visual perception of a trichromatic flicker stimulus (mixture of red, green and blue stimuli) beyond the CFF. Macular function as measured by photo-stress recovery time (PRT) was found to be independent of the CFF measurements for red, green and blue lights. However, a statistical correlation was found between the contrast modulation for CFF for red and green stimuli and PRT. Finally, wavefront measurements demonstrate that high-order aberrations improve the temporal resolution of the visual function.

Correlation between color vision, visual acuity, contrast sensitivity and photostress recovery in the visually impaired: a cross-sectional study

Background: To investigate the correlation of colour vision, visual acuity, contrast sensitivity, and photostress recovery time test scores in visually impaired patients. Materials and methods: A total of 133 subjects were enroled and 133 eyes were examined. The pathological group consisted of 76 (57.1%) males with an average age of 68.0 (SD=13.2) and 57 (42.9%) females, with an average age of 68.1 (SD=15.2), Mann–Whitney U test was used to evaluate the differences in K-colour tests, HRR, visual acuity, Contrast Sensitivity test and photostress recovery time test between two different groups of severity. Results: Correlations were found among colour vision tests, visual acuity, contrast sensitivity, and photostress recovery time scores in eyes with age-related macular degeneration, with diabetic retinopathy, with optic nerve diseases, and various other retinal diseases (P<0.05). In patients with moderate-visual impairments. Conclusions: The colour vision test scores correlate with the scores of visual acuity, contrast sensitivity, and photostess recovery time test. It may be a useful clinical surrogate for functional vision.

THE EFFECTIVENESS OF USING SCREENS ON COMPUTER MONITORS AGAINST EYE MUSCLE FATIGUE OF EMPLOYEES AT THE AMBON CITY EDUCATION OFFICE IN 2023

Eye fatigue is a somatic disorder in the ciliary muscle of the eye that is forced to work to see close objects for long periods of time. Computers as electronic devices use electrical energy and electromagnetic radiation waves that are harmful to eye health. The installation of Antiglare Screen on a computer monitor is believed to reduce complaints of eye muscle fatigue so it needs to be reviewed for the effectiveness of its use. It is known the effectiveness of using screens on computer monitors to reduce eye muscle fatigue of employees at the Ambon City Education Office in 2023. Quantitative research design with quasy experiment method. Using Simple Random Sampling technique as many as 30 respondents. Data collection techniques using questionnaires and interventions using screen monitors measured by the photostress recovery test method. The measurement results are analyzed by the repeated-measured anova statistical test. The average prevalence value of eye muscle fatigue ≥ 50 seconds before the screen installation intervention on a computer monitor. After the intervention, post-measurement of 1 right eye on the fourth day amounted to 14.833 seconds, the OR value was 0.028, for the left eye it was 14.633 seconds, the OR value was 0.001. Post measurement-2 of the right eye on the sixth day of 26.367 seconds of OR value of 0.026, for the left eye of 25.533 seconds OR value 0.016. Furthermore, Post measurement-3 right eye on day 10 amounted to 35,200 seconds OR value -0.001, for left eye 35,700 seconds OR value -0.038. There was a difference in the average fatigue of the eye muscles in three post-measurements using the photostress recovery test method. Post-measurement variable-3 on day 10 of the intervention using a computer monitor screen had an effect on reducing eye muscle fatigue. The longer respondents use antiglare screen, the less eye muscle fatigue. Although there were respondents who had refractive errors, the use of screen monitors was effective in reducing fatigue of the right eye OR (-0.001) and left eye OR (-0.038). Computer users must have occupational safety and health awareness in using computers. Pay attention to the arrangement of the workspace and optimize eye rest time by occasionally turning your eyes to the green area filled with trees outdoors.

Maximal incremental exercise improves macular photostress recovery time and lowers intraocular pressure in healthy athletes

ObjectivesBetter visual performance in athletes compared to non-athletes could suggest improved macular function through physical exertion. The study aimed to investigate the effect of maximal incremental treadmill (MIT) exercise on macular function. DesignAn interventional study comparing the effect of maximal incremental treadmill (MIT) exercise until volitional exhaustion between athletes (n = 26) and non-athletes (n = 26). MethodsParticipants underwent an ophthalmological assessment involving repeated measurements of the photostress recovery time (PSRT) at baseline and post-exercise. PSRT was recorded after a 10-second exposure of the macular to an intense light source from an ophthalmoscope positioned 2 cm in front of the eye. Secondary outcome measures also recorded included the best-corrected visual acuity (BCVA) and the intraocular pressure (IOP). ResultsCompared to the baseline, MIT exercise markedly improved the PSRT of athletes from 42.7 ± 1.6 s to 39.6 ± 1.4 s (P < 0.001), while having no significant changes in the PSRT of non-athletes. After adjusting for exercise duration, the exercise intervention showed significant effects on the PSRT improvement in the athletes compared to non-athletes after exercise [F(1,49) = 16.941, P < 0.001], with estimated marginal means of 3.00 s and 0.47 s, respectively. Also, the exercise intervention resulted in significant improvements in IOP (P < 0.001) and BCVA (P < 0.01) of both groups. ConclusionsMIT exercise improves macular function, BCVA, and reduced IOP in healthy athletes. Maximal incremental exercise may be recommended for competitive sports athletes seeking optimal visual performance, as long as it does not adversely impact other relevant non-visual factors.

Effect of xanthophyll-rich food and supplement intake on visual outcomes in healthy adults and those with eye disease: a systematic review, meta-analysis, and meta-regression of randomized controlled trials

Xanthophyll intake is known to improve eye health; however, its benefits on visual outcomes have not been systematically studied, particularly in a population with eye diseases. A systematic review, meta-analysis, and meta-regression were conducted to investigate the effect of xanthophyll intake on visual outcomes, and further subgroup analysis was performed on the basis of eye disease status. The PubMed, Scopus, Embase, CINAHL, Cochrane, and Web of Science databases were searched, and relevant randomized controlled trials were identified. For systematic review, meta-analysis, and meta-regression, 43, 25, and 21 articles were selected, respectively. Xanthophyll intake enhanced macular pigment optical density (MPOD) for both heterochromatic flicker photometry (weighted mean difference [WMD], 0.05; 95% confidence interval [CI], 0.03-0.07) and autofluorescence imaging (WMD, 0.08; 95%CI, 0.05-0.11) measurements and decreased photostress recovery time (WMD, -2.35; 95%CI, -4.49 to -0.20). While enhancement in visual acuity logarithm of the minimum angle of resolution was observed in response to the xanthophyll-rich food and supplement intake only for patients with eye disease (WMD, -0.04; 95%CI, -0.07 to -0.01). Meta-regression showed a positive correlation between change in MPOD (heterochromatic flicker photometry) and the corresponding change in serum lutein levels (regression coefficient = 0.068; P = 0.00). Intake of xanthophyll-rich food or supplements can improve eye health. Additional improvement in visual acuity was observed in patients with eye disease. A positive association between MPOD and serum lutein level, while absent with dietary xanthophyll intake, suggests the importance of bioavailability when examining the effect of xanthophyll on eye health. PROSPERO registration no. CRD42021295337.

PERBEDAAN TINGKAT KELELAHAN MATA PADA MAHASISWA DENGAN GANGGUAN REFRAKSI DAN TANPA GANGGUAN REFRAKSI

Eye fatigue or asthenopia are symptoms that arise due to excessive use of the visual system that is in an imperfect condition to obtain visual acuity. Refractive error is one of the individual elements that affects eye fatigue. People with asthenopia have an accommodating reaction to refractive error. Eye fatigue is a condition that needs to be addressed because it can have a negative impact on a patient's quality of life. The purpose of this study was to determine the difference in the level of eye fatigue in medical students with refractive errors and without refractive errors at the Faculty of Medicine and Health Sciences, Warmadewa University. This research is an analytic observational study with a case control research design. Sampling was carried out in a total sampling with a total sample of 114 people, with total sample of 57 people in each case and control group. Data were obtained by measuring photostress recovery test (PSRT), checking visual acuity and consist of questionnaire.&#x0D; The results of the study on the subject of eye fatigue showed low eye fatigue level of 26.4%, moderate eye fatigue level of 40.4% and severe eye fatigue level of 35.1%. The results of the bivariate analysis using chi square test showed that there was a relationship between refractive errors and eye fatigue (p value = 0.000) and there were differences in the level of eye fatigue in students with and without refractive errors (p value = 0.01).&#x0D;

Effect of Cataract Extraction with Intraocular Lens Implant on Contrast Sensitivity, Colour Vision and Photostress Recovery Time

A cataract is a cloudy area in the lens of the eye that can lead to a reduction in vision and visual functions. This study was a clinical study aimed at determining the effect of cataract extraction with intraocular lens (IOL) implant on contrast sensitivity, color vision and photostress recovery time. A total of 70 patients who visited Ajeromi General Hospital, Lagos, Nigeria were used for the study. Contrast sensitivity was assessed using the Pelli-Robson contrast sensitivity chart. The colour vision of the subjects was assessed using Ishihara Pseudochromatic colour vision chart and the photostress recovery time was assessed using a bright ophthalmoscope light. Results showed that the mean contrast sensitivity of the subjects before cataract extraction with IOL implant was 1.04±0.08. After cataract extraction, the mean was 2.19±0.07. The mean colour vision test value before cataract extraction with IOL implant was 14.41±0.53. After cataract extraction, the mean was 16.00±0.00. The mean Photostress Recovery Time before cataract extraction with IOL implant was 55.77±1.81 seconds. After cataract extraction, the mean was 29.11±0.83 seconds. SPSS data analysis with the Paired sample T-Test at 0.05 level of significance showed a significant improvement (P&lt;0.05) in contrast sensitivity, color vision and photostress recovery time before and after cataract extraction with IOL implant. It was recommended that all patients with monocular and bilateral cataract be referred for cataract extraction with intraocular lens (IOL) implant. Keywords: Cataract, Intraocular lens, Contrast sensitivity, Color vision, Photostress recovery time

Photostress Recovery Time as a Potential Predictive Biomarker for Age-Related Macular Degeneration.

The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort. We analyzed photostress recovery time (PRT) and AMD in >1800 AugUR study participants aged 70+ years. On color fundus images from baseline and 3-year follow-up, presence of AMD was graded manually (Three Continent AMD Consortium Severity Scale). Visual acuity (VA) was assessed via Early Treatment Diabetic Retinopathy Study (ETDRS) charts. After a 30-second bleaching of the macular region via direct ophthalmoscope, PRT was measured as the seconds to regain VA. First, we analyzed 1208 AugUR participants cross-sectionally (288 with early AMD, and 78 with late AMD). Prolonged PRT was associated with early and late AMD versus no AMD (median PRT = 119.5, 198.0 versus 80.0 seconds, respectively; logistic regression odds ratio [OR] = 1.109-1.165 per 10 seconds, P values < 0.0001). Sensitivity analyses using alternative models or restricting to participants after cataract surgery revealed similar ORs. Second, the association was confirmed in an independent cross-sectional AugUR sample (n = 486). Third, in longitudinal analysis of 233 AugUR participants without AMD, prolonged PRT was associated with incident AMD ascertained 3 years later (follow-up time = 3.2 ± 0.2 years, OR = 1.112-1.162 per 10 seconds, P < 0.05). Overall, we demonstrate a significant association of prolonged PRT with AMD cross-sectionally and longitudinally in elderly individuals. Prolonged PRT might capture retinal function impairment after cell damage before early AMD is visible via color fundus imaging. Our results suggest PRT as quantitative predictive biomarker for incident AMD, making it potentially worthwhile also for clinical care.

Photostress Recovery Time after Flash-Lighting Is Increased in Myopic Eyes

Background: It is well-known that non-pathological axial myopic eyes present physiological and functional differences in comparison with emmetropic eyes due to altered retinal anatomy. Photostress tests have shown very significant capabilities to discriminate a normal retina from an abnormal retina. Accordingly, the aim of this work was to investigate the differences between myopic and emmetropic eyes in the measured photostress recovery time (PSRT) after retinal light-flashing in a population of young healthy subjects. Methods: A coaxial illumination total disability glare instrument was employed to measure the recovery time after photostress was induced by a 240 milliseconds flash-lighting (535 nm) exposure on 66 myopic and 66 emmetropic eyes. The measurements were carried out for different combinations of glare angles and contrasts of the visual stimuli. Results: In general terms, PSRT in myopic eyes was found at a statistically higher than in emmetropic eyes (Bonferroni correction). For both groups, the measured recovery strongly depends on the contrast of the test object used to measure baseline recovery function and markedly less on the source of glare angles explored. When the PSRTs obtained for different glare angles are averaged, the differences between PSRTs drastically increase with the reduction in the contrast of the stimuli between both groups of study. Conclusions: PSRT is higher for myopic than for young healthy emmetropic eyes (1.2 s and 0.2 s for 5% and 100% contrast test object, respectively). Though seemingly small, the magnitude of this finding can be relevant when flash-lighting happens while driving a car or while performing actions where the reaction time after a visual stimulus can be critical.

Exploration of fluoroquinolone-induced retinal pigment epithelium layer changes in the pathogenesis of macular degeneration

PurposeFluoroquinolone toxicity studies in animals (cats, rabbits and mice) showed that acute retinal degenerations appear clinically related to phototoxicity. The aim of this study was to evaluate the association between the administration of oral fluoroquinolone and the onset of clinically or subclinically detectable acute retinal degeneration in humans. Material and MethodsThis study included patients that received oral fluoroquinolone treatment (ciprofloxacin, levofloxacin or moxifloxacin) for variable systemic diseases diagnosed by the Department of Urology and Infectious Diseases (study group, n=76), and age and sex matched otherwise healthy subjects (control group, n=50). All the subjects underwent a detailed ophthalmologic examination including tests for visual acuity, intraocular pressures, color vision, photostress recovery time and contrast sensitivity measurements, central foveal thickness, subfoveal choroidal thickness, ganglion cell complex thickness and 10/2 Humphrey visual field test. Color fundus and fundus autofluorescence photographs were also obtained. Examinations and tests were repeated at 1st week and 1st month in the study group. ResultsThere was no statistically significant difference among visual acuity, intraocular pressure, photostress recovery time, color vision, contrast sensitivity measurements, central foveal thickness, subfoveal choroidal thickness, average ganglion cell complex thickness, superior ganglion cell complex thickness, inferior ganglion cell complex thickness, focal loss volume, global loss volume, mean deviation, pattern standard deviation values in treatment group at baseline, 1st week and 1st month (p > 0.05, for the comparison of each parameters). There was not any alteration among color fundus and fundus autofluorescence photographs obtained at baseline, 1st week and 1st month in treatment group. All parameters within the study and control groups were similar throughout the study period (p > 0.05, for the comparison of each parameter). ConclusionThis study evaluated the association between the administration of oral fluoroquinolone and the onset of acute retinal degeneration. Preliminary results of this study showed that use of oral fluoroquinolone had no detectable impact on retinal degeneration at acute phase.

Design of a novel smartphone-based photostress recovery time test for detecting abnormalities in the macula. A cross-sectional study

BackgroundThe study aims to present a new smartphone-based photostress recovery time test (K-PSRT test) that measures the stimulus-specific loss of visual sensitivity, as well as the differentiation between normal from abnormal macular function. This novel test defines a new standardized photostress application as an alternative tool for incorporation into clinical practice. Materials and methodsA total of 48 visually impaired eyes and 47 normal sighted age-matched controls eyes were enrolled in the study. The median age in subjects with impairment was 71.0 years, while the median age in normal subjects was 70.0 years. A light produced by the smartphone camera at approximately 5 cm distance, perpendicular to the eye up 10 s filled the pupil. The photostress recovery time was assessed immediately after the exposure by asking the subjects to read correctly at least three successive letters of size corresponding to the previous line of the BCVA line at a distance of 40 cm. The digital photostress testing was performed with the best-corrected visual acuity (BCVA). The patients were examined twice within 2 weeks. Correlations among the recovery times, the visual acuity, and the contrast sensitivity function as well as correlations concerning each specific ocular disease were also performed. Furthermore, correlations among technology, usability, and ease of performance in both groups were analyzed. ResultsThe initial median photostress recovery time in patients with impaired eyes was 83.5 (68.5, 126.0), while in the normal individuals was 39.0 (14.0, 43.0). The median visual acuity in individuals with impairment was 0.59 logMAR (0.40, 0.90), whereas in the normal individuals was −0,06 logMAR. Test-retest reliability study was performed on 26 eyes (16 males, 10 females) for visually impaired eyes as well as on 35 normal eyes (19 males, 16 females). Concerning the reliability, the average Intraclass Correlation Coefficients (with 95% confidence intervals) ICC (95% CI) = 0,99 (0,98–1,00), indicating significant correlation between them (p < 0.01). The coefficient of repeatability for eye measurements reaches clinically acceptable levels, which is demonstrated with increased repeatability and consistency. The recovery time in patients with diabetic retinopathy was statistically significantly lower than in those with dry age-related macular degeneration (p = 0.027) and those with wet age-related macular degeneration (p = 0.032). The patient group has lower scores concerning technology, usability, and ease of performance compared to the normal. ConclusionsThis new testing modality (K-Photostress Recovery time test), is designed to be an easily implemented measurement in ophthalmic practice, and it can expand our understanding of macular function. The above findings support the usefulness of a novel reproducible photostress application as an indicator of macular pathology.

PHOTOSTRESS RECOVERY TIME IN A DEFINED NIGERIAN POPULATION

In a randomized visual screening exercise carried out in Oredo Local Government area of Edo State, weinvestigated the Photo Stress Recovery Time (PSRT) of two hundred volunteers with age ranging from 11 to 70 (mean age of 33.30 ± 12.74years). Each subject was adapted to the ambient room lighting for 5minutes thereafter a flashlight was shone into the eye for 10 seconds; PRST was assessed immediately after the 10 seconds. Results indicated that the mean PSRT distribution in the sample population ranged from10.34 ± 4.21seconds to 46.98 ± 15.83seconds for all the age groups, with males having a slightly higher PSRT than females in all the age groups except the presbyopic age group. There was a positive relationship between age and PSRT which was highly significant (r = 0.96) with a linear regression equation of PSRT = 0.785 + 0.60(age). The maximum percentage mean differencein PSRT was 27.46± 1.83%. In conclusion therefore, this study has been able to establish age related PSRT scores in a definedhealthy Nigerian population thatmay serve as a quick reference for comparing normal physiological PSRT values and PSRT values arising from impending retinal/macular lesions.

EVO+ Implantable Collamer Lens KS-aquaPORT Location, Stability, and Impact on Quality of Vision and Life.

To determine the longitudinal variation in the KS-aquaPORT central hole location of the phakic EVO+I Implantable Collamer Lens (ICL) (STAAR Surgical) and analyze its influence on visual performance, quality of vision (QoV), and quality of life (QoL). A prospective study was performed including 36 patients who had EVO+ ICL implantation. The KS-aquaPORT central hole location (Cartesian and polar coordinates) was determined with respect to the pupil center and visual axis. The effect of time (6-month follow-up) on central hole location was analyzed using linear mixed models. The effect of the KS-aquaPORT location on visual performance, QoV, and QoL parameters was assessed with multivariate regression models. With respect to the visual axis, no significant changes in KS-aquaPORT location were found during follow-up. With respect to the pupil center, the X-coordinate and radius of KS-aquaPORT location showed modest, but significant (P ≤ .05) differences between 1-week and 3-month postoperative visits, and between 1-week and 6-month visits. X-coordinate variation was significant (P = .022) between 1-and 6-month visits. With respect to the visual axis, greater KS-aquaPORT decentration was associated with worse visual acuity (X-coordinate: P = .004; radius: P = .006), and inferior decentration with longer xenon-type glare photostress recovery time (P = .021). With respect to the pupil center, a lower radius was associated with better QoV scores (P ≤ .01) and temporal decentration produced higher ring-shaped dysphotopsia (P = .007). EVO+ ICL KS-aquaPORT location appears to be clinically stable up to 6 months postoperatively. A central location of the EVO+ ICL KS-aquaPORT hole is preferred because it allows reduced perception of dysphotopic phenomena that can result in better QoV. [J Refract Surg. 2022;38(3):177-183.].

Macular Pigment Response to Lutein, Zeaxanthin, and Meso-zeaxanthin Supplementation in Open-Angle Glaucoma: A Randomized Controlled Trial

PurposeTo evaluate macular pigment response to carotenoid supplementation in glaucomatous eyes.DesignDouble-masked, randomized, placebo-controlled clinical trial, the European Nutrition in Glaucoma Management Study (ClinicalTrials.gov identifier, NCT04460365).ParticipantsSixty-two participants (38 men, 24 women) with a diagnosis of open-angle glaucoma were enrolled. Forty-two were randomized to receive the active supplement, 20 participants were allocated to placebo.MethodsMacular pigment optical density (MPOD) was measured by autofluorescence using the Heidelberg Spectralis scanning laser ophthalmoscope. Macular pigment optical density volume within the central 6° of retinal eccentricity as well as MPOD at 0.23°, 0.51°, 0.74°, and 1.02° were recorded at baseline and at 6-month intervals over 18 months. Visual function was assessed using visual acuity, mesopic and photopic contrast sensitivity under glare conditions, photo stress recovery time, microperimetry, and Glaucoma Activities Limitation 9 questionnaire. Advanced glaucoma module scans of retinal nerve fiber layer thickness and ganglion cell complex thickness over the central 6° of retinal eccentricity also were completed at each study visit.Main Outcome MeasuresChange in MPOD after supplementation with 10 mg lutein, 2 mg zeaxanthin, and 10 mg meso-zeaxanthin or placebo over 18 months.ResultsA mixed-model repeated measures analysis of variance revealed a statistically significant increase in MPOD volume (significant time effect: F(3,111) = 89.31, mean square error (MSE) = 1656.9; P < 0.01). Post hoc t tests revealed a significant difference in MPOD volume at each study visit for the treatment group (P < 0.01 for all), but no change in the placebo group (P > 0.05 for all). A statistically significant increase in mesopic contrast sensitivity under glare conditions was noted at 18 months in the treatment group, but not placebo. No other structural or functional changes were observed. No serious adverse events were noted during the trial.ConclusionsMacular pigment can be augmented in glaucomatous eyes by supplementation with a formulation containing the carotenoids lutein, zeaxanthin, and meso-zeaxanthin. The greatest relative benefit was observed in those with the lowest baseline levels, but increases were noted across all participants and each retinal eccentricity. The potential benefits of MP augmentation for macular health in glaucoma merit further long-term evaluation.

Photostress Recovery Time Among Welders in Owerri Municipal Council, Southeast, Nigeria

Purpose: The photostress recovery time (PSRT) scores of welders were measured based on age, workexperience and welding-method.Methods: A quasi-experimental study was conducted among 50 purposively sampled welders, who had clear ocular media, healthy fundi and visual acuities of 6/6 or better in the tested eyes. The pre-bleach distant visual acuity of the right eye was determined with the Snellen’s visual acuity chart, while direct ophthalmoscopy was done to rule out media opacities, retinopathies and maculopathies. The right eye was dazzled for 10 seconds with the light of a direct ophthalmoscope held at 2cm from the eye. The time required in seconds to read at least, three optotypes on the line directly above the baseline acuity was recorded as the PSRT.Results: The 22-31 years age group recorded the least mean PSRT (16±8.8seconds), followed by the 32-41 age group (19.9±6.8 seconds), while the 42-51 years category had the highest mean PSRT (31.4±10.5seconds). Age associated significantly (p˂0.05) with mean PSRT. Welders within the 1-12 years’ work experience had the least mean PSRT (15.9±8.1seconds) while those within the 25-36 years recorded the highest mean PSRT (33.4±9.3seconds). The observed difference in mean PSRT with years of work experience was statistically significant (p˂0.05). Gas welders had significantly (p˂0.05) higher mean PSRT (26.6±9.9secs) than electric arc welders (16.6±9.2secs).Conclusion: Gas welding, increasing age and work-experience were found to be predictive markers of elevated photostress recovery time (PSRT) among welders. This underscores the need for eye-care practitioners to routinize PSRT tests in the ocular assessment of welders.&#x0D; Keywords: Photostress recovery time (PSRT); electric-arc; gas welding; welders; age.

Effect of the EVO+ Visian Phakic Implantable Collamer Lens on Visual Performance and Quality of Vision and Life

To assess the effect of EVO+ (V5) Visian implantable collamer lens implantation on mesopic visual performance, quality of vision (QoV), and quality of life (QoL). Prospective interventional case series. Thirty-six eyes of 36 participants who underwent EVO+ implantation for myopia were evaluated preoperatively and at postoperative visits at 1 week and 1, 3, and 6 months. Visual acuity (VA) and mesopic contrast sensitivity (CS) with and without halogen- and xenon-type glare sources were evaluated at each visit. Subjective QoV was assessed with the QoV questionnaire and QoL assessed with the Quality of Life Impact of Refractive Correction (QIRC) questionnaire at each visit. Ring-shaped dysphotopsia was also assessed at each postoperative visit. Linear, cumulative link and logit mixed models were fitted to analyze the effect of the EVO+. Following EVO+ implantation, VA significantly (P ≤ .012) improved at the 4 postoperative visits. Mesopic CS progressively improved at 1, 3, and 6 months postoperatively (P ≤ .012). Halogen glare CS decreased at 1 week and halogen and xenon glare CS improved at 6 months (P ≤ .016). Photostress recovery time after halogen glare improved at 3 and 6 months (P ≤ .004). QoV scores improved at 1 week and 3 and 6 months (P ≤ .001). QIRC scores improved postoperatively (P < .001). Ring-shaped dysphotopsia decreased at 3 and 6 months (P ≤ .007). EVO+ implantation provides good mesopic visual performance, QoV, and QoL during up to 6 months follow-up. Some activities performed under mesopic conditions with glare sources may be affected during the first postoperative week. Ring-shaped dysphotopsia is negligibly bothersome 6 months after surgery.

Relationship of Sighting Ocular Dominance with Macular Photostress Test Time and Thickness of the Middle Macular Layers.

The mechanisms of sighting ocular dominance, which is particularly important in monovision therapies and sports vision, are not fully understood yet. Whether the macula affects ocular dominance or ocular dominance affects the macula is also a subject of interest. The aim of this study was to investigate the relationship of sighting ocular dominance with macular photostress test time and middle macular layer thickness. One-hundred eyes of 50 healthy adult volunteers were included in this cross-sectional study. Sighting eye dominance was decided by a hole-in-the-card test. The macular photostress test was performed by exposing the eye to the ophthalmoscope light for 10 seconds and measuring the time taken to return to visual acuity within one row of pre-light exposure acuity. The spectral-domain optical coherence tomography examinations were performed to measure thickness of middle macular layers (i.e., outer nuclear, outer plexiform, inner nuclear, and inner plexiform). Refractive error and intraocular pressure (IOP) measurements were also recorded. The comparison of dominant and nondominant eyes in the aspect of refractive error, IOP, and macular photostress test time did not show statistically significant differences (P > .05). The thicknesses of macular outer nuclear, outer plexiform, inner nuclear, and inner plexiform layers were similar in the dominant and nondominant eyes (P > .05). In addition, macular photostress time was not statistically significantly correlated with the thickness of middle macular layers (P > .05). The thickness of middle macular layers and macular photostress recovery time are similar in dominant and nondominant eyes.

Disability glare and nighttime driving performance among commercial drivers in Ghana.

ObjectiveGlare caused by the headlights of on‐coming vehicles risk safe driving at night. The study aimed to determine the relationship between glare exposure and nighttime driving performance among commercial drivers in Ghana.MethodsThis cross‐sectional study involved commercial drivers with complaints of nighttime driving difficulties (N = 80; mean age = 41.5 ± 11.1 years). A questionnaire was used to investigate nighttime driving performance following glare exposure. We measured contrast sensitivity and visual acuity under photopic conditions. With an experimental setup in a mesopic setting, we measured visual acuity with and without glare exposure. The difference between the two mesopic visual acuities was quantified as disability glare index. With the same setup, photostress recovery time was also measured. Regression analyses were used to determine the relationship between nighttime driving performance score and the measures taken in both photopic and mesopic settings.ResultsThe average nighttime driving performance score was 47.8 ± 17.5. Driving performance was negatively correlated with all variables (R = –0.87 to –0.30, all p < .01), except contrast sensitivity (R = 0.74, p < .01). A multiple linear regression showed that the model with all variables explained 83.8% of the variance, but only disability glare index was a significant predictor of nighttime driving performance following glare exposure (standardized B = –0.61, p < .01).ConclusionOur results show that the change in mesopic visual acuities following glare can predict nighttime driving performance. This measure can be incorporated into the assessment of driving fitness by licensing departments to evaluate whether a person can drive safely at night amidst glare exposure.

The Effect of Blue-blocking Lenses on Photostress Recovery Times.

The selective reduction in visible wavelengths transmitted through commercially available blue-blocking lenses (BBLs) is known to influence the appearance and contrast detection of objects, particularly at low light levels. This influence may impair the human retinal receptor response time to dynamic light changes during photostress events. This study aimed to assess whether BBLs selectively affect photostress recovery times (PSRTs) for chromatic and achromatic stimuli of different Weber contrasts that were viewed on a dark black background. Photostress recovery times were measured in 12 younger participants (18 to 39 years old) with no history of ocular disease or abnormal vision. Photostress recovery times were evaluated for four brands of BBLs, which were compared with a control lens. In these experiments, after exposure to an intense light source for 5 seconds, the time taken to recover vision and correctly identify a computer-generated letter stimulus viewed under low and high luminance levels was determined, which means perception is likely to be governed by mesopic and photopic conditions. Across conditions, the letter stimulus was achromatic and chromatic and could differ in luminance contrast. Under photopic stimulus conditions, although reducing luminance contrast increased PSRTs, BBLs had no significant effect on PSRTs relative to control lens. However, under mesopic stimulus conditions, BBLs significantly affect PSRTs for both achromatic (F2.006,8.02 = 61.95, P < .0001) and chromatic stimuli (F3,16 =139.01, P < .0001), particularly for blue targets, which had considerably longer PSRTs (38.40 seconds). The brand of BBL was also shown to selectively affect PSRTs, with those with transmittance profiles that block the most blue light having longer PSRTs. The present study suggests that, although the color and contrast of the target stimuli affected recovery times, the difference in recovery times between different types of BBLs was noticed only under low-light-level stimulus conditions.

Contrast-Sensitivity Function and Photo Stress-Recovery Time in Prediabetes.

PurposeThe purpose of this study was to assess contrast sensitivity and macular function test in prediabetes.MethodsParticipants aged 25–45 years with or without diabetes were enrolled and classified as normal, prediabetic, and diabetic based on their HbA1C values. They underwent a comprehensive eye examination, and those with diabetic retinopathy, cataract, glaucoma, and high myopia were excluded. Participants with best-corrected visual acuity of 0 logMAR were included. Contrast-sensitivity function (CSF) was measured using a Pelli–Robson chart, and photo stress–recovery time (PSRT) assessed using direct ophthalmoscopy for the 70 eligible participants. Mean values were compared among the three groups.DesignThis was a cross-sectional observational study.ResultsIn the 70 participants, mean CSF was 1.71±0.10, 1.64±0.11, and 1.61±0.08 log units in the normal, prediabetic, and diabetic groups, respectively (p<0.001). Similarly, PSRT was found to be 35.80 seconds, 41.63 seconds, and 47.77 seconds in the normal, prediabetic, and diabetic groups, respectively (p<0.001).ConclusionThe data suggested that reduced CSF and delayed PSRT seen in subjects with prediabetes could give valuable clinical insight into early changes before diabetes and microvascular damage is incurred. A future study with a larger sample could help substantiate the results.