Contrast-Sensitivity Function and Photo Stress-Recovery Time in Prediabetes.

Abstract

PurposeThe purpose of this study was to assess contrast sensitivity and macular function test in prediabetes.MethodsParticipants aged 25–45 years with or without diabetes were enrolled and classified as normal, prediabetic, and diabetic based on their HbA1C values. They underwent a comprehensive eye examination, and those with diabetic retinopathy, cataract, glaucoma, and high myopia were excluded. Participants with best-corrected visual acuity of 0 logMAR were included. Contrast-sensitivity function (CSF) was measured using a Pelli–Robson chart, and photo stress–recovery time (PSRT) assessed using direct ophthalmoscopy for the 70 eligible participants. Mean values were compared among the three groups.DesignThis was a cross-sectional observational study.ResultsIn the 70 participants, mean CSF was 1.71±0.10, 1.64±0.11, and 1.61±0.08 log units in the normal, prediabetic, and diabetic groups, respectively (p<0.001). Similarly, PSRT was found to be 35.80 seconds, 41.63 seconds, and 47.77 seconds in the normal, prediabetic, and diabetic groups, respectively (p<0.001).ConclusionThe data suggested that reduced CSF and delayed PSRT seen in subjects with prediabetes could give valuable clinical insight into early changes before diabetes and microvascular damage is incurred. A future study with a larger sample could help substantiate the results.