The topological magnetoelectric effect is associated with the photonic spin-orbit interaction. However, due to the proportionate fine structure constant of the topological term, the topological magnetoelectric effect is usually weak. In this paper, we demonstrate that the axion term enables manipulation of the spin Hall shift of light around Fano resonance. And, the excited surface plasmon near the nanoparticle's interface could enhance the topological magnetoelectric effect for several orders. Numerical simulation of near field and far-field scattering confirms our theoretical results. Our work may pave the way to exploit the topological magnetoelectric effect in practical applications, such as optical sensing and nanoprobing.