To solve the problem of the long execution time of the traditional thermalenergy feedback regulation mechanism of human life system, a method ofanalyzing the thermal energy feedback regulation mechanism of human lifesystem based on photonic radiation was proposed. The energy responseentropy of human living system is calculated by analyzing the change ofhuman living system’s thermal energy. The photonic counter is designedby using photonic radiation technology to extract the weak optical signal ofthermal energy of the system and output energy accumulation. The quadraticprogramming algorithm is used to solve the optimal solution of thermalenergy, and the neural network model is combined with the energy accu-mulation of photon counter to realize the thermal feedback regulation. So far,the design of energy feedback regulation mechanism of human living systemhas been completed. The experimental results show that compared withthe traditional feedback control mechanism, the designed energy feedbackcontrol mechanism based on photonic radiation has a shorter implementationtime and is suitable for practical engineering.