Photon Beam Research Articles

Enhancing Precision in L-band Electron Paramagnetic Resonance Tooth Dosimetry: Incorporating Digital Image Processing and Radiation Therapy Plans for Geometric Correction.

Following unforeseen exposure to radiation, quick dose determination is essential to prioritize potential patients that require immediate medical care. L-band electron paramagnetic resonance tooth dosimetry can be efficiently used for rapid triage as this poses no harm to the human incisor, although geometric variations among human teeth may hinder accurate dose estimation. Consequently, we propose a practical geometric correction method using a mobile phone camera. Donated human incisors were irradiated with calibrated 6-MV photon beam irradiation, and dose-response curves were developed by irradiation with a predetermined dose using custom-made poly(methyl methacrylate) slab phantoms. Three radiation treatment plans for incisors were selected and altered to suit the head phantom. The mean doses on tooth structures were calculated using a commercial treatment planning system, and the electron paramagnetic resonance signals of the incisors were measured. The enamel area was computed from camera-acquired tooth images. The relative standard uncertainty was rigorously estimated both with and without geometric correction. The effects on the electron paramagnetic resonance signal caused by axial and rotational movements of tooth samples were evaluated through finite element analysis. The mean absolute deviations of mean doses both with and without geometric correction showed marginal improvement. The average relative differences without and with geometric correction significantly decreased from 21.0% to 16.8% (p = 0.01). The geometric correction method shows potential in improving dose precision measurement with minimal delay. Furthermore, our findings demonstrated the viability of using treatment planning system doses in dose estimation for L-band electron paramagnetic resonance tooth dosimetry.

Dichroism Effects in the Ionization of Polarized Atoms by Short Circularly Polarized Laser Pulses

The dichroism effects, i.e., asymmetries of the ionization probability with respect to the inversion of either the atomic orientation (magnetic dichroism, MD) or the circular polarization degree of the photon beam (circular dichroism, CD), are investigated using the time-dependent perturbation theory (PT). It is shown that the magnitude of these effects depends not only on the polarization states of the atom and laser pulse but also on the intensity and duration of the latter. We find that the CD can also be observed in the ionization of oriented initial bound states, which is impossible in long-pulse ionization. Predictions of our PT analysis are supported by the results obtained by numerical solutions of the time-dependent Schrödinger equation (TDSE) describing the ionization of the excited 2P-states of the hydrogen atom.

Adapting a practical EPR dosimetry protocol to measure output factors in small fields with alanine.

Modern radiotherapy techniques often deliver small radiation fields. In this work, a practical Electron Paramagnetic Resonance (EPR) dosimetry protocol is adapted and applied to measure output factors (OF) in small fields of a 6 MV radiotherapy system. Correction factors and uncertainties are presented and OFs are compared to the values obtained by following TRS-483 using an ionization chamber (IC). Irradiations were performed at 10cm depth inside a water phantom positioned at 90cm source to surface distance with a 6 MV flattening filter free photon beam of a Halcyon radiotherapy system. OFs for different nominal field sizes (1×1, 2×2, 3×3, 4×4, normalized to 10×10 cm2 ) were determined with a PinPoint 3D (PTW 31022) IC following TRS-483 as well as with alanine pellets with a diameter of 4mm and a height of 2.4mm. EPR readout was performed with a benchtop X-band spectrometer. Correction factors due to volume averaging and due to positional uncertainties were derived from 2D film measurements. OFs obtained from both dosimeter types agreed within 0.7% after applying corrections for the volume averaging effect. For the used alanine pellets, volume averaging correction factors of 1.030(2) for the 1×1 cm2 field and <1.002 for the larger field sizes were determined. The correction factor for positional uncertainties of 1mm was in the order of 1.018 for the 1×1 cm2 field. Combined relative standard uncertainties uc for the OFs resulting from alanine measurements were estimated to be below 1.5% for all field sizes. For IC measurements, uc was estimated to be below 1.0%. A practical EPR dosimetry protocol is adaptable for precisely measuring OFs in small fields down to 1×1cm2 . It is recommended to consider the effect of positional uncertainties for field sizes <2×2cm2 .

A highly-compact and ultra-fast homogeneous electromagnetic calorimeter based on oriented lead tungstate crystals

Progress in high-energy physics has been closely tied to the development of high-performance electromagnetic calorimeters. Recent experiments have demonstrated the possibility to significantly accelerate the development of electromagnetic showers inside scintillating crystals typically used in homogeneous calorimeters based on scintillating crystals when the incident beam is aligned with a crystallographic axis to within a few mrad. In particular, a reduction of the radiation length has been measured when ultrarelativistic electron and photon beams were incident on a high-Z scintillator crystal along one of its main axes. Here, we propose the possibility to exploit this physical effect for the design of a new type of compact e.m. calorimeter, based on oriented ultra-fast lead tungstate (PWO-UF) crystals, with a significant reduction in the depth needed to contain electromagnetic showers produced by high-energy particles with respect to the state-of-the-art. We report results from tests of the crystallographic quality of PWO-UF samples via high-resolution X-ray diffraction and photoelastic analysis. We then describe a proof-of-concept calorimeter geometry defined with a Geant4 model including the shower development in oriented crystals. Finally, we discuss the experimental techniques needed for the realization of a matrix of scintillator crystals oriented along a specific crystallographic direction. Since the angular acceptance for e.m. shower acceleration depends little on the particle energy, while the decrease of the shower length remains pronounced at very high energy, an oriented crystal calorimeter will open the way for applications at the maximum energies achievable in current and future experiments. Such applications span from forward calorimeters, to compact beam dumps for the search for light dark matter, to source-pointing space-borne γ-ray telescopes, to decrease the size and the cost of the calorimeter needed to fully contain e.m. showers initiated by GeV to TeV particles.

Proof-of-concept of proton and photon measurements for large-area 2D dosimeters utilising optically stimulated luminescence

Reusable high-resolution 2D dosimeters have a great potential for radiotherapy verification and quality assurance, not least due to the reduced cost and simpler calibration procedures implied by reusability. We have performed proof-of-concept measurements in both photon and proton beams with a reusable 2D dosimeter (5×7 cm2; 1 mm thickness) based on optically stimulated luminescence, using a readout setup scalable to 3D. Our data indicated a strong linear-energy-transfer quenching for this type of dosimeter.

Sulfur speciation in dacitic melts using X-ray absorption near-edge structure spectroscopy of the S K-edge (S-XANES): Consideration of radiation-induced changes and the implications for sulfur in natural arc systems

Abstract The synchrotron technique of micro X-ray absorption near-edge structure spectroscopy at the sulfur K-edge (S-XANES) provides a unique opportunity to measure the proportion of different oxidation states of sulfur (S) in silicate glasses. Although applied extensively in the analysis of basaltic silicate glasses, few S-XANES studies have investigated variations in S oxidation states with fO2 in felsic silicate glasses. In addition, no study has systematically compared the S-XANES results obtained from the same samples at different photon flux densities to quantify the relationship between exposure time and changes in S speciation in silicate glass, as has been done for Fe and V. This study evaluates observed differences in S speciation measured in experimentally produced H2O-saturated dacitic glasses over a range of reducing to oxidizing conditions (from log fO2 = ΔFMQ-0.7 to ΔFMQ+3.3; FMQ is the fayalite-magnetite-quartz mineral redox buffer) and equilibrated at 1000°C and 300 MPa. S-XANES spectra were collected at three different photon flux densities using three microspectroscopy beamlines. As is observed in S-XANES analyses of basaltic silicate glasses, beam-induced changes to the S6+/ΣS are observed as a function of photon flux density and beam exposure time. Our results demonstrate that silicate glasses of dacitic composition undergo beam-induced photo-reduction in samples equilibrated at ΔFMQ &amp;gt; +1.75 and photo-oxidation if equilibrated at ΔFMQ &amp;lt; +1. The time required to observe beam-induced changes in the spectra varies as a function of flux density, and our study establishes an upper photon density limit at ~1.0 × 1012 photons/μm2. The S6+/ΣS calculated from spectra collected below this absorbed photon limit at intermediate flux densities (~1−4 × 109 photons/sec per μm2) are affected by beam damage, as no conditions were found to be completely free of beam-induced changes. However, the S6+/ΣS ratios calculated below the limit at intermediate flux densities are consistent with thermodynamic constraints, demonstrating that S6+/ΣS ratios calculated from S-XANES spectra can be considered reliable for estimating the oxygen fugacity. Our results carry important implications for the S budget of felsic magmas and dissolution mechanisms in evolved melts. While our results from all three flux densities show the presence of S4+ dissolved in relatively oxidized (ΔFMQ &amp;gt; +1.75) dacitic glass, even in the spectra exposed to the lowest photon densities, we are unable to rule out the possibility that the S4+ signal is the result of instantaneous X-ray irradiation induced beam damage using S-XANES alone. When our spectra are compared to S-XANES spectra from basaltic silicate glasses, important differences exist in the solubility of S2- and S6+ between dacitic silicate melts, pointing to differences in solubility mechanisms as melt composition changes. This study highlights the need for further investigation into beam damage systematics, presence of S4+, and the solubility mechanisms of different oxidation states of S as silicate melt composition changes.

The role of standards laboratories in reducing uncertainty in clinical dosimetry: A Canadian perspective

As a National Metrology Institute, the National Research Council Canada (NRC) provides confidence in measurement results, and data traceable to SI units. This paper outlines some of the ways that the NRC contributes to reducing measurement uncertainty in clinical medical physics dosimetry. These activities include, (i) the improvement of existing primary standards and traceability for established beam modalities, such as MV photon and electron beams; (ii) improving measurement accuracy for new beam modalities through the development of transportable systems which permit operation at the user’s facility; (iii) contributing to new dosimetry protocols, best practice reports and educational outreach; and (iv) supporting the verification of clinical implementation by offering dosimetry auditing capabilities through coordination with the clinical medical physics community.

Characterization of a water-based liquid scintillator for use in megavoltage radiotherapy beams

The measurement of the dose delivered in radiotherapy treatments is carried out using dosimeters that are often expensive to produce and sometimes toxic to humans and the environment, which leads to more complex and rigorous clinical manipulations. It is in this context that it is necessary to provide new types of scintillators that would no longer have these problems while having properties equivalent to those of human tissues. Thus, the following study presents the performance of a water-based liquid scintillator used at radiotherapy energies. The characteristics studied include the proportionality of the scintillation signal to the dose, the scintillation efficiency at two different energies as well as the identification of the Cherenkov portion of the signal for photon beams of 180 kVp, 6 MV as well as 18 MV. Spectral measurements of the scintillation solution and a solution of distilled water were acquired in order to isolate the contribution of the scintillation signal from the spectrum obtained, and then compared to a commercial scintillator, Ultima Gold. The signal exhibits a linear dose relationship with a correlation coefficient of 0.999 and lower scintillation efficiency than Ultima Gold.

Background studies and normalization of signal events in the Mu2e experiment

The Mu2e experiment is currently being constructed at Fermilab to search for the neutrino-less conversion of negative muons into electrons in the field of an aluminum nucleus. The experiment aims at a sensitivity of four orders of magnitude higher than previous related experiments, which implies highly demanding accuracy requirements both in the design and during the operation. To achieve such a goal, two important tasks should be accomplished. First, it is essential to estimate precisely the particle yields and all the backgrounds that could mimic the monoenergetic conversion electron signal. Second, it is necessary to normalize the signal events accurately. The normalization of the signal events is planned to be done using a detector system made of an HPGe detector and a Lanthanum Bromide detector, which will measure the rate of muons stopped on the aluminum target by looking at the emitted characteristic X-and γ-rays of energies up to 1809 keV. Therefore, it is essential to evaluate the detector system's performance before the start of the actual experiment. In this study, the first task was addressed by an extensive campaign of Monte Carlo simulations to investigate the relevant parameters and their impact on the experiment's sensitivity. The second task was handled by taking advantage of the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) pulsed Bremsstrahlung photon beam at the ELBE facility. The detector system was tested at the ELBE facility under timing and background conditions similar to the ones expected at the Mu2e experiment. The study presents and discusses the simulation results and the detector system testing campaign.

On the comparison of two NIPAM gel dosimeters with high resolution 3D MRI sequences

Polymer gel dosimeters allow the measurement of a dose distribution in 3 dimensions. Irradiation induces polymerization reactions in the long chains of the gel molecules, which is characterized by a change in the transverse relaxation time T2. Gel dosimetry is mainly advantageous for its high resolution, but can also be expensive. The main goal of this project is to compare two normoxic polymer gel recipes made with NIPAM as monomer. The analysis is based on the quality of the images obtained for a fixed MRI scan time and a comparative cost of analysis of each 1L phantom. The ΔT2 maps are obtained by scanning the gels before and after irradiation with 3D sequences and the DESPOT2 technique is used to reconstruct the T2 maps. The phantoms were irradiated with 8 photon beams of 6 MV with a fixed 250 MU, 4 at two opposite sides of the jar (AP-PA configuration), to obtain 4 dose distributions of 4.7 Gy, 8.9 Gy, 13.2 Gy and 17.3 Gy. The SNR is then determined in the ΔT2 maps in function of the dose step and the concentration of NIPAM in the phantom. The first gel phantom is made with 15% NIPAM and has a total cost of $1561.65, including products and MRI scan costs. The SNR obtained for the 4 dose steps are 10.02, 31.18, 45.12 and 37.54. The contrast between the T2 before and after the irradiation in the 4 regions of dose are 0.45, 0.66, 0.78 and 0.85. The second phantom contained 5% NIPAM, cost 1186.85$ and the SNR obtained are 16.80, 27.08, 30.11 and 26.17 and the ΔT2 are of 0.61, 0.75, 0.79 and 0.77 for the 4 dose steps respectively. The comparison of the two recipes has shown that the increase of NIPAM concentration does not allow a significant increase in image quality for MRI. The recipe with 5% of NIPAM has a lower dynamic range but a better sensitivity at lower dose and is less expensive than the one with 15% of NIPAM. The results also show that by increasing the NIPAM concentration 3-fold, the cost of a 1L phantom increases by 30%.

One approach for selection of materials available for 3D printing of a dosimetry pelvic phantom: numerical simulation

Pelvic organ tumors are a serious problem in the field of oncology and account for one-third of the total number of the most common locations of neoplasms. Radiation therapy is often used to treat these types of cancer. A necessary procedure in the application of radiation therapy is the verification of the dosimetric plan to ensure maximum accuracy of radiation and minimize the negative effects of overexposure. To achieve these goals, dosimetry phantoms are used to mimic the structure and properties of biological tissues. Additive technologies can be an effective method for manufacturing such phantoms due to their high-precision ability to replicate both body geometry and anatomical structures. Today, the search and development of materials suitable for both additive technologies and assessing the interaction of ionizing radiation with matter is a relevant task. In this study, models of biological tissues and organs, as well as materials for 3D printing, were created. The features of Co-60 photon beam interaction with these materials were analyzed by numerical simulation. The calculated results demonstrated the suitability of plastic materials based on polylactide for simulating individual biological tissues and human organs from the point of view of interaction with ionizing radiation.

Fading correction for calibration of a novel 2D OSL-film dosimeter

A new film dosimeter based on optically stimulated luminescence (OSL) was calibrated for high-resolution 2D dosimetry in the context of radiotherapy patient-specific quality assurance (PSQA). The OSL-film signal is linear with the dose and decays with time, in a process called fading. Two models were proposed to characterize the fading: (1) a linear model independent from the delivery and of practical use thanks to the straightforward signal-to-dose conversion, and (2) a delivery-dependent model, to investigate whether a more simplified model may be sufficient to accurately determine the fading independently from the specific-irradiation conditions. The models were used in a nonlinear regression over an experimental dataset acquired with a 6MV photon beam in standard calibration settings. Both models were accurate and showed an adjusted-R 2 of 0.98 (1) and 0.99 (2). The residual analysis on both models allowed to define the minimum scanning time to have a discrepancies between the models <1%. Under this condition the OSL fading can be assumed independent on the irradiation parameters. As a consequence, within these boundary conditions, the linear model can be used for the OSL-film calibration.

Dose profile evaluation for small fields of a LINAC 6 MV beam using a solid water phantom

Radiotherapy is basically used in oncology and consists of the use of ionizing radiation to stop neoplastic cells from reproducing or to kill cells. Radiotherapy is one of the three main modalities of treatment for malignant diseases such as cancer, the other two are chemotherapy and radiosurgery. Unlike other medical specialties that rely primarily on the clinical knowledge and experience of specialist physicians, radiotherapy relies heavily on modern technology and the collaborative effort of several professionals whose coordinated team approach greatly influences the outcome of treatment. Linear accelerators with jaw or multileaf (MLC) field colimators are used to irradiate patients undergoing therapy and use fields with dimensions ranging from 4×4 to 40×40 cm². However, looking for the delivery of prescribed doses increasingly conforming to the target volume, small field beam openings are being used in advanced photon beam radiotherapy. In this work, the absorbed dose distribution of an X-ray beam was recorded using a solid water phantom. This phantom was irradiated using small fields with 1×1, 2×2, 3×3 and 5×5 cm². The 6 MV X-ray beam was generated on a Synergy Platform model linear accelerator from the manufacturer Elekta, and sheets of radiochromic film were used to record the dose profiles within the phantom. The solid water phantom loaded with radiochromic film was positioned 1.0 m away from the focus of the X-ray beam. The longitudinal profile of absorbed dose obtained showed the maximum dose value at 1.26 cm (peak) depth inside the phantom. The smaller field size (1×1) generated a smaller maximum absorbed dose (peak). Axial dose profiles were recorded at 1 cm depth and showed a plateau in the central region of the field. The mean absorbed dose at the plateau measured at 1 cm depth ranged from 98% to 90% of the maximum dose for the 5x5 and 1x1 cm² fields, respectively. The experiments performed showed a variations in the absorbed dose values due to the size of the fields. These variations occurred as in the amplitude of peak value in the depth profile as in the axial plane of distribution.

Neutron polarisation transfer, [formula omitted], in π+ photoproduction off the proton, [formula omitted

We report a first measurement of the double-polarisation observable, Cx′, in π+ photoproduction off the proton. The Cx′ double-polarisation observable represents the transfer of polarisation from a circularly polarised photon beam to the recoiling neutron. The MAMI circularly polarised photon beam impinged on a liquid deuterium target cell, with reaction products detected in the Crystal Ball calorimeter. Ancillary apparatus surrounding the target provided tracking, particle identification and determination of recoil nucleon polarisation. The Cx′ observable is determined for photon energies 800-1400 MeV, providing new constraints on models aiming to elucidate the spectrum and properties of nucleon resonances. This is the first determination of any polarisation observable from the beam-recoil group of observables for this reaction. Inclusion of the new data in the database of the SAID partial wave analysis shifted the solution to a new global minima which, not only gives better agreement with the current data, but also improves the description of a range of other single and double polarisation observables for charged pion photoproduction.

Helicity dependent cross sections for the photoproduction of π0π± pairs from quasi-free nucleons

Photoproduction of π0π±-pairs from quasifree nucleons bound in the deuteron has been investigated to study the helicity dependence of this reaction. Measurements with a liquid deuterium target were used to extract the unpolarized cross sections for reactions on protons and neutrons. A deuterated, longitudinally polarized solid-butanol target, together with a circularly polarized photon beam, determined the double polarization observable E. From these results the spin-dependent cross sections σ1/2 and σ3/2, corresponding to the anti-parallel and parallel spin configurations of the beam photon and target nucleon, have been derived. The measurements were performed at the Mainz MAMI accelerator with tagged, circularly-polarized photon beams produced via bremsstrahlung from longitudinally polarized electron beams. The reaction products were detected with an almost 4π solid-angle covering calorimeter composed of the Crystal Ball and TAPS detectors, supplemented by plastic scintillation detectors for charged particle identification. The results are sensitive to sequential decays of nucleon resonances via intermediate states and also to the decay of nucleon resonances by emission of charged ρ mesons, and are compared to recent model results.

Radionuclide-free efficiency calibration of an HPGe detector using monochromatic photon beams calibrated with a cryogenic radiometer

A cryogenic electrical-substitution radiometer was used for the primary calibration of monochromatic photon beams at synchrotron, which are in turn employed to determine the intrinsic efficiency of an HPGe detector between 3.5 keV and 8 keV. This allowed the determination of the thickness of the dead layer, which enabled the calculation of the efficiency up to 55 keV, where the active thickness is not determinant. The geometrical efficiency was determined through the measurement of a radioactive source at variable distances.

Delivery time reduction for mixed photon-electron radiotherapy by using photon MLC collimated electron arcs

Objective. Electron arcs in mixed-beam radiotherapy (Arc-MBRT) consisting of intensity-modulated electron arcs with dynamic gantry rotation potentially reduce the delivery time compared to mixed-beam radiotherapy containing electron beams with static gantry angle (Static-MBRT). This study aims to develop and investigate a treatment planning process (TPP) for photon multileaf collimator (pMLC) based Arc-MBRT. Approach. An existing TPP for Static-MBRT plans is extended to integrate electron arcs with a dynamic gantry rotation and intensity modulation using a sliding window technique. The TPP consists of a manual setup of electron arcs, and either static photon beams or photon arcs, shortening of the source-to-surface distance for the electron arcs, initial intensity modulation optimization, selection of a user-defined number of electron beam energies based on dose contribution to the target volume and finally, simultaneous photon and electron intensity modulation optimization followed by full Monte Carlo dose calculation. Arc-MBRT plans, Static-MBRT plans, and photon-only plans were created and compared for four breast cases. Dosimetric validation of two Arc-MBRT plans was performed using film measurements. Main results. The generated Arc-MBRT plans are dosimetrically similar to the Static-MBRT plans while outperforming the photon-only plans. The mean heart dose is reduced by 32% on average in the MBRT plans compared to the photon-only plans. The estimated delivery times of the Arc-MBRT plans are similar to the photon-only plans but less than half the time of the Static-MBRT plans. Measured and calculated dose distributions agree with a gamma passing rate of over 98% (3% global, 2 mm) for both delivered Arc-MBRT plans. Significance. A TPP for Arc-MBRT is successfully developed and Arc-MBRT plans showed the potential to improve the dosimetric plan quality similar as Static-MBRT while maintaining short delivery times of photon-only treatments. This further facilitates integration of pMLC-based MBRT into clinical practice.

Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry.

Parameningeal location of rhabdomyosarcoma (PM RMS) is known to be an unfavorable prognostic factor. Scarce data are available on radiotherapy (RT) concepts with regard to outcome. Treatment and outcome of 395 children with PM RMS registered within two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry (1995-2021) were evaluated. Patients were IRS group II (n=15) and III (n=380) and received systemic treatment according to the enrolled protocols: I2VA (n=172), VAIA/CEVAIE (n=223). Delayed resection was performed in 88/395 (22%) patients, and RT was additionally given in 79/88 (90%) resected patients. RT was the predominant local treatment in 355/395 (90%) patients: hyperfractionated accelerated photon (HART; n=77), conventionally fractionated photon (n=91) or proton beam (n=126), brachytherapy (n=4), heavy ions (n=1), not available (n=56). In the subgroup of RT as only local treatment (n=278), no intracranial tumor extension and complete remission at end of treatment were significant positive prognostic factors. No significant difference on tumor outcome was seen between different radiotherapy concepts. Long-term toxicity with mostly endocrinological and visual deficiencies was reported in 161/279 (58%) surviving patients with a lower trend after proton beam RT (48%) when compared to HART or conventionally fractionated photon RT (71% and 72%, respectively). Ten-year event-free and overall survival in the overall group were 62% (±5, 95% confidence interval [CI]) and 67% (±5, 95% CI); in the RT-only group 67% (±6, 95% CI) and 71% (±6, 95% CI), respectively. CWS data confirm the recent RT concept in PM RMS. Long-term sequelae as endocrinological and visual deficiencies need to be addressed.

Kinetic Energy of Secondary Particles Produced from Various Electromagnetic Interactions in Water: A Monte Carlo Study

Advancements in imaging systems including Electronic Portal Imaging Devices (EPIDs) play a great role in radiotherapy treatment. It was developed as a verification tool for patient setup during radiotherapy sessions and also become a promising tool for the determination of the accurate placement of radiation beams. However, as part of quality assurance, individual patient treatments are often verified by patient-specific quality control measurements such as before treatment (pretreatment) or during treatment (in vivo). It has been shown that in vivo dosimetry using an electronic portal imaging device (EPID) is an effective QC tool to detect errors and this method has been clinically applied to various treatments. The introduction of advanced EPID technology has led to an interest in its application for dose conformation and dose deposition. Moreover, dose deposition is subject to uncertainties due to several factors, including the presence of secondary particles. Thus, knowing the physical processes that produced the secondary particles as well as their average kinetic energy will help to provide valuable information about the effective filtering of these particles or the possible use of these particles for other applications. In this study, Monte Carlo simulations are performed to determine the average kinetic energy of detected secondary particles, specifically photons, electrons, and positrons produced by each particular physical interaction as a function of detector position using GATE v9.0. The virtual radiotherapy set-up is composed of the box water phantom, which is the target in the simulations with a dimension of 20 cm × 20 cm × 20 cm, an EPID system (detector), and a beam source in which it uses three (3) beams situated at varying positions with an energy of 6 MeV. The monoenergetic pencil beam source is placed 90 cm away from the center of the target and is directed toward the target (+x-axis) while the EPID (detector) is set as 120 cm SDD (source-to-detector distance). Moreover, the photon beam with 10 million primaries is set with varying field sizes of 1 cm × 1 cm, 3 cm × 3 cm, 6 cm × 6 cm, and 9 cm × 9 cm. Overall, the results show that the highest average kinetic energy among secondary particles produced by each physical interaction are electrons coming from Compton scattering (∼ 3 MeV), followed by positrons and electrons from pair production (∼ 2.4 MeV), photons from annihilation and bremsstrahlung (∼ 0.5 MeV), and electrons from ionization (∼ 0.13 MeV).

A Method for &lt;i&gt;In Vivo&lt;/i&gt; Dosimetry Using an Electronic Portal Imaging Device

The implementation of advanced radiotherapy techniques such as Intensity-Modulated RadiationTherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) allows much more accuratecontrol of the irradiation area and more conformal dose delivery. Since these treatments are characterizedby high dose gradients and hence small error margins, they also require advanced and highlyeffective treatment verification techniques. Fortunately, an imaging modality, originally intended forset-up verifications, called the Electronic Portal Imaging Device (EPID) was reported to have hugepotential for dosimetry and treatment verification applications. However, methods and algorithmspreviously developed for EPID dosimetry are not yet widely adopted in cancer centers due to complexitiesin the implementation. These motivate more investigation and development of new methodsto encourage cancer centers to practice EPID dosimetry and improve patient safety.This research generally aims to develop an in-vivo dosimetry method that can be used in the future toapproximate the actual dose delivered inside the target by utilizing the transmitted fluence detectedby the EPID. In this study, Monte Carlo simulations are carried out using the Geant4 Application forTomographic Emission (GATE) to implement a virtual set-up composed of a water target irradiatedwith a monoenergetic 2 MeV photon beam and an EPID model to detect the total transmitted fluence.A mathematical model has been proposed to calculate the target absorbed dose by utilizing the transmittedprimary fluence. This involves back-projection of the transmitted fluence to determine fluencevalues at certain depths inside the irradiated homogeneous medium. This is followed by the calculationof the collision kerma using the back-projected fluence and the values of the linear attenuation coefficientand mass energy absorption coefficient in the National Institute of Standards and Technology(NIST) database. The results show accurate prediction of the fluence values inside the target, calculationof the corresponding values of the collision kerma, and determination of the proportionalityconstant β that relates the collision kerma to the target absorbed dose.