Photoinduced Electron Transfer Process Research Articles

Host-Guest Approach to Promoting Photocatalysis Based on Consecutive Photo-Induced Electron-Transfer Processes via Efficient Förster Resonance Energy Transfer.

Supramolecular artificial light-harvesting system with highly efficient host-guest energy transfer pathway provides an ideal platform for optimizing the photochemistry process. The consecutive photo-induced electron transfer (conPET) process overcomes the energy limitation of visible-light photocatalysis, but is often compromised by mismatching between the absorption of ground state dye and its radical, weakening the efficiency of photoredox reaction. By encapsulating a conPET photocatalyst rhodamine 6G into metal-organic cage, the supramolecular approach was undertaken to tackle the intrinsic difficulty of matching the light absorption of photoexcitation between rhodamine 6G and its radical. The highly efficient Förster resonance energy transfer from the photoexcited cage to rhodamine 6G forced by host-guest encapsulation facilitates the conPET process for the single-wavelength light-driven activation of aryl halides by stabilizing and accelerating the production and accumulation of the rhodamine 6G radical intermediate. The tunable and flexible nature of the supramolecular host-guest complex renders the cage-based encapsulation strategy promising for the development of ideal photocatalysts toward the better utilization of solar energy.

Thio and Seleno- Psoralens as Efficient Triplet Harvesting Photosensitizers For Photodynamic Therapy.

The Psoralen (Pso) molecule finds extensive applications in photo-chemotherapy, courtesy of its triplet state forming ability. Sulfur and selenium replacement of exocyclic carbonyl oxygen of organic chromophores foster efficient triplet harvesting with near unity triplet quantum yield. These triplet-forming photosensitizers are useful in Photodynamic Therapy (PDT) applications for selective apoptosis of cancer cells. In this work, we have critically assessed the effect of the sulfur and selenium substitution at the exocyclic carbonyl (TPso and SePso, respectively) and endocyclic oxygen positions of Psoralen. It resulted in a significant redshifted absorption spectrum to access the PDT therapeutic window with increased oscillator strength. The reduction in singlet-triplet energy gap and enhancement in the spin-orbit coupling values increase the number of intersystem crossing (ISC) pathways to the triplet manifold, which shortens the ISC lifetime from 10-5 s for Pso to 10-8 s for TPso and 10-9 s for SePso. The intramolecular photo-induced electron transfer process, a competitive pathway to ISC, is also considerably curbed by these exocyclic functionalizations. In addition, a maximum of 115 GM of two-photon absorption (2PA) with IR absorption (660-1050 nm) confirms that the Psoralen skeleton can be effectively tweaked via single chalcogen atom replacement to design a suitable PDT photosensitizer.

Design and Construction of the Uranyl Coordination Polymer with Multifunction Stimulus Response: Fluorescent Sensors for Halide Ions and Photochromism.

It can provide ideas for the use of uranium elements in the treatment of spent fuel from nuclear wastewater to explore the application potential of uranium element. Thus, it is necessary to research the structure and properties of a novel uranyl coordination polymer (CP) for uranium recovery and reuse. Herein, we designed and prepared a new uranyl CP U-CMNDI based on UO22+ and H2CMNDI (H2CMNDI = N, N'-bis(carboxymethyl)-1,4,5,8-naphthalenediimide). Structural analysis shows that two uranyl ions are connected by two parallel deprotonated CMNDI ligands to form a discrete uranyl dimer structure. U-CMNDI can act as a potential stimulus-responsive halide ion sensor by a fluorescence "turn on" response in water. The limit of detection for fluoride (F-), bromide (Br-), iodide (I-), and chloride (Cl-) is 5.00, 5.32, 5.49, and 5.73 μM, respectively. The fluorescence "turn on" behavior is based on the photoinduced electron transfer (PET) mechanism between halide ions and electron-deficient NDI cores. In addition, U-CMNDI demonstrates a color response to ultraviolet light, exhibiting reversible photochromic behavior with a notable color change. The color change mechanism can contribute to the PET process and the radical process.

Unique Synthetic Strategy for Probing in Situ Lysosomal NO for Screening Neuroinflammatory Phenotypes against SARS-CoV-2 RNA in Phagocytotic Microglia.

In the pathogenesis of microglia, brain immune cells promote nitrergic stress by overproducing nitric oxide (NO), leading to neuroinflammation. Furthermore, NO has been linked to COVID-19 progression, which has caused significant morbidity and mortality. SARS-CoV-2 infection activates inflammation by releasing excess NO and causing cell death in human microglial clone 3 (HMC3). In addition, NO regulates lysosomal functions and complex machinery to neutralize pathogens through phagocytosis. Therefore, developing lysosome-specific NO probes to monitor phagocytosis in microglia during the COVID-19 infection would be a significant study. Herein, a unique synthetic strategy was adopted to develop a NO selective fluorescent probe, PDM-NO, which can discriminate activated microglia from their resting state. The nonfluorescent PDM-NO exhibits a turn-on response toward NO only at lysosomal pH (4.5-5.5). Quantum chemical calculations (DFT/TD-DFT/PCM) and photophysical study revealed that the photoinduced electron transfer (PET) process is pivotal in tuning optical properties. PDM-NO demonstrated good biocompatibility and lysosomal specificity in activated HMC3 cells. Moreover, it can effectively map the dynamics of lysosomal NO against SARS-CoV-2 RNA-induced neuroinflammation in HMC3. Thus, PDM-NO is a potential fluorescent marker for detecting RNA virus infection and monitoring phagocytosis in HMC3.

Rational Design of a Highly Sensitive Carboxylesterase Probe and Its Application in High-Throughput Screening for Uncovering Carboxylesterase Inhibitors.

Tracking carboxylesterases (CESs) through noninvasive and dynamic imaging is of great significance for diagnosing and treating CES-related metabolic diseases. Herein, three BODIPY-based fluorescent probes with a pyridine unit quaternarized via an acetoxybenzyl group were designed and synthesized to detect CESs based on the photoinduced electron transfer process. Notably, among these probes, BDPN2-CES exhibited a remarkable 182-fold fluorescence enhancement for CESs within 10 min. Moreover, BDPN2-CES successfully enabled real-time imaging of endogenous CES variations in living cells. Using BDPN2-CES, a visual high-throughput screening method for CES inhibitors was established, culminating in the discovery of an efficient inhibitor, WZU-13, sourced from a chemical library. These findings suggest that BDPN2-CES could provide a new avenue for diagnosing CES-related diseases, and WZU-13 emerges as a promising therapeutic candidate for CES-overexpression pathological processes.

Development of an “on-off-on” fluoroprobe utilizing an anthrylimidazole-based fluorescent ionic liquid for sensitive Cr(VI) and ascorbic acid detection

Developing a rapid detection method of Cr(VI) and ascorbic acid (AA) is vital in the food and environmental fields. Herein, an anthrylimidazole-based fluorescent ionic liquid (AI-FIL) with the advantageous fluorescent properties was successfully prepared and used to construct a promising “on-off-on” fluoroprobe for rapid/sensitive Cr(VI) and AA detection. Cr(VI) could effectively quench the fluorescence of AI-FIL owing to the inner-filter effect and photoinduced electron-transfer process. However, the decreased fluorescence could be rapidly recovered by AA owing to the redox reaction between AA and Cr(VI). For Cr(VI) detection, a satisfactorily linear response (0.03–300 μM) was achieved with the corresponding detection limit of 9 nM. For AA detection, a good linearity from 1 to 1000 μM was obtained with the resultant detection limit of 0.3 μM. Moreover, the AI-FIL based fluoroprobe was successfully utilized for Cr(VI) and AA detection in food and water samples with satisfactory accuracy and precision.

Rapid sequential detection of Al3+ and glyphosate using an “Off-On-Off” fluorescent probe based on salicylate modified layered double hydroxides

A fluorescent probe based on salicylate modified layered double hydroxide (LDH-SA) is presented, enabling the swift sequential detection of Al3+, fosetyl-Al and glyphosate in aqueous environment. The probe was synthesized using a simple co-precipitation procedure, and its properties and synthesis conditions were thoroughly characterized and optimized. A unique “off-on-off” fluorescent response was observed when the probe sequentially interacted with Al3+ and glyphosate, and the detection method based on this phenomenon was established. The limits of detection for Al3+ and glyphosate were determined as 0.03 μmol/L and 0.03 mg/L, respectively, with rapid detection periods of one minute and four minutes. The LDH-SA/Al3+ complex requires Al3+ to generate a chelation-gathered fluorescence effect, which is the mechanism by which it quenches LDH-SA. This is possible due to the inhibition of excited-state intramolecular proton transfer and photoinduced electron transfer processes within LDH-SA after incorporating Al3+. Upon interaction with glyphosate, competitive complexation between glyphosate and Al3+ is initiated, which leads to a recovery of the fluorescence spectrum of LDH-SA and demonstrating the “off-on-off” behavior. An “INHIBIT” logic gate system was devised utilizing the response, indicating potential applications in fluorescence-based devices. Such a rapid, sequential detection capacity is impressive. It attests to the utility of LDH-SA as a probe for Al3+ or glyphosate, and suggests promise for applications in pollutant analysis or environmental monitoring applications.

The future of drug Monitoring: Highly selective ratiometric sensing of mefenamic acid by simple AIEE active probe supported through Extensive fluorometric and DFT studies

Over intake of mefenamic acid (MA) cause morbidity, mortality, liver damage, and hepatic necrosis. For this reason, it is of great importance to discover novel methodologies that provide sharp detection timing, improved sensing efficiency, and profound reproducibility in MA detection. In our current research, we synthesized a naphthalic anhydride based probe PPN which revealed excellent sensing potential towards MA. Probe PPN exhibited ratiometric fluorescence against MA based on complex formation and photoinduced electron transfer (PET) process. Detection mechanism was verified through Density functional theory (DFT) calculations and 1H NMR titration experiments. The type of interaction between probe PPN and MA was investigated through quantum theory of atoms in molecules (QTAIM) analysis and noncovalent interaction (NCI) analysis and was further evaluated via spectroscopic analysis. Moreover, the probe PPN was practically employed to the sensing of MA in artificial urine, pharmaceutical wastewater, and blood samples. Probe PPN is the most streamlined probe designed ever for the sensing of MFA in complex environments with extreme selectivity and sensitivity.

Anthrapyrazolone functionalized Oligo(ethylene glycol)methyl ether methacrylates based fluorescent polymeric hydrogel for selective detection of Tetracycline drug

Tetracycline (TC) antibiotics are essential for treating bacterial infections; however, overuse and improper disposal place the environment in danger and promote the growth of drug-resistant microorganisms. Monitoring their impact on living organisms is vital. Polymeric-based hydrogels offer promise in antibiotic detection due to their versatility and biocompatibility, despite their uncommon use for this purpose. In this study, we have synthesized a fluorescent polymeric hydrogel, P(OEGMA-co-DIMA) utilizing oligo(ethylene glycol)methyl ether methacrylates (OEGMA) and laboratory-synthesized fluorescent anthrapyrazolone containing monomer, 2-(benzo[1,2,3-cd:4,5,6-c’d]bis(indazole)-2(7H)-yl)ethyl methacrylate (DIMA) for the fluorometric detection of TC in the aqueous medium. The P(OEGMA-co-DIMA) hydrogel exhibited exceptional affinity towards TC while exhibiting high selectivity. The chemosensing behavior of the hydrogel was also compared with the DIMA monomer. Upon adding TC, emission analysis revealed a notable quenching in the emission intensity of the P(OEGMA-co-DIMA) hydrogel as well as the DIMA monomer. The Stern Volmer rate constants (Ksv) of the hydrogel (Ksv = 9.99 x 103 M−1) in water and DIMA (Ksv = 25.63 x 103 M−1) in acetonitrile showed a higher quenching rate constant with a limit of detections (LODs) of 1.3 nM and 0.11 nM. Turn-off fluorescence behavior occurs via a static quenching mechanism through a photoinduced electron transfer process and intermolecular hydrogen bonding. To validate the selectivity, the interference analyses in an aqueous medium with different antibiotics are provided. To rationalize the real-time applicability of the hydrogel, studies were extended to water samples obtained from deionized water, tap water, lake water, and also in milk samples. The recovery rate and LOD for real samples ranged from 83.8% to 111% and 0.83 to 3.6 nM, respectively.

Photoinduced One-Electron Chloride Oxidation in Water Using a Pentacationic Ir(III) Photosensitizer.

A novel iridium(III) photosensitizer containing pyridinium-decorated terpyridines has been used for the photo-oxidation of chloride in water. Despite its abundance, the very positive one-electron reduction potential (E° Cl•/- = 2.1-2.4 V vs NHE) restricted its use in energy conversion schemes and artificial photosynthesis. The kinetics of the photoinduced electron transfer process were investigated through Stern-Volmer quenching experiments and nanosecond transient absorption spectroscopy, which provided unambiguous evidence that photoinduced chloride oxidation occurred with a quenching rate constant kq = 5.0 × 1010 M-1 s-1. Complementary spectroelectrochemistry and photolysis experiments confirmed the formation of the reduced photosensitizer and showcased the redox and photostability of the Ir(III) photosensitizer that holds great promise for the HX splitting approach.

Series of Viologen-Based Metal-Organic Polyhedra with Photo/Electrochromic Behavior for Inkless Printing and UV Detection.

The fabrication of molecular crystalline materials with fast, multistimuli-responsive behavior and the construction of the corresponding structure-activity relationship are of extraordinary significance for the development of smart materials. In this context, three multistimuli-responsive functional metal-organic polyhedra (MOP), {[Dy2(bcbp)3(NO3)1.5(H2O)7]·Cl4.2·(NO3)0.3·H2O}n (1), {[Dy2(bcbp)4(H2O)8]Cl6}n (2), and {[Eu2(bcbp)4(H2O)10]Cl6·H2O}n (3; bcbp = 1,1'-bis(4-carboxyphenyl)-4,4'-bipyridinium), were successfully prepared and characterized. All of the compounds exhibit rapid and reversible photochromic and electrochromic dual-responsive behaviors. Furthermore, benefiting from the well-defined crystal structure and different responsive behaviors, the photoinduced electron transfer (PIET) process and structure-activity relationship were explored. In addition, considering the excellent photochromic performance, function filter paper and smart organic glass were successfully prepared and used for ink-free printing and UV light detection.

Simultaneous detection of Cu2+ and amoxicillin based on the copper and nitrogen-regulated fluorescent probe

A novel fluorescence-based probe represented as Cu, N-CDs, was developed for the dual sensingdetection of Cu2+ and amoxicillin (AMO), which had a high quantum yield up to 60.08 %, along with excellent photoluminescent properties and remarkable stability. When detecting Cu2+, the fluorescence signal from Cu, N-CDs probe experienced quenching due to photoinduced electron transfer (PET). Subsequently, the introduction of AMO led to the recovery of the probe's fluorescence. This recovery was likely attributed to the superior affinity between Cu2+ and AMO, resulting in the displacement of Cu2+ from the Cu, N-CDs and blocked the PET process. Notably, the detection limits of Cu2+ and AMO were determined 18 nM and 9 nM, respectively. We further demonstrated the practical utility of the Cu, N-CDs probe through its successful application in the analysis of Cu2+ and AMO in Chinese herbal medicine and milk samples. Overall, our findings highlighted the potency of Cu, N-CDs as versatile and effective tools for the detection of Cu2+ and AMO, paving the way for their broad applications in the safety analysis of food and pharmaceutical.

Porphyrin-BODIPY Dyad: Enhancing Photodynamic Inactivation via Antenna Effect.

A porphyrin-BODIPY dyad (P-BDP) was obtained through covalent bonding, featuring a two-segment design comprising a light-harvesting antenna system connected to an energy acceptor unit. The absorption spectrum of P-BDP resulted from an overlap of the individual spectra of its constituent parts, with the fluorescence emission of the BODIPY unit experiencing significant quenching (96 %) due to the presence of the porphyrin unit. Spectroscopic, computational, and redox investigations revealed a competition between photoinduced energy and electron transfer processes. The dyad demonstrated the capability to sensitize both singlet molecular oxygen and superoxide radical anions. Additionally, P-BDP effectively induced the photooxidation of L-tryptophan. In suspensions of Staphylococcus aureus cells, the dyad led to a reduction of over 3.5 log (99.99 %) in cell survival following 30 min of irradiation with green light. Photodynamic inactivation caused by P-BDP was also extended to the individual bacterium level, focusing on bacterial cells adhered to a surface. This dyad successfully achieved the total elimination of the bacteria upon 20 min of irradiation. Therefore, P-BDP presents an interesting photosensitizing structure that takes advantage of the light-harvesting antenna properties of the BODIPY unit combined with porphyrin, offering potential to enhance photoinactivation of bacteria.

Rapid Construction of Double Crystalline Prussian Blue Analogue Hetero-Superstructure.

The controllable construction of complex metal-organic coordination polymers (CPs) merits untold scientific and technological potential, yet remains a grand challenge of one-step construction and modulating simultaneously valence states of metals and topological morphology. Here, a thiocyanuric acid (TCA)-triggered strategy is presented to one-step rapid synthesis a double-crystalline Prussian blue analogue hetero-superstructure (PBA-hs) that comprises a Co3[Fe(CN)6]2 cube overcoated with a KCo[Fe(CN)6] shell, followed by eight self-assembled small cubes on vertices. Unlike common directing surfactants, TCA not only acts as a trigger for the fast growth of KCo[Fe(CN)6] on the Co3[Fe(CN)6]2 phase resulting in a PBA-on-PBA hetero-superstructure, but also serves as a flange-like bridge between them. By combining experiments with simulations, a deprotonation-induced electron transfer (DIET) mechanism is proposed for formation of second phase in PBA-hs, differing from thermally and photo-induced electron transfer processes. To prove utility, the calcined PBA-hs exhibits enhanced oxygen evolution reaction performance. This work provides a new method to design of novel CPs for enriching chemistry and material science. This work offers a practical approach to design novel CPs for enriching chemistry and material science.

Controlled photoinduced electron transfer via triplet in polymer matrix using electrostatic interactions

Drawing inspiration from highly efficient natural photosynthetic systems, we developed an artificial photoinduced electron transfer (PET) system within a poly(N-methyl-4-vinylpyridinium) (P4VPMe) polymer matrix. This system features 5,10,15,20-tetrakis-(4-sulfonatophenyl) porphyrin (TPPS) and its zinc complex (ZnTPPS) as electron donors and methylviologen (MV2+) as the electron acceptor. In the presence of an excess of P4VPMe, ZnTPPS exists as individual molecules rather than self-aggregating, favoring PET. Under these conditions, P4VPMe inhibits the formation of ground-state charge-transfer complex between ZnTPPS and MV2+. This shifts the main PET process from singlet to triplet states. ZnTPPS in an excess of P4VPMe demonstrates over a tenfold increase in catalytic activity for the photoinduced oxidation of MV2+ compared to ZnTPPS alone.

A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS2/ZnS quantum dots.

A fluorescent sensing material based on the ternary core-shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron transfer process. The quenching constant was much higher for MIP@ZAIS QDs than the non-imprinted polymer@QDs, indicating that MIP@ZAIS QDs could selectively recognize RFP. Under the optimized conditions, the sensor had a good linear relationship at the RFP concentration range of 5.0 to 300nM and the limit of detection was 1.25nM. The respond time of the MIP@ZAIS QDs was 5min, and the imprinting factor was 6.3. It also showed good recoveries ranging from 98 to 101%, for analysis of human plasma samples. The method is simple and effective for the detection of RFP and offers a practical application for the rapid analysis of human plasma samples.

A novel low-cytotoxicity fluorescent probe applied to monitor pH in vivo and in vitro

Environmental pH plays an irreplaceable role in both cellular processes and production, and anomalous pH changes within cells may lead to various diseases. To tackle this issue, we designed and synthesized the novel low-cytotoxicity fluorescent probe called NAP-MP. The probe incorporates 1,8-naphthalimide as the fluorescence emitter, 1-methylpiperazine as the pH-sensitive moiety, and utilizes 3-aminopropyltriethoxysilane to improve its biocompatibility. The fluorescence of NAP-MP inhibits the photoinduced electron transfer (PET) process with the protonation of 1-methylpiperazine, resulting in the enhancement of fluorescence intensity. Density functional theory calculations have also confirmed the fluorescence mechanism. The probe demonstrates high selectivity, photostability and recyclability. The hydrogel prepared by the probe can detect different concentrations of ammonia in the air. In addition, due to its low toxicity and good biocompatibility, this probe has been successfully employed to observe pH changes in living HeLa cells. Overall, the development of this probe offers significant potential in the field of pH sensing, allowing for precise monitoring of pH levels in both environmental and biological systems.

The flexible DADM-based covalent organic frameworks constructed by flexible knots and 4,4′-diaminodiphenylmethane as a linker for fluorescence sensing nitrophenol and adsorping iodine

Enrichment of nitro-aromatic compounds (NACs) and radioactive iodine seriously threatens the health of humans, therefore, trace detection of NACs and the efficient capture and storage of radioactive iodine have attracted a great deal of attention in recent years. Herein, we present two highly efficient flexible DADM-based covalent organic frameworks (DADM-based COFs) for the fluorescence sensing of o-nitrophenol (o-NP) and p-nitrophenol (p-NP) and reversible iodine capture, namely TDADM and HDADM. The resulting TDADM and HDADM have excellent thermal and chemical stability, some crystallinity and high BET surface areas of 1035 and 958 m2 g−1, respectively. For fluorescence sensing, TDADM and HDADM show high sensitivity to o-NP and p-NP with quenching constants (Ksv) of 6.77 × 103 and 3.39 × 104 L mol−1, respectively. The fluorescence quenching of TDADM is caused by the action of photo-induced electron transfer (PET) processes. The fluorescence quenching of HDADM is caused by the co-action of PET and resonance energy transfer (RET) processes. For iodine capture, TDADM and HDADM exhibit high iodine capture capacities, which are severally up to 4.08 and 5.32 g g−1. Such high iodine adsorption amounts are caused by the electron transfer of the electron-rich flexible DADM-based COFs to the electron-deficient I2 into the polyiodide anion complexes.

A multifunctional Eu-MOF with multi-color and proton conduction switching and its anti-counterfeiting applications

Lanthanide metal-organic frameworks (Ln-MOFs) have exhibited remarkable capabilities in color change, luminescence, proton conduction through the strategic modification of metal nodes, organic ligands and channels or pores. By modifying the electron-deficient bipyridinium to contain carboxylic acid moieties and coordinating them with the luninescent Eu3+ ion, a unique and versatile Eu-MOF has been synthesized. Under UV light conditions, the complex shows an obvious color change from colorless to blue, which is due to the formation of viologen radicals after photoinduced electron transfer (PIET) process. As we all know, the changed color is caused by the alteration of absorption intensity, ultimately impacting its luminescence as well. Thus, the bright and strong red fluorescence of this complex is quenched upon continuous UV light irradiation, which may be attributed to intramolecular energy transfer from the excited state of the europium ion to the colored state of the CV ligand. Based on the control of multiple colors of the complex, the designed encryption model can realize multiple anti-counterfeiting of real numbers. In addition, the conductivity of this compound increases significantly after UV illumination, showing excellent photo-modulated proton conductivity. In short, our work has proposed a multifunctional bipyridinium-based Ln-MOF with photochromism, photo-switchable photoluminescence and proton conduction, which offers valuable insights for the creation of versatile switchable materials based on MOFs.

Effective Detection of Cu(II) Ions Based on Carbon Dots@Exfoliated Layered Double Hydroxides Composites Fluorescence Probe.

A series of carbon dots@exfoliated layered double hydroxides (CDs@LDH) composites were hydrothermally fabricated by Mg/Al LDH and formamide. The results of FTIR, UV-vis, and XPS spectra in company with HRTEM images showed that crystalline nano CDs formed on the single layer of LDH by Mg-C bond. With the increase of solvothermal reaction time from 2 to 6h, the band gap and the binding energy of aminic and graphitic N species of CDs@LDH composites decreased, whereas the crystallinity increased. The fluorescence peaks of CDs@LDH composites could be deconvoluted into short-wavelength (416nm) and large-wavelength (443nm) components by Gaussian function, and the fluorescence intensities of both components enhanced with the extension of the solvothermal reaction time. The simultaneous enhancements of fluorescence lifetime and quantum yield resulted from the relatively high electron density in graphitic nitrogen of CDs@LDH, whereas the reduction of nonradiative rate was due to the high crystallinity in the carbon core of CDs@LDH. A strong exciton-lattice interaction also has been validated based on the excitation and emission spectra of CDs@LDH, so the fluorescence emission of CDs@LDH composite was heavily related to its crystalline carbon core and nitrogen-containing groups. CDs@LDH with high nitrogen-containing exhibited a superior detection property for Cu2+ ion sensing with the linear range of 26.90 ~ 192.20μM and a limit of detection of 0.1957μM. The photo-induced electron transfer (PET) process dominated the fluorescence quenching of CDs@LDH by Cu2+ ion since the fluorescence lifetime decreased with the increase of Cu2+ ion concentration.