Bismuth selenide is a promising semiconductor for optoelectronics and energy conversion, including solar cells and aerospace applications. However, it degrades at high temperatures, affecting stability. According to the previous literature, we can solve this problem and easily tune under high pressure, but no reports are available for response against acoustic shock waves. To explore this, commercially available Bi2Se3 was purchased and tested under acoustic shock wave exposure. Bi2Se3 was subjected to 100, 200, 300, and 400 acoustic shock waves with 0.59 MPa transient pressure at 520 K temperature and 1.5 Mach number. Before and after shock-loaded Bi2Se3 samples were characterized using XRD, Raman, UV-DRS, PL, and FE- SEM and EDX. Under acoustic shock waves, Bi2Se3 exhibits increased crystallite size and reduced strain rate, promoting good thermal stability. It also shows a smaller bandgap and enhanced PL intensity, which ensures efficient solar cell operation. As a result, the material demonstrates improved thermal insulation and durability, which are crucial for stability and protection in extreme conditions for aerospace applications. These improvements make Bi2Se3 more suitable for solar cell and aerospace applications.