Close resemblance of human and minipig skin in hair density, pigmentation, morphology, vasculature, and immunological reactivity makes minipig highly suitable for visual grading of erythema, edema, inflammatory reactions, sensitization, and photo damage. Rabbit is highly sensitive to irritants. Thicker epidermis (50–140μ m) in pig/human absorbs much less than rodents (10–20μ m). Dermal esterases converting prodrug to drug have similar efficiency in pig/human; it is 3 orders of magnitude greater in rat. Similar total hepatic cyt 450 concentration in pig and human is 48 and 93% less than in rat and rabbit, respectively. Properties of pig P450 isozymes are similar to human homologs. Because of longer GI, transit time in pig/man is 4 times greater than dog. Extrapolation of risk from pig to human is probably more realistic. Also similar cardiovascular, pulmonary, urogenital, and GI systems, clinical pathology, moderate growth (2kg/month), more tissue/fluids, and reuse of animals after wash also make minipig desirable for PK/PD, repeat dose, safety pharmacology, and juvenile studies. Hypothetical examples using mini pigs experimentally infected with T. mentagrophytes (dermatophytoses), C. albicans (candidiasis), and A. fumgatus (aspergillosis) to evaluate the safety and efficacy of antifungal combination dermal products shall be discussed. Abstract content are not related to any policy or guideline of FDA