Introduction: Microvillous Inclusion Disease (MID) is a rare disorder characterized by onset of intractable secretory diarrhea in early infancy. Patients with MID typically require long-term total parenteral nutrition(TPN) as a result of severe malabsorption. The Gastroenterology Department has had the opportunity to follow a relatively large number of children with MID over a long period of time, because of the increased frequency of this condition in the Navajo population (J. of Pediatrics, 1999). In these patients, which include a total 10 children (7 Navajo, 2 Hispanic, and 1 Caucasian), comorbidities were noted that were not observed in other patients who require long-term TPN. Methods: Medical records were reviewed of patients with MID and other gastrointestinal conditions requiring long term use of TPN. All patients were under the care of members of the Gastroenterology Division at Phoenix Children’s Hospital. A Privacy Compliance Waiver was obtained prior to chart reviews. Results: Short Stature has been noted in 9/10. Pancreatitis has been seen in 4, with 3 developing chronic pancreatitis. Hematologic problems have been seen in 3 patients (2 with Coombs positive anemia and 1 with aplastic anemia). Chronic renal problems have also been noted in 3 patients. Conclusion: In a large number of children with MID, followed at a single center, comorbidities have been noted which are dissimilar to those seen in other children with gastrointestinal conditions requiring long term use of TPN.