Phlegm Stasis Research Articles

Effect of Huatan Quyu Decoction on Stable Angina Pectoris Patients with Coronary Heart Disease of Phlegm and Blood Stasis Syndrome

Effect of Huatan Quyu Decoction on Stable Angina Pectoris Patients with Coronary Heart Disease of Phlegm and Blood Stasis Syndrome

Observation on the Effect of Tongmai Huazhuo Decoction on Hypertension Caused by Phlegm and Blood Stasis

Observation on the Effect of Tongmai Huazhuo Decoction on Hypertension Caused by Phlegm and Blood Stasis

中医证候痰瘀互结证现代研究进展

中医证候痰瘀互结证现代研究进展

Body constitution of traditional Chinese medicine caused a significant effect on depression in adult women

Backgroundand purpose: Depression is a common mental disorder and reduces quality of life. As traditional Chinese medicine constitution (TCMC) has become an increasingly popular complementary and alternative approach for early detection and treatment of disease, this study investigated the relationship of female-related factors and constitution with depression. Materials and methodsThis cross-sectional study included 1423 women from the Taiwan Biobank. A questionnaire of 44 items was used covering a variety of factors and the Body Constitution Questionnaire. The constitution types were divided into Yang-deficiency, Yin-deficiency, and Phlegm stasis. ResultsYang (p = 0.022) or Yin (p = 0.017) deficiencies, being single (p = 0.027–0.033), previous use of women's health supplements (p = 0.005–0.008), and smoking (p = 0.033–0.036) were associated with a higher risk of depression. ConclusionIntegration of TCMC with Western medicine may be an alternative option towards depression prevention and alleviation.

Clinical application of Xingnaojing Injection in treatment of 11 674 cases of cerebral infarction: a real world study

To analyzed the actual clinical application of Xingnaojing Injection in treating cerebral infarction in the real world, selected HIS(hospital information system) database of inpatients in 39 hospitals across the country, and conducted descriptive analysis and association rule analysis on the information of 11 674 patients with cerebral infarction using Xingnaojing Injection. The results showed that the average age of the patients was 69.69 years. TCM syndrome of phlegm stasis and collaterals stagnation was the most(37.56%), followed by wind-phlegm obstruction of collaterals(19.01%). Virtual syndrome accounted for 21.06%. Intravenous drip was the most important route of administration(96.50%). Iv infusion single dose of 10-20 mL(52.44%), other off-label doses accounted for a larger proportion(47.56%). Continuous use of the drug within 3 days(55.45%), 15-28 days accounted for 6.96%, >28 days accounted for 0.89%. The top 10 Western drugs used in combination mainly include antihypertensive drugs, acid-suppressing drugs to protect stomach, drugs to improve brain circulation, drugs to protect brain nerves and drugs to fight infection. The top 10 of Chinese patent medicines are mainly activating blood circulation and removing stasis, clearing heat and clearing the surface, etc. According to the analysis of association rules, three types of clinical drug use modes for the combination of Chinese and Western medicine were obtained, mainly including the first type: Xingnaojing Injection+nifedipine(nifedipine, nifedipyridine, Lixinping)+levoflo-xacin+Huayu Tongmai agent. The second category: Xingnaojing Injection+omeprazole+edaravone+Huayu Tongmai agent; The third category: Xingnaojing Injection+ganglioside and ganglioside derivatives+edaravone+Huayu Tongmai agent. The results show that Xingnaojing Injection is not a standard drug in the treatment of cerebral infarction. At the same time, the combined use of drugs is mainly recommended by the guidelines and conventional treatment drugs, reflecting the clinical application of integrated traditional Chinese and Western medicine.

Clinical effect of Zhibitai capsule in the treatment of senile hyperlipidemia patients with phlegm and blood stasis syndrome

Objective To investigate the clinical efficacy and safety of Zhibitai capsule in the treatment of senile hyperlipidemia patients with phlegm and blood stasis syndrome. Methods From June 2014 to June 2015, 126 elderly patients with primary hyperlipidemia of phlegm and blood stasis syndrome admitted to Hangzhou Hospital of Traditional Chinese Medicine were randomly divided into control group and observation group, with 63 cases in each group.The patients in the control group were given basic treatment plus atorvastatin calcium tablets, and the patients in the observation group were treated with Zhibitai capsule on the basis of the control study.Both two groups received continuous treatment for 12 weeks.The clinical efficacy, TCM syndrome integral, blood lipid, hemorheology and adverse reactions of the two groups were observed. Results The total effective rate in the observation group was 92.1%(58/63), which was higher than 81.0%(51/63) in the control group, and the difference was statistically significant(χ2=8.199, P 0.05). Conclusion Zhibitai capsule can effectively improve the clinical efficacy, improve TCM syndromes, reduce blood lipids and improve hemorheology parameters in elderly patients with hyperlipidemia syndrome of phlegm and blood stasis syndrome, with no obvious adverse reactions, which is worthy of clinical promotion. Key words: Hyperlipidemia; Senile; Phlegm and blood stasis syndrome; Zhibitai capsule; Chinese patent medicine; Hemorheology; Clinical efficacy; Blood lipid

The correlations between traditional Chinese medicine syndromes of histiocytic necrotizing lymphadenitis and its pathological types

Objective To investigate the interaction between traditional Chinese medicine (TCM) syndromes of histiocytic necrotizing lymphadenitis (HNL) and pathological types of HNL, so as to discover the distribution rule of TCM syndromes for indiction of intervention of HNL. Methods A total of 166 patients with HNL were included. The baseline data of the patients, clinical feature, the four diagnosis information of TCM and histopathological of cervical lymph node were collected. The syndromes of TCM were judged. The pathological types were confirmed by cervical lymph node biopsy. The Multi-way ANOVA was used to analyze the correlation between traditional Chinese medicine syndromes of HNL and its pathological types. Results Among the 166 patients, the ratio of different types are as follow: wind-heat and phlegm-toxin syndrome (57.83%, 96/166), heat-toxin exuberance syndrome (34.34%, 57/166), and phlegm and blood stasis syndrome (7.83%, 13/166). The pathological types include proliferative type (57.83%, 96/166), necrotizing type (35.54%, 59/166), and xanthomatous type (6.63%, 11/166). There were significant differences in targeted lymph node diameter, pain scores, body temperature (F value were 3.737, 34.484, 34.805, all Ps 0.05) among three TCM Syndrome types were notsignificant. There were significant differences in pain scores, body temperature (F value were 12.153, 25.931, all Ps 0.05) among three pathological types. The corresponding analysis result showed that, on point sets, wind-heat and phlegm-toxin syndrome were correlated with proliferative type, heat-toxin exuberance syndrome correlated with necrotizing type, and phlegm and blood stasis syndrome correlated with xanthomatous type (χ2=235.100, P<0.001). Conclusions There is a close correlation between syndrome types of TCM and pathological types of HNL. The pathological change of wind-heat and phlegm-toxin syndrometends toproliferative type, heat-toxin exuberance syndrome tends to necrotizing type, and phlegm and blood stasis syndrome tends to xanthomatous type. Key words: Histiocytic necrotizing lymphadenitis; Syndrome differentiation classification; Pathological conditions, signs and symptoms; Correlation of data

The Discriminative Efficacy of Retinal Characteristics on Two Traditional Chinese Syndromes in Association with Ischemic Stroke.

We aimed to investigate the efficacy of an objective method using AI-based retinal characteristic analysis to automatically differentiate between two traditional Chinese syndromes that are associated with ischemic stroke. Inpatient clinical and retinal data were retrospectively retrieved from the archive of our hospital. Patients diagnosed with cerebral infarction in the department of acupuncture and moxibustion between 2014 and 2018 were examined. Of these, the patients with Qi deficiency blood stasis syndrome (QDBS) and phlegm stasis in channels (PSIC) syndrome were selected. Those without retinal photos were excluded. To measure and analyze the patients' retinal vessel characteristics, we applied a patented AI-assisted automated retinal image analysis system developed by the Chinese University of Hong Kong. The demographic, clinical, and retinal information was compared between the QDBS and PSIC patients. The t-test and chi-squared test were used to analyze continuous data and categorical data, respectively. All the selected clinical information and retinal vessel measures were used to develop different discriminative models for QDBS and PSIC using logistic regression. Discriminative efficacy and model performances were evaluated by plotting a receiver operating characteristic curve. As compared to QDBS, the PSIC patients had a lower incidence of insomnia problems (46% versus 29% respectively, p=0.023) and a higher tortuosity index (0.45 ± 0.07 versus 0.47 ± 0.07, p=0.027). Moreover, the area under the curve of the logistic model showed that its discriminative efficacy based on both retinal and clinical characteristics was 86.7%, which was better than the model that employed retinal or clinical characteristics individually. Thus, the discriminative model using AI-assisted retinal characteristic analysis showed statistically significantly better performance in QDBS and PSIC syndrome differentiation among stroke patients. Therefore, we concluded that retinal characteristics added value to the clinical differentiation between QDBS and PSIC.

Clinical study of Huatan-Quzhuo decoction combined with western medicine routine therapy for the patients with carotid artery atherosclerotic plaque

Objective To investigate the effectiveness and safety of Huatan-Quzhuo decoction in combination with western medicine for the treatment of carotid atherosclerotic plaques. Methods A total of 194 patients with carotid atherosclerosis were selected were randomly divided into two groups, 97 in each group. The control group was treated with simvastatin. The observation group was treated with Huatan-Quzhuo decoction on the basis of the control group. The serum levels of interleukin-1 (IL-1), tumor necrosis factor α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) were observed before and after treatment in the two groups. The Sod, IMT, number of plaques, number of vulnerable plaques and area of plaques, carotid artery intima-media thickness (IMT), number of plaques, number of vulnerable plaques, and area of plaques were detected. Results After treatment, the levels of TC, TG, and LDL-C in the observation group were significantly lower than those in the control group (t were 4.546, 6.712, 4.872, P<0.01). After treatment, the IMT (0.85 ± 0.11 mm vs. 1.08 ± 0.13 mm, t=13.302), number of plaques (0.74 ± 0.36 vs. 1.02 ± 0.42, t=4.985), number of vulnerable plaques (0.24 ± 0.25 vs. 0.41 ± 0.27, t=4.550), and plaque area (50.06 ± 9.73 mm2vs. 68.52 ± 11.24 mm2, t=12.230) in the observation group were significantly lower than those in the control group (P<0.01). The levels of IL-1, TNF-α and MDA in the observation group were significantly lower than the control group (t were 13.089, 4.769, 10.442, P<0.01). The level of SOD was observation group was significantly higher than the control group (t=11.636, P<0.01). Conclusions The combination of Huatan-Quzhuo decoction and western medicine in the treatment of carotid artery atherosclerosis can regulate the level of blood lipids, improve the degree of atherosclerosis, reduce the degree of inflammation and oxidative stress. Key words: Atherosclerosis; Huatan-Quzhuo decoction; Simvastatin; Syndrome of phlegm and blood stasis blocking collaterals

The correlation between Erα gene polymorphism and the distribution pattern of fascia syndrome in women with knee osteoarthritis

Objective To study the correlation between Erα gene polymorphism and the distribution pattern of TCM meridian syndrome in women with knee osteoarthritis. Methods A total of 120 Knee osteoarthritis (KOA) female patients admitted to our hospital between January 2018 and December 2018 were selected as the observation group, and 120 healthy female subjects accepted physical examination at our hospital over the same period were selected as the control group. The Erα gene distribution of estrogen receptor was compared between the two groups to identify the differences between KOA women and healthy women. The TCM syndromes and meridians types of the patients in the observation group were defined to evaluate the degree of KOA. The correlation among KOA status, Erαgenotypes, TCM syndromes and meridians was analyzed. Results The distribution of Erα gene XbaI was significantly different between the observation group and the control group (χ2=35.339, P<0.001). There was a statistical difference in the distribution of XbaI genotypes between mild to moderate and severe patients in the observation group (χ2=29.088, P<0.001). There was a moderate correlation between the Lequesne score and the fascia type in KOA women, and a high correlation between the Lequesne score and the TCM syndrome differentiation type, and a moderate correlation between the Lequesne score and the Erα gene and the XbaI genotype (P<0.05). The Erα gene polymorphisms, meridians and syndrome differentiation were moderately correlated (P<0.05). Conclusions In female patients with knee osteoarthritis, the conditions are more serious in patients with complex type of tendons, deficiency of liver and kidney, phlegm and blood stasis, Erα gene xx genotype, and there is a clear correlation between the TCM type of tendons and ER gene polymorphism. Key words: Osteoarthritis, knee; Female; Estrogen receptor alpha; Genotype; Syndrome differentiation classification; Syndrome type

Influences of Xinnaoning capsules on aorta calcium sensing receptor of rats with myocardial infarction and endothelial protection mechanisms based on the theory of phlegm and blood stasis

Objective To observe the impacts of Xinnaoning capsules on the aortic intimal structure, serum levels of diponectin (APN) and calcium sensing receptor (CaSR) expression in rats with myocardial infarction, and explore the endothelial protection mechanisms of Xinnaoning. Methods 15 male Sprague Dawley (SD) rats in sham operation group were randomly selected from 60 rats, the rest 45 rats were fed with high fat diet for 6 weeks and received coronary artery ligation operation. The successful modeling rats were randomly divided into model group, western medicine group and traditional Chinese medicine(TCM) group, and fed with high fat diet for 8 weeks. The sham operation group fed with normal diet. The western medicine group and TCM group received atorvastatin and Xinnaoning capsules, respectively; the sham operation group and model group received same amount of distilled water. After treatment of 4 weeks, the aortic intimal structure was observed by hematoxylin-eosin (HE); the serum levels of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) were measured by microplate test; serum levels of APN and CaSR expression were determined by enzyme linked immunosorbent assay (ELISA) and Western blot, respectively. Results Compared with sham operation group, aortic intimal structure derangement and plaque formation in intima in model group, and serum levels of TG, TC, LDL and CaSR expression were increased; HDL and APN were decreased (P 0.05). Conclusions Xinnaoning capsules are effective for myocardial infarction. Key words: Myocardial infarction; CARDIOVASCULAR AGENTS (TCD); Adiponectin; Receptors, calcium-sensing; Rats

苍附苁仙汤对肾虚痰瘀型多囊卵巢综合征患者中医证候及糖代谢的影响

苍附苁仙汤对肾虚痰瘀型多囊卵巢综合征患者中医证候及糖代谢的影响

苗药紫金牛、铁扫帚对COPD稳定期痰瘀互阻兼气阴两虚证患者的临床疗效观察

苗药紫金牛、铁扫帚对COPD稳定期痰瘀互阻兼气阴两虚证患者的临床疗效观察

Comparative evaluation in treating qi-yin deficiency and phlegm stasis syndrome of type 2 diabetes mellitus in a rat model

Abstract Objective To compare the efficacy of traditional Chinese medicine (TCM), western medicine and integrative medicine in treating type 2 diabetes mellitus (T2DM) in a rat model. Methods The T2DM rat model was established with a high-fat diet (HFD) for 35 days and a single injection of streptozotocin (STZ, 30 mg/kg). The T2DM-induced rats were divided into three groups, and treated with Yiqi Yangyin Huatan (YQYYHT) granules (3.84 g/kg per day), pioglitazone (1.35 mg/kg per day) or YQYYHT granules + pioglitazone (3.84 g/kg per day+1.35 mg/kg per day) respectively for 14 days. Clinical features and behavioral changes, as well as T2DM indicators, were recorded to evaluate therapeutics effects in each treatment group. Results The T2DM rat model expressed insulin resistance (IR), with features similar to qi-yin deficiency and phlegm stasis syndrome, including decreased cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP) ratio, decreased levels of Na+-K+-ATPase, superoxide dismutase (SOD) and high density lipoprotein-cholesterol (HDL-C), and increased levels of serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL-C). All three treatment groups showed significant decreases in fasting blood glucose (FBG) and fasting insulin (Fins), and improvement of TCM syndrome to different degrees. Importantly, YQYYHT improved the most of the indicators of T2DM, followed by integrative medicine and pioglitazone alone. Conclusion Compared with western medicine or integrative medicine, prescription of TCM based on syndrome differentiation may offer more advantages in the prevention and treatment of T2DM.

The study of differentially expressed serum protein in patients with different traditional chinese medicine syndromes of knee osteoarthritis

Objectives: To study the distribution characteristics of patients with knee osteoarthritis (KOA) of different traditional Chinese medicine (TCM) syndromes and to reveal the differences from the perspectives of expressions of serum inflammatory indicators. Methods: One hundred and thirty-four patients with KOA treated in our hospital from January 2013 to March 2016 and referring to TCM syndrome types were included in the study and were divided into three types: Yin in kidney and liver\tendon and vesselstasissyndrome,s pleen and kidney deficiency wet injection the osteomere syndrome, kidney Yang and weak\phlegm stasis syndrome; 24 healthy persons who took physical examination in our hospital were selected as the normal control group. Patients' blood was collected in the morning as the blood samples, and the levels of inflammatory factors (5-TH, interleukin-6 [IL-6], and tumor necrosis factor-α [TNF-α]) were measured in serum. Results: The most common TCM syndrome of KOAin the clinical trialsis Yin in kidney and liver\tendon and vesselstasissyndrome, the percents of spleen and kidney deficiency\wet injection the osteomere syndrome and kidney Yang and weak\phlegm stasissyndrome are near, the former is slightly higher than the latter by 3.97%. The levels of IL-6 and TNF-α in the three groups were significantly higher than those in the normal control group, whereas the 5-TH level was significantly lower in the three groups than that in the normal control group (P

Characteristics of syndrome distribution and dampness pathogen in patients with multiple sclerosis in south of the Five Ridges area

Objective To explore the distribution of syndromes and the characteristics of damp-induced disease in patients with multiple sclerosis in Lingnan area, and to improve the reference for TCM treatment of MS patients. Methods A retrospective analysis of the general information of 268 patients with multiple sclerosis (MS) admitted to our hospital from March 2015 to 2016 was conducted. And the information on four diagnoses of Chinese medicine, including the main manifestations, tongue pulse, frequency were for the cluster analysis. The Multivariate logistic regression analysis was used to analyze the factors influencing MS syndromes. The distribution and dynamic changes of the symptoms of the patients at the initial diagnosis, 4 weeks after treatment and 8 weeks after treatment were observed, and the dynamic changes of the syndrome form were analyzed. Results In the course of the development of MS patients, the sigle syndrome and 6 syndromes can appear simultaneously. Among them, there were syndrome of the wind, wet, phlegm, heat and blood stasis. At the 4 and 8 weeks after treatment, 2nd syndromes gradually increased, but the 3rd syndromes and 4th syndromes remain unchanged, and the 5th syndrome significantly decreased. The syndrome is complicated and changeable from the side of the development process.The results of multi factor Logistic regression analysis showed that purple tongue was an important factor of blood stasis [OR (95% CI)= 2.357(1.996-3.017)], and the yellow greasy coating was an important factor of hot dampness [OR (95% CI)= 3.654(3.125-4.876)], and the thin and weak pulse was the important factor of the deficiency of liver and kidney[OR (95% CI)=3.983(2.349-4.218)]; deficiency pulse was an important factor affecting Qi and blood deficiency syndrome[OR (95% CI)=2.852(2.068-3.192)]; limb twitching was an important factor affecting kidney yang deficiency syndrome [OR (95% CI)=3.850(1.037-16.524)], and the above data were statistically significant (P<0.05). For patients with damp heat attacking vesselssyndrome, the most frequent clinical symptoms were the spinal sensory disorders, cranial nerve disorders and cerebellar symptoms, emotional disorders and mental disorders, consciousness disorders and epilepsy, two bowel movements and weakness. Conclusions The wind, wet, phlegm, heat and blood stasis of the MS patients in south of the Five Ridges gradually increase. With the treatment, the syndrome combination was gradually simplified, the essential contradiction gradually revealed, the single syndrome gradually merged, the 2 syndrome gradually increased, the 3 syndrome and the 4 syndrome remained constant. Key words: Multiple sclerosis; Lingnan; Syndrome evolution law; Pathogenic dampness

Diagnostic Accuracy of Chinese Medicine Diagnosis Scale of Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: A Study Protocol.

Phlegm and blood stasis syndrome (PBSS) is one of the main syndromes in coronary heart disease (CHD). Syndromes of Chinese medicine (CM) are lack of quantitative and easy-implementation diagnosis standards. To quantify and standardize the diagnosis of PBSS, scales are usually applied. To evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. Six hundred patients with stable angina pectoris of CHD, 300 in case group and 300 in control group, will be recruited from 5 hospitals across China. Diagnosis from 2 experts will be considered as the "gold standard". The study design consists of 2 phases: pilot test is used to evaluate the reliability and validity, and diagnostic test is used to assess the diagnostic accuracy of the scale, including sensitivity, specificity, likelihood ratio and area under the receiver operator characteristic (ROC) curve. This study will evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. The consensus of 2 experts may not be ideal as a "gold standard", and itself still requires further study. (No. ChiCTR-OOC-15006599).

Correlation Analysis between Traditional Chinese Medicine Syndromes and Gastrointestinal Bleeding after Percutaneous Coronary Intervention.

Objective To explore the characters of traditional Chinese medicine (TCM) syndromes after percutaneous coronary intervention (PCI) and to provide syndrome study theoretical evidence for TCM differentiation treatment after PCI through retrospective study. Methods Patients with coronary heart disease (CHD) who underwent PCI in Cardiovascular Intervention Center of Wangjing Hospital during Dec. 2012 to Dec. 2014 and met the inclusion criteria were enrolled. Retrospective study was then conducted based on patients' clinical document and angiography data to explore the distribution pattern of TCM syndromes. Results 801 patients were recruited in the study. TCM syndromes in descending order of their incidence were Qi deficiency and blood stasis syndrome, heart blood stasis syndrome, Qi and Yin deficiency syndrome, phlegm and blood stasis syndrome, Qi stagnation and blood stasis syndrome, Yang asthenia syndrome, heart and kidney yin deficiency syndrome to cold congeal, and blood stasis syndrome in a more to less order. Qi deficiency and blood stasis syndrome was in the most (occurring in 298 patients, 37.20%); Qi and Yin deficiency syndrome occurred in 163 patients (20.35%); heart blood stasis syndrome was shown in 126 patients (15.73%); phlegm and blood stasis syndrome was shown in 95 patients (11.86%). Conclusion Qi deficiency and blood stasis syndrome was closely associated with post-PCI bleeding, implying that this syndrome might serve as a powerful predictor of GI bleeding as well as a potential supplement to the current predicting and scoring system of bleeding such as CRUSADE.

TCM comprehensive external therapy for acne oriented by damp-heat constitution

Acne is a kind of common skin disease in modern young people. Damp-heat constitution is the pathological basis of acne. Influenced by external factors, damp-heat constitution can lead to acne in the three pattern types, including lung meridian wind-heat, spleen and stomach damp-heat and phlegm stasis congestion and stagnation. Therefore, according to the thought of traditional Chinese medicine, the only way to completely solve the problem of recurrent acne is to correct the damp-heat constitution. TCM external therapy has always been the common therapy for acne, but the specific application scheme of the therapy has not been systematically summarized. In this paper, the relationship between damp-heat constitution and acne, and the design of TCM external therapy for acne on the face oriented by damp-heat constitution will be systematically discussed on the basis of long-term clinical practice and theory summary.

Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke

By studying the relationship between syndromes, physique and MMP-9, IL-6 and MTHFR gene polymorphisms in patients with ischemic stroke,The relationship between MMP-9, IL-6 and MTHFR gene polymorphism was analyzed in patients with ischemic stroke.The data were collected by collecting the data of patients with ischemic stroke, and the statistical analysis was carried out. Syndrome：61 cases of ischemic stroke patients with stroke phlegm stasis syndrome in patients with the highest frequency, a total of 30 cases; Physical constitution： phlegm is ischemic stroke patients prone to physical, a total of 20 cases; The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, Phlegm constitution and physical condition after the onset of symptoms tend to wind phlegm stasis syndrome; Syndrome and MMP-9, IL-6 relationship：The distribution of MMP-9 and IL-6 in patients with qi and phlegm stasis syndrome and qi deficiency and blood stasis syndrome was significantly different from that in Z test (P<0.05). The level of MMP-9 in patients with qi deficiency and blood stasis syndrome was significantly higher than that in patients with wind phlegm and blood stasis syndrome;The level of IL-6 in patients with phlegm and blood stasis syndrome was significantly higher than that in patients with qi deficiency and blood stasis syndrome. Syndrome, constitution and MTHFR gene polymorphism： among the 61 samples, 34 were heterozygous mutations, 15 were pure and mutated, 12 had no mutation, The mutation rate of this locus was 4.08 times that of patients without mutations.The genotype of MTHFR C677T in patients with phlegm dampness tends to be CT genotype. Wind phlegm stasis syndrome in patients with easy to appear after the TT genotype; Yin deficiency syndrome in patients prone to miscellaneous and mutations, the performance of CT genotype; Analysis of the relationship between syndromes and physique in patients with ischemic stroke,Phlegm and dampness, flat quality patients after the onset of easy to show the wind phlegm stasis syndrome; Qi deficiency after the onset of symptoms in patients with Qi and blood stasis. Suggesting that before the onset of such as for the partial physical conditioning, may be on the prevention of ischemic stroke have a certain effect; Analysis of the relationship between syndromes and MMP-9 and IL-6 in patients with ischemic stroke, Wind phlegm stasis syndrome and IL-6 levels are related, Qi deficiency and blood stasis syndrome and MMP-9 levels are related. Analysis of the relationship between syndromes and MTHFR gene polymorphism in patients with ischemic stroke, TT genotype after the onset of symptoms prone to wind phlegm stasis syndrome, CT genotype patients after the onset of easy manifestations of Yin deficiency wind syndrome; Analysis of the relationship between physique and MTHFR gene polymorphism in patients with ischemic stroke, CT genotype is easy to show phlegm.For more in-depth understanding of pathogenesis of ischemic stroke to provide the basis, For the clinical treatment and prevention to provide intervention strategies.