Phi Coefficient Research Articles

Lipid management in systemic lupus erythematosus according to risk classifiers suggested by the European Society of Cardiology and disease-related risk factors reported by the EULAR recommendations

BackgroundThe European Alliance of Associations for Rheumatology recommended that lipid-lowering therapy (LLT) in systemic lupus erythematosus (SLE) should follow general population guidelines. We examined the eligibility for LLT in SLE...

Survey on currently applied interventions in neonatal resuscitation (SCIN): A study protocol.

Around 140 million children are born every year and post-natal transition is uncomplicated in the vast majority. However, around 5%-15% of neonates receive supportive interventions during transition. Recent data on the interventions used is scarce. More data on the frequencies with which these interventions are used is needed to evaluate neonatal resuscitation, guide recommendations and to generate hypotheses for further research. The following protocol describes an international, multicentre survey on the interventions currently applied during neonatal resuscitation. To determine the frequencies at which different supportive interventions recommended by European Resuscitation Council (ERC) guidelines for neonatal resuscitation are used. To compare the frequencies between hospitals and patient groups and to investigate possible factors influencing any differences found. Participating hospitals will collect data on all interventions performed during neonatal resuscitation over a period of 6 months. All hospitals providing perinatal care are eligible regardless of size and designated level of neonatal care. Every neonate requiring more interventions than basic drying and tactile stimulation during the first 30 min of life will be included. The targeted sample size is at least 4,000 neonates who receive interventions. After anonymization, the data is pooled in a common database and descriptive and statistical analysis is performed globally and in subgroups. Possible correlations will be investigated with phi coefficient and chi square testing. Consent of the institutional review board of the Technical University Dresden was obtained for the local data collection under the number BO-EK-198042022. Additionally, approval of local ethical or institutional review boards will be obtained by the participating hospitals if required. Results will be published in peer-reviewed journals and presented at suitable scientific conferences.

Allocation of resources for risk management activities by business organisations in developing countries: Evidence from Zambia

This study evaluates resources allocated for risk management by business organisations (financial and non-financial firms) in developing countries, using Zambia as a case study. Primary data collected from 158 organisations were analysed using MegaStat. The findings revealed that the majority (54.5%) of organisations, especially non-financial institutions, only commit resources to risk mitigation on an Adhoc or post-event basis, while 45.5% showed a budgeted approach. A significant part of the budgeted 45.5% was used for risk management activities, and 54.5% was used for regular daily operations. Despite this variation, all organisations engaged reported a significant expenditure on risk management, at least on Adhoc. At 4 degrees of freedom (df), which was one less than the total number of possible outcomes, a non-parametric test for significance yielded a scientific P-value of 1.57e-0.7, (a numerical magnitude of 0.0014, P< 0.05). This suggests that the correlation and pattern of the findings were not random or by chance, but they carried a statistical significance. The study's main findings demonstrate that some business organisations in Zambia and other developing countries incur significant expenditure with a higher portion of their budgets to respond to risk management needs. Business organisations which do not have formal risk structures do so informally due to pressure from emerging business risks. The findings also indicated that financial institutions in developing countries allocate more resources towards risk management than non-financial institutions. The Phi coefficient (degree of association) was 0.486, showing a moderately significant relationship between the variables (risk management and resource allocation). Business organisations in Zambia and other developing nations must develop sound risk mitigation plans and allocate resources for risk management.

Determination of the mycobiome in the lower respiratory tract of horses with equine asthma

Fungal particles are important allergenic components involved in the development of equine asthma. The aim of this study was to evaluate the mycobiome composition of the lower respiratory tract in asthmatic horses using fungal culture, quantitative multiplex real-time PCR analysis (FungiMultiPlex) and Next-Generation Sequencing approach. Bronchoalveolar lavage fluid (BALF) samples obtained from 45 client-owned horses diagnosed with equine asthma were analysed by fungal culture (19 samples), FungiMultiPlex (34 samples), and Next-Generation Sequencing (14 samples). The fungal culture was positive in 11/19 (58%) cases, and FungiMultiPlex was positive in 19/34 (56%) cases. No fungal PCR product was detected by Next-Generation Sequencing analysis. Fungal culture and FungiMultiPlex methods were performed simultaneously on eight horses only. Association of results of these methods was calculated using Phi coefficient (φ= 0.333), and concordance between the methods was not confirmed (P = 0.420). The results of this study suggest that the fungal culture and quantitative multiplex real-time PCR might be considered diagnostically useful to assess the presence of fungi in BALF in a semiquantitative and quantitative manner, respectively. The Next-Generation Sequencing method seems to be less diagnostically suitable due to technical obstacles pertinent to both the low concentration of microbial agents in the rather diluted BALF samples, and, also, due to the relatively high environmental background contamination of the collected material. Based on our data, we advocate the use of the combination of quantitative multiplex real-time PCR and fungal culture in a routine clinical diagnostic setting.

Innovations and Tourism Regions: are Innovations Perceived as A Problem in Regional Development in European Tourism?

This article examines innovative aspects of the development of tourism regions in Europe. The article aims to determine the intensity of the perception of innovation in the tourism region as a problem in its development. The ambition of the article is to assess the problems in the development of tourism regions in Europe in the field of innovation as a possible starting point for optimizing changes in local and regional tourism policy. The research analyses the positions of 95 regional tourism experts from 17 European countries. The database was based on a databank of 150 representatives of academia and 275 representatives of regional tourism organizations. To analyse the properties of categorical data and the relationships between them, we used Gamma, Kendall’s Tau-b, Somers’ D C|R, Spearman correlation coefficient, Phi Coefficient, Contingency Coefficient, Cramer’s V and the decision tree algorithm. The maturity of the innovation environment of tourism regions and their level of development influence the perception of innovations as a problem in their development. Southern European tourism regions perceive innovation as a problem in their development most intensively. Tourism regions with stronger innovation activity have a well-established quality management system and a comprehensive and systematically addressed supply of seasonal and off-season products. Tourism regions ranked in the emerging innovator group perceive the specified problems in the implementation of innovations more intensively. This reflects the lack of coordination of the product portfolio, both in terms of range and quality, in countries where the innovation environment is poorly developed. A key recommendation to mitigate the perception of innovations as a problem in the development of Europe’s tourism regions is to focus attention on the implementation of regional policy instruments that stimulate the participation of tourism in the synergy effects of the existing innovation environment of the economy.

COVID-19 outbreak after 100 days without community transmission: Epidemiological analysis of factors associated with death

BackgroundOutbreak of SARS-CoV-2 pandemic has caused millions of deaths and lifelong consequences since December 2019. We attempted to evaluate the incidence, distribution, and risk factors associated with death after applying the social distance strategy to the second wave of SARS-CoV-2 in the Danang outbreak in Vietnam. MethodsWe retrospectively reviewed the online the Danang Hospital reports, gathering the epidemiological history of confirmed SARS-CoV-2 patients. We then conducted a descriptive analysis of Fisher's Phi Coefficient and Cramer's, along with multiple logistic regression models to test the effects of symptomatology and control measures performed by Vietnamese government. The last report we examined on August 29, 2020. ResultsA total of 389 SARS-CoV-2 confirmed cases were related to the Danang outbreak are included in our analysis with a mean age of 47.1 (SD = 18.4), involving 154 men and 235 women, with 34 cases of death and 355 were alive. The study showed significant results related to age, quarantine measures, previous negative SARS-CoV-2 test, and a range of symptoms, including shortness of breath and myalgia (p-value <0.05). Our multiple-variable analysis suggested the significant risk of death was related to age, severe symptomology, undetected SARS-CoV-2 test results, and prior quarantined SARS-CoV-2 history. ConclusionsVietnamese authorities had implemented successful quarantine practices to control the SARS-CoV-2 outbreaks. However, this virus has shown dynamic spread beyond the ability of the country to control its transmission. Adequate screening, social distancing, and adequate care of elderly and healthcare workers can lower the risk of future outbreaks.

Sociodemografske varijable kao korelati čitalačkih interesovanja i recepcije književnih dela učenika osnovne škole

Starting from the observation that in the teaching of literature, the powers of literary art that could strengthen students' interest in reading and reception of works are insufficiently used, the authors examine the influence of socio-demographic factors on the characteristics of students' interest in reading (gender, academic achievement, educational status of mother and father, language of instruction). The research involved determining the connection between the understanding of unknown and lesser-known words and expressions in passages from literary works (epic-lyrical -folk ballad and epic genre -epic and novel) with socio-demographic factors. The research was carried out using the survey research method, the technique used was a survey, and the instrument was a questionnaire. The sample consisted of 478 5th-grade students from elementary schools in the Republic of Serbia, where classes are taught in Serbian and Hungarian. The following statistical tests were applied: the chi-square (ch²) test, one-factor analysis of variance, t-test (t) of independent samples, phi (Phi) coefficients and Cramer's V indicator within the program IBM SPSS 20.0. The research results showed that students' reading interests significantly correlate with socio-demographic factors, especially gender, academic achievement, father's and mother's educational status, while the mother's educational status is also related to library member-ship. It can be stated that students have difficulties with unknown and less familiar words and expressions (foreign words, dialectal words, localisms and archaisms) while reading literary works, and that the language of instruction is a significant socio-demographic factor that is related to the sum of perceived words and their understanding. It is concluded that it is possible to create an environment that stimulates students' reading interests, which opens up space for modern methodical systems and procedures for interpreting unknown words and expressions in the literary-communicative context of literature teaching.

Hubungan Persepsi Masyarakat dengan Pencapaian Vaksinasi Lengkap Covid-19 di Wilayah Kerja Puskesmas Molawe

The achievement of the third dose of covid-19 vaccination is still low. The achievement of vaccination at the Molawe Public Health Center dose I was 84.57%, dose II 62.66%, and dose III 13.43%., which mean the achievement of the complete dose of Covid-19 vaccination so that efforts to increase vaccination achievements are in with target (Puskesmas Molawe, 2022). This study aimed to determine the factors related to the achievement of complete vaccination olf the Covid-19 in the Molawe Public Health Center.This type of research was a descriptive-analytic study with a cross-sectional design. The study population was the total vaccination targets in the Working Area of Molawe Public Health Center as many as 3039 people , the sample of the study was 97 respondents using the Purposive Random Sampling technique.The results showed a fairly strong relationship between public knowledge and the achievement of complete Covid-19 vaccination (p = 0.000 and phi coefficient (φ) = 0.404). There waas a weak relationship between community attitudes and the achievement of complete vaccination of Covid-19 (p = 0.001 and phi coefficient (φ) = 0.345). There was a weak relationship between public motivation and the achievement of complete Covid-19 vaccination (p value = 0.004 and phi coefficient (φ) = 0.290).The author's advice that the implementation of the covid-19 vaccination be further improved by developing interesting program to increase public interest in participating in the implementation of the complete covid-19 vaccination.

The Relationship Between Parents' Communication With Students Towards Emotional Intelligence In The First Year Of The Faculty Of Medicine Undana

&#x0D; Background: Emotional intelligence is the ability of a person to regulate their emotional life by maintaining emotional harmony and expression through the skills of self-control, self-motivation, empathy and social skills. Emotional intelligence in adolescents are fundamentally formed based on the patterned form a relationship when communicating with parents.&#x0D; Objective: To analyze the relationship between parents and students' communication with emotional intelligence in the first year of the Faculty of Medicine Undana&#x0D; Methods: This study is an observational analytical method with a cross-sectional design carried out on first-year students at the Faculty of Medicine, Nusa Cendana University. The sampling technique is simple random sampling with a sample of 120 resopondents. This study used the Parent-Adolescent Communication Scale (PACS) questionnaire and the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF). The data was analyzed univariately and bivariately using the phi coefficient test. &#x0D; Results: Phi coefficient test shows that there was no significant relationship of emotional intelligence with father communication (p=0.44) and maternal communication (p=0.447). &#x0D; Conclusion: There is no significant relationship between Parents' and Students' Communication towards Emotional Intelligence In the First Year of the Faculty of Medicine Undana &#x0D; Keywords: Parental Communication, Emotional Intelligence, First Year

Accident patterns and prevention measures for occupational injuries in the Philippine food and beverage manufacturing industry.

The manufacturing industry is one of the catalysts for the Philippines. However, this sector is one of the most dangerous industries in the Philippines considering the frequency of occupational injuries. To determine the primary and root causes of recorded accidents, demographics of the person involved, and solutions to prevent the recurrence of certain accidents. This study analyzed 185 occupational injury cases in a food and beverage manufacturing company in the Philippines from January to December 2018. A comprehensive classification system was established to examine and code each case in terms of age, gender, working shift, employee type, tenure, department, category, activity during the accident, root cause of injury, injury classification, direct cause of injury, type of injury, part of body injured, agent of injury, and location of the accident. Cramer's V analysis and Phi coefficient analyses were employed on the subject cases to determine the significant factors and the corresponding extent of significance. The results showed that the majority of the occupational injuries were caused by stepping on, striking against, or stuck by objects (77 cases, 41.6%), caught in between (34 cases, 18.4%), fall (34 cases, 18.4%), and exposure or contact with extreme temperatures (24 cases, 13%). Interestingly, female workers who had accidents were more likely due to inadequate hazard information or lack of procedures whereas male workers were more likely due to failure to secure. The prevention measures such as passive safeguards and personal protective equipment, pictograms, and regular safety audits were derived from the results of these analyses. This study is the first comprehensive analysis of occupational injuries in the food and beverage industry in the Philippines. The findings can be applied to positively influence the effectiveness of prevention and rehabilitation programs mitigating workplace injuries and illnesses.

The Ecological Roles of Medium and Small Carnivores in the Terrestrial Animal Community in Liancheng National Nature Reserve, China.

It is vitally important to understand the ecological roles of medium and small carnivores in the context of the massive decline in the number of large carnivores around the world. Based on a spatial association network of terrestrial birds and mammals, this study analyzed the ecological roles of medium and small carnivores in the community in Liancheng National Nature Reserve. From October 2019 to June 2020, we obtained 3559 independent detections of 20 terrestrial birds and mammals from 112 camera traps. There are seven species that are medium and small carnivores present in the study area, including red fox (Vulpes vulpes), leopard cat (Prionailurus bengalensis), Chinese mountain cat (Felis bieti), stone marten (Martes foina), Asian badger (Meles leucurus), Siberian weasel (Mustela sibirica) and mountain weasel (Mustela altaica). By calculating the Phi coefficient of all species pairs, a spatial association network composed of twelve species was constructed. We analyzed the characterization of spatial associations by the Shannon-Wiener index and Lambda statistic. The results showed that: (1) the status of the network reflects the changes of community composition and structure after the decline in large carnivores and other species; (2) with the exception of the Chinese mountain cat and stone marten, the other five medium and small carnivores were located in the network, which played an important role in the complexity of the network and the maintenance of the community; (3) the medium and small carnivores could not take the place of the large carnivores in order to control the population of herbivores, such as Siberian roe deer (Capreolus pygargus) and Himalayan marmot (Marmota himalayana). The results of this study provide guidance for determining the direction and focus of conservation efforts.

A surgeon's dress code - the patients' perspective

The dress code for surgeons has evolved over time from formal suit-and-tie to crisp white coat, and currently to various forms of smart-casual attire; however, there is no stipulated or rigid uniform guideline. It is important to explore and discuss the various forms of attire in relation to patients' ideals and perceptions of a surgeon. An observational study in the form of a paper-based questionnaire was carried out at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Chris Hani Baragwanath Academic Hospital (CHBAH) and Wits Donald Gordon Medical Centre (WDGMC). Seven questions (Q1-Q7) were posed with various dress categories to select from in each question, namely: formal, smart, smart-casual and scrubs. Descriptive analysis of the survey responses, and the determination of the association between survey responses and a) hospital, b) gender, c) age group was performed. Fisher's exact test was used where the requirements for the chi-square test could not be met. Attire groups with n < 15 were not analysed. The strength of the associations was measured by Cramer's V and the phi coefficient respectively. Data analysis was carried out using SAS v9.4 for Windows. A 5% significance level was used. A total of 387 questionnaires were filled out with a total of 376 fully completed and eligible samples in consenting participants of 18 years and older. In all seven questions, scrubs were the preferred attire. Overall, for Q1-Q5 and Q7, after scrubs, smart was the next most popular attire. For Q6, after scrubs, smart, smart-casual and formal were all popular, indicating some leeway on weekends and public holidays. There was a significant association between each of the responses to the question and hospital (p < 0.0001). At CHBAH, patients preferred scrubs more and smart attire less, compared to CMJAH and WDGMC. At CMJAH, preference for formal attire was greater when compared to the other two hospitals. Overall, patients preferred their surgeons to be dressed in scrubs as this attire easily identified surgeons and instilled confidence in the wearer.

Trend of Work-related Injuries in the Philippines from 2010-2020

Introduction. Although Occupational Health and Safety (OSH) has been introduced as early as 1971, the protection of workers remained insufficient globally as 360 million occupational accidents occurred annually. In the Philippines, the incidence rate of occupational injury is 4.27 percent which indicates that there are around 4 cases of occupational injuries with workdays lost per 100 workers.Objective. The study aims to determine the trend of work-related injuries using hospital data entries from 2010-2020, and factors that contribute to work-related injuries and worker fatalities in the Philippines.Methods. The work-related data from the Department of Health’s Online National Electronic Injury SurveillanceSystem (ONEISS) from 2010 to 2020 was processed and analyzed in the study using exploratory data analysispresented as table and graphs, and logistic regression and phi-coefficient analysis for statistical inference. Therelationships between patient fatality, type of injury sustained, and external factors for occupational injuries and fatalities were analyzed.Results. A total of 72,897 (6.6%) work-related injuries and worker fatalities were analyzed in this study. The reports of occupational injuries and fatalities increased and peaked in 2019 and declined by 2020. Phi coefficient determined that all injuries sustained were significantly associated with work-related activities. Phi coefficient showed that all types of injuries were significantly associated with patient fatality. The external causes that were found to be significantly associated with patient fatality using phi coefficient were contact with sharp objects, exposure to forces of nature, fall, and transport and vehicular crash. Fall was significantly associated with patient fatality while also increasing its odds (OR=2.57, 95% CI: 1.76 – 3.75), and increased odds for multiple injuries (OR=2.30, 95% CI: 2.17 – 2.45), abrasion (OR=2.10, 95% CI: 1.97 – 2.24), and fracture (OR=9.66, 95% CI: 8.92 – 10.46). Transport/vehicular crash was significantly associated with increased patient fatality (OR=2.94, 95% CI: 2.22 – 3.88), multiple injuries (OR=6.77, 95% CI: 6.48 – 7.07), abrasion (OR=12.87, 95% CI: 12.34), and fracture (OR=4.12, 95% CI: 3.82 – 3.45). &#x0D; Conclusion. The study determined the relationship between work-related injuries, patient fatalities, types of injuries, and external causes of injuries based on the ONEISS data from 2010 to 2020. It is recommended that the study results be used in evaluating work-related accidents and in conducting comprehensive health assessments.

Revisiting chronic low back pain: evidence that it is not non-specific.

There is a common symptom pattern with most chronic low back pain (CLBP), suggesting that there is a common underlying etiology, belying the term "nonspecific." Many studies of CLBP and its treatment have been conducted with the assumption of nonspecificity, and as a result, treatment has not been focused, thus there has not been a significant change in CLBP prevalence over the past several decades. It is the thesis of this study to show that there is an underlying, specific cause of CLBP and that the presumption that CLBP is nonspecific is misdirected. The lumbosacropelvic (LSP) region, including the sacroiliac joint (SIJ), is part of a neuromusculoskeletal (NMSK) feedback system, and it is proposed here that CLBP is the result of a change in the feedback (afferent) aspect in that system. The objectives of this study are to show that CLBP presents as a pattern of symptoms that actually represents the final common pathway for a dysfunctional LSP joint system. Rather than being "nonspecific," the majority of CLBP has an underlying cause that is quite specific and predictable. A total of 252 patients were seen for CLBP, 67% of whom were diagnosed with an SIJ dysfunction. The presence of pain was recorded from seven structures most closely associated with CLBP. The conditional probabilities of having each pain generator given a SIJ dysfunction and an SIJ dysfunction given the presence of the pain generator were estimated, and associations were analyzed utilizing chi-square tests. Phi coefficients and odds ratios were utilized to quantify the strength of the association. The multivariable logistic regression model was fit to relate thepresence or absence of the SIJ dysfunction to the seven pain generators. The associations between SIJ dysfunction and each pain generator were statistically significant. Phi coefficients indicated moderate strengths of these bivariate associations. Iliolumbar ligament (ILL) and psoas muscle (PSM) were significant predictors of SIJ dysfunction in the multivariable model. Seven pain generators had a strong association with SIJ dysfunction. This empirical clinical evidence supports our hypothesis that LSP system dysfunction, as evidenced by SIJ dysfunction, is a common source of symptom patterning associated with CLBP and is most likely the causal element. This is evidence that most CLBP is not "nonspecific" but rather the result of changes made by the NMSK control system for the LSP region.

Characteristics and prognosis of distant metastasis after primary treatment for early-stage extranodal nasal-type natural killer/T-cell lymphoma from the China Lymphoma Collaborative Group database.

This study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early-stage extranodal nasal-type natural killer (NK)/T-cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrospectively reviewed. The cumulative incidence of DM was assessed using Fine and Gray's competing risk analysis. The correlation between DM sites was evaluated using phi coefficients, while DM sites were classified using hierarchical clustering. Regression analysis was used to assess the linear correlation between DM-free survival (DMFS) and overall survival (OS). The 5-year cumulative DM rate was 26.2%, with the highest annual hazard rate being in the first year (14.9%). The most frequent DM sites were the skin and soft tissues (SSTs, 32.4%) and distant lymph nodes (LNs, 31.3%). DM sites were categorized into four subgroups of distinct prognosis - distant LN, SST, extracutaneous site, and lymphoma-associated hemophagocytic lymphohistiocytosis. SST or distant LN, solitary metastasis, and late-onset DM demonstrated a relatively favorable prognosis. Contemporary chemotherapy significantly decreased DM rates and improved DMFS. Decreased DM rates were further associated with increased OS probabilities. Our findings improve the understanding of the variable clinical behaviors of early-stage ENKTCL based on four distinct DM sites and thus provide guidance for future therapeutic decisions, metastatic surveillance, and translational trial design.

Information identification skills and research output of academic librarians in universities in South-South Geopolitical Zone of Nigeria

This study investigated the relationship between information identification skills and the research output of academic librarians in universities in the South-South Geopolitical Zone of Nigeria with a corresponding specific objective, research question, and research hypothesis. To effectively drive the study two theories were adopted. The theory of social-cultural learning for the independent variable (information identification skills), and the theory of self-efficacy for the dependent variable (research output of academic librarians). More so, a conceptual review of literature on information identification skills and research output was carried out and a specific empirical review of the literature with extrinsic similarity and dissimilarity to the study was also done. The study adopted the correlational research design as the research design while the study area was the South-South Geopolitical Zone of Nigeria. The population of the study comprised 252 academic librarians from 14 libraries and faculties. The census technique was used to select the research participants 252. The researcher-developed questionnaire entitled: “Information Identification Skills and the Research Output of Academic Librarians Questionnaire (IISROALQ)” was used to collect data while the reliability test results using the Cronbach Alpha formula in SPSS showed an average coefficient of .83 which signified that the instrument was reliable for the study. Data was collected from the various universities by the researchers and their trained assistants by following the requisite ethical procedures. The data collected was analysed using frequencies and percentages for the research question, while the test of hypothesis at ≤ 0.05 level of significance was carried out with the Chi-Square Test of Independence. The result showed that information identification skills have a positive significant relationship with the research output of academic librarians with p-value = 0.00, and Phi coefficient of 2.49 indicating a very large extent of a positive relationship. In conclusion, it was recommended that the National University commission should make proficient utilization of information literacy skills by academic librarians as part of the requirement to assess their suitability for performance within the scholarly communities. Also, the university management should give attention to constant information literacy skills programs to enhance the literacy skills of the academic staff to be able to produce quality and rich research output.

Peripheral muscle oxygenation and symptoms of stress in adolescents with and without temporomandibular disorder.

To compare peripheral muscle oxygenation levels and the prevalence of psychological stress in adolescents with and without temporomandibular disorder (TMD). A cross-sectional study was performed with adolescents submitted into two groups: those diagnosed with TMD (DG) and control (CG). Muscle oxygenation was measured by near-infrared spectroscopy in the masseter and upper trapezius muscles. Symptoms of stress were assessed by Lipp's Stress Symptom Inventory for Adults or Child Stress Scale. A Student t-test was used for intergroup comparisons and association between categorical variables by chi-square test, phi coefficient of correlation, odds ratio, and two-way ANOVA. Fifty-three adolescents were evaluated and a significant reduction was observed in the oxyhemoglobin level in the masseter muscle at rest (p = 0.04) and contraction (p = 0.02). A greater total hemoglobin level was found in the upper trapezius muscle at rest in DG (p = 0.03), with a significant difference in the tissue saturation index during contraction (p = 0.05) intergroup. Individuals in the DG were 4.523 times more likely to exhibit signs and symptoms of stress than in CG. Adolescents from DG showed reduced masseter oxyhemoglobin values at rest and during contraction and showed more signs and symptoms of stress than healthy controls. In the upper trapezius, DG showed higher values of total circulating hemoglobin, essential for greater blood flow and efficient maximum voluntary contraction. Changes in tissue oxygenation and stress in adolescents with TMD prompted the earlier treatment of this population to prevent disease progression into adulthood.

CNSC-05. ELECTROPHYSIOLOGICAL PATTERNS OF GLIOMA-INDUCED NEURONAL NETWORK REMODELING ARE CONSERVED ACROSS TUMOR SUBTYPE

Abstract Recent evidence indicates that diffuse gliomas engage with neurons at the single-unit and circuit level through differing mechanisms. Certain malignant gliomas form glioma-neuron excitatory glutamatergic synapses and modulate neuron-neuron synapses through activity-dependent paracrine signaling, while others establish glioma-glioma connections via tumor microtubes. It is therefore possible that diffuse gliomas remodel neuronal circuits in a defined and predictable manner and demonstrate distinct electrophysiological profiles with prognostic and therapeutic significance. Here we apply machine learning principles in 140 patients across glioma subtypes to uncover unique electrophysiological features non-invasively via magnetoencephalography (discovery dataset) followed by feature validation using subdural electrocorticography (validation dataset). Following spatial-temporal registration, we fit an elastic net logistic regression classifier to distinguish between power spectra arising from glioma-remodeled cortex and within-subject control conditions. Model significance was determined non-parametrically by re-training each model 1,000 times with randomly permuted class labels and testing the true phi coefficient against the null distribution. In the discovery dataset, we were able to classify glioma infiltration based on tumor intrinsic neuronal activity (p &amp;lt; 0.05) in 127 patients (90.7%). We identified 30 electrophysiological features which revealed increased power in the delta range (1-4 Hz) and decreased power in the beta range (12-20 Hz) as a unique signature of glioma remodeling (p &amp;lt; 0.05) which was preserved in the validation dataset as well as across WHO 2021 diffuse glioma subtypes. In order to identify gene expression programs and signaling mechanisms that may contribute to glioma-induced remodeling but are potentially not identified in the current clinical classification scheme, we assessed targeted, next generation sequencing and DNA mutations as covariates, which again demonstrated the significance of the delta-beta spectral features. These data support converging mechanisms of glioma-induced neuronal network remodeling across tumor subtypes, setting the stage for novel therapies such as neuromodulation.

Components of intersectoral partnerships and positive health outcomes in highly vulnerable areas in São Paulo/Brazil: a mixed methods study

Introduction: Studying highly vulnerable areas is challenging, but it can support intersectoral actions to tackle the social inequalities prevalent therein. Objective: This research explores the relationship between the central constituents of intersectoral collaborations and the positive results of intersectoral actions in areas of high social vulnerability in São Paulo, Brazil. It also analyzes the perception of professionals in basic health units (BHU) regarding the results related to those actions. Methods: This study employed methodological triangulation and the mixed method sequential explanatory strategy. First, we applied an online form validated by face and content for BHU managers. Then, we used the SPSS Statistics software to perform nonparametric tests. Statistical significance was set at p &lt; 0.05, and 95% confidence intervals and phi coefficients were calculated. After identifying the units that carried out intersectoral actions with different partners, we conducted focus groups in four of them with 26 health professionals until saturation. Finally, we integrated quantitative and qualitative data. Results: The bivariate analysis showed that the creation of healthy habits and environmental improvements were associated with the central components of intersectoral partnerships. The content analysis presented steps to elaborate the actions and arrive at the results from the central elements. Integration of the results explained how the results related to the actions were elaborated, considering the central elements of the collaborative processes. Conclusions: Partners negotiate with patients or communities to adhere to the care provided through the collaborative process. However, they recognized that they needed to evaluate the proposed actions regularly.

PEMANFAATAN PELAYANAN KESEHATAN OLEH PESERTA BPJS KESEHATAAN DI PUSKESMAS LIPAT KAJANG KECAMATAN SIMPANG KANAN KABUPATEN ACEH SINGKIL TAHUN 2021

This study aims to determine the utilization of health services by BPJS Kesehatan participants at the Fold Kajang Health Center in 2022. This study is an analytic study with a cross sectional design. This research was conducted at the Fold Kajang Health Center in 2022. The population of this study was the BPJS Health participants at the Fold Kajang health center totaling 7401 people. The sample in this study were 99 people. Data were analyzed using chi square test. The results of this study indicate that 36.8% who utilize health services, which are not optimally utilize as much as 10.5%. The results of the Chi-Square statistical test obtained the value of = 0.000. The results of the phi coefficient test obtained the value of = 0.072, this indicates that the relationship is strong in the category of weak relationship (0.01-0.25). It can be concluded that there is a relationship between the BPJS Participant factor and the utilization of Health Services at the Fold Kajang Health Center in 2022 (weak relationship). There is a relationship between BPJS health participants and the utilization of health services at the Fold Kajang Health Center. There is no relationship between the role of health workers on the utilization of health services at the Fold Kajang Health Center. There is no relationship between the attitude factors towards the utilization of health services at the Fold Kajang Health Center. There is a relationship between the factors of access to the utilization of health services at the Fold Kajang Health Center and there is a relationship between the knowledge factor on the utilization of health services at the Fold Kajang Health Center.Keywords: Utilization of Health Services, BPJS Health