The mole fraction solubilities of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide (BPPO) in different organic solvents such as methanol, ethanol, ethyl acetate, cyclohexane, 2-propanol, acetonitrile, n-hexane, dichloromethane, dichloroethane, chloroform, benzene, and toluene were measured at a designated temperature of (295 to 345) K by the gravimetrical method. The solubilities of BPPO in dichloromethane, dichloroethane, chloroform, benzene, and toluene were all higher than 25 g·100 g–1 at 295.4 K. The mole fraction solubilities (x) of BPPO in methanol, ethanol, ethyl acetate, cyclohexane, 2-propanol, acetonitrile, and n-hexane were correlated as a function of temperature. Results showed that the calculated solubilities were in good agreement with the experimental solubility data.