Phenylarsonic Acid Research Articles

The quantitative separation on the micro-scale of phenylarsenious acid, phenylarsonic acid, arsenious acid and arsenic acid in simple solution and in urine

The quantitative separation on the micro-scale of phenylarsenious acid, phenylarsonic acid, arsenious acid and arsenic acid in simple solution and in urine

Changes undergone by phenylarsenious acid and phenylarsonic acid in the animal body

Changes undergone by phenylarsenious acid and phenylarsonic acid in the animal body

THE FATE OF ARSENIC IN THE BODY FOLLOWING TREATMENT OF RABBITS WITH CERTAIN ORGANIC ARSENICALS

1. The effect of changing the valency of the arsenic and of introducing substituents into the benzene ring on the distribution in the body and excretion of an aromatic arsenical has been studied, using phenylarsenoxide, phenylarsonic acid, m‐amino‐p‐hydroxyphenylarsen‐oxide (mapharsen), and m‐amino‐p‐hydroxyphenylarsonic acid, injected intravenously into rabbits.2. A high arsenic content was found in liver and kidney in all cases, and also in lung in the case of phenylarsenoxide.3. The ratio between the total amounts of arsenic excreted in the urine and in the feces varied widely with the different compounds, but the urinary output predominated in all experiments. The arsonic acids were cleared from the body more rapidly than the corresponding arsenoxides. Of the latter, unsubstituted phenylarsenoxide was the more slowly excreted.4. The slow rate of clearance of phenylarsenoxide may explain its high toxicity as compared with the other arsenicals studied. It is thought that the slow excretion and high toxicity of phenylarsenoxide, as compared with mapharsen, may be due to slower oxidation to the corresponding arsonic acid.

Effect of Merthiolate (Lilly) on Certain Specific Precipitation Reactions

Merthiolate (Lilly), a substituted benzoic acid, has been shown to interfere, in concentrations usually used for preservation, with the specific precipitation of antisera against beef serum or sheep serum coupled with diazotized p-aminobenzoic acid, p-arsanilic acid, or p-(p-aminophenylazo) phenylarsonic acid. In some systems increased precipitation was observed, while in others decreased precipitation was observed.

The Serological Properties of Simple Substances. V. The Precipitation of Polyhaptenic Simple Substances and Antiserum Homologous to the p-(p-Azophenylazo)-phenylarsonic Acid Group and its Inhibition by Haptens

The Serological Properties of Simple Substances. V. The Precipitation of Polyhaptenic Simple Substances and Antiserum Homologous to the p-(p-Azophenylazo)-phenylarsonic Acid Group and its Inhibition by Haptens

Ionization Constants of Several Substituted Phenylarsonic Acids

Ionization Constants of Several Substituted Phenylarsonic Acids

Detoxication of a Substituted Phenyl Stibonate in the Rat by Administration of p-Aminobenzoic Acid

The writer has reported1 experiments that demonstrated the highly protective powers of p-aminobenzoic acid when administered in substantial but well tolerated quantities to rats that simultaneously had received high lethal doses of Carbarsone, “Tryparsamide,” arsan-ilic acid, and Acetarsone. Further experiments, to be published in extenso elsewhere, have shown that p-aminobenzoic acid provides equally high protection against other penta-valent arsenicals including phenyl arsonic acid and also against at least one of the trivalent arsenical antisyphilis drugs.In view of the therapeutic value placed upon some of the less toxic antimony compounds in the treatment of such important tropical diseases as kala-azar and schistosomiasis, it seems desirable to record the capacity of p-aminobenzoic acid to protect rats against acute fatal doses of the German proprietary drug, “Stibosan” (sodium m-chloro p-acetyl amino phenyl stibonate), the only pentavalent antimony compound which was presently available for test pu...

Sulfophenylarsonic Acids and Certain of their Derivatives. V. p-(p-Sulfophenyl)-and p-(p-Sulfonamidophenyl)-phenylarsonic Acids1

Sulfophenylarsonic Acids and Certain of their Derivatives. V. p-(p-Sulfophenyl)-and p-(p-Sulfonamidophenyl)-phenylarsonic Acids¹

Phenylarsonic acid as a qualitative test for tin

Phenylarsonic acid as a qualitative test for tin

Phenylarsonic Acid as a Reagent for the Determination of Tin

Phenylarsonic Acid as a Reagent for the Determination of Tin