In the field of deep-water oil and gas extraction, the intermittent gas blocking phenomenon in helical-axial multiphase pumps leads to decreased pump performance and reliability, severely limiting their large-scale application and promotion in engineering projects. To address this challenge, this study is based on the principle of jet flow field control to flow separation, utilizing external energy for active intervention to suppress the separation phenomena and improve the hydraulic efficiency within the impeller flow channel. The research reveals that the jets achieved a reconstruction of the internal flow in the helical-axial gas-liquid mixed transport pumps. Using orthogonal experimental methods, a preliminary predictive analysis of the factors influencing the effectiveness of the jet system was conducted. The study explored the impact of jet parameters on enhancing the performance of helical-axial gas-liquid mixed transport pumps from the perspective of diminishing gas aggregation at the trailing edge of the rotor cascade and curtailing backflow conditions, and established a mathematical model for the head and efficiency of helical-axial multiphase pumps under jet active control. Research indicates that the jet velocity significantly impacts the efficiency enhancement of multiphase pumps, with an optimal jet speed coefficient, Cjet = 10, identified. Beyond this speed, the benefits brought by increased jet velocity do not compensate for the costs of introducing high-speed jets, and instead, may lead to a reduction in the efficiency of the pump. Jet flow field control methods alleviate the suction side gas aggregation downstream of the jet holes and in the flow domain traversed by the jets, effectively reducing the aggregation of gas phases in the rear channel of the rotor and suppressing backflow near the trailing edge of the rotor cascade. Jet control measures strengthen the working capacity of the blade in the flow direction beyond 0.35 times the length of the streamline, expanding the working range of the blade and enhancing the work efficiency of the multiphase mixed transport pump. Higher jet velocities result in more significant enhancements of blade working power, especially under conditions of high initial gas content, where the relative increase in blade load is more pronounced.