In a state of compassion fatigue, peoples work performance and social status are easily affected, and in severe cases, they may even cause some influence and harm to others. Therefore, it is important to study the factors that tend to affect empathy fatigue, the people who are prone to empathy fatigue and how to alleviate empathy fatigue, so as to reduce the occurrence of empathy fatigue. In this paper, the relationship between hypersensitive people and empathy fatigue and how to intervene and alleviate this fatigue phenomenon is studied through theoretical analysis and questionnaire survey. The analysis of the data from the questionnaire revealed that the more oversensitive people are, the more likely they are to develop the phenomenon of empathy fatigue, as well as the explanation that self-care and self-compassion can effectively intervene and alleviate empathy fatigue. This study has some limitations, which are explained at the end of this paper.