Phenanthrene Alkaloids Research Articles

Differentiation [formula omitted] by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria

Differentiation [formula omitted] by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria

Inhibition of protein synthesis in ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine

The phenanthroindolizidine alkaloids tylophorine and tylocrebrine and the phenanthroquinolizidine alkaloid cryptopleurine inhibit incorporation of leucine into protein in Ehrlich ascites-tumour cells by 50% at 1 × 10 −6 M, 2 × 10 −7 M, and 2 × 10 −8 M respectively, but do not inhibit incorporation of uracil into nucleic acids at 10 −5 M. Cryptopleurine inhibits leucine incorporation into protein in a cell-free system from Ehrlich cells, but at 10 −5 M does not inhibit protein synthesis in Escherichia coli.

Tlie alkaloids of Atherosperma moschatum Labill. II. Non-phenolic alkaloids

Of the new non-phenolic alkaloids previously reported in the bark of Atherosperma moschatum Labill., atherospermidine has been shown to have the methoxylspermatheridine structure (II), while atherosperminine (VIII) and a further new base, methoxyatherosperminine (IX), have proved to be members of the small group of phenanthrene alkaloids.

Action of Colchicine on a Transplanted Malignant Lymphoid Neoplasm in Mice of the C3H Strain

Colchicine is one of the alkaloids obtainable from the bulb, seeds, and leaves of Colchicum autumnale, Linnaeus. This plant, commonly called “false saffron,” “bastard saffron,” “dog-killer,” and “floating-light,” is a bulbous liliaceous plant which blooms during the fall in the wet meadows of Central and Southern Europe, the leaves and seeds appearing the following spring. Its use as a quasi-specific remedy against the acute crises of gout dates back to ancient times, perhaps to the Byzantines. By these people, the Arabs, Salernitians, and others it was called “hermodact.” This name, however, includes three botanical species: quintofolium, or long hermodact, Egyptian colchicum, or small hermodact, and Colchicum autumnale , which was imported from the East. The first formula for this drug we owe to Jacques Psychriste, physician and counsellor of Emperor Leon the Great (457–475 A.D.). The physicians of that time prescribed it mixed with large doses of scammony or alternated with Persian pills of aloe, for they attributed evacuant and cathartic properties to the drug. The irritating effect on the digestive tract was to be soothed by aromatics and sweetmeats. Colchicum was declared to be deadly by Dioscorides and its use was abandoned for centuries. The first scientific works on colchicum were contributed by Sennert (17th century), Stoerck (1763), Armstrong, Haden, Scudamore, Want and Williams (19th century). Colchicine was isolated by Houde in 1887. It occurs in the form of a yellow powder or thin yellow flakes; it is odorless and more soluble in cold than in warm water. The aqueous solution is yellowish, levorotatory, unstable in the light, and very bitter to the taste. The alkaloid is soluble, also, in ethyl alcohol and in chloroform, but only slightly so in ether. It has no well defined melting-point and is decomposed by heat. Its empirical formula is given by Windaus (1924) as C22H25NO6; its structural formula as To quote from Fieser (13), it is a “phenanthrene alkaloid, for it has been degraded to a tetramethoxymethylphenanthrene and to 9-methylphenanthrene.”

On the Relations between the Chemical Constitution and Pharmacological Action of Phenanthrene Alkaloids

On the Relations between the Chemical Constitution and Pharmacological Action of Phenanthrene Alkaloids