Phase Transfer Research Articles

Трансфер технологий как фактор инновационного развития АПК

The relevance of the study is increasing, firstly, in connection with the well-known geopolitical events that caused the aggravation of the problem of import substitution, and secondly, the activation of the "Federal Scientific and Technical Program for the Development of Agriculture for 2017-2030," which clearly sets the task of creating conditions for the interaction of business and science. "Technology transfer" becomes a direct link between them, as well as a conductor and translator of the achievements of fundamental and applied research. "Transfer" by authors means "the introduction or phased transfer with copyright of intellectual property (product) throughout the life cycle with state and (or) municipal financial, legal and other support. It is indicated that the existing technology transfer centers in the agro-industrial complex, formed by regional universities, cannot cope with the functions assigned to them. The use of digital and technological platforms as well as ecosystems is discussed. The problem of risks that occur in the interactions of participants with each other and with system coordinators is raised. The features of the modern "technology transfer" associated with the presence of negative factors and "barriers" are taken into account. It is proposed to use institutional analysis and fuzzy cognitive modeling. The terminology for assessing the "innovation potential" of an agricultural organization, the "level of innovation activity" and others is analyzed. The term "organization's readiness for innovative development" is proposed. The need is expressed for greater involvement in the sphere of "technology transfer" of development institutions, as well as the use of "innovative vouchers." The "field" of technology transfer activities such as public-private partnerships (PPPs) is being substantiated. A scheme is proposed for the formation, transfer, commercialization and scaling of advanced production technologies. A universal transfer mechanism has been developed not only for technologies, but also for other products of intellectual activity. The results of the functioning of the existing transfer of developed advanced production technologies are demonstrated, it is argued that the introduction of the developed mechanism of "technology transfer" will help accelerate the pace of innovative development of the agro-industrial complex.

Enhancing oxidative desulfurization using sludge-derived ferrate (VI) for dibenzothiophene: An optimization study

Sulfur emissions pose a substantial threat to human health and the environment. To address this, stringent regulations limit sulfur content in fuels, and innovative desulfurization technologies are under active investigation. Oxidative desulfurization (ODS) employs oxidants to convert sulfur compounds into more readily recoverable sulfones. This study explores high-shear mixing in ODS, known as mixing-assisted oxidative desulfurization (MAOD), focusing on dibenzothiophene (DBT) oxidation in model fuels and pyrolysis oil. Fe(VI) derived from drinking water treatment sludge via wet oxidation is utilized in the MAOD process. The research evaluates the impact of ferrate concentration (400–600 ppm), phase transfer agent (PTA) concentration (100–300 mg per 50 mL of fuel), agitation speed (4,400 to 10,800 rpm), and temperature (40–60 °C) on % DBT conversion. Experimental sulfur conversions range from 63.4 % to 99.6 %. Through response surface methodology, optimal parameters of 537 ppm Fe(VI), 114 mg PTA per 50 mL of model fuel, 8,157 rpm agitation speed, and 41.7 °C are determined. These parameters are applied to pyrolysis oil, achieving a desulfurization efficiency of 53.2 %. Notably, increasing Fe(VI) concentration, agitation speed, and temperature significantly enhances sulfur reduction. The study underscores the potential of using potassium ferrate derived from drinking water treatment sludge in MAOD for effective desulfurization and provides insights into the impact of operating conditions on desulfurization efficiency. Ultimately, the research contributes to advancing environmentally friendly and cost-effective desulfurization technologies.

Amphiphilic Polymer Electrolyte Blocking Lattice Oxygen Evolution from High‐Voltage Nickel‐rich Cathodes for Ultra‐Thermal Stabile Batteries

AbstractNi‐rich cathodes have been intensively adopted in Li‐ion batteries to pursuit high energy density, which still suffering irreversible degradation at high voltage. Some unstable lattice O2− species in Ni‐rich cathodes would be oxidized to singlet oxygen 1O2 and released at high volt, which lead to irreversible phase transfer from the layered rhombohedral (R) phase to a spinel‐like (S) phase. To overcome the issue, the amphiphilic copolymers (UMA‐Fx) electrolyte were prepared by linking hydrophobic C−F side chains with hydrophilic subunits, which could self‐assemble on Ni‐rich cathode surface and convert to stable cathode–electrolyte interphase layer. Thereafter, the oxygen releasing of polymer coated cathode was obviously depressed and substituted by the Co oxidation (Co3+→Co4+) at high volt (>4.2 V), which could suppressed irreversible phase transfer and improve cycling stability. Moreover, the amphiphilic polymer electrolyte was also stable with Li anode and had high ion conductivity. Therefore, the NCM811//UMA‐F6//Li pouch cell exhibited outstanding energy density (362.97 Wh/kg) and durability (cycled 200 times at 4.7 V), which could be stalely cycled even at 120°C without short circuits or explosions.

Water-Soluble Alumina-Coated Indium Phosphide Core-Shell Quantum Dots with Efficient Deep-Red Emission Beyond 700nm.

Solution-processed colloidal III-V semiconductor-based quantum dots (QDs) represent promising and environmentally-friendly alternatives to Cd-based QDs in the realms of optoelectronics and biological applications. While InP-based core-shell QDs have demonstrated efficientlight-emitting diode (LED) performance in the visible region, achieving deep-red emission (above 700nm) with a narrow linewidth has proven challenging. Herein, the study presents a novel strategy for synthesizing InP/ZnSe/ZnS core-shell-shell QDs tailored for emission in the first biological transparency window. The resulting QDs exhibit an emission wavelength up to 725nm with a narrow peak full width at half maximum (FWHM) down to 107 meV (45nm). To enhance the biocompatibility and chemical stability of the QDs, their surface is further capped with a layer of amorphous alumina resulting in an InP/ZnSe/ZnS/Al2O3 heterostructure. This surface passivation not only ensures environmental- and photostability but also enhances the photoluminescence quantum yield (PLQY). The alumina capping enables the aqueous phase transfer via surface ligand exchange using mercaptopropionic acid (MPA) while maintaining the initial quantum yield. The resulting QDs demonstrate a significant potential for advancing next-generation optoelectronic technologies and bio-applications.

Artificial magnetosomes: Molecularly restructured SPIONs with enhanced potential for magnetic imaging

Magnetosomes represent an elegant example of ultrastable nanomaterials that nature produces by encapsulating magnetic nanoparticles in liposomal sub-compartments of magnetotactic bacteria. Materials chemists continue to strive for ways to mimic the performance of natural systems, but the artificial synthesis of magnetosomes remains unrealized. Here, we report molecular restructuring of the surface of oleic-acid-capped superparamagnetic iron oxide nanoparticles (SPIONs) to produce magnetosomes. Our strategy involves the use of triethylamine as an amphiphilic surfactant that through a combination of ligand exchange and rearrangement mechanisms, facilitates an organic-to-aqueous phase transfer of SPIONs while turning them into magnetosomes. These liposome-encapsulated SPIONs showed dynamic aqueous stability alongside noticeably improved magnetic properties. This improved their performance as contrast agents for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), the latter revealing a 33.5 % improvement in signal sensitivity over the original SPIONs. The presented strategy is extendable to prepare liposomal dispersions of other biomedically important nanomaterials.

The MEMENTO code for modeling of macroscopic melt motion in fusion devices

The MEMENTO (MEtallic Melt Evolution in Next-step TOkamaks) code is a new numerical implementation of the physics model originally developed for the MEMOS-U code with the objective to self-consistently describe the generation of melt and its subsequent large scale dynamics in fusion devices and to assess the damage of metallic reactor armor under powerful normal and off-normal plasma events. The model has been validated in multiple dedicated EUROfusion experiments. MEMENTO solves the heat and phase transfer problem coupled with the incompressible Navier–Stokes equations in the shallow water approximation for the thin liquid film over the solid metal and with the current propagation equations on a domain that features a time-evolving deforming metal-plasma interface. The code utilizes non-uniform and adaptive meshing along with sub-cycling in time facilitated by the AMReX open-source framework as well as AMReX’s built-in parallelization capabilities.

Effect of surfactants on the permeation rate and selectivity of polyamide composite membranes for organic solvent nanofiltration

Solvent-resistant membranes are pivotal in industrial separations. This study aims to develop thin-film composite polyamide (TFC-PA) membranes with enhanced organic solvent nanofiltration (OSN) capabilities. Polyallylamine hydrochloride (PAAH) was used as the aqueous amine and isophthaloyl chloride (IPC) as the crosslinker to form the polyamide active layer by interfacial polymerization (IP) on a polyacrylonitrile (PAN) support. The impact of using anionic sodium dodecyl sulfate (SDS) and cationic cetyltrimethylammonium bromide (CTAB) to act as phase transfer agents during IP was investigated to understand their potential for facilitating the transfer of PAAH to the organic phase for reaction with IPC. The SDS and CTAB were separately dissolved into the PAAH solutions before IP to evaluate their effects on membrane properties. Extensive characterization including SEM, EDX, AFM, Water Contact Angle, ATR-FTIR, and Solid (CP-MAS) 13C NMR revealed various chemical and structural features of the membrane. The membrane M2 (PAAH-IPC) (exhibited >98% rejection for various anionic and cationic dyes. The inclusion of SDS during interfacial polymerization led to a substantial 3-fold increase in methanol permeate flux from 31 L m−2 h−1 to 119 L m−2 h−1, at a pressure of 15 bar. Conversely, the addition of CTAB resulted in membranes with higher permeate flux but insufficient dye rejection. Moreover, after three weeks of static aging of the membranes no significant changes were detected in either permeability or solute rejection, substantiating the stability of membranes.

TBAB-catalyzed assisted C-C/C-N bond formations: An efficient approach to dihydrobenzo[b][1,8]naphthyridin derivatives via metal free Cascade annulation

An eco-friendly, metal-free approach for synthesizing dihydrobenzo[b][1,8]naphthyridine derivatives has been established. This method employs ortho-chloroquinolin-α,β-unsaturated ketones as dipolarophiles and acyclic enaminones as amphiphilic nucleophiles, enabling a formal [3 + 3] annulation reaction under phase-transfer catalysis to offed the targeted products. It boasts transition-metal-free conditions, broad functional group compatibility, and straightforward operational procedures.

Transient energy transfer and cascade analysis for stratified turbulent channel flows

A comprehensive and fine-grained transient analysis of the kinetic budget equation in the spectral and spatial domains for channel flow subjected to stable stratification is performed, through a series of large eddy simulations (LES) at a bulk Reynolds number of 2200 and for Froude numbers of 0.5, 2.0, 4.5 and 6.8, thereby covering a range of stratification strengths from high to low. The dynamic Smagorinsky eddy viscosity-based sub-grid scale (SGS) model is used for closure. Validation of the methodology is carried out by comparing the turbulent flow LES results to previously published channel flow results. The analysis is focussed on the effect of stratification on the energy cascade process of an initially turbulent flow in a channel configuration. The terms in the kinetic budget equation, in the homogeneous and inhomogeneous directions, are compared for different Froude numbers to assess the effects of weak and strong stratification on turbulent statistics. Transient results are plotted to highlight the role played by different terms in the budget equation and to understand the formation of the gravity waves in the core or outer regions of the wall-bounded flow in the presence of stratification. The energy cascade reveals some interesting observations about the functions of viscous diffusion, pressure diffusion, and inhomogeneous energy transfer in the initial phase of the development of flow, which in turn helps to explain the stationary waves observed in the presence of strong stratification.

Urea-Based [2]Rotaxanes as Effective Phase-Transfer Organocatalysts: Hydrogen-Bonding Cooperative Activation Enabled by the Mechanical Bond.

We finely designed a set of [2]rotaxanes with urea threads and tested them as hydrogen-bonding phase-transfer catalysts in two different nucleophilic substitutions requiring the activation of the reactant fluoride anion. The [2]rotaxane bearing a fluorinated macrocycle and a fluorine-containing urea thread displayed significantly enhanced catalytic activity in comparison with the combination of both noninterlocked components. This fact highlights the notably beneficial role of the mechanical bond, cooperatively activating the processes through hydrogen-bonding interactions.

Computer-aided drug design supporting sunscreen research: a showcase study using previously synthesized hybrid UV filter-antioxidant compounds.

Although quantum mechanical calculations have proven effective in accurately predicting UV absorption and assessing the antioxidant potential of compounds, the utilization of computer-aided drug design (CADD) to support sustainable synthesis research of new sunscreen active ingredients remains an area with limited exploration. Furthermore, there are ongoing concerns about the safety and effectiveness of existing sunscreens. Therefore, it remains crucial to investigate photoprotection mechanisms and develop enhanced strategies for mitigating the harmful effects of UVR exposure, improving both the safety and efficacy of sunscreen products. A previous study conducted synthesis research on eight novel hybrid compounds (I-VIII) for use in sunscreen products by molecular hybridization of trans-resveratrol (RESV), avobenzone (AVO), and octinoxate (OMC). Herein, time-dependent density functional theory (TD-DFT) calculations performed in the gas phase on the isolated hybrid compounds (I-VIII) proved to reproduce the experimental UV absorption. Resveratrol-avobenzone structure-based hybrids (I-IV) present absorption maxima in the UVB range with slight differences between them, while resveratrol-OMC structure-based hybrids (V-VIII) showed main absorption in the UVA range. Among RESV-OMC hybrids, compounds V and VI exhibited higher UV absorption intensity, and compound VIII stood out for its broad-spectrum coverage in our simulations. Furthermore, both in silico and in vitro analyses revealed that compounds VII and VIII exhibited the highest antioxidant activity, with compound I emerging as the most reactive antioxidant within RESV-AVO hybrids. The study suggests a preference for the hydrogen atom transfer (HAT) mechanism over single-electron transfer followed by proton transfer (SET-PT) in the gas phase. With a strong focus on sustainability, this approach reduces costs and minimizes effluent production in synthesis research, promoting the eco-friendly development of new sunscreen active ingredients. The SPARTAN'20 program was utilized for the geometry optimization and energy calculations of all compounds. Conformer distribution analysis was performed using the Merck molecular force field 94 (MMFF94), and geometry optimization was carried out using the parametric method 6 (PM6) followed by density functional theory (DFT/B3LYP/6-31G(d)). The antioxidant behavior of the hybrid compounds (I-VIII) was determined using the highest occupied molecular orbital (εHOMO) and the lowest unoccupied molecular orbital (εLUMO) energies, as well as the bond dissociation enthalpy (BDE), ionization potential (IP), and proton dissociation enthalpy (PDE) values, all calculated at the same level of structural optimization. TD-DFT study is carried out to calculate the excitation energy using the B3LYP functional with the 6-31G(d) basis set. The calculated transitions were convoluted with a Gaussian profile using the Gabedit program.

Simultaneous purification and oxidation of the as-synthesized MWCNTs with KMnO4 using phase transfer catalyst at three different pH medium by the hydrothermal method

Improving and streamlining current oxidation techniques for experimental is the main goal of the research described in the present article. By applying the pressure created while on the hydrothermal process to an autoclave walled with Teflon, simplifying the procedure was accomplished. By comparing the degrees of functionalization attained with the dispersibility in the substantially pure and functionalized multi-walled carbon nanotubes (MWCNTs) final product, the beneficial effect of the procedure was evaluated. In order to achieve this, the study looked at and investigated how as-synthesized MWCNTs from Fe-Mo/MgO catalyst were simultaneously purified and oxidized using the chemical vapor deposition (CVD) method. Aliquot-336 was used as phase transfer catalyst (PTC) by hydrothermal method under three different pH conditions. Following functionalization, nanotubes of carbon might easily combine with various chemical reagents to generate homogeneous dispersions or even well-aligned structures because of the functional groups linked to their surfaces. In this case, a chemical called reagent potassium permanganate (KMnO4) is necessary in order to target particular π-bonds while entirely destroying the nanotubes' graphene structures. The techniques have been explained in terms of mechanism, and the Fourier transform-infrared (FT-IR) spectroscopy has confirmed the functionalizations of the CNTs. These approaches were further explored through FT-Raman spectrum analysis, thermal assessments, energy dispersive X-ray spectroscopy (EDX), TEM (transmission electron microscopy) along with the help of EDX, and visible-near IR absorption and UV–visible absorption spectroscopy (ABS) procedures.

Assessment of organic solvents for 2,5-furandicarboxylic acid (FDCA) and distribution in water/cyclohexanone biphasic system

2,5-furandicarboxylic acid (FDCA) is one of the most promising sugar-derived building blocks aimed to produce greener polymers, such as the 100 % recyclable bioplastic polyethylene furanoate (PEF). One incipient field of research is the development of liquid–liquid biphasic systems for FDCA production from 5-hydroxymethylfurfural (HMF) to increase selectivity and minimize undesirable by-product formation. In this work, we first performed an assessment of potential organic green solvents to form biphasic systems considering operability, along with safety, health, and environmental implications. This analysis guided the selection of eight organic solvents in which the solubility of FDCA was measured: cyclohexanone, diethyl ether, isobutyl acetate, methyl isobutyl ketone, methyl ethyl ketone, methoxycyclopentane, tert-butylmethyl ether, and octan-1-ol. The results revealed the superior performance of cyclohexanone as a solvent for the organic phase/water FDCA distribution owing to its higher FDCA solubility (1.364 g/L at 293.15 K). Thus, the FDCA distribution coefficient (KFDCA) between water and cyclohexanone was examined at several temperatures (293.15–313.15 K) and various initial aqueous concentrations to gain deeper insight into the thermodynamics of the phase transfer process and the influence of pH on FDCA distribution between water and cyclohexanone. The resulting enthalpy and entropy of transfer were −15.3 ± 1.0 kJ mol−1 and −44.9 ± 4.6 J K−1 mol−1, thus the highest value of KFDCA (4.83) was obtained at 293.15 K, together with a very high separation factor (81.5) which shows the great potential of cyclohexanone to extract FDCA from aqueous solutions.

Water-based quantum dots liquid scintillator for particle physics

Liquid scintillators are typically composed from organic compounds dissolved in organic solvents. However, usage of such material is often restricted due to fire safety and environmental reasons. Because of this, R&D of water-based liquid scintillators is of extreme relevance; yet, no such scintillators have been made commercially available as yet. Here, we investigate an alternative, water-based quantum dots liquid scintillator. Pre-determined and controllable optical properties of the quantum dots, as well as the existence of large libraries of established protocols for their dispersion in aqueous solutions, make them an attractive option for nuclear and particle physics applications. We characterize the optical properties of water-based quantum dots liquid scintillator and find that most of its optical properties are preserved upon quantum dots' phase transfer into water, through the addition of an oleic acid hydrophilic layer. Using the developed scintillator, the time and charge responses from atmospheric muons are measured, highlighting the practical viability of water-based quantum dots liquid scintillators for nuclear and particle physics, special interest on neutrino physics.

Electrophilic C(sp2)-H Cyanation with Inorganic Cyanate (OCN-) by PIII/PV=O-Catalyzed Phase Transfer Activation.

An organophosphorus -catalyzed method for the direct electrophilic cyanation of C(sp2)-H nucleophiles with sodium cyanate (NaOCN) is reported. The catalytic deoxyfunctionalization of the OCN- anion is enabled by the use of a small-ring phosphacyclic (phosphetane) catalyst in combination with a terminal hydrosilane O-atom acceptor and a malonate-derived bromenium donor. In situ spectroscopy under single-turnover conditions demonstrate that insoluble inorganic cyanate anion is activated by bromide displacement on a bromophosphonium catalytic intermediate to give a reactive N-bound isocyanatophosphonium ion, which delivers electrophilic "CN+" equivalents to nucleophilic (hetero)arenes and alkenes with loss of a phosphine oxide. These results demonstrate the feasibility of deoxyfunctionalization of insoluble inorganic salts by PIII/PV=O catalyzed phase transfer activation.

Electrophilic C(sp2)–H Cyanation with Inorganic Cyanate (OCN–) by PIII/PV=O‐Catalyzed Phase Transfer Activation

An organophosphorus redox‐catalyzed method for the direct electrophilic cyanation of C(sp2)–H nucleophiles with sodium cyanate (NaOCN) is reported. The catalytic deoxyfunctionalization of the OCN– anion is enabled by the use of a small‐ring phosphacyclic (phosphetane) catalyst in combination with a terminal hydrosilane O‐atom acceptor and a malonate‐derived bromenium donor. In situ spectroscopy under single‐turnover conditions demonstrate that insoluble inorganic cyanate anion is activated by bromide displacement on a bromophosphonium catalytic intermediate to give a reactive N‐bound isocyanatophosphonium ion, which delivers electrophilic “CN+” equivalents to nucleophilic (hetero)arenes and alkenes with loss of a phosphine oxide. These results demonstrate the feasibility of deoxyfunctionalization of insoluble inorganic salts by PIII/PV=O catalyzed phase transfer activation.

Prospects for the Detection of the Sgr A* Photon Ring with Next-generation Event Horizon Telescope Polarimetry

The Event Horizon Telescope (EHT) has imaged two supermassive black holes, Messier 87* (M87*) and Sagittarius A* (Sgr A*), using very-long-baseline interferometry (VLBI). The theoretical analyses of each source suggest magnetically arrested disk (MAD) accretion viewed at modest inclination. These MADs exhibit rotationally symmetric polarization of synchrotron emission caused by symmetries of their ordered magnetic fields. We leverage these symmetries to study the detectability of the black hole photon ring, which imposes known antisymmetries in polarization. In this Letter, we propose a novel observational strategy based on coherent baseline averaging of polarization ratios On a rotating basis to detect the photon ring with 345 GHz VLBI from the Earth’s surface. Using synthetic observations from a likely future EHT, we find a reversal in polarimetric phases on long baselines that reveals the presence of the Sgr A* photon ring in a MAD system at 345 GHz, a critical frequency for lengthening baselines and overcoming interstellar scattering. We use our synthetic data and analysis pipeline to estimate requirements for the EHT using a new metric: SNRPR, the signal-to-noise ratio of this polarimetric reversal signal. We identify long, coherent integrations using frequency phase transfer as a critical enabling technique for the detection of the photon ring and predict a SNRPR ∼ 2−3 detection using proposed next-generation Event Horizon Telescope parameters and currently favored models for the Sgr A* accretion flow. We find that higher sensitivity, rather than denser Fourier sampling, is the most critical requirement for polarimetric detection of the photon ring.

Phase transfer catalysts shift the pathway to transmetalation in biphasic Suzuki-Miyaura cross-couplings

The Suzuki-Miyaura coupling is a widely used C-C bond forming reaction. Numerous mechanistic studies have enabled the use of low catalyst loadings and broad functional group tolerance. However, the dominant mode of transmetalation remains controversial and likely depends on the conditions employed. Herein we detail a mechanistic study of the palladium-catalyzed Suzuki-Miyaura coupling under biphasic conditions. The use of phase transfer catalysts results in a remarkable 12-fold rate enhancement in the targeted system. A shift from an oxo-palladium based transmetalation to a boronate-based pathway lies at the root of this activity. Furthermore, a study of the impact of different water loadings reveals reducing the proportion of the aqueous phase increases the reaction rate, contrary to reaction conditions typically employed in the literature. The importance of these findings is highlighted by achieving an exceptionally broad substrate scope with benzylic electrophiles using a 10-fold reduction in catalyst loading relative to literature precedent.

An Investigation of N-Hydroxyphthalimide Catalyzed Aerobic Oxidation of Toluene without Metal Ions in Liquid Phase: Effect of Solvents and Phase Transfer Catalysts.

The selective oxidation of toluene to yield value-added oxygenates, such as benzyl alcohol, benzaldehyde, and benzoic acid, via dioxygen presents a chlorine-free approach under benign conditions. Metal-free catalytic processes are preferred to avoid metal ion contamination. In this study, we employed N-hydroxyphthalimide (NHPI) as a catalyst for the aerobic oxidation of toluene to its oxygenated derivatives. The choice of solvent exerted a significant impact on the catalytic activity and selectivity of the catalyst NHPI at reaction temperatures exceeding 70 °C. Notably, hexafluoroisopropanol substantially enhanced the selective production of benzaldehyde. Furthermore, we identified didecyl dimethyl ammonium bromide, featuring two symmetrical long hydrophobic chains, as a potent enhancer of NHPI for the solvent-free aerobic oxidation of toluene. This effect is ascribed to its unique symmetrical structure, extraction capabilities, and resistance to thermal and acid/base conditions. Based on the product distribution and control experiments, we proposed a plausible reaction mechanism. These findings may inform the industrial synthesis of oxygenated derivatives from toluene.

Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV.

AXL+ Siglec-6+ dendritic cells (ASDC) are novel myeloid DCs which can be subdivided into CD11c+ and CD123+ expressing subsets. We showed for the first time that these two ASDC subsets are present in inflamed human anogenital tissues where HIV transmission occurs. Their presence in inflamed tissues was supported by single cell RNA analysis of public databases of such tissues including psoriasis diseased skin and colorectal cancer. Almost all previous studies have examined ASDCs as a combined population. Our data revealed that the two ASDC subsets differ markedly in their functions when compared with each other and to pDCs. Relative to their cell functions, both subsets of blood ASDCs but not pDCs expressed co-stimulatory and maturation markers which were more prevalent on CD11c+ ASDCs, thus inducing more T cell proliferation and activation than their CD123+ counterparts. There was also a significant polarisation of naïve T cells by both ASDC subsets toward Th2, Th9, Th22, Th17 and Treg but less toward a Th1 phenotype. Furthermore, we investigated the expression of chemokine receptors that facilitate ASDCs and pDCs migration from blood to inflamed tissues, their HIV binding receptors, and their interactions with HIV and CD4 T cells. For HIV infection, within 2 hours of HIV exposure, CD11c+ ASDCs showed a trend in more viral transfer to T cells than CD123+ ASDCs and pDCs for first phase transfer. However, for second phase transfer, CD123+ ASDCs showed a trend in transferring more HIV than CD11c+ ASDCs and there was no viral transfer from pDCs. As anogenital inflammation is a prerequisite for HIV transmission, strategies to inhibit ASDC recruitment into inflamed tissues and their ability to transmit HIV to CD4 T cells should be considered.