The rapid development of magnetic materials provides the possibility for the application of permanent magnet stirring (PMS). Numerical and experimental investigations were employed with respect to the solidification process of the Al-2Sc alloy controlled by a novel PMS using NdFeB permanent magnets under various rotation speeds (0, 50, 100 and 150 r/min). The simulated results reveal that the maximum electromagnetic force increases proportionally from 4.14 to 12.39 kN/m3 and the maximum tangential velocity increases from 0.13 to 0.36 m/s when the rotation speed of PMS enhances from 50 to 150 r/min in the ingot melt. Besides, the experimental results demonstrate that PMS can achieve a uniform distribution of blocky Al3Sc precipitated phase in the longitudinal direction under the impact of a forced fluid flow. Moreover, increasing rotation speed of PMS is beneficial to refining aluminum grain size significantly and decreasing the texture intensity in the alloy. In addition, the Brinell hardness of Al-2Sc alloy is increased by 33% to 27.8 HB and the tensile strength is enhanced by 34% to 128.2 MPa, due to the improved distribution of the strengthening Al3Sc phase and the grain refinement of Al matrix under the impact of PMS. This work provides an effective application of NdFeB permanent magnets in the metal cast field.