Active Phase Research Articles

A wiggling filamentary jet at the origin of the blazar multi-wavelength behaviour

Blazars are beamed active galactic nuclei (AGNs) known for their strong multi-wavelength variability on timescales ranging from years down to minutes. Many different models have been proposed to explain this variability. We aim to investigate the suitability of the twisting jet model presented in previous works to explain the multi-wavelength behaviour of BL Lacertae, the prototype of one of the blazar classes. According to this model, the jet is inhomogeneous, curved, and twisting, and the long-term variability is due to changes in the Doppler factor due to variations in the orientation of the jet-emitting regions. We analysed optical data of the source obtained during monitoring campaigns organised by the Whole Earth Blazar Telescope (WEBT) in 2019--2022, together with radio data from the WEBT and other teams, and gamma -ray data from the Fermi satellite. In this period, BL Lacertae underwent an extraordinary activity phase, reaching its historical optical and gamma -ray brightness maxima. The application of the twisting jet model to the source light curves allows us to infer the wiggling motion of the optical, radio, and gamma -ray jet-emitting regions. The optical-radio correlation shows that the changes in the radio viewing angle follow those in the optical viewing angle by about 120 days, and it suggests that the jet is composed of plasma filaments, which is in agreement with some radio high-resolution observations of other sources. The gamma -ray emitting region is found to be co-spatial with the optical one, and the analysis of the gamma -optical correlation is consistent with both the geometric interpretation and a synchrotron self-Compton (SSC) origin of the high-energy photons. We propose a geometric scenario where the jet is made up of a pair of emitting plasma filaments in a sort of double-helix curved rotating structure, whose wiggling motion produces changes in the Doppler beaming and can thus explain the observed multi-wavelength long-term variability.

Effect of topical magnesium sulfate on labor duration and childbirth experience: a randomized controlled trial

BackgroundMagnesium sulfate is used topically to reduce the duration of labor in some regions of the country. However, there is insufficient evidence about its effectiveness. This study aimed to determine whether topical magnesium sulfate reduces labor duration and improves childbirth experience (primary outcomes).MethodsIn this randomized controlled trial, the participants were 98 women with low-risk, singleton, and full-term pregnancies admitted to a teaching hospital in Iran. They were randomly assigned to the intervention group (receiving 50% magnesium sulfate) or the control group (receiving distilled water) stratified by parity and onset of labor. The participants, interventionists, and data collectors were blinded. During the vaginal examination at the beginning of the active phase of labor, 10 mL of magnesium sulfate or distilled water was poured on the cervix of the uterus. Data collection was performed by the researcher with continuous monitoring up to two hours post-delivery and follow-up at 4–5 weeks postpartum. The Childbirth Experience Questionnaire 2.0 was used to examine childbirth experience. We performed a modified intention-to-treat analysis, excluding those whose outcome of interest could not be assessed. Independent-samples t-tests were used to compare the groups in terms of the mean of the primary outcomes.ResultsParticipant recruitment took place between December 2021 and December 2022. Thirty-three percent were primiparous and 37% had induced labor. Three women in the intervention group and seven in the control group underwent emergency cesarean sections. All 49 women assigned to each group were included in the analysis of labor duration outcome, while one and two women were excluded from the analysis of childbirth experience score due to loss to follow-up. In the intervention group, compared to the control group, the mean duration of the intervention until delivery was significantly shorter (1.59 vs. 2.93 h; MD -1.34, 95% CI [-1.88 to -0.79]) and the childbirth experience score was higher (3.1 vs. 2.3, MD 0.84; 95% CI [0.59 to 1.08]).ConclusionsAccording to the results of this trial, pouring 10 mL of 50% magnesium sulfate on the cervix at the beginning of the active phase of labor probably reduces labor duration and improves the childbirth experience.Trial registrationEthics Committee of Tabriz University of Medical Sciences: IR.TBZMED.REC. 1400.726. Iranian Registry of Clinical Trials: IRCT20100414003706N40 Registration date: 21/11/2021 (https://en.irct.ir/trial/58323).

Unravelling the seasonal dietary dynamics of the endangered garden dormouse (Eliomys quercinus) in Flanders, Belgium

The garden dormouse (Eliomys quercinus) faces significant population declines across Europe, prompting urgent conservation measures. A critical aspect of these efforts is understanding the species’ dietary composition and preferences within specific areas and how this changes throughout the year. We compared garden dormouse diets between two habitats in West Flanders, Belgium with faecal analysis from May to October, covering almost their entire active phase. Our findings revealed a diverse diet of both plant and animal matter, with notable variations between habitats and seasons. Blackberries and other fruits, leaves, and to a lesser extent flowers, were the predominant plant-based food sources in both study areas, with seasonal fluctuations indicating a dietary shift throughout the dormice’s active period. Spring diets consisted primarily of young leaves and flowers, changing to increased fruit consumption in summer. Beetles emerged as a main animal food source throughout the entire active period. Snails were prominently eaten in the woody area, while millipedes prevailed in the diet in the dune environment, both more in spring than later in the active season. These insights highlight the importance of maintaining diverse fruit sources and preserving beetle, snail, and millipede populations for garden dormouse conservation. This study provides valuable insights into dormouse dietary preferences and thus contributes to targeted conservation strategies being essential for the survival of the dormouse.

Dynamic Behavior of Pt Multimetallic Alloys for Active and Stable Propane Dehydrogenation Catalysts.

Improving the use of platinum in propane dehydrogenation catalysts is a crucial aspect to increasing the efficiency and sustainability of propylene production. A known and practiced strategy involves incorporating more abundant metals in supported platinum catalysts, increasing its activity and stability while decreasing the overall loading. Here, using colloidal techniques to control the size and composition of the active phase, we show that Pt/Cu alloy nanoparticles supported on alumina (Pt/Cu/Al2O3) displayed elevated rates for propane dehydrogenation at low temperature compared to a monometallic Pt/Al2O3 catalyst. We demonstrate that the enhanced catalytic activity is correlated with a higher surface Cu content and formation of a Pt-rich core and Cu-rich shell that isolates Pt sites and increases their intrinsic activity. However, rates declined on stream because of dynamic metal diffusion processes that led to a more uniform alloy structure. This transformation was only partially inhibited by adding excess hydrogen to the feed stream. Instead, cobalt was introduced to provide trimetallic Pt/Cu/Co catalysts with stabilized surface structure and stable activity and higher rates than the original Pt/Cu system. The structure-activity relationship insights in this work offer improved knowledge of propane dehydrogenation catalyst development featuring reduced Pt loadings and notable thermal stability for propylene production.

Heliospheric Effect on Solar Activity Parameters during MaximumPhase of Solar Cycle 24 (2012-2015)

Abstract The time series of daily data of solar activity proxies, namely the sunspot number (SSN), sunspot area (SSA), solar radio flux (F10.7), modified coronal index (MCI), solar flare index (FI), and cosmic ray intensity (CRI), were analyzed to understand the solar activity modulations and short-term periodicities therein. Rieger-type, and other short-term periods, including the solar rotational period that covers the maximum activity phase period (maximum phase of solar cycle 24). The wavelet power spectra and Periodogram of SSN, SSA, F10.7, MCI, FI, and CRI exhibited a significant short-term period. The heliospheric effects exist for a particular period (~27 days) and it is related to the solar activity phenomena. The cross-correlation coefficients and time lags between the cosmic ray intensity and solar activity parameters were estimated to be 200, 46, 281, 39, and 47 days for SSN, SSA, F10.7, MCI, and FI respectively during the time series 2012-2015 (maximum phase of solar cycle 24).

Spectral aging analysis of the 3C 219 double-double radio galaxy

Context. Double-double radio galaxies are characterized by intermittent jet-formation activity. The exact reasons for this behavior are not yet fully understood. Studying these objects and their environment allows us to find common characteristics and compare them with the general population of radio galaxies. 3C 219 is a well-known and thoroughly studied radio galaxy. Among the many explanations for its unusual “partial jet” structure, intermittent activity seems to be the leading one. However, this hypothesis has never been tested using aging analysis. Aims. The aim of this paper is to put constraints on the active galactic nucleus duty cycle and dynamics of radio lobe expansion in 3C 219, in both the inner and outer double. This will provide us with information on the behavior of the central engine and the interaction of the radio lobes with the ambient medium, allowing us to verify whether the structure of 3C 219 is the result of intermittent activity and to search for its possible causes. Methods. We performed a spectral aging analysis of the 3C 219 double-double radio galaxy using archival Karl G. Jansky Very Large Array and Low Frequency Array data. We present detailed spectral age maps and constructed a spectral age profile. We compared ratios of linear sizes and luminosities in individual phases of activity with lobe expansion velocities in the plane of the sky derived from the age profile to infer hot-spot advance velocities through the surrounding medium and the orientation of the jet axes. Results. The galaxy shows a general asymmetry in the distribution of plasma with respect to the inferred jet axis in the original phase of activity, suggesting an influence of the intracluster medium on the formation of the radio structure. The advance speed of hot spots in the outer double is typical of classical FRII sources expanding into an ambient thermal medium, while for the inner double, the lower limit is estimated to be ∼0.28 c. The radio galaxy has experienced a very short quiescent period of no more than 2 Myr, which is ≲7% of its total lifetime. Conclusions. The most plausible explanation for the double-double radio structure in 3C 219 is a rapid jet reorientation along the line of sight, which may be the result of a minor merger. Further study of the 3C 219 inner double is needed. High-resolution maps are required to probe its structure in sufficient detail, while high-frequency observations are necessary to better constrain the durations of the quiescent and restarted phases.

Assessment of Borač-Kotlenik magmatic massif rock mass technical properties as potential source for optimal development of regional road infrastructure based on local stone materials

The Borač-Kotlenik magmatic massif in central Serbia is mainly made up of effusive and pyroclastic rocks, formed in three main phases of volcanic activity: 1. dacite and andesite, 2. quartz-latite and dacite, and 3. basaltoid rocks. Rock mass samples from this magmatic massif have been examined and mined in numerous localities during the XX century for purposes of building and reconstruction works of local and regional road networks. The examination process continues today for purposes of ‘Morava corridor’ highway building and its demand for the local stone material of the specified quality. The results of rock mass technical properties' tests have shown that its quality for road building purposes depends significantly on petrologic type, soundness, and hydrothermal alteration type. Oxidation alteration types can cause a significant decrease in compressive strength, an increase in porosity and water absorption, especially as oxidation chemical processes cause increased susceptibility to weathering, thus making the rock mass unusable in road construction profile layers above the embankment. Testing results demonstrate that effusive volcanic rocks of the Borač-Kotlenik magmatic massif generally can be used in the road building process. For this purpose, it is necessary to select the conformable rock mass zones at each locality, where hydrothermal alteration and weathering products are absent in order to obtain the best available stone material of volcanic origin.

In Situ Transformed CoOOH@Co3S4 Heterostructured Catalyst for Highly Efficient Catalytic OER Application.

The deprived electrochemical kinetics of the oxygen evolution reaction (OER) catalyst is the prime bottleneck and remains the major obstacle in the water electrolysis processes. Herein, a facile hydrothermal technique was implemented to form a freestanding polyhedron-like Co3O4 on the microporous architecture of Ni foam, its reaction kinetics enhanced through sulfide counterpart transformation in the presence of Na2S, and their catalytic OER performances comparatively investigated in 1 M KOH medium. The formed Co3S4 catalyst shows outstanding catalytic OER activity at a current density of 100 mA cm-2 by achieving a relatively low overpotential of 292 mV compared to the pure Co3O4 catalyst and the commercial IrO2 catalyst. This enhancement results from the improved active centers and conductivity, which boost the intrinsic reaction kinetics. Further, the optimized Co3S4 catalyst exhibits admirable prolonged durability up to 72 h at varied current rates with insignificant selectivity decay. The energy dispersive X-ray spectroscopy (EDX) and Raman spectra measured after the prolonged OER stability test reveal a partial transformation of the active catalyst into an oxyhydroxide phase (i.e., CoOOH@Co3S4), which acts as an active catalyst phase during the electrolysis process.

Partially Fluorinated Alumina With Enhanced Stability: Application To Catalysis Under Aggressive Conditions

AbstractHere, we report the design of new aluminum hydroxyfluoride, mainly composed of amorphous phase, with enhanced stability under HF gas in term of textural properties, especially the specific surface area and the acidity. The material has been synthesized through an EISA (evaporation‐induced self‐assembly) route using liquid crystals as templates. Thanks to this stability, the catalyst designed by the dispersion of the active phase on this support shows a higher accessibility and activity of the active sites than the ones obtained by other methods

Key Ingredients for the Modeling of Single‐Atom Electrocatalysts

AbstractSingle‐atom catalysis is gaining interest also because of its potential applications in a broad spectrum of electrochemical reactions. The reactivity of single‐atom catalysts (SACs) is typically modeled with first principles approaches taking insight from heterogenous catalysis. An increasing number of studies show that the chemistry of SACs is more complex than often assumed, and shares many aspects in common with coordination chemistry. This evidence raises challenges for computational electrocatalysis of SACs. In this perspective we highlight a few fundamental ingredients that one need to consider to provide reliable predictions on the reactivity of SACs for electrochemical applications. We discuss the role of the local coordination of the metal active phase, the need to use self‐interaction corrected functionals, in particular when systems have magnetic ground states. We highlight the formation of unconventional intermediates with respect to classical metal electrodes, the need to include the stability of SACs in electrochemical conditions and the role of solvation in the analysis of new potential catalytic systems. This brief account can be considered as a tutorial underlining the importance of treating the reactivity of SACs. In fact, neglecting some of these aspects could lead to unreliable predictions failing in the design of new electrocatalysts.

Modeling a biofluid-derived extracellular vesicle surface signature to differentiate pediatric idiopathic nephrotic syndrome clinical subgroups

Idiopathic Nephrotic Syndrome (INS) is a common childhood glomerular disease requiring intense immunosuppressive drug treatments. Prediction of treatment response and the occurrence of relapses remains challenging. Biofluid-derived extracellular vesicles (EVs) may serve as novel liquid biopsies for INS classification and monitoring. Our cohort was composed of 105 INS children at different clinical time points (onset, relapse, and persistent proteinuria, remission, respectively), and 19 healthy controls. The expression of 37 surface EV surface markers was evaluated by flow cytometry in serum (n = 83) and urine (n = 74) from INS children (mean age = 10.1, 58% males) at different time points. Urine EVs (n = 7) and serum EVs (n = 11) from age-matched healthy children (mean age = 7.8, 94% males) were also analyzed. Tetraspanin expression in urine EVs was enhanced during active disease phase in respect to the remission group and positively correlates with proteinuria levels. Unsupervised clustering analysis identified an INS signature of 8 markers related to immunity and angiogenesis/adhesion processes. The CD41b, CD29, and CD105 showed the best diagnostic scores separating the INS active phase from the healthy condition. Interestingly, combining urinary and serum EV markers from the same patient improved the precision of clinical staging separation. Three urinary biomarkers (CD19, CD44, and CD8) were able to classify INS based on steroid sensitivity. Biofluid EVs offer a non-invasive tool for INS clinical subclassification and “personalized” interventions.

Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation

BackgroundInsomnia is more prevalent in individuals with Autism Spectrum Disorder (ASD), can worsen core-symptoms and reduces quality of life of both individuals and caregivers. Although ASD is four times more prevalent in males than females, less is known about sex specific sleep differences in autistic individuals. Recent ASD studies suggest that sleep problems may be more severe in females, which aligns with the sex bias seen in insomnia for the general population. We have previously shown that male mice with a mutation in the high confidence ASD gene Shank3, Shank3∆C, recapitulate most aspects of the ASD insomnia phenotype. The objective of the present study was to leverage the Shank3∆C model to investigate sex-specific effects in sleep using polysomnography.MethodsAdult male and female Shank3∆C and wildtype (WT) littermates were first recorded for 24 h of baseline recordings. Subsequently, they were sleep deprived (SD) for five hours via gentle handling and allowed 19 h of recovery sleep to characterize the homeostatic response to SD. Vigilance states (rapid eye movement (REM) sleep, non-rapid eye movement (NREM) sleep and wake) were assigned by manual inspection using SleepSign. Data processing, statistical analysis and visualization were conducted using MATLAB.ResultsSex and genotype effects were found during baseline sleep and after SD. At baseline, male Shank3∆C mice sleep less during the dark period (active phase) while female Shank3∆C mice sleep less during the light period (rest phase) and sleep more during the dark period. Both male and female Shank3∆C mice show reduced spectral power in NREM sleep. We detect a significant effect of sex and genotype in sleep onset latency and homeostatic sleep pressure (sleepiness). In addition, while male Shank3∆C mice fail to increase sleep time following SD as seen in WT, female Shank3∆C mice decrease sleep time.ConclusionsOverall, our study demonstrates sex differences in sleep architecture and homeostatic response to SD in adult Shank3∆C mice. Thus, our study demonstrates an interaction between sex and genotype in Shank3∆C mice and supports the use of the Shank3∆C model to better understand mechanisms contributing to the sex differences in insomnia in ASD in clinical populations.

Development of the Arabian-Nubian Shield along the Marsa Alam-Idfu transect, Central-Eastern Desert, Egypt: geochemical implementation of zircon U-Pb geochronology

The magmatic complex along the Marsa Alam-Idfu transect, Central-Eastern Desert of Egypt, represents the northern segment of the Arabian–Nubian Shield (ANS), which developed within the framework of the East African Orogen. The basement rocks of the Arabian-Nubian Shield have been developed through three distinct phases of magmatic activity: the island-arc, the syn-orogenic, and the post-orogenic phases. Transitioning of the magmatic phases from the syn-orogenic to the post-orogenic, identifies changing the tectonic regime from a compressional to an extensional setting. The scarcity of comprehensive regional geochronological data that rely on precise isochron methods, such as the zircon U-Pb technique, could limit the comprehensive understanding of this region’s geological and tectonic history. That would raise a number of uncertainties ranging from the timing of the different magmatic activities and timing of changes in the tectonic regime to the existence of the pre-Pan-African crust in the CED. Our study provides new insights into the aforementioned uncertainties through zircon U-Pb dating of different rock units along the Marsa Alam-Idfu transect, CED, Egypt. The resulting ages ranged from 729 ± 3 Ma to 570 ± 2 Ma, constraining the temporal evolution of the ANS in the studied region into (1) the island-arc phase, represented by a metamorphic sample with an age of 729 ± 3 Ma. (2) the syn-orogenic phase, represented by calc-alkaline and alkaline granitic samples with ages ranging from 699 ± 4 Ma to 646 ± 2 Ma. These two phases indicate initiation of the compressional subduction regime in the CED since 729 ± 3 Ma and being dominated till 646 ± 2 Ma. (3) the post-orogenic phase, represented by metavolcanics, volcanic rocks, and alkaline plutonic samples with ages ranging from 623 ± 3 Ma to 570 ± 2 Ma. This phase suggests dominance of the compressional-to-extensional tectonic transition setting from 623 ± 3 Ma to 600 ± 1 Ma along with the Dokhan volcanism and activation of post-collision tensional regime activated at 582 ± 3 Ma. Our findings discourage the proposed dominance of the island-arc and syn-orogenic phases in the CED and the classical restriction of older magmatic activity to calc-alkaline granitic rocks and younger magmatic activity to alkaline granitic rocks. Additionally, we identified evidence of local magmatic sources by dating five grains with Mesoproterozoic (pre-Arabian–Nubian Shield) xenocrysts with ages ranging from 1549 ± 4 to 1095 ± 25 Ma.

Cardiovascular Response and Locomotor Demands of Elite Basketball Referees During International Tournament: A Within- and Between-Referee Analysis.

There is little knowledge about within- and between-referee variation (WBRV) in cardiovascular responses (CVR) and locomotor game demands (LMD). Thus, the primary aim of this study was to assess the WBRV of CVR and LMD in male basketball referees during elite international games in preparation [e.g., warm-up (WU) and re-warm-up (R-WU)] and active game phases. The secondary aim was to explore quarter-by-quarter differences in CVR and LMD. Thirty-five international male referees took part in this study (age, 40.4 ± 5.4 years; body height, 184.9 ± 5.7 cm; body weight, 85.1 ± 7.5 kg; BMI, 24.0 ± 1.7 kg × m-2; fat%, 18.8 ± 4.7% and VO2max, 50.4 ± 2.2 L × kg-1 × min-1. In total, 76 games (e.g., 228 officiating cases) were analyzed during the FIBA elite men's competition. They officiated 4.5 games on average (range 3-9 games). Each referee used the Polar Team Pro system to measure CVR [e.g., heart rate (HR), time spent in different HR intensity categories] and LMD (e.g., distance covered, maximal and average velocity, and number of accelerations). Results showed that the referees had bigger WBRV during the active and preparation (e.g., W-U than R-WU) phase when variables of higher CVR and LMD intensity were observed (e.g., time spent at higher HR zones, distance covered in higher speed zones). The WBRV, CVR, and LMD were higher during WU than R-WU. Moreover, the referees had a lower CVR and LMD in the second half. In conclusion, the referees should establish and follow consistently a game-to-game preparation routine and attempt to spread their on-court preparation time equally within the crew. A half-time preparation routine should be improved to re-establish a sufficient activation level similar to that achieved in pre-game preparation.

Transcatheter valve replacement as rescue treatment for heart failure in infective endocarditis. A multinational series.

Abstract Background Transcatheter valve replacement (TVR) could be a therapeutic alternative for refractory heart failure in patients with infective endocarditis (IE) unsuitable for open surgery. However, evidence of tis use in this scenario is limited to isolated case reports. Purpose We aimed to describe the clinical characteristics and outcome of IE patients in whom a TVR was performed during the active phase of infection in a multinational case series. Methods This retrospective study was conducted in 23 referral hospitals for IE and TVR procedure in 8 countries. All consecutive adult patients (≥18 y) with definite IE in whom a TVR was performed during antimicrobial treatment of within the 3 three months after its withdrawal were included. The inclusion period was between July 2011 and July 2023. Baseline, IE-related, TVR-related, outcome and follow-up (min. 3 months) variables were collected. Results Forty-five patients [median age 74 years (IQR 64 – 82), 35 males (78%), median Charlson comorbidity index 6 (4 – 7) points] were included in the study: 42 aortic TVR, 2 mitral TVR and 1 tricuspid TVR. In 20 patients (44%) TVR was performed on a native valve and in 25 on a prosthetic valve. The most frequent microorganisms causing IE were streptococci (n=16, 36%), staphylococci (n=13, 29%) and enterococci (n=5, 11%). Acute heart failure was present in 41 (91%). Of them, 23 (51%) developed acute pulmonary oedema or cardiogenic shock. The main reasons for excluding open surgery were: high surgical risk [n=39, 87%; median EuroSCORE 17 (9 – 28)] and technical impossibility (n=3, 7%). TVR was performed during antimicrobial treatment in 27 cases (60%) [median 25 (13 – 54) days after initiation] and within the first three months after its completion in 18 (40%) [median 25 (17 – 68) days after discontinuation]. Four patients (9%) died during admission. Over a median follow-up of 10 (6 -30) months, 7/41 patients (17%) died and there were 2/41 (5%) relapses, one of which required open valve replacement surgery 17 days after TVR procedure. Two other patients underwent open surgery due to paravalvular leaks (11 and 44 days after TVR). All cases of relapse and open surgery occurred when TVR was performed during antibiotic treatment. Conclusion TVR could be an option as rescue treatment for heart failure in selected IE patients unsuitable for open surgery. This represents a paradigm shift in the management of IE and may change the natural history of the disease in patients who would otherwise die.

Kinetic analysis of the self-discharge of the NiOOH OER active phase in KOH electrolyte: insights from in-situ Raman and UV–Vis reflectance spectroscopies

NiOOH has been established as the active phase of NiO-based electrocatalysts in the alkaline Oxygen Evolution Reaction (OER). Here, we investigate the self-discharge behavior of NiOOH electrodes under open circuit potential (OCP) conditions in 1 M KOH electrolyte by monitoring phase changes via in-situ Raman and UV–Vis reflectance spectroscopies and performing kinetic analyses on the OCP and spectroscopic data. Our findings reveal a linear phase change from NiOOH to Ni(OH)2 over time, indicative of a 0th-order reduction reaction. Contrarily, the OCP evolution associated with this phase reduction displayed a combination of linear and exponential decay patterns as a result of various kinetics, including Faradaic processes and diffusion-controlled mechanisms, influencing the self-discharge potential over 1.25 V (vs RHE). An additional linear region at lower potentials (<1.25 V (vs RHE)) suggests that charge redistribution due to the phase change from α-Ni(OH)2 to β-Ni(OH)2 dominates the self-discharge, a behavior confirmed by in-situ UV–Vis reflectance spectroscopy. These findings highlight the effectiveness of combining in-situ Raman and UV–Vis spectroscopy with electrochemical data for real-time monitoring of electrochemical processes, here potential-dependent electrocatalyst phase changes, leading to a more detailed and accurate understanding of the dynamic behavior, phase change kinetics, and self-discharge behaviors of solid electrocatalysts that can guide the design of more efficient and durable energy storage and conversion materials.

Analysis of Bone Phenotype Differences in MEN1-Related and Sporadic Primary Hyperparathyroidism Using 3D-DXA.

Background: The rarity and variability of MEN1-related primary hyperparathyroidism (mPHPT) has led to contradictory data regarding the bone phenotype in this patient population. Methods: A single-center retrospective study was conducted among young age- and sex-matched patients with mPHPT and sporadic hyperparathyroidism (sPHPT). The main parameters of calcium-phosphorus metabolism, bone remodeling markers, and bone mineral density (BMD) measurements were obtained during the active phase of hyperparathyroidism before parathyroidectomy (PTE) and 1 year after. Trabecular Bone Score (TBS) and 3D-DXA analysis of the proximal femur were used to evaluate the differences in bone architecture disruption between groups. Results: Patients with mPHPT had significant lower preoperative BMD compared to sPHPT at lumbar spine-LS (p = 0.002); femur neck-FN (p = 0.001); and total hip-TH (p = 0.002). 3D-DXA analysis showed the prevalence of cortical rather than trabecular bone damage in mPHPT compared to sPHPT: cortical thickness (p < 0.001); cortical surface BMD (p = 0.001); cortical volumetric BMD (p = 0.007); and trabecular volumetric BMD (p = 0.029). One year after, PTE DXA and 3D-DXA parameters were similar between groups, while 3D-visualisation showed more extensive regeneration in cortical sBMD and cortical thickness in mPHPT. Conclusions: mPHPT is associated with lower preoperative BMD values with predominant architecture disruption in the cortical bone. The absence of differences in DXA and 3D-DXA parameters 1 year after PTE between mPHPT/sPHPT combined with significantly lower BMD in mPHPT at the initial stage may indicate faster bone recovery after surgery in mPHPT than in sPHPT.

New Materials for Thin-Film Solid-Phase Microextraction (TF-SPME) and Their Use for Isolation and Preconcentration of Selected Compounds from Aqueous, Biological and Food Matrices.

Determination of a broad spectrum of analytes, carried out with analytical instruments in samples with complex matrices, including environmental, biological, and food samples, involves the development of new and selective sorption phases used in microextraction techniques that allow their isolation from the matrix. SPME solid-phase microextraction is compatible with green analytical chemistry among the sample preparation techniques, as it reduces the use of toxic organic solvents to the minimum necessary. Over the past two decades, it has undergone impressive progress, resulting in the development of the thin-film solid-phase microextraction technique, TF-SPME (the thin-film solid-phase microextraction), which is characterized by a much larger surface area of the sorption phase compared to that of the SPME fiber. TF-SPME devices, in the form of a mostly rectangular metal or polymer substrate onto which a thin film of sorption phase is applied, are characterized, among others, by a higher sorption capacity. In comparison with microextraction carried out on SPME fiber, they enable faster microextraction of analytes. The active phase on which analyte sorption occurs can be applied to the substrate through techniques such as dip coating, spin coating, electrospinning, rod coating, and spray coating. The dynamic development of materials chemistry makes it possible to use increasingly advanced materials as selective sorption phases in the TF-SPME technique: polymers, conducting polymers, molecularly imprinted polymers, organometallic frameworks, carbon nanomaterials, aptamers, polymeric ionic liquids, and deep eutectic solvents. Therefore, TF-SPME has been successfully used to prepare analytical samples to determine a broad spectrum of analytes in sample matrices: environmental, biological, and food. The work will be a review of the above-mentioned issues.

Temperature and water availability induce chronic stress responses in Zebra finch (Taeniopygia guttata).

Animals initiate physiological mechanisms to re-establish homeostasis following environmental stress. To understand how bird physiology responds to abiotic stress, we quantified changes in hematological markers of chronic stress response and body condition of male zebra finches (Taeniopygia guttata) acclimated for 18 weeks to hot and cool temperatures (daytime temperature: 40°C and 23°C) with water available ad libitum or restricted during half of the active phase. Ambient temperature induced greater chronic stress than restricted water availability. While cool compared to hot temperatures induced higher numbers of heterophils and H : L ratios and declined total leucocyte counts, water restriction decreased the number of lymphocytes compared to water ad libitum. Body condition correlated with hematological parameters showing that birds with better condition had greater capacity to face environmental stress. Therefore, prolonged exposure to cool periods may result in chronic stress in zebra finches, especially, if body condition is weakened.

The Impact of Post-Activation Performance Enhancement Protocols on Vertical Jumps: Systematic Review

Background: The post-activation performance enhancement (PAPE) protocol is frequently utilized to enhance athletic performance through high-intensity stimuli. Despite its popularity, the effectiveness and mechanisms of PAPE remain unclear, particularly in the context of improving jump performance in sports. Methods: A systematic review was conducted following the PRISMA guidelines. A comprehensive search was conducted across databases including Scopus, Web of Science, PubMed, and EBSCO up to 31 March 2024. Results: Initially, 481 studies were identified, of which 8 were finally included, involving a varied number of participants, each focusing on the impact of PAPE on jump performance. These studies predominantly indicated that PAPE protocols can lead to short-term improvements in jump performance. Two publications demonstrated a positive effect on jump height, and one of them reported a questionable effect on jump height in the initial time period, while the remaining five publications showed a positive impact on jump performance. The average increase in height achieved based on the intervention from the publications was 4.03% (p &lt; 0.05). Variability in effectiveness was noted depending on the type of exercises used in the activation phase, timing of performance post activation, and individual physiological characteristics. Conclusions: PAPE protocols can effectively enhance jump performance in athletic populations, although outcomes vary based on protocol specifics and individual differences. These findings support the need for individualized approaches in the application of PAPE protocols to optimize athletic performance.