PURPOSE: We studied the effect of a comprehensive lifestyle intervention (nutrition, physical activity, pharmacy, and behavioral counseling) on health related outcomes in 42 stage 3 & 4 (eGFRs 15-59 ml/min/1.73m2) CKD patients (age 60.2 ± 9.2, BMI 34.5 ± 7.8). METHODS: Patients were assigned randomly to a treatment (T, n= 27) or usual care (UC, n= 15) group, and asked to attend four test sessions: baseline (BL), month 1 (M1), month 3 (M3) and month 6 (M6). Anthropometrics, medication use, three-day nutritional intake, central (cSBP/cDBP) & brachial blood pressures (bSBP/bDBP), augmentation index ([email protected]), Short Physical Performance Battery (SPPB) test, the six-minute walk test (6MWT), leg strength & power, self-efficacy to adhere to diet and physical activity (PA) recommendations, and the KDQOL were assessed at each visit. PA levels and inflammatory markers (IL6 & hsCRP) were assessed at BL and M6. Patients in T received individual counseling at BL, M1, & M3 with biweekly follow-up phone contact. Patients in UC were asked to follow the instructions of their nephrologist. RESULTS: All data are presented as means ± SD. Primary outcome variables were analyzed by 2 x 2 mixed factor ANOVAs. See table for some of the findings:CONCLUSION: In conclusion, this program led to reductions in bSBP, cSBP and cDBP at M3 which were attenuated at M6. Patients in T felt less restricted by their disease than the UC group. This home- based program resulted in no improvements in functional outcomes (SPPB or 6MWT). Supervised, in-center programs are preferred when working with CKD patients.