ABSTRACT: The objective of this study was to compare the overall health care charges of managed care organization (MCO) patients with gastroesophageal reflux disease (GERD) with comparison groups of MCO members. The study consisted of a retrospective review of eligibility data and claims filed for services dated January 1, 1994 through December 31, 1994 in a private benefit plan including HMOs and preferred provider organizations serving commercial and Medicare markets in the Midwest and South. Patients were continuously eligible for drug benefits and were not enrolled in a capitated benefit plan. The GERD group (n=5,254) inclusion required a claim with a diagnosis of GERD. Three comparison groups, age- and gender-matched to the GERD group, were randomly selected (n=5,254 in each group). The first comparison group inclusion required membership in the MCO plan in 1994 whether or not claims were submitted. The second group inclusion required that at least one claim had been submitted in 1994. The third requ...