Pharmaceutical Business Research Articles

Pharmaceutical Marketing Management in India

Background: In order to identify key tactics and their gaps, the researcher self- designed questionnaire responses from 80 respondents (who either work at managing level in a pharmaceutical company or own their own firm) on Google through convenience sampling across several areas in India. Additionally, the researcher solicited consumer input on marketing assistance, strategies, and tools. We are going to present research on how pharmaceutical firms' marketing tactics change over time as they transition from one to other. It will additionally shine light on the many marketing techniques and tools that pharmaceutical businesses use. Results: A comprehensive cohort comprising 160 patients satisfying the criteria was included in the study. The duration of the study was six months, and the data were collected from the Department of Nephrology of a Government Medical College. Businesses must use digital marketing, or digital devices for marketing (TAB), to improve efficient advertising after studying pharmaceutical marketing strategies and proposing various strategies for conversation. Digital platforms also play a significant role in facilitating effective feedback and surveys related to marketing strategies. For the healthcare sector to effectively communicate and implement strategies, medical representatives must rotate on a regular basis. The supply chain pricing strategy must also adapt to local requirements in order to enhance sales development. The pricing plan for the supply chain must be adjusted to the demands of the region in order to boost sales. In the pharmaceutical sector, developing new medicines and improving existing ones are necessary to boost sales and generate income. This study includes many details and outcomes that need to be analysed further to improve the current pharmaceutical scenario. Work must be done on quality, the use of advanced techniques, and the implementation of new schemes that benefit the MR team

Value of pharmaceuticals: Improving product demand through innovative research and development in Palestinian and Jordanian firms

This study investigates the sustainability of the pharmaceutical business in Palestine and Jordan by examining the impact of R&D intensity on company performance. The study sample consisted of pharmaceutical companies listed on the Amman and Palestine Stock Exchanges, where the descriptive analytical approach was used to achieve the study's objectives, which numbered (6) companies for ten years from 2013 to 2022. The study's dependent variable, "Performance and value of the company’s Return on Assets (ROA), Earnings Per Share (EPS), and Tobin's Q, and the independent variables were R&D intensity (RDI) and selling and marketing expenses (SMI). A statistical analysis package (STATA) was used to achieve the study's objectives and test its hypotheses. The study analyzed the impact of variables (RDI, SMI,) on the performance and value of pharmaceutical companies. Variables (RDI, SMI, FS, CP, and LEV) had no significant influence on these factors. However, the MS has a significant impact on these factors. The study also found that while variables (SMI and FS) had a significant effect on pharmaceutical companies' performance and value, the variables (RDI, MS, CP, and LEV) had no significant influence on either. This study offers significant implications for the sustainability of pharmaceutical companies, investors, and academic research centers. Governments, including health ministries, should reevaluate R&D spending to bring about a qualitative change that will allow these businesses to innovate and sustainably contribute to the preservation of healthcare.

Exploring Nanoparticles: Types, Advantages, Challenges, and Applications in Drug Delivery and Technology

ABSTRACT: Recently the use of particulate systems, such as nanoparticles, has physically altered and improved the pharmacokinetic and pharmacodynamic aspects of many different types of pharmaceutical compounds. They have been used in vivo to protect the drug entity in systemic circulation, restrict drug access to the desired locations, and deliver the drug at a steady and controlled rate to the site of action. Without a doubt, the size of medication delivery research is getting smaller and smaller. Nanotechnologies are therefore emerging as a field in medicine that promises to produce significant therapeutic benefits. One of the most challenging issues facing the pharmaceutical business is the development of effective, small delivery devices that can safely and accurately deliver a medication to a designated site of action. They are working to reformulate the blockbuster drugs that are presently on the market and add new indications in order to maintain valuable scientific findings and therapeutic advancements. Nano emulsions, liposomes, and lipid or polymeric nanoparticles are the fundamental elements of nano delivery systems.

Public Perception on Pharmaceutical Marketing Practices in India — An Exploratory Study

Pharmaceutical marketing practices are primarily designed to address the needs of healthcare practitioners in promoting good health. However, this focus has led to information asymmetry between the public (stakeholders) and the pharmaceutical industry, resulting in both positive and negative perceptions of pharmaceutical marketing practices among the Indian public. A Systematic review of literature (SLR), applying the TCCM (Theory, Characteristics, Context, Method) framework, bibliometric analysis, and science mapping using VOSviewer, was conducted to review four decades of existing literature (1980-2021) to identify knowledge gaps and areas for further research on public perception of pharmaceutical marketing practices in India. Using an inductive approach guided by conventional grounded theory and theoretical sampling, data collected from the public were analyzed using descriptive statistics to arrive at findings and conclusions. A public perception model, based on the Machiavellian concept, is proposed using PLS-SEM with a random sample from the collected primary data (survey). This study may help regulatory agencies and the pharmaceutical industry assess and remodel their marketing practices according to the prevailing perceptions of the public, the largest stakeholders in the pharmaceutical business.

Public Health Care Management in India: Innovative Solutions for Future Health Challenges

There are substantial natural connections between development, poverty, and public health. In terms of public health, the healthcare sector in India is expanding at one of the quickest rates. India's health management is estimated to be worth over US$ 200 billion and is expanding at a compound annual growth rate of 22.9%. More than 65% of the market is accounted for by healthcare delivery, which includes hospitals, diagnostic centres, and pharmaceutical businesses. This business has grown more quickly as a result of rising income levels, more job opportunities, access to foreign markets, and quick technology improvements. Numerous investigations and international research findings have acknowledged the significance of this relationship. There has been much debate over the lengthy history of healthcare services over the appropriate role and stability of both the public and private sectors in providing healthcare services. These intermediate goals act as stepping stones towards the more general health system goals, which include financial risk protection, equity and efficiency in the delivery of health services, overall health gains, and awareness of the health system's ability to meet the needs of its population. Public-private collaborations have become a new tool for health challenging as a result of these goals' realization.

Investigation of spectroscopic characterization, crystal structure, and antitumor activity of a novel 2ATP molecule

In this section, the spectroscopic characteristics of 2-amino-toysl-pyridine (2ATP) are fully examined, using both experimental and computational investigations guided by density functional theory (DFT). It will facilitate our computational research using the B3LYP approach to use the basis set 6–311++G(d,p). Comprehensive assignments of vibrational modes were obtained from the vibrational spectra, which comprised FT-Raman and FT-IR spectroscopy and were recorded in the region of 3500–400 cm−1 and 4000–500 cm-1, respectively, using the Vibrational Energy Distribution Analysis (VEDA) approach. The net atomic charges inside the molecule were ascertained by using Mulliken population analysis, natural atomic charges, and electrostatic potentials (CHELPG). The structural conformations of 2ATP were determined using NMR spectroscopy in a CDCl3 solvent. The donor-acceptor interactions of the 2ATP molecule at the 6–311++G(d,p) level were studied by means of a Natural Bond Orbital (NBO) study. Studies of the ultraviolet (UV) spectrum in ethanol were used to assess the effects of the solvent. An assessment was made of the energy difference between the lowest unoccupied molecular orbital (LUMO) and the highest occupied molecular orbital (HOMO) in order to understand charge transfer processes that suggest the molecule may have biological activity. Molecular electrostatic potential (MEP) surfaces were used to predict the nucleophilic and electrophilic sites in molecules. The non-covalent interactions were evaluated using the reduced density gradient (RDG) approach. The Multiwfn software was used to analyze the topological properties of the 2ATP, including the Localized Orbital Locator (LOL) and Electron Localization Function (ELF). Further attention was drawn to the compound's exceptional pharmacological potential when its ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics were evaluated. Not to add, molecular docking experiments were carried out to evaluate the feasibility of 2ATP as a bioactive material with possible uses in the pharmaceutical business.

Ginger (Zingiber officinale Roscoe; Family: Zingiberaceae) in Non-Alcoholic Fatty Liver Disease: Review on the Existing Scientific Evidence and Way Forward

Abstract: Non-alcoholic fatty liver disease (NAFLD) is today the most prevalent hepatic disorder in the world. Although many pharmaceutical agents have been investigated for their potential to prevent or treat NAFLD, currently, there is no standard treatment to manage this ailment. Reports indicate that ginger and its phytochemicals gingerol and zingerone are effective in mitigating NAFLD in experimental study models. Furthermore, randomised control trials have demonstrated that ginger is also effective in preventing NAFLD in both adults and children. Mechanistic studies suggest that ginger mediates these beneficial effects by activating many pathways, such as reducing free radicals, dyslipidemia, and hepatic fat deposition. Concomitantly, ginger also increases antioxidant enzyme levels and insulin-sensitive effects, and all these pharmacological actions provide beneficial outcomes. In this review, the evidence from experimental and clinical trials has been emphasised. In addition, an attempt has been made to identify the gaps for future study to address for the benefit of the medical, pharmaceutical, nutraceutical, and agricultural businesses.

Solubility, the Main Concern for Poorly Water-soluble Drugs: Techniques and Alternatives

: The most important variable that affects a drug's bioavailability is its aqueous solubility. One of the biggest issues facing the pharmaceutical business is improving water solubility, which is the key to improving therapeutic efficacy. During the first screening procedure, over 50% of recently created medications are discovered to be insoluble or weakly soluble. The solubility of the medicine can be increased using a variety of techniques. The method entails both chemical and physical drug modifications. Any medicine that is absorbed must be present at the absorption site in the form of a solution. Poorly soluble medications can be made more soluble using a variety of approaches, like physical and chemical alterations to the drug and other strategies. Using a surfactant, complexation, and so on are examples of solid dispersion. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. In order to serve as a quick reference, this study attempted to gather information on various solubility improvement methods and organize it systematically.

Person-centered Pharmaceutical Business

Person-centered Pharmaceutical Business

Pengaruh Return on Asset, Net Profit Margin, Firm Size dan Debt To Equity Ratio Terhadap Harga Saham pada Perusahaan Subsektor Farmasi yang Terdaftar di Bursa Efek Indonesia (BEI) Periode Tahun 2015-2022

Finding and elucidating the relationship between stock prices and return on asset, net profit margin, firm size, and debt to equity ratio is the goal of this study. Secondary data from www.idx.co.id are the ones utilized. Twenty-five pharmaceutical sub-sector businesses listed on the Indonesia Stock Exchange for the Financial Report Period of 2016–2022 comprise the study population, and the sample size comprises forty financial reports from these companies. Using a purposive sampling strategy, the Sampling Technique employs nonprobability sampling. Utilizing both a descriptive and verification technique, the study methodology is quantitative. Maximum Value, Minimum Value, Mean, and Standard Deviation are the components of descriptive statistical analysis. Validation The tests used in statistical analysis include the determination coefficient test, the product moment correlation coefficient test, the multiple linear regression test, and the classical assumption test. Partially (t-test) and fully (f-test) concurrent hypothesis testing is done. The following conclusions were drawn from the partial hypothesis testing (t-test) results: (1) Return on Asset has a positive and substantial effect on stock price; (2) Net Profit Margin has no effect on stock price; and (3) Firm Size has no effect on stock price”. (4) The debt to equity ratio is unaffected by the price of stocks. Return on Asset, Net Profit Margin, Firm Size, and Debt to Equity Ratio were found to have no simultaneous effects on Stock Price based on the findings of the simultaneous hypothesis testing (f-test).

Drug Tracing System Using Blockchain Technology

Healthcare supply chains are complicated networks that span various departmental and geographical limits and provide the foundation for many benefits that are necessary for everyday life .The difficulties of this systems can result in contaminations such as erroneous data and lack of clarity and poor data origin. one issue of present supply chain restrictions is the production of counterfeit drugs, which not only has negative impact on people health but also has negative impact on financial status of pharmaceutical business. A recent research emphasised the importance of a well founded end-to-end track and trace system for health care supply chains .The smart contract ensures data provenance and gives all participants access to a secure unalterable transaction history .Moreover, it eliminates the need for intermediaries we give a high-level overview of thesystem architecture and algorithms that form the basis of the key elements of our proposed solution. we test and analyse the system to find how effectively it can enhance traceabilityinside health care supply chains before providing a cost and security analysis Keywords— Drug Counterfeiting , Supply Chain, Blockchain, Traceability, Healthcare, Trust, Securit

Development of Uv-visible and Hplc Analytical Methods for Quantitative Analysis of Antiulcer Drugs in Dosage Forms

Precise measurement of active pharmaceutical ingredients (APIs) in dosage forms is crucial in the pharmaceutical business to guarantee the quality, effectiveness, and safety of the product. This research is focused on creating and confirming analytical techniques for accurately measuring the amount of antiulcer medicines in different types of medication. The measurement of antiulcer medicines in their respective formulations was carried out using two analytical techniques: UV-Visible spectroscopy and High-Performance Liquid Chromatography (HPLC). UV-Visible spectroscopy is a straightforward and cost-effective method that allows for quick examination. It is particularly useful for regular quality control applications. HPLC, in contrast, offers exceptional sensitivity, specificity, and precision, facilitating the isolation and measurement of many constituents in complex matrices. The technique development procedure included optimizing experimental parameters, including solvent systems, detection wavelengths, column types, mobile phase composition, and flow rates. The reliability and robustness of the suggested procedures were ensured by validation studies done in accordance with ICH recommendations. The adequacy of the procedures for their intended purpose was assessed by evaluating parameters such as linearity, precision, accuracy, specificity, and robustness. The UV-Visible and HPLC techniques that were developed showed exceptional linearity over the examined concentration range, with correlation values (R²) above 0.99. The precision experiments showed low relative standard deviations (RSDs), suggesting excellent repeatability and moderate accuracy. The accuracy checks demonstrated that the recovery values were within acceptable ranges, therefore verifying the dependability of the methodologies used for quantitative analysis.

Sustainable Supply Chain Performance Model of Thai’s Pharmaceutical Business

Sustainable Supply Chain Performance Model of Thai’s Pharmaceutical Business

Key performance indicators of marketing mix effectiveness in the pharmaceutical business

The article is devoted to the study of determining key performance indicators of the marketing mix effectiveness in the pharmaceutical business. The problems and contradictions in ensuring the effectiveness of marketing in pharmaceutical companies are emphasized. Theoretical and applied foundations for implementing the marketing mix in the pharmaceutical business are highlighted. The expediency of following the «5Ps» and «6Ps» marketing mix is justified due to their correspondence to the specific features of marketing in the pharmaceutical business. Based on the research, a system of key performance indicators of the marketing mix effectiveness in the pharmaceutical business is identified.

Exploring the Hepatoprotective Potential of Plants: A Comprehensive Review

The liver is an important organ that aids in the metabolism and elimination of xenobiotics from the body. Liver injury or malfunction is a serious public health issue that affects not only doctors and nurses, but also the pharmaceutical business and drug regulatory bodies. Excessive alcohol use, toxic chemicals (particular antibiotics, chemotherapeutic drugs, carbon tetrachloride (CCL4), thioacetamide (TAA), and microorganisms all induce liver cell harm. In this scenario, the current synthetic medications to treat liver problems promote more liver damage. As a result, herbal drugs have grown in popularity and are widely used. For a long time, herbal remedies have been utilized to treat liver problems. There are a variety of herbal preparations on the market. The goal of this review is to compile information on promising phytochemicals from medicinal plants that have been investigated in hepatotoxicity models utilizing cutting-edge scientific methods.

Wockhardt Ltd.: Will the strategic change work?

PurposeWockhardt Ltd. is a global, research-based pharmaceuticals and biotechnology company headquartered in India. The company went through an ambitious period of growth, mainly using acquisitions as its primary inorganic growth strategy until the 2008 financial crisis. This period saw Wockhardt struggling to meet its financial obligations while at the same time confronting legal and regulatory challenges. Post this period, the company executed several strategic changes to its businesses to facilitate a recovery. The case asks students to assess Wockhardt’s strategic response to the crisis and its future success as a pharmaceutical company in an industry marked by intense competition.Design/methodology/approachThe case is based on secondary data sources and publicly available information. The company’s data and its history over the past six decades have been examined. Newspaper articles, journal articles, company annual reports and analyst firm reports have been used to gather information and have been cited accordingly. Financial data have been obtained from the Centre for Monitoring Indian Economy (CMIE) Prowess database.FindingsThe case highlights some interesting findings from Wockhardt’s handling of its financial problems and subsequent recovery process. Key insights come from its multi-pronged strategy to first stabilize and then continue to expand its core pharmaceuticals business by identifying new markets for its products and alternate channels for growth.Originality/valuePrevious cases on Wockhardt have focused on the financial aspects of the crises, particularly the corporate debt restructuring (CDR) process that was undertaken, the challenges of hedging foreign currency risk and the drawbacks of using foreign currency convertible bonds (FCCBs). In this case, we emphasize the unique aspects of Wockhardt’s business strategy, from its initial acquisition-based inorganic growth, its crisis response and management and finally the strategic execution of its recovery and continued expansion.

Guidelines for biomimetic 3D/4D printing in drug delivery

Four-dimensional printing, sometimes known as 4DP, is becoming an increasingly popular area of study. Utilization of “shrewd” materials in 3D printing considers the making of items that answer non-mechanical boosts (like dampness, electric or attractive fields, UV, temperature, pH, or particle arrangement) by progressively changing their shape after some time, as modified. These things could be printed with a shape-moving component that is constrained by a PC. Gadgets made with 4D printing innovation exploit time as the final aspect in their activity. 4D shrewd designs have been concentrated on in the logical writing for a really long time, much before the coming of 3D printing. Medicine delivery at the nano-, miniature, and full-scale scales have all been investigated utilizing ideas from shape development and self-gathering. This study lays forward a far-reaching set of rules for utilizing biomimetic 3D/4D printing techniques in drug delivery frameworks. Biomimetic 3D/4D printing has arisen as a game-changing method in the field of medicine delivery, considering unmatched accuracy and command over drug discharge qualities. In particular, this study looks at the manners by which 3D and 4D printing are being utilized as prescription delivery techniques and with regards to customized medication in the pharmaceutical business.

Unraveling the internal drivers of pharmaceutical company performance in Europe: A DEMATEL analysis

Research background: Internal business factors are vital to how a company achieves its goals. The present study of internal drivers of pharmaceutical company performance is very insightful, as it has the potential to boost further competitiveness, it may allow health authority personnel to have guidelines to make strategic decisions, as well as inspire investor confidence, ensure regulatory compliance and performance benchmarking, and support talent acquisition and retention. In addition, it can identify the important internal factors that need to receive more priority. Purpose of the article: The European pharmaceutical industry is currently facing multiple challenges. This paper aims to map the relative relationships among the internal factors that influence the business performance of pharmaceutical companies in Europe by using the DEMATEL approach. Method: There are two phases of the present study, an extensive literature review and the use of the decision-making trial and evaluation laboratory (DEMATEL) technique. To identify the key internal drivers and their cause-and-effect relationship with pharmaceutical company performance in Europe, data from experts were obtained using the predesigned DEMATEL questionnaire. Findings & value added: The extensive literature review from the Web of Science and Scopus databases found that seven internal factors are very demanding in the case of European pharmaceutical business performance. The main elements that have the highest impact on pharmaceutical business performance in Europe are human resources competencies, the information system, technological competitiveness, and the patent system. However, financial profitability, research and development competencies, alliances with other companies, and supply chain management are the factors that are affected more by other factors. The study is the first attempt to identify the internal business performance of the pharmaceutical sector in Europe by working with pragmatic and perceptive decisions from pharmaceutical stakeholders in Europe.

Fabrication, structural elucidation, and DFT calculation of some new hydrophilic metal chelates based on N N′‐(1‐methyl‐2‐oxoindolin‐3‐ylidene)benzohydrazide ligand: Pharmaceutical studies and molecular docking approach

Some novel FeIII, CuII, and PdII chelates incorporating N′‐(1‐methyl‐2‐oxoindolin‐3‐ylidene)benzohydrazide (MIBA) were fabricated. The tested compounds were investigated using thermogravimetric analysis (TGA), CHN, spectra analysis (IR, mass spectra, and NMR), melting point, magnetic moments, molar conductance, ultraviolet–visible spectroscopy, powder X‐ray diffraction, and computational studies. The conductance results showed that the tested FeIII, CuII, and PdII chelates are electrolytes. Magnetic and electronic spectra are applied to deduce the coordinating ability of the tested ligand, and the geometric structure of the studied chelates is found to be octahedral, distorted octahedral, and square planar for FeIII, CuII, and PdII chelates, respectively. The TGA study of these studied complexes displays that the hydrated H2O molecules, acetate, and nitrate are removed in the first and second degradation steps followed directly by degradation of the studied ligand leaving metal oxide as residue. The thermodynamic factors, like ΔS*, ΔH*, E*, A, and ΔG* are evaluated from the TGA curves and explained. The density functional theory (DFT)/B3LYP computation method was applied for the estimation of the molecular electrostatic potential (MEP; highest occupied molecular orbital [HOMO] and lowest unoccupied molecular orbital [LUMO]) energy for the studied compounds. In an in vitro study, the antimicrobial effects of the prepared compounds were screened on various strains of bacteria and fungi. It was found that tested compounds exposed a good biological efficacy through IC50 results close to reference drugs and antitumor potential against (MCF‐7, Hep‐G2, and HC‐T116) cell lines. The data obtained displayed that the studied chelates showed promising antitumor activity. The studied metal chelates were screened for in vitro antioxidant efficacy using DPPH assay. The studied compounds explained dynamic satisfying performance. Also, the crystal structures of breast cancer protein (PDB ID: 3HB5) and Escherichia coli (PDB ID: 2VF5) were performed by molecular docking simulation. Data of docking simulation suggestions are which tested compounds have biological behavior as well as have obvious benefit in the pharmaceutical business.

МОДЕЛЬ ОБРАЩЕНИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ НА БАЗЕ ОТЕЧЕСТВЕННОЙ АНАЛИТИЧЕСКОЙ ПЛАТФОРМЫ LOGINOM

Striving to improve the economic efficiency of pharmaceutical business in an unstable market situation and high competition requires the subjects of drug circulation to implement modern approaches to the organization of their activities. In these conditions, an important problem that the management has to solve in the process of circulation of medicines is the problem of quality of source information accompanying the business processes of pharmaceutical activities. The source information is not intended for the purposes of analysis, is presented, as a rule, rather raw material that requires preliminary processing by special methods, including their sampling, purification and transformation. The article discusses the advantages of practical application of the capabilities of Loginom analytical platform, which implements the above mentioned methods of pre-processing of raw material and allows solving the tasks of modeling the characteristics of drug circulation. Based on the concept of low-code architecture that provides visual design of complex data analysis scenarios, without involving IT-specialists and realize programming tasks by the business user. The object of the research was the current data obtained from the accounting system of material assets of a wholesale pharmaceutical organization. When organizing a request to the accounting system, based on the considerations of commercial confidentiality, it was decided to limit the 12-month time period and the assortment group, including only antibiotics. During the research, a data processing scenario was developed in the Loginom environment, representing the sequence of actions that need to be carried out to analyze the data. A processing script is a combination of data processing nodes configured by the developer to solve a specific problem. Each script node performs a separate operation on specific data. The drug circulation model scenario developed during the study, consisting of five nodes, includes two nodes with initial data “Receipt Data” and “Consumption Data”, as well as nodes “Data Combination”, “Sorting” and “Grouping”. The developed drug circulation model is an alternative to modeling based on the popular Excel spreadsheet processor, the capabilities of which are limited by the volume of processed data, low productivity on large volumes, the difficulty of automating the execution of sequences of actions, and the inconvenience of reusing processing scripts.