Background: Over the years, role-playing simulations have gradually become part of pharmacy teaching. The aim of this study is to characterise the potential of the patient partner, in relation to the student and the teacher, to interpret the role of the patient and to carry out the debriefing during role-playing simulations of pharmaceutical dispensing. Methods: Experimental simulations were set up to compare students, patient partners and teachers in the role of patient. Each simulation was subject to observations (n = 30) focusing on the quality of the role plays and debriefings performed. Results: In addition to the realism provided, the patient partner showed the greatest adaptability in their roles of his role, able to both make more complex and simplify the situation according to the student's needs. Regarding the debriefing, the teacher seemed to be the one most able to detect the points of improvement in the performance achieved regarding communication and pharmaceutical skills. Conclusion: Students, teachers or patient partners bring different resources that should be used thoughtfully by teachers according to the educational objectives of the simulation. However, it is important to be aware that the ability of the patient partners to participate in such lessons depends on their training and experience.
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