Pharmaceutical Institutions Research Articles

An Important Study for Pune District Perspective Tops Self-Reported Private Co-Educational By Pass Pharmaceutical Institutions in Number of Abandoned Children

Human has two more undocumented blood cells seen. The real reason is early marriage, which is prevalent in many parts of pune district.“These girls are married off at 23 and by the age of 27 for they have three children”.“By the age of 30 they are separated and the children are abandoned.”

Why Pure Vegetarianism is Not All that Great an Idea for India. An Important Study for Pune District Perspective Tops Self-Reported Private Co- Educational Pharmaceutical Institutions in Number of Abandoned Children

Why Pure Vegetarianism is Not All that Great an Idea for India. An Important Study for Pune District Perspective Tops Self-Reported Private Co- Educational Pharmaceutical Institutions in Number of Abandoned Children

Sexual Species Mix Afterglow Lasts up to Three Hours: Evidence for High Prevalence and Rapid Transmission of Skin Pulp Efflux Among Pure Widow Female Individuals Attending Non-Governmental Pharmaceutical Institutions in Pune, India

Happy sex life. Happy employees. The ‘feel good’ factor from having good sex can last you 12 hours! Want to stay happy and perform better at work? Start performing better in bed, as a study reveals, workers who had sex the night before are doing better at their jobs the next day. According to researchers from pune university a happy sex life boosts their own job satisfaction which, in turn, gives them a better work-life balance. They came to work happier and more fulfilled, immersed themselves more in the tasks they have given and enjoyed their job more as a result, researcher is associate professor affiliated pune university, Rahul Hajare. We make jokes about people having a ‘spring in their step,’ but it turns out this is actually a real thing and we should pay attention to it,” researcher explained. Sexual intercourse triggers the release of dopamine, a neurotransmitter associated with the reward centres in the small brain, as well as oxytocin, a neuropeptide associated with social bonding and attachment. The ‘feel good’ factor from sex lasts for approximately 12 hours. The team looked at 1.5 married employees from an unnamed office-based business, monitoring their work performance and their sex habits. Those who had sex with their partners, at home, performed their work tasks better the next day than those who did not have sex. They found that maintaining a healthy relationship that includes a healthy sex life will help employees stay happy and engaged in their work, which benefits the employees and the organisations they work for. In contrast, sacrificing sex in order to work is only likely to lower any feel good factor and raise levels of stress. This is a reminder that sex has social, emotional and physiological benefits, and it’s important to make it a priority. Just make time for it,” researcher explained.

Evaluation of Indian Deprived Widow Female Sex Perspective Tests about Pelvis Decline Self-Reported Non-Governmental by-Pass Pharmaceutical Institutions in India

Evaluation of Indian Deprived Widow Female Sex Perspective Tests about Pelvis Decline Self-Reported Non-Governmental by-Pass Pharmaceutical Institutions in India

Study of the state of readiness of pharmaceutical institutions of Ukraine for implementation of integrated quality systems

One of the most promising ways to increase the efficiency of pharmaceutical enterprises in the field of quality assurance of medicines is the introduction of integrated quality systems (IQS).
 The aim of the work is to study of the state of readiness of pharmaceutical institutions (pharmaceutical warehouses, pharmacies) and hospital pharmaceutical services of Ukraine for the implementation of integrated quality systems.
 The materials of the research are: scientific publications; regulatory legal acts of the Ministry of Health of Ukraine; public reporting information of the State Service of Ukraine on Medicines and Drug Control; information posted on professional specialized websites and official websites of pharmaceutical enterprises, hospitals, health departments of local government; information obtained in the process of direct observation and questionnaire survey. Research methods are: systematic review, generalization, observation, questionnaire survey, mathematical-statistical, graphical modeling.
 The paper analyzes the availability of certificates of conformity to the requirements of good distribution practice (GDP) in wholesale pharmaceutical enterprises of Ukraine. The geography of the location of certified pharmaceutical warehouses in different regions of Ukraine is considered. In the context of the prospect of formation of IQS, the experience of a wholesale pharmaceutical company with respect to environmental, hygiene and safety and social responsibility is demonstrated. Based on the study of public information, the state of implementation of certified quality management systems (QMS) based on the standard ISO 9001 in pharmacies and hospitals of Ukraine is considered. The expediency of the development of the pharmaceutical IQS as an integral part of the overall QMS of the hospital is shown. Through the questionnaire survey of pharmacists, the state of readiness of Ukrainian pharmacies for the implementation of IQS based on the requirements of good practices and international standards in the field of quality, ecology, health and safety and social responsibility was explored. The state of implementation of good pharmaceutical practice (GPP), the requirements of the ISO 9001 standard, the risk management process for medicines quality, corrective and preventive actions has been studied in pharmacies. Positive tendencies and problems in the context of the readiness of pharmacies of Ukraine for the implementation of IQS have been established. Priority steps for improving the state of readiness of Ukrainian pharmacies for the implementation of IQS are identified.
 The research results confirm that over the last years the pharmaceutical sector of Ukraine has made significant progress towards increasing the readiness of pharmaceutical institutions for the implementation of integrated quality systems.

Management of Hepatitis C Infection in children in the era of Direct-acting Antiviral Agents.

Chronic hepatitis C certainly is a global health burden in children as well as in adults. Spontaneous viral clearance can occur in early childhood but is uncommon thereafter. Although the majority of cases are asymptomatic during childhood and young adulthood, without an effective treatment, children who acquire HCV via vertical transmission can develop chronic liver disease and other complications including end-stage liver disease and hepatocellular carcinoma in adulthood. Efforts from worldwide health organizations, the pharmaceutical industry, and clinical and research institutions have resulted in very effective interferon-free therapy with direct-acting antiviral agents (DAAs) for HCV-infected children. In this manuscript, we will briefly review the epidemiology of HCV in children, historic treatment, current published data on DAAs in children and conclude with suggestions for management of the child with HCV in the era of DAAs.

Issues on carcinogen contaminated antihypertensive drugs and constructing drug safety management system

European Medicines Agency withdrew valsartan from European market in July 2018 because it was contaminated with carcinogen, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA). Medicines and Healthcare Products Regulatory Agency also found the same contamination and withdrew it from England market. US Food and Drug Administration followed the action after confirming its contamination. Ministry of Food and Drug Safety (MFDS) conducted testing all the valsartans at Korean market and withdrew some of them from market after confirming the contamination with NDMA. MFDS provided the pharmaceutical companies and laboratory institutions with the manual for testing both NDMA and NDEA and educated relevant personnels. MFDS also evaluated the health impact of the contaminated valsartan on the hypertensive patients who took the valsartan, which was shown to be very low risk of additional cancer incidence. MFDS pronounced strengthening of the safety management for the raw materials of the medicines. For guaranteeing the safety of medicines, more comprehensive drug safety management system from developing new drugs to consuming the medicines should be established. For achieving such a goal, active participation of all the stakeholders of the medicines including governmental agencies including MFDS and Ministry of Health and Welfare, the National Assembly, healthcare professionals, pharmaceutical companies, mass media, and general population including patients should be needed.

Investigation of making managerial decisions specificity within the organizational culture of pharmaceutical institutions

Aim. To study the specifics of making managerial decisions in pharmaceutical institutions (PhI) taking into account the peculiarities of their organizational culture (OC).Results. The researches were conducted using scientific methods – questionnaires, sample observations, focus groups, expert assessments, involvement of competent experts and modeling have clarified in the framework of the OC PhI the basic requirements for the competences of the specialists of pharmacy (SPh), which are necessary for the adoption of management decisions . These include: timeliness, reasonableness, efficiency, consistency, efficiency, authority, situationality, flexibility, consistency and compliance with the management hierarchy. It has been established that the SF decision-making process should be focused on the awareness of the situation and the necessary final result taking into account the specifics of the OC. The requirements for the SPh, which make management decisions taking into account the specifics of the Federal Law, are outlined. Thus, the SPh, when making managerial decisions, should first of all be able to use professional knowledge and skills, to observe timelines, to have the desire to make positive decisions, in particular to have knowledge of the basics of management science. At the same time, when making managerial decisions in the conditions of OC PhI, risks can not be completely avoided due to the flow of individual SPhs that carry it out. According to the opinion of respondents, such managerial decisions should be weighed and conscious, but the specifics of the SPh activities allow the SPh to have certain intuition and impulsiveness in making decisions in an uncertain situation. Studies have shown that in the conditions of the OC PhI should pay considerable attention to the preparation of an order to execute a management decision by the staff of the Federal Reserve. Respondents indicate that in such an order the answers to the questions (to the extent of significance) should be answered: the purpose, time, performance and terms, methods and means, place, performers. However, the risks remain and most often they are related to the lack of clear formulation of the management decisions, not taking into account all the factors of influence for implementation, the adoption of decisions with insufficient information about the nature of the problem is not consistent with the performers. Therefore, conditions have been studied that should facilitate the successful implementation of management decisions in the Federal Law. Among these conditions are the allocation: the use of reliable information and its completeness, the existence of standard operating procedures for all types of work, a sufficient number of qualified executives, the observance of technology management processes, proper workflow in the implementation of management decisions. Studies have shown that the SPh, as subjects of making managerial decisions in the context of the OC PhI, should be aware of the advantages and disadvantages of different options for their adoption in general (American, German, Japanese, Ukrainian schools) and thus be able to construct their most appropriate procedure specifically in therefore, or another PhI. To successfully solve this problem, we have proposed an optimal version of the procedure for the preparation and adoption of management decisions in the Federal Law, taking into account the specifics of the OC. It combines ten consistently related actions, from understanding the task, studying and evaluating the situation and circumstances, to implementing a solution and feedback on obtaining results.Conclusions. According to the results of the researches, the aspects of making managerial decisions within the specifics of the OC PhI were clarified. On this basis, the optimal version of the procedure of preparing and taking management decisions is proposed, taking into account the results of personal research of their aspects in the Federal Law.

Elaboration of psychodiagnostic tools for assessing the level of development of professionally important socio-psychological characteristics of a specialist in pharmacy

Aim. To select tests that will allow assessing the level of development of socio-psychological characteristics (SPChs) of specialists in pharmacy. Materials and methods. The methods of expert evaluations, analytical, comparative and logical meth ods were used. Practical psychologist and professionals specializing in the staff recruitment for pharmaceutical institutions took part in the survey. The results of the expert survey are convergent, the degree of consistency of expert representations is high, and it is confirmed by the coefficient of concordance, which is equal to 0.826. The actual value of the Pearson criterion is considerably greater than the table one (χ 2 f > χ 2 tabl ). Results. On the basis of the research conducted it has been found that for selection of specialists in pharmacy and determination of their SPChs the following methods are more often used abroad: survey with the subsequent interviewing; qualification with the subsequent interviewing; testing and / or interviewing; testing for professional competence with the practical examination. Due to the algorithm for selection of tests for the evaluation of professionally important SPChs of specialists in pharmacy the final list of psychodiagnostic testing methods of pharmacy specialists was formed. It included Questionnaire (16PF) by Raymond B. Cattell, Stambulova’s method, “Vocabulary Labyrinth” method, questionnaire for determining the level of self-esteem, V. Boyko’s diagnostic method for communicative attitude, as well as the assessment of communicative and organizational inclinations in the process of communication. Conclusions. The methods of psychodiagnostic testing proposed can assess the level of development of socio-psychological characteristics of a specialist in pharmacy.

Adaptive Designs: Results of 2016 Survey on Perception and Use

The DIA Adaptive Designs Scientific Working Group has a devoted subteam to performing surveys, literature reviews, and registry reviews every 4 years to assess the perception and use of adaptive designs (ADs) in the development of drugs and biologics. A survey was distributed to pharmaceutical companies, academic institutions, and contract research organizations to collect information about the usage of ADs of different types and perception of challenges for their use. Literature and registry reviews were conducted to assess the prevalence of ADs of different types in drug and biologics development. These results were compared to previous surveys and reviews using summary statistics. ADs appear to be more widely considered in the last 4 years as compared to earlier 4-year periods. The most common types of ADs remain early stopping, treatment group adaptations, and sample size re-estimation. Both stopping early for safety and changing the endpoint of the analyses were rarely mentioned in literature prior to 2012 but are now appearing more frequently. The barriers of change management and negative experiences by some institutions with ADs remain a source of concern. Additional, consistent training would be helpful to choose the right adaptation(s) needed for specific clinical trials and for planning appropriately for operational efficiency such as for drug supply management and data management. The perceived barrier of regulatory acceptance also remains a concern, which could be alleviated by additional interaction with agencies and an update of the FDA draft guidance to industry on adaptive designs.

Facts File (Extended) of Pune University Pharmaceutical Institutions Privately Manage Shares Misleading Story. Towards the View of Culturally Determined Agency

Facts File (Extended) of Pune University Pharmaceutical Institutions Privately Manage Shares Misleading Story. Towards the View of Culturally Determined Agency

Route Evaluation of Domestic Violence and Epileptic Seizure (“Fit”) Experience Among Recently Married Women Residing in Slums Communities’ Pharmaceutical Institutions in Pune District, India

journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine.

Co- Relation of Domestic Violence and Epileptic Seizure (“Fit”) Experience Among Recently Married Women Residing InSlums Communities’ Pharmaceutical Institutions In Pune District, India

Co- Relation of Domestic Violence and Epileptic Seizure (“Fit”) Experience Among Recently Married Women Residing InSlums Communities’ Pharmaceutical Institutions In Pune District, India

Adverse drug reaction reporting in institutions across six Chinese provinces: a cross-sectional study

ABSTRACTBackground: Although China’s adverse drug reaction (ADR) reporting and monitoring has developed rapidly, many challenges remain. This study assessed ADR monitoring and reporting in China and identified monitoring problems.Research design and methods: A cross-sectional survey was conducted of ADR reporting institutions in six Chinese provinces in April–December 2014. Questionnaires assessed ADR systems, basic resources, and pharmacovigilance activity.Results: Of 720 questionnaires distributed, the response rate was 81.8%. About 93% (n = 371) of pharmaceutical companies and medical institutions had established ADR monitoring departments/units. Few institutions (26%, n = 104) allocated an ADR budget; 7% (n = 30) had received ADR monitoring funding in the last year (2013). Almost all institutions (99%, n = 555) had computers and 47% (n = 263) had a network database. Many institutions conducted public education about drug safety (49%, n = 283), medicine utilization reviews/quality surveys (28%, n = 158), and medicine consultation services (88%, n = 511). Institutions in eastern, central, and western China differed significantly on implementation of existing regulations and pharmacovigilance activities.Conclusions: The institutions surveyed have established ADR monitoring systems. However, these systems have flaws. Urgent improvements are needed in funding, basic resources, reporting processes, and other pharmacovigilance activities.

Route evaluation of domestic violence and epileptic seizure (“fit”) experience among recently married women residing inslums communities’pharmaceutical institutions in Pune District, India

Route evaluation of domestic violence and epileptic seizure (“fit”) experience among recently married women residing inslums communities’pharmaceutical institutions in Pune District, India

Co- Relation of Domestic Violence and Epileptic Seizure (“Fit”) Experience among Recently Married Women Residing Inslums Communities’ Pharmaceutical Institutions in Pune District, India

Co- Relation of Domestic Violence and Epileptic Seizure (“Fit”) Experience among Recently Married Women Residing Inslums Communities’ Pharmaceutical Institutions in Pune District, India

The study of the individual competencies of a modern leader in the pharmaceutical sector of healthcare

Aim. To study the individual competencies of a modern leader as the coordinator of the organizational system in the pharmaceutical sector of healthcare in the context of adaptive management of the organizational culture.Materials and methods. The following scientific methods were used: logical, analytical, economic and statistical, survey, selective observation, focus group, expert assessments.Results. The pharmaceutical sector (PhS) of healthcare is characterized by a high social and medical orientation, and requires effective management. At the epicenter of the emerging managerial relationships there is the leader as the coordinator of the organizational system, which he/she directs towards a certain goal – pharmaceutical provision of the population and healthcare institutions. Therefore, it is important to determine the individual competencies that the leaders of pharmaceutical institutions should meet taking into account the professional specificity in a particular institution. According to the results of the survey of respondents our studies have identified 10 competencies of the PhS modern leader. In addition, the directions for formation of each of the competencies selected (40 components of the directions) have been determined.Conclusions. It has been found that the competencies of a modern leader of a pharmaceutical institution studied and directions for their formation allow us to specify the programs for improving senior management of the pharmacy specialists, to envisage subjects for their education in the system of the postgraduate education, in particular self-education, internships, and the experience exchange. In a complex, this will increase the effectiveness of the overall organizational and management maintenance in the PhS, which is important for its further development.

90 90 90 Formulas and Symptoms of Adrenal Fatigue Syndrome (AFS) of Adult Men

Early decompressive adrenal fatigues have one of the leading causes of neurological disorders and stroke in pharmaceutical Institutions. Health has the ability of a biological system convert into personal satisfaction. The world health organization (WHO) literature for human health in a broader sense in its 1948 constitution as “a state of complete physical and well-being and not merely the absence of disease or infirmity. It has been subject to controversy, in particular as poor transportation facility in pharmacy institution lacking operational value, the ambiguity in developing low health strategies and because of the problem created by use of the word “social determinants of health†, which makes it practically impossible to achieve healthy environments. Understanding student health and disease with private based co-educational pharmaceutical institution has not transportation facility and low quality food in suburban areas of developing cities in India cannot ignore. Early decompressive adrenal insufficiency has accepted in medical science due to health imbalance. Adrenal fatigue especially from junior students to senior students living with private institution with poor quality of life and facility can translate into permanent disability in the world. We cannot compare adrenal fatigue with joint pain. Adrenal fatigue cannot ignore because it has weaken immunity has unfortunately not measured in the above series.

Assessment of the Depression-Level Effectiveness of the Curse Words in Young Adults in Private Co-Educational Pharmaceutical Institutions in Pune University Pharmaceutical Institutions Living With Poor Sanitation, India: A Pre-planned, Causal-Pathway-Based Analysis

Depression and substance abuse is on the increase all over the world. The poor and the rich are also involved in this dangerous habit that has impact not only on reproductive health but also has an impact on family, society, increase in health care expense and increased criminal activity. Health care providers are more concerned with treating the victims and less concerned on its prevention. Pregnant women bear greater brunt and there is adverse pregnancy outcome. Low birth weight, preterm labour, increased in miscarriage and raised perinatal mortality is some of the adverse effects. Children of such parents are more likely to inherit this bad trait. Children living in abusive homes where drugs and alcohol abuse occur simultaneously are often deprived of more than just the basics of food and shelter. Depression is defined as, “Any act on the part of the husband, partner or family which causes physical, mental, social or psychological trauma to the woman and prevent sher from developing her personality.” Reason for the increase in depression violence are; urbanization, industrialization, growth of urban slums, co-education and co - working in offices and factories, modern movies, television, obscene and pornographic literature and decreasing religious restrictions.

Regulation of Pharmacy Council of India and Assessment of Quality Life Among single Mother -By-Choice ‘Residing in slums Linkage Pharmaceutical Institutions in Pune, India

Regulation of Pharmacy Council of India and Assessment of Quality Life Among single Mother -By-Choice ‘Residing in slums Linkage Pharmaceutical Institutions in Pune, India