Abstract Susceptibility to viral and fungal diseases is a major factor limiting profit in the production of virginia-type peanuts (Arachis hypogaea L.) in the South Carolina coastal plain. Field tests were conducted over a three-year period (2006–08) to evaluate the disease resistance of 47 experimental virginia-type breeding lines and eight cultivars. Relative to commercially available standards, cultivar Bailey (recently released by N. C. State Univ.), three sister lines (N03088T, N03089T, and N03090T), and N03091T were found to have consistently less susceptibility to tomato spotted wilt tospovirus; late leaf spot, Cercosporidium personatum (Berk. and Curt.) Deighton; and stem rot, Sclerotium rolfsii Sacc. The level of field resistance measured for these three diseases was comparable to that of a resistant runner-type cultivar, Georgia-03L. Yield was highly correlated with multiple disease resistance, and yield performance of some resistant lines exceeded the best commercial standard cultivars under reduced fungicide programs. Potential negative attributes of Bailey, its sister lines, and N03091T were a greater susceptibility to leafhopper injury, Empoasca fabae (Harris), and a relatively larger plant size at maturity, without well defined rows to facilitate digging. Other lines that demonstrated reduced susceptibility to both tomato spotted wilt and stem rot were N03005J and N02009. Although only evaluated in the last test year, five Univ. of Florida lines (FLMR7, FLMR9, FLMR12, FLMR14, and FLMR15) and Georgia-08V (recently released by the Univ. of Georgia) also showed some reduction in stem rot susceptibility relative to the standard (cultivar NC-V 11). Equally important, many experimental lines were identified with significantly greater disease susceptibility than current commercial cultivars. Under South Carolina production conditions, these lines would be poor candidates for advancement. Deployment of the multiple disease resistance found in these experimental cultivars offers several potential benefits beyond direct yield improvement: reduction of fungicide input costs for both foliar and soil disease control, prolonging the utility of currently available fungicides, and reduction of weather related harvest risk by allowing earlier initial planting dates.