pH-responsive Polymer Research Articles

PH-responsive glucose-powered Janus polymer brushes nanomotors for drug delivery and controlled release

Nanostructured drug delivery system (NDDS) has attracted significant attention from the scientific community due to their biocompatibility, stability and modifiability. However, the limited delivery efficiency and low delivery dosages of NDDS have been pressing issues for scientists. In this study, we develop glucose-powered Janus nanomotors (G@JAP@P-ADM) with enhanced diffusion, which is fabricated by formation of glucose oxidase (GOx) and poly[2-(methacryloyloxy)ethyltrimethylammonium chloride] (PMETAC) polymer brushes on opposite surface of gold-platinum (AP) NPs, and adriamycin (ADM) loading on PMETAC chains, and completed efficient drug and high dosages delivery via pH-responsive of the cation polymer brushes and the ADM drug. In glucose solutions, such nanomotors show the self-propulsion motion via cascade reaction and exhibit effective uptake capability to the cancer cells via enhanced diffusion. Fortunately, the cation PMETAC brushes not only enhance diffusion of the nanomotors, but also realize high dose ADM drug delivery via pH-responsive of electrostatic interactions and morphology transformations. Moreover, the ADM also can release itself from polymer chains of nanomotor via charge reversal of pH-responsive. Based on these advantages, the nanomotors increase the ADM drugs dosage at the cancer cell and promote apoptosis. Therefore, such glucose-driven nanomotors exhibit great potential for NDDS and supply novel strategies for enhancing the drug dosage and delivery efficiency.

Photothermal-driven pH-responsive fiber composite membrane for oil-wastewater purification

Oil spills and the discharge of organic wastewater have posed a severe danger to environmental security. To address this issue, various functional oil/water separation materials for wastewater purification have been developed. In this work, MXene/PPy was loaded on PP fiber by simple in-situ polymerization and vacuum-assisted filtration technology. Polypropylene was modified by dopamine (PDA) through in-situ polymerization, to improve the loading fastness of MXene/PPy on the surface of PP. To increase the durability of the fiber membrane, the pH-responsive polymer (PDM) was simply immersed on the outer layer. The successfully prepared PP-MXene/PPy-PDM has excellent pH response and photothermal conversion performance. When pH= 2, the water contact angle (WCA) was 52°. When pH= 12, WCA was 125°. The surface of PP-MXene/PPy-PDM was heated to 104.6 ℃ in ten minutes under the irradiation of 2 kW·m−2. PP-MXene/PPy-PDM could continuously separate oil/water mixture for 12 h, and the highest separation flux was 3.87 kg·m−2·h−1. Moreover, PP-MXene/PPy-PDM has excellent stability, corrosion resistance and recyclability. This study provided a new strategy for preparing intelligent responsive fiber composite membrane for oil-water separation, which has a wide range of practical applications in the treatment of oily wastewater.

Excellent performance of pH sensitive artificial muscles under large loading

The pH-responsive artificial muscle is a chemical-driven actuator without external power input. However, the low work density and adequate stability limit their practical applications. Herein, we combine the porous pH-responsive polymer with carbon fiber bundles for obtaining the coiled hybrid fiber. The coiled carbon fiber (CNF) yarn enhances the strength of hybrid fiber, and the swelling pH sensitive polymer limited to CNF provide a large stroke for hybrid fiber untwisting, resulting in an excellent work capacity and a high cycle life. When the load weight is 600 times the weight of the fiber itself, its work density reaches 287 kJ/m3. In addition, the hybrid fiber can reach a maximum stretching and contraction of 47% at a load of 400 times its own weight. The breaking stress of the obtained artificial muscle can reach more than 100 MPa. At the same time, the constructed porous polymer hydrogels improve the response rate of the artificial muscle, the response time is shortened to 10 min and do not decay in hundreds of cycles, which is further shown that the limiting effect of carbon fiber on the polymer improve the stability of the artificial muscle. It is indicated that the pH-responsive composite fibers have a high potential for use in artificial muscles, pH sensors and mechanical system.

A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics

Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment. So, this study aimed to develop an intelligent catechin colon-targeting delivery system with a high loading capacity. This was done by coating surface-decorated mesoporous silica nanoparticles with a pH-responsive enteric polymer called Eudragit®-S100. The pristine wormlike mesoporous silica nanoparticles (< 100 nm) with high surface area and large total pore volume were effectively synthesized and modified with the NH2 group using the post-grafting strategy. Various parameters, including solvent polarity, catechin-carrier mass ratio, and adsorption time, were studied to improve the loading of catechin into the aminated silica nanoparticles. Next, the negatively charged Eudragit®-S100 was electrostatically coated onto the positively charged aminated nanocarriers to shield the loaded catechin from the acidic environment of the stomach (pH 1.9) and to facilitate site-specific delivery in the acidic environment of the colon (pH 7.4). The prepared nanomaterials were evaluated using several methods, including The Brauner-Emmett-Teller, surface area analyzer, zeta sizer, Field Emission Scanning Electron Microscope, Powder X-Ray Diffraction, Fourier Transform Infrared Spectroscopy, Energy-Dispersive X-ray Spectroscopy, and Differential Scanning Calorimetry. In vitro dissolution studies revealed that Eudragit®-S100-coated aminated nanomaterials prevented the burst release of the loaded catechin in the acidic environment, with approximately 90% of the catechin only being released at colonic pH (pH > 7) with a supercase II transport mechanism. As a result, silica nanoparticles coated with Eudragit®-S100 would provide an innovative and promising approach in targeted nanomedicine for the oral delivery of catechin and related medicines for treating diseases related to the colon, such as colorectal cancer and irritable bowel syndrome.

Enhancement for drag reducer release efficiency from inverse polymer emulsion using pH-responsive dynamic covalent surfactant

The increasing global fossil resources consumption requires convert the sights into the exploitation of tight oil resources. Polymer emulsion drag reducers are widely used in hydraulic fracturing techniques for inhibition of fluid turbulence and reservoir stimulation for enhanced oil recovery. However, the poor release efficiency and requirement for extra hydrophilic surfactant for phase inversion limit the practical application. Herein, a hydrophobic surfactant oleylamine-4-carboxybenzaldehyde (OA-CBA) was synthesized with oleic amine (OA) and 4-carboxybenzaldehyde (CBA). OA-CBA exhibited pH-responsive behavior, attributing to the existence of dynamic covalent bond in OA-CBA. The OA-CBA stabilized monomer emulsions, consisted of acryla-mide (AM), 2-acrylamide-2-methylpropane sulfonic acid (AMPS) and Acrylic acid (AA), suggests remarkable dynamic and storage stability, which supply stable microreactors for polymerization. Furthermore, polymer emulsion with pH-responsive behavior was obtained by inverse emulsion polymerization upon redox initiation. The polymer drag reducer was completely released within 10 s upon adjusting the pH value to 2.26. Notably, the pH-responsive polymer emulsion exhibited 18 times faster release time compared to traditional polymer emulsion stabilized by Span 80, along with a 63.2% drag reduction rate. The rapid release of the polymer was realized by regulating pH merely instead of introduction of extra hydrophilic surfactant, which reconciles the contradiction of stability and release of polymer from emulsions.

Electronic inputs to cue the emergence of hydrogel structure and to confer function

Electrode-imposed electronic inputs can generate various cues that can control the emergence of hierarchical structure and confer function to hydrogel systems. Here we describe three such top-down cues. Electrolytic reactions can create pH cues that can induce the electrodeposition of pH-responsive self-assembling polymers (e.g., chitosan and alginate). The electric field provides a long-range cue that can induce polymer chains to migrate toward (or away from) the electrode and can align the polymer chains within the assembling hydrogel network (e.g., collagen). The electrochemical generation of diffusible oxidants provides a molecular cue that can induce oxidative assembly - typically through the formation of covalent bonds (e.g., disulfide bonds). Here, we review recent results on the use of these three cues for the electrofabrication of hydrogels and we illustrate how complementary capabilities from biotechnology allow the creation of functional hydrogel systems. Overall, we envision that electro-bio-fabrication could emerge as a scalable additive manufacturing method as well as a flexible approach for distributed manufacturing in public maker spaces.

Elucidating the Effect of Amine Charge State on Poly(β-amino ester) Degradation Using Permanently Charged Analogs.

With synthetic ease and tunable degradation lifetimes, poly(β-amino ester)s (PBAEs) have found use in increasingly diverse applications, from gene therapy to thermosets. Protonatable amines in each repeating unit impart pH-dependent solution behavior and lifetimes, with acidic conditions favoring solubility, yet slowing hydrolysis. Due in part to these interconnected phenomena governing pH-dependent PBAE degradation, predictive degradation models, which would enable user-defined lifetimes, remain elusive. To separate the effects of charge state and solution pH on PBAE degradation, we synthesized poly(β-quaternary ammonium ester)s (PBQAEs), which differ from their parent PBAEs only by an additional methyl group, generating polymers with pH-independent cationic charge. Like PBAEs, PBQAE hydrolysis accelerates with increasing pH, although at a given pH, PBAE degradation outpaces PBQAE degradation. This difference is more pronounced in basic solutions, suggesting that deprotonated PBAE amines accelerate hydrolysis, providing an additional tuning parameter to PBAE lifetime and informing the degradation of PBAEs and other pH-responsive polymers.

PH-Responsive graphene oxide/poly (methacrylic acid) hybrid nanofiltration membrane performance for water treatment

Graphene oxide (GO) membranes have been proposed for water treatment. GO can be used to prepare membranes that remove organic molecules, such as model dyes from contaminated wastewater. In practical applications, wastewater is often acidic or alkaline. The physico-chemical properties of GO are only weakly affected by pH, and this can lead to poor membrane performance for the removal of positively charged model compounds. In this work, we used pH-responsive poly (methacrylic acid) (PMAA) to prepare GO-PMAA materials through chemical crosslinking. GO-PMAA materials with different compositions were used to prepare membranes via physical intercalation. The membranes were tested for removal of five different dyes of different sizes and valency (including those that are positively charged, negatively charged, and neutral at neutral pH). We identify a membrane composition that works well for the removal of negatively charged methyl orange and Evans blue under acidic conditions (with 73.1% and 99.7% rejection, respectively) with improved water permeance compared to membranes prepared with GO alone. In addition, we evaluated the long-term stability of the nanofiltration membrane. After continuous operation for 20 h, the rejection rate of MnB by 5p-nGOM was about 85.37%, and the water permeance relatively stable, while the rejection rate of MnB by nGOM was about 26.59%, and the water permeance changed greatly. These findings indicate that GO membranes modified with pH-responsive polymers can achieve superior performance with respect to separation, water permeance, long-term operation, and pressure resistance, compared to GO membranes.

Self-Immolative Polymer Nanoparticles with Precise and Controllable pH-Dependent Degradation.

Polymer nanoparticles have generated significant interest as delivery systems for therapeutic cargo. Self-immolative polymers (SIPs) are an interesting category of materials for delivery applications, as the characteristic property of end-to-end depolymerization allows for the disintegration of the delivery system, facilitating a more effective release of the cargo and clearance from the body after use. In this work, nanoparticles based on a pH-responsive polymer poly(ethylene glycol)-b-(2-diisopropyl)amino ethyl methacrylate) and a self-immolative polymer poly[N,N-(diisopropylamino)ethyl glyoxylamide-r-N,N-(dibutylamino)ethyl glyoxylamide] (P(DPAEGAm-r-DBAEGAm)) were developed. Four particles were synthesized based on P(DPAEGAm-r-DBAEGAm) polymers with varied diisopropylamino to dibutylamino ratios of 4:1, 2:1, 2:3, and 0:1, termed 4:1, 2:1, 2:3, and 0:1 PGAm particles. The pH of particle disassembly was tuned from pH 7.0 to pH 5.0 by adjusting the ratio of diisopropylamino to dibutylamino substituents on the pendant tertiary amine. The P(DPAEGAm-r-DBAEGAm) polymers were observed to depolymerize (60-80%) below the particle disassembly pH after ∼2 h, compared to <10% at pH 7.4 and maintained reasonable stability at pH 7.4 (20-50% depolymerization) after 1 week. While all particles exhibited the ability to load a peptide cargo, only the 4:1 PGAm particles had higher endosomal escape efficiency (∼4%) compared to the 2:3 or 0:1 PGAm particles (<1%). The 4:1 PGAm particle is a promising candidate for further optimization as an intracellular drug delivery system with rapid and precisely controlled degradation.

PH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

Small interfering RNA (siRNA) has a promising future in the treatment of ocular diseases due to its high efficiency, specificity, and low toxicity in inhibiting the expression of target genes and proteins. However, due to the unique anatomical structure of the eye and various barriers, delivering nucleic acids to the retina remains a significant challenge. In this study, we rationally design PACD, an A-B-C type non-viral vector copolymer composed of a hydrophilic PEG block (A), a siRNA binding block (B) and a pH-responsive block (C). PACDs can self-assemble into nanosized polymeric micelles that compact siRNAs into polyplexes through simple mixing. By evaluating its pH-responsive activity, gene silencing efficiency in retinal cells, intraocular distribution, and anti-angiogenesis therapy in a mouse model of hypoxia-induced angiogenesis, we demonstrate the efficiency and safety of PACD in delivering siRNA in the retina. We are surprised to discover that, the PACD/siRNA polyplexes exhibit remarkable intracellular endosomal escape efficiency, excellent gene silencing, and inhibit retinal angiogenesis. Our study provides design guidance for developing efficient nonviral ocular nucleic acid delivery systems.

PH-responsive polyacrylic acid chemical cross-linking for end-of-life reverse osmosis membrane rejuvenation

An in-situ chemical cross-linking rejuvenation technique for reverse osmosis (RO) membranes was developed and investigated utilizing pH-responsive polymer with multiple carboxyl groups to improve the salt rejection and performance stability of end-of-life RO membranes. Polyacrylic acid (PAA) was used as a rejuvenating agent to cross-link with amino groups on the degraded RO membrane through EDC/NHS activated reaction. Indicated by ATR-FTIR, XPS, Zeta potential and SEM analyses, the covalent bonds between carboxyl groups and amino groups were generated on the PAA-rejuvenated membrane. The end-of-life RO membrane elements with an average NaCl rejection of 92.68 % could be recovered to 97.26 % by PAA rejuvenation. As a result of pH responsivity, PAA-rejuvenated membranes exhibit excellent rejection stability after continuous 12 cycles of alkali and acid alternate cleaning. The adjustable salt rejection and the durability of PAA-rejuvenated membrane elements were validated in real water tests for 185 days at a coal mine water treatment plant, indicating the practical application potentiality. The effects of initial end-of-life RO membrane condition on PAA rejuvenation are also provided.

Real-time monitoring of the dissolution of pH-responsive polymer coatings by capacitive sensing with signal protection mechanism

Accurate assessment of pH-responsive polymer dissolution in vitro is crucial for formula design in drug delivery systems. This study developed a high-performance capacitive sensing system (Cap-S) with a screen-printed carbon electrode (SPCE) for real-time monitoring and evaluating the dissolution rate of EUDRAGIT® FL 30 D-55 and L 30 D-55 polymers. The linear detection range of the Cap-S is 1.000–4.000 pF (R2 = 0.9909) with a sensitivity (0.309 fF/fF). The sensor system exhibited a tri-phasic response with a dual-sigmoidal curve, allowing for accurate measurement of the dissolution time of polymers to reach 50 % capacitance shift (T50 %). The Cap-S showed outstanding temporal resolution (0.1 s) in monitoring polymer dissolution without the need for an electroactive probe commonly used in electrochemistries. It also provides a realistic and discriminative in vitro dissolution assessment of enteric-coated formulations in Hanks' buffer (T50 % = 409 s and > 5.6 h to FL 30 D-55 and L 30 D-55, respectively) versus Sorensen's phosphate-buffered saline (T50 % = 532 s and =1761 s to FL 30 D-55 and L 30 D-55, respectively), among others. The approach is a compact and precise method for real-time monitoring and quantitative assessment of polymer dissolution.

Carbomer/arginine intelligent viscoelastic fluid with adjustable CO2-responsive viscosity

Environmentally responsive intelligent viscoelastic fluids have been used in many fields in recent years. The rheological behavior of different intelligent viscoelastic fluids can be changed by different stimulation methods. Among them, CO2, as a non-toxic green and abundant stimulus method, has attracted much attention. Therefore, CO2-responsive intelligent viscoelastic fluids have been continuously reported, in which viscoelastic fluids with CO2-responsive viscosity increase have been more reported, while those with CO2-responsive viscosity decrease have been less reported. Herein, carbomer (CBM), as a pH-responsive polymer with potential CO2-responsiveness, is applied to CO2-responsive viscosity decreasing viscoelastic fluids. CBM and arginine (Arg) formed a new CO2-responsive viscoelastic fluid, which achieved a significant decrease in viscosity after CO2-response. Firstly, by comparing the effects of NaOH and Arg on the rheological behavior of CBM solution, it is demonstrated that Arg can extend the viscosity variation range of CBM solution before and after CO2-response, and Arg can switch between “physical crosslinking agent” and “viscosity reducing agent”, and it is verified from the microscopic perspective. Then, the effects of Arg concentration and CBM concentration on the CO2-responsiveness and rheological behavior of CBM/Arg viscoelastic fluid were investigated. The multiple reversible CO2-responsive viscosity of CBM/Arg viscoelastic fluid was verified. Finally, the viscoelastic variations of CBM/Arg viscoelastic fluid before and after the response were investigated by dynamic rheology.

Dual-Pronged Attack: pH-Driven Membrane-Anchored NIR Dual-Type Nano-Photosensitizer Excites Immunogenic Pyroptosis and Sequester Immune Checkpoint for Enhanced Prostate Cancer Photo-Immunotherapy.

Prostate cancer (PCa) is a frustrating immunogenic "cold" tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis is an excellent immunogenic cell death form that can effectively activate the antitumor immune response, promote cytotoxic T-lymphocyte infiltration, and convert tumors from "cold" to "hot." However, the in vivo application of pyroptosis drugs is seriously limited, and the upregulation of tumor PD-L1 caused by photo-immunotherapy further promotes immune escape. Herein, a new nano-photosensitizer (YBS-BMS NPs-RKC) with pH-response integrating immunogenic pyroptosis induction and immune checkpoint blockade is developed. The pH-responsive polymer equipped with the cell membrane anchoring peptide RKC is used as the carrier and further encapsulated with the near-infrared-activated semiconductor polymer photosensitizer YBS and a PD-1/PD-L1 complex small molecule inhibitor BMS-202. The pH-driven membrane-anchoring and pyroptosis activation of YBS-BMS NPs-RKC is clearly demonstrated. In vitro and in vivo studies have shown that this dual-pronged therapy stimulates a powerful antitumor immune response to suppress primary tumor progression and evokes long-term immune memory to inhibit tumor relapse and metastasis. This work provides an effective self-synergistic platform for PCa immunotherapy and a new idea for developing more biocompatible photo-controlled pyroptosis inducers.

PH-responsive polyzwitterion covered nanocarriers for DNA delivery

The success of gene therapy relies on gene nanocarriers to achieve therapeutic effects in vivo. Surface shielding of poly(ethylene glycol) (PEG), known as PEGylation, onto gene delivery carriers is a predominant strategy for extending blood circulation and improving therapeutic outcomes in vivo. Nevertheless, PEGylation frequently compromises the transfection efficiency by decreasing the interactions with the cellular membrane of the targeted cells, thereby preventing the cellular uptake and the subsequent endosomal escape. Herein, we developed a stepwise pH-responsive polyplex micelle for the plasmid DNA delivery with the surface covered by ethylenediamine-based polycarboxybetaines. This polyplex micelle switched its surface charge from neutral at pH 7.4 to positive at tumorous and endo−/lysosomal pH (i.e., pH 6.5 and 5.5, respectively), thus enhancing the cellular uptake and facilitating the endosomal escape toward efficient gene transfection. Additionally, the polyplex micelle demonstrated prolonged blood circulation as well as enhanced tumor accumulation, leading to highly effective tumor growth suppression by delivering an antiangiogenic gene. These results suggest the usefulness of a pH-responsive charge-switchable shell polymer on the surface of the polyplex micelle for the efficient nucleic acid delivery.

Retraction: pH responsive polymer micelles enhances inhibitory efficacy on metastasis of murine breast cancer cells.

[This retracts the article DOI: 10.3389/fphar.2018.00543.].

PH-Responsive Polymer Films Based on Click Polymerization for Food Freshness Monitoring: Non-Toxic, Non-Leaking, and Antibacterial.

With the requirements for food safety and quality, there has been increasing attention on intelligent food packaging, especially pH-responsive intelligent packaging. However, the toxicity of indicators and the vulnerability of composite films to leakage tend to change the composition of food and endanger human health. In this study, 2-allyoxy-1-hydroxy-anthraquinone (AhAQ), a pH-responsive plant dye that was modified from alizarin (AI), was grafted onto the pH-responsive intelligent film (AhAQF) via click polymerization. The obtained AhAQF film shows color change in response to ammonia vapor and exhibits adequate reversibility after treatment with volatile acetic acid. The obtained AhAQF exhibits zero leakage, owing to the covalent immobilization of AhAQ. Thus, the prepared pH-responsive films are non-toxic and antibacterial and show promising application prospects in visual food intelligent packaging and gas-sensitive labels.

A stimuli-responsive nanocarrier for diagnosis of seizures and inhibition of glutaminase in epilepsy

Epilepsy is marked by unpredictable and recurrent episodes of seizures. It is characterized by glutamate excitotoxicity and changes in stimuli such as pH, temperature and oxidative environment. This study aimed to formulate novel nanoparticulate theranostic nanocarrier for combined effects of diagnosis and treatment of epilepsy by: i) in-situ detection of epileptic conditions through characteristic changes in pH through the synthesis of pH-responsive polymer (CS-g-PD) and ii) ‘on-demand’ therapeutic alleviation of epileptic seizures through an inhibitor of glutaminase, 6-diazo-5-oxo-norleucine (DON). The formulation of DON-CS-g-PD-SLNs possessed nanodimensions (∼197.56 ± 17.87) nm and zeta potential (4.19 ± 0.29), with entrapment efficiency of (80.29 ± 0.006%). The coating pH-responsive polymer showed good sensitivity for acidic conditions by releasing the drug in pH 6.4 and resisting release in higher pH 7.2. In-vivo studies in Wistar rats showed suppression of epileptic seizures, escalation in the duration latency and reduction in duration of convulsions and recovery period. Furthermore, it was also successful in reducing the levels of glutaminase (p < 0.0001) in the brain of PTZ-kindled rats, thereby leading to a decrease in glutamate levels (p < 0.01). Hence, the nanocarriers show promising potential as ‘on-demand’ theranostics in epilepsy by reducing both the incidence and severity of convulsions.

PH-responsive polymeric nanostructures for cancer theranostics

Responsive polymeric nanostructures are being designed to improve the efficiency of existing treatment techniques by delivering therapeutics in precise locations. The properties of the particles can be altered to act as a probe for imaging applications also. Hence, an effective theranostic agent can be tailor-made to meet the requirements. The pH variability has aroused considerable interest in nano-responsive-stimulus production since the mild acidic condition is a hallmark of the tumor microenvironment. The cargo sealed inside the carrier will be released either by swelling or disassembly of the carrier as they meet a pH drop. The modification strategy for the synthesis of pH-responsive polymers is discussed in the manuscript. Fabrication of pH-responsive theranostic agents can conquer major limitations of conventional treatment techniques. Herein we reported imperative insights on recent pH-sensitive polymeric nanomaterials for the treatment of various disease conditions, especially cancer.

PH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications.

Nanomaterials such as pH-responsive polymers are promising for targeted drug delivery systems, due to the difference in pH between tumor and healthy regions. However, there is a significant concern about the application of these materials in this field due to their low mechanical resistance, which can be attenuated by combining these polymers with mechanically resistant inorganic materials such as mesoporous silica nanoparticles (MSN) and hydroxyapatite (HA). Mesoporous silica has interesting properties such as high surface area and hydroxyapatite has been widely studied to aid in bone regeneration, providing special properties adding multifunctionality to the system. Furthermore, fields of medicine involving luminescent elements such as rare earth elements are an interesting option in cancer treatment. The present work aims to obtain a pH-sensitive hybrid system based on silica and hydroxyapatite with photoluminescent and magnetic properties. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption methods, CHN elemental analysis, Zeta Potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM), vibrational sample magnetometry (VSM), and photoluminescence analysis. Incorporation and release studies of the antitumor drug doxorubicin were performed to evaluate the potential use of these systems in targeted drug delivery. The results showed the luminescent and magnetic properties of the materials and showed suitable characteristics for application in the release of pH-sensitive drugs.