SummaryTen exclusively gastrostomy‐fed, neurologically impaired children (4.5‐14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein‐ or a whey‐based formula for 48 h each and then crossed over to the other formula. One 24‐h pH probe study each was performed while being fed casein‐ and whey‐based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey‐based formula (p < 0.05). Whey‐based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3‐12 months old) with documented gastroesophageal reflux using 24‐h pH probe monitoring while consuming a casein‐based formula. The formula was changed to a whey‐based formula and the pH probe study repeated within 3‐5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey‐formula was not significantly different from that with the casein‐based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey‐based formula in infants with gastroesophageal reflux cannot be made.