Event Abstract Back to Event The Na+/H+ exchangers of intracellular compartments. Proton leaks or loading mechanisms ? Nina Milosavljevic1, MIchael Monet2, Isabelle Lena2, Frederic Brau3, Sandra Lacas-Gervais4, Sylvain Feliciangeli3, Mallorie Poet2 and Laurent Counillon2* 1 University of Manchester, Faculty of Life Sciences, United Kingdom 2 University of Nice-Sophia Antipolis, Biology, France 3 IPMC, UMR 7275, France 4 CCMA, France Background and aim. The Na+/H+ exchangers NHE 7, 8 and 9 are expressed in intracellular vesicles. NHE7 and NHE6 genes are situated on the X chromosome (Xp11.3 and Xq26.3, respectively) and NHE9 is on chromosome 3 (3q24). Mutations in the genes encoding these exchangers have been linked to autism-spectrum neurological disorders and neurodegeneration. In addition, the overexpression of NHE7 in human breast carcinoma cells enhances cell-cell adhesion, anchorage-independent tumor growth, invasion and tumor formation in vivo. These transporters are mostly believed to exchange cytosolic potassium for protons and to alkalinize vesicles, an important function for the maintenance of steady state pH in intracellular compartments. However, their intracellular localization prevented direct functional measurements. Methods. Using somatic cell genetics, we selected a cell line that expresses wild-type NHE7 at the plasma membrane. This enabled for the first time the detailed measurement of the exchanger’s parameters and constants using fast kinetics of ion transport. Conclusions / Discussion. These measurements show unexpected functions for NHE7 and provide new clues for the biological roles and pathological implications of these intracellular NHEs. Keywords: modelling, Membranes, Proton transporters, Vesicular Transport Proteins, human diseases Conference: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer, Garching, Germany, 10 Oct - 12 Oct, 2013. Presentation Type: Abstract Topic: 1. Biophysics of pH Citation: Milosavljevic N, Monet M, Lena I, Brau F, Lacas-Gervais S, Feliciangeli S, Poet M and Counillon L (2014). The Na+/H+ exchangers of intracellular compartments. Proton leaks or loading mechanisms ?. Front. Pharmacol. Conference Abstract: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer. doi: 10.3389/conf.fphar.2014.61.00030 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jan 2014; Published Online: 07 Feb 2014. * Correspondence: Prof. Laurent Counillon, University of Nice-Sophia Antipolis, Biology, Nice, 06108, France, Laurent.Counillon@unice.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nina Milosavljevic MIchael Monet Isabelle Lena Frederic Brau Sandra Lacas-Gervais Sylvain Feliciangeli Mallorie Poet Laurent Counillon Google Nina Milosavljevic MIchael Monet Isabelle Lena Frederic Brau Sandra Lacas-Gervais Sylvain Feliciangeli Mallorie Poet Laurent Counillon Google Scholar Nina Milosavljevic MIchael Monet Isabelle Lena Frederic Brau Sandra Lacas-Gervais Sylvain Feliciangeli Mallorie Poet Laurent Counillon PubMed Nina Milosavljevic MIchael Monet Isabelle Lena Frederic Brau Sandra Lacas-Gervais Sylvain Feliciangeli Mallorie Poet Laurent Counillon Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.