Almost all the helium discovered worldwide has been found by chance in the drilling for hydrocarbons. Targets were usually anticlinal structures located by seismic surveys. The association of helium and natural gas in reservoirs is purely coincidental because the source rocks for each are different—natural gas is mainly produced from diagenesis of carbon rich shale whereas Helium- 4 is derived mainly from the decay of uranium/thorium in the crust. A new geochemical exploration system for helium in the Phanerozoic is considered highly desirable by industry. The current exploration system in the Phanerozoic uses a modified petroleum system concept that has been used successfully for decades to high-grade plays and de-risk oil and gas prospects. Like a petroleum system, the helium system is identified by its source rock, reservoir, trap, seal, and migration pathways. However, this approach is expensive taking years to complete and can be a limiting factor for countries/provinces/states to develop their resources. As a precursor to ground helium/hydrogen surveys for exploration in the Phanerozoic, hyperspectral (satellite) surveys assess huge areas for their helium potential as well as any associated hydrocarbons. These areas may be even devoid of any previous exploration for hydrocarbons. This is followed with geochemical soil gas surveys of the more prospective trends to locate drilling locations. Both methods ascertain whether helium anomalies, which represent helium reservoirs at depth, are associated with hydrocarbons or nitrogen. Helium reservoirs associated with nitrogen are higher in helium content but are deeper, close to the basement. Hyperspectral and geochemical soil gas surveys are also applicable for projects that begin with helium analysis of old wells followed by seismic and drilling. Typically, exploration companies lease vast areas surrounding the legacy well, but their initial focus is on seismic in the area around the legacy well to determine the size and configuration of the helium reservoir and trap penetrated by the well and this is followed by drilling. It is not known at this point whether this reservoir is the best prospect because the helium discovered is usually associated with hydrocarbon (HC), not with nitrogen with much higher helium concentration in the lower Phanerozoic. Rarely do legacy wells penetrate deep enough to this level. Any cost-effective exploration program for helium is best accomplished by hyperspectral and follow-up geochemical soil gas surveys.