Petah Tikva Research Articles

Dupilumab-induced ocular surface disease (DIOSD) in patients with atopic dermatitis: clinical presentation, risk factors for development and outcomes of treatment with tacrolimus ointment

AimTo identify risk factors for the development of dupilumab-induced ocular surface disease (DIOSD) in adult patients with atopic dermatitis (AD) and describe outcomes of treatment.MethodsA retrospective institutional cohort study performed...

Health Care Resource Utilization and Costs for Patients with Tardive Dyskinesia.

Tardive dyskinesia (TD) is an often-irreversible movement disorder affecting any part of the body. Patients experience debilitating symptoms that lower quality of life and increase mortality. Prolonged exposure to dopamine antagonists, which are frequently prescribed for psychiatric disorders as neuroleptic (antipsychotic) drugs, is a common cause of TD. The estimated prevalence of TD is 20%-50% among patients on antipsychotics, and the reported incidence of TD ranges from < 1% to 42%, depending on the antipsychotics studied. However, there are few real-world studies examining health care utilization and the economic burden of TD. To assess health care utilization and costs in a sample of patients with TD from the commercially insured and Medicare supplemental U.S. A retrospective analysis was conducted using Truven MarketScan Commercial and Medicare administrative claims data. Patients were included in the TD group if they had the first TD diagnosis (index date) between January 1, 2008, and September 30, 2014, with ≥ 1 inpatient or ≥ 2 outpatient nondiagnostic claims for TD (ICD-9-CM code 333.85). Patients without TD were randomly assigned an index date. Further inclusion criteria for all patients were ≥ 12 months of pre- and post-index medical and pharmacy continuous enrollment and no evidence of TD claims during the pre-index period. Patients with TD were directly matched to patients without TD within subgroups for schizophrenia, major depressive disorder, bipolar disorder, and other psychiatric disorders and propensity matched on other demographic and clinical factors. Descriptive statistics on the incidence of resource utilization and costs of health care were reported. Of 3,397 patients with TD, 834 met the selection criteria and were matched to 834 non-TD controls. Patients with TD generally had significantly greater utilization during the 12 months after TD diagnosis than in the 12 months before TD diagnosis. Their rates for health care utilization and costs were also substantially higher than for those without TD. During the post-TD-diagnosis time, inpatient admissions (55.5% vs. 26.1%; P < 0.001) and emergency room visits (61.5% vs. 50.6%; P < 0.001) occurred more for patients with TD than for patients without TD. Total health care costs were significantly greater for patients with TD than for those without TD ($54,656 vs. $28,777; P < 0.001). Patients diagnosed with TD demonstrate significantly higher health care utilization and costs compared with non-TD patients. This study was funded by Teva Pharmaceuticals (Petach Tikva, Israel). Truven Health Analytics, an IBM Watson Health Company, received payment from Teva Pharmaceuticals for the analysis in this study. Carroll is employed by Teva Pharmaceuticals and Irwin is employed by Truven Health Analytics, an IBM Watson Health Company.

Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas.

To compare the biomechanical properties of the unilateral operated corneas in patients who had undergone Descemet membrane endothelial keratoplasty (DMEK) for pseudophakic bullous keratopathy (PBK) with those of the contralateral normal corneas. This was a retrospective cohort study conducted at university hospitals (Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel, and S. Fyodorov Eye Microsurgery State Institution, Moscow, Russia). Forty eyes of 20 patients who underwent DMEK for unilateral PBK 3.5 to 36months ago and with normal fellow eyes were included in the study. An ocular response analyzer was used to measure the corneal biomechanical properties in the operated and normal fellow eyes. The main outcome measures were corneal hysteresis (CH) and corneal resistance factor (CRF). The mean CH (8.4 ± 1.5mmHg vs. 8.2 ± 1.5mmHg, P = 0.707) and the mean CRF (8.7 ± 1.6mmHg vs. 8.3 ± 1.6mmHg, P = 0.419) values did not show any statistically significant difference between the operated and the normal fellow eyes. In our study, the corneas that underwent DMEK for PBK showed normal values for biomechanical parameters. These findings support the previous studies that have reported near complete visual, functional, and ultra-structural rehabilitation of the corneas following DMEK.

Anterior Chamber Rebubbling With Perfluoropropane (C3F8) After Failed Rebubbling Attempts for Persistent Descemet Membrane Endothelial Keratoplasty Graft Detachments.

To describe the clinical outcomes of using C3F8 as a tamponade agent for the attachment of partially detached Descemet membrane endothelial keratoplasty (DMEK) grafts after failure of previous rebubbling attempts. Interventional case series. We reviewed the medical records of all DMEK surgeries performed at Rabin Medical Center (Petach Tikva, Israel) between January 2016 and December 2018 in which 10% C3F8 tamponade was used for graft reattachments. Patient demographic details, indication for surgery, early postoperative endothelial cell loss, postoperative visual acuity, intraoperative and postoperative complications as well as graft survival were noted. Five patients were included in this case series. Indications for DMEK were pseudophakic bullous keratopathy (n = 3), failed penetrating graft (n = 1), and Fuchs endothelial dystrophy (n = 1). In 4 of 5 cases, SF6 tamponade was used at the end of the initial DMEK surgery. In 1 case, air tamponade was used. In all cases, partial graft detachment was seen 1 to 2 weeks postoperatively, and anterior chamber rebubbling was performed using 20% SF6 gas. A second C3F8-assisted rebubbling was performed 10 to 70 days after the primary DMEK surgery. In all cases, complete graft attachment was achieved, and the corneas cleared. Early endothelial cell loss rates averaged at 44% ± 26% (range 20%-74%). One case which had a previous trabeculectomy with chronic preoperative and postoperative hypotony had failed 6 months after surgery. All the other grafts were clear at last visit. Tamponade using nonexpansile 10% C3F8 gas can attach partially detached DMEK grafts after the failure of previous air- or SF6-assisted rebubbling attempts.

A short history of Mulabbis (Petah Tikva, Israel)

ABSTRACTThe following article summarizes our current knowledge of the history of Tell Mulabbis (in modern Petah Tikva). As a key archaeological site in the Yarkon River basin, it was inhabited during the Roman, Byzantine, Early Islamic, Crusader, Mamluk and Late Ottoman periods. Based on the published results of recent excavations, older scholarship, and hereto-unnoticed written evidence, the article examines and interprets Mulabbis's material culture within the broader contexts of the region's historical geography. Although possessing important advantages like access to water and arable land, the site was inhabited only intermittently due to malaria and changing economic and political circumstances. Within the framework of Ottoman Archaeology, the article suggests the need to pay closer attention to ‘recent’ archaeological layers. For example, the few Ottoman material remains published so far, testify to continued cultural exchange and economic ties between Mulabbis, the mountainous interior, and the southern parts of Palestine.

First trimester glycosylated hemoglobin as a predictor of gestational diabetes mellitus.

To evaluate the potential role of glycosylated haemoglobin (HbA1C) as an early biomarker for gestational diabetes. In a retrospective analysis, healthy women who went on to give birth to a singleton newborn in a tertiary medical center in Petach Tikva, Israel, underwent measurement of HbA1C in the first trimester (up to 12weeks of pregnancy) between August 1, 2007, and December 31, 2014. Women with type 1 or type 2 diabetes, HbA1C ≥6.5%, and/or fasting plasma glucose ≥126mg/dL were excluded, as were women whose glucose levels had already been tested before 24weeks of pregnancy. Data were extracted from a maternal and neonatal database. The primary outcome measure was the association between first trimester HbA1C and adverse pregnancy outcome, primarily, gestational diabetes. The cohort included 142 women. HbA1C concentration was linearly and inversely correlated to length of gestation (r=-0.317, P<0.001). Higher HbA1C was associated with gestational diabetes. An HbA1C concentration of ≥5.45% predicted gestational diabetes with 83.3% sensitivity, 69% specificity, and gave positive and negative predictive values of 53% and 90.8%, respectively. Early pregnancy HbA1C could serve as a predictor of gestational diabetes. Ideally, HbA1C should be considered in multi-parameter prediction models to enhanceaccuracy.

45 Long-term Treatment with Deutetrabenazine Is Associated with Continued Improvement in Tardive Dyskinesia: Results from an Open-label Extension Study

AbstractStudy ObjectiveTo evaluate long-term efficacy of deutetrabenazine in patients with tardive dyskinesia (TD) by examining response rates from baseline in Abnormal Involuntary Movement Scale (AIMS) scores. Preliminary results of the responder analysis are reported in this analysis.BackgroundIn the 12-week ARM-TD and AIM-TD studies, the odds of response to deutetrabenazine treatment were higher than the odds of response to placebo at all response levels, and there were low rates of overall adverse events and discontinuations associated with deutetrabenazine.MethodPatients with TD who completed ARM-TD or AIM-TD were included in this open-label, single-arm extension study, in which all patients restarted/started deutetrabenazine 12mg/day, titrating up to a maximum total daily dose of 48mg/day based on dyskinesia control and tolerability. The study comprised a 6-week titration and a long-term maintenance phase. The cumulative proportion of AIMS responders from baseline was assessed. Response was defined as a percent improvement from baseline for each patient from 10% to 90% in 10% increments. AlMS score was assessed by local site ratings for this analysis.Results343 patients enrolled in the extension study (111 patients received placebo in the parent study and 232 patients received deutetrabenazine). At Week 54 (n=145; total daily dose [mean±standard error]: 38.1±0.9mg), 63% of patients receiving deutetrabenazine achieved ≥30% response, 48% of patients achieved ≥50% response, and 26% achieved ≥70% response. At Week 80 (n=66; total daily dose: 38.6±1.1mg), 76% of patients achieved ≥30% response, 59% of patients achieved ≥50% response, and 36% achieved ≥70% response. Treatment was generally well tolerated.ConclusionsPatients who received long-term treatment with deutetrabenazine achieved response rates higher than those observed in positive short-term studies, indicating clinically meaningful long-term treatment benefit.Presented at: American Academy of Neurology Annual Meeting; April 21–27, 2018, Los Angeles, California, USA.Funding Acknowledgements: This study was supported by Teva Pharmaceuticals, Petach Tikva, Israel.

62 Predictors of Tardive Dyskinesia in Psychiatric Patients Taking Concomitant Antipsychotics

AbstractBackgroundTardive dyskinesia (TD) is typically caused by exposure to antipsychotics, is often irreversible, and can be debilitating. TD symptoms can increase the social stigma of patients with comorbid psychiatric disorders, negatively impact quality of life, and potentially increase medical morbidity and mortality. An increased risk of developing TD has been associated with factors such as older age, female sex, underlying mental illness, and long-term use and higher doses of antipsychotics. The association of TD with the use of typical versus atypical antipsychotics has also been evaluated, with mixed results. To date, predictive models assessing the joint effect of clinical characteristics on TD risk have not been developed and validated in the US population.Study ObjectiveTo develop a prediction model to identify patient and treatment characteristics associated with the occurrence of TD among patients with psychiatric disorders taking antipsychotic medications, using a retrospective database analysis.MethodsAdult patients with schizophrenia, major depressive disorder, or bipolar disorder who were taking oral antipsychotics, and who had 6months of data prior to the index date were identified from Medicaid claims from six US states. The index date was defined as the date of the first claim for an antipsychotic drug after a claim for the underlying disorder but before TD diagnosis. A multivariate Cox prediction model was developed using a cross-validated version of the least absolute shrinkage and selection operator (LASSO) regression method to improve prediction accuracy and interpretability of the model. The predictive performance was assessed in a separate validation set via model discrimination (concordance) and calibration.ResultsA total of 189,415 patients were identified: 66,723 with bipolar disorder, 68,573 with depressive disorder, and 54,119 with schizophrenia. The selected prediction model had a clinically meaningful concordance of 70% and was well calibrated (P=0.46 for Hosmer–Leme show goodness-of-fit test). Patient’s age at index date (hazard ratio [HR]: 1.03), diagnosis of schizophrenia (HR: 1.73), dosage of antipsychotic at index date (up to 100mg/day chlorpromazine equivalent; HR: 1.40), and presence of bipolar and related disorders (HR: 1.16) were significantly associated with an increased risk of TD diagnosis. Use of atypical antipsychotics at index date was associated with a modest reduction in the risk of TD (HR=0.94).ConclusionsThis study identified a group of factors associated with the development of TD among patients with psychiatric disorders treated with antipsychotics. This may allow physicians to better monitor their patients receiving antipsychotics, allowing for the prompt identification and treatment of TD to help maintain quality of life.Presented at: American Psychiatric Association Annual Meeting; May 5–9, 2018, New York, New York, USAFunding Acknowledgements: This study was supported by Teva Pharmaceuticals, Petach Tikva, Israel.

The Official Journal of ATTD Advanced Technologies &amp; Treatments for Diabetes Conference Berlin, Germany—February 20–23, 2019

The Official Journal of ATTD Advanced Technologies &amp; Treatments for Diabetes Conference <i>Berlin, Germany—February 20–23, 2019</i>

TRADING SECRETS: CONSTRUCTIONS AND CONTEXTS OF TWO MIDDLE EASTERN JEWISH GUARDS IN THE EARLY PETAH TIKVA AGRICULTURAL COLONY

AbstractTwo Arabic-speaking Jewish guards worked in the European Jewish agricultural colony of Petah Tikva soon after its founding, northeast of Jaffa, in 1878: Daud abu Yusuf from Baghdad and Yaʿqub bin Maymun Zirmati, a Maghribi Jew from Jaffa. The two men, who worked as traders among Bedouin but were recruited for a short time by the colony, offer a rare glimpse of contacts between Ashkenazi and Middle Eastern Jews in rural Jewish colonies established in the last quarter of the 19th century, colonies that are often regarded as detached from their local and Ottoman landscape. The article first argues that Zionist sources constructed these two men as bridges to the East in their roles as teachers of Arabic and perceived sources of legitimization for the European Jewish settlement project. It then reads beyond the sparse details offered in Ashkenazi Zionist sources to resituate these men in their broad imperial and regional context and argue that, contrary to the local Zionist accounts, the colony was in fact likely to have been marginal to these men's commercial and personal lives.

Introduction and General

Introduction and General Christopher T. Begg, Victor H. Matthews, Robert D. Miller, Thomas Hieke, and David A. Bosworth 728. Walter Ameling, Hannah M. Cotton, Werner Eck, Avner Ecker, Benjamin Isaac, Alia Kushnir-Stein, Haggai Misgar, Jonathan Price, Peter Weiß, and Ada Yardani (eds.), Corpus Inscriptionum Iudaeae/Palaestinae, Vol IV. Iudaea/Idumaea, Part 1 2649–3324; Vol. IV Iudaea/Idumαea, Part 2 3325–3978 (Berlin/Boston: de Gruyter, 2018). Pp. xxvi + 1-758 (Part 1); xi + 759-1580 (Part 2). €140,14 (Part 1); €140,14 (Part 2). ISBN 978-3-11-053744-4 (Part 1); 978-3-11-054364-3 (Part 2). The fourth volume of the Corpus Inscriptionum Iudaeae Palestinae (CHIP) is dedicated to the inscriptions from Iudaea proper and Idumaea. The two parts (IV 1-2) contain all the inscriptions from these areas with the exception of the ostraca. The latter have been found in this area in such huge quantities that they could not be included here; two other volumes will be dedicated to them in the future. The inscriptions are arranged, as in volume II, in a north-to-south order. The volume begins with Kefar Sirkin near Petah Tikva at the northwest end and terminates at Masada in the southeast. When more than one settlement occupies the same latitude, the inscriptions are in a west to east order. The territory covered in the volume was divided at least since the 2nd cent. a.d. between different communities or cities, but almost nowhere is it possible to assign the inscriptions to a specific territory of an ancient community or city. Consequently, most of the material had to be associated with a modern settlement and its surrounding area, rather than with an ancient one. Inscriptions found in a single place, when numerous, are divided into groups acccording to content, following the practice adopted in previous volumes. (Preface, Vol. 4, Part 1, p. v., adapted.) For each of the almost 1,300 inscriptions in the volume, the editors provide (to the extent possible) the following data: introductory notes concerning the given inscription's language, content, date, dimensions, and findspot; text in the characters of the language used (Greek, Aramaic, Latin, Armenian, etc.); transcription; translation; historical and philo-logical commentary; and bibliography, along with line drawings and/or photos of the item in question. Part 2 concludes with an index of personal names for all volumes in the series hitherto published and a series of maps plus a key to locations on these maps.—C.T.B. 729. Michael Barram, Missional Economics: Biblical Justice and Christian Formation (The Gospel and Our Culture; Grand Rapids, MI: Eerdmans, 2018). Pp. xviii + 263. Paper $26. ISBN 978-0-8028-7507-5. This is a book of reflections on biblical economic justice and Christian discipleship. Its chapters work through both OT and NT texts that deal with such topics as the socioeconomic [End Page 227] realties of ancient Israel, including laws protecting widows, orphans, and resident aliens, and provisions (gleaning) for the poor. The economic reasoning in prophets like Amos, Isaiah, and Micah are also explored, as is the situation reflected in the Sermon on the Mount and the concept of "all things in common" found in Acts and the Pauline letters. B.'s concluding chapter addresses questions of missional hermeneutics, the concept of human dignity, as well as methods and mission, with a focus on the liberation of the oppressed from economic and social forms of bondage.—V.H.M. 730. Odette Boivin, The First Dynasty of the Sealand in Mesopotamia (SANER 20; Berlin/Boston: de Gruyter, 2018). Pp. xii + 292. €81,26. ISBN 978-1-5015-1639-9. The reconstruction of the history of mid-2nd-millennium Babylonia has been complicated by a dire lack of sources. The Sealand kings who controlled part of the area in this period have long been known only indirectly. A recently published palatial archive, however, now enables us to illuminate this hitherto elusive polity from the inside. A study of this archive and a reassessment of the relevant historiographical...

The Relationship Between Women’s Intention to Request a Labor Epidural Analgesia, Actually Delivering With Labor Epidural Analgesia, and Postpartum Depression at 6 Weeks: A Prospective Observational Study

(Anesth Analg. 2018;126:1590–1597) At the Beilinson Campus of the Rabin Medical Center in Petach Tikva, Israel, a proportion of women who intend to deliver with labor epidural analgesia (LEA) are often unable to receive it due to a lack of available nursing staff, labor rooms, or anesthesiologists at the time of request. As there is no study to date that has specifically examined the relationship between birth plan, satisfaction with LEA, and development of postpartum depression (PPD), the authors of the present study examined the impact of delivering without analgesia when such was not the intended plan. They hypothesized that the PPD rate at 6 weeks would be highest among women who intended to deliver with LEA but who actually delivered without.

Image Crisis in Legia Warszawa Sports Klub Following Accusationsof Attacking Members of Hapoel Petah Tikva Team by Legia’s Fans – Situation Analysis and Evaluation

Abstract Today sports plays a very important role in marketing, brand image building and also in the entire promotion process in organizations. In order to obtain the planned and crucial for every entity involved effects, there should be the relationship between the product and the sport [Pogorzelski, 2010, p 14]. Not every sport provides the opportunity of shaping the image safely and at the level expected by the entity involved.

Adjusting insulin doses in patients with type 1 diabetes who use insulin pump and continuous glucose monitoring: Variations among countries and physicians.

To evaluate physicians' adjustments of insulin pump settings based on continuous glucose monitoring (CGM) for patients with type 1 diabetes and to compare these to automated insulin dose adjustments. A total of 26 physicians from 16 centres in Europe, Israel and South America participated in the study. All were asked to adjust insulin dosing based on insulin pump, CGM and glucometer downloads of 15 patients (mean age 16.2 ± 4.3 years, six female, mean glycated haemoglobin 8.3 ± 0.9% [66.8 ± 7.3 mmol/mol]) gathered over a 3-week period. Recommendations were compared for the relative changes in the basal, carbohydrate to insulin ratio (CR) and correction factor (CF) plans among physicians and among centres and also between the physicians and an automated algorithm, the Advisor Pro (DreaMed Diabetes Ltd, Petah Tikva, Israel). Study endpoints were the percentage of comparison points for which there was full agreement on the trend of insulin dose adjustments (same trend), partial agreement (increase/decrease vs no change) and full disagreement (opposite trend). The percentages for full agreement between physicians on the trend of insulin adjustments of the basal, CR and CF plans were 41 ± 9%, 45 ± 11% and 45.5 ± 13%, and for complete disagreement they were 12 ± 7%, 9.5 ± 7% and 10 ± 8%, respectively. Significantly similar results were found between the physicians and the automated algorithm. The algorithm magnitude of insulin dose change was at least equal to or less than that proposed by the physicians. Physicians provide different insulin dose recommendations based on the same datasets. The automated advice of the Advisor Pro did not differ significantly from the advice given by the physicians in the direction or magnitude of the insulin dosing.

Molecular-based diagnosis of Clostridium difficile infection is associated with reduced mortality

Polymerase chain reaction (PCR) for the diagnosis of Clostridium difficile infection (CDI) might result in overdiagnosis. The clinical outcomes of symptomatic CDI patients diagnosed by PCR remain uncertain. We aimed to determine whether patients whose diagnosis of CDI was based on PCR had different characteristics and clinical outcomes than those diagnosed by toxin immunoassay. Consecutive CDI patients, hospitalized at Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel, between January 2013 and January 2016, were identified retrospectively and included in the study. Diagnosis of CDI was based on PCR or diagnosis by immunoassay for C. difficile toxin. The main outcome was 30- and 90-day all-cause mortality. The PCR group included 165 patients and the immunoassay group included 157 patients. In comparison to the immunoassay group, patients in the PCR group were more likely to be younger, to be independent, to undergo previous abdominal surgery, and to use laxatives. The 30-day mortality rate in the PCR group was significantly lower than that in the immunoassay group, 29/165 (18%) vs 49/157 (31%), respectively; p = 0.028. On multivariate analysis, PCR diagnosis was associated with reduced mortality, OR 0.48 (95% CI 0.26-0.88). PCR-based diagnosis of CDI is associated with reduced all-cause mortality rates. Further studies are needed to determine the management of patients with discrepant immunoassay and PCR diagnosis of CDI.

Return: Asylum (The Dress, 1855–2019)

Return:Asylum (The Dress, 1855–2019) Michal Heiman (bio) Click for larger view View full resolution Figure 1. Michal Heiman, Anisa Ashkar (b. Acre, 1979), artist, Return: Asylum (The Dress, 1855–2019), 2015. Courtesy of the artist. [End Page 459] Click for larger view View full resolution Figure 2. Michal Heiman, Ora Cohen (b. Acre, 1966), photographer, performing artist, Return: Asylum (The Dress, 1855–2019), 2013. Courtesy of the artist. [End Page 460] Click for larger view View full resolution Figure 3. Michal Heiman, Lital Arielly (b. Ashkelon, 1984), artist, Return: Asylum (The Dress, 1855–2019), 2013. Courtesy of the artist. [End Page 461] Click for larger view View full resolution Figure 4. Michal Heiman, Mask: Plate 34, by Dr. Hugh W. Diamond, ca. 1855, Return: Asylum (The Dress, 1855–2019), 2016. Courtesy of the artist. [End Page 462] Click for larger view View full resolution Figure 5. Michal Heiman, Camea Smith (b. Ramat Gan, 1992), artist, Return: Asylum (The Dress, 1855–2019), 2013. Courtesy of the artist. [End Page 463] Click for larger view View full resolution Figure 6. Michal Heiman, Dr. Reuven Barak (b. Buenos Aires, Argentina, 1953), Chinese medicine practitioner, lecturer, Return: Asylum (The Dress, 1855–2019), 2016. Courtesy of the artist. [End Page 464] Click for larger view View full resolution Figure 7. Michal Heiman, Emily Heiman (b. Tel Aviv, 1997), student of Theatre and Literature, Return: Asylum (The Dress, 1855–2019), 2013. Courtesy of the artist. [End Page 465] Click for larger view View full resolution Figure 8. Michal Heiman, Ahuva Pinkas, (b. Rishon le-Zion, 1936–2017), Art Gallery Director, Return: Asylum (The Dress, 1855–2019), 2016. Courtesy of the artist. [End Page 466] Click for larger view View full resolution Figure 9. Michal Heiman, Said Abu Shakra (b. Umm el-Fahem, 1956), founding director of the Umm el-Fahem Art Gallery, Return: Asylum (The Dress, 1855–2019), 2016. Courtesy of the artist. [End Page 467] Click for larger view View full resolution Figure 10. Michal Heiman, Merav Michaeli (b. Petah Tikva, 1996), Israeli Knesset member, Return: Asylum (The Dress, 1855–2019), 2016. Courtesy of the artist. [End Page 468] Michal Heiman A Pilgrim Woman Michal Heiman Michal Heiman is an artist, curator, theoretician, and creator of the Michal Heiman Tests No. 1–4 (M.H.T.s). She is the founder of the Photographer Unknown archive (1984). Her enactment and installation works, photography and film series, and her lectures/performances are deeply rooted in the political, familial, and social arenas. She teaches at the Bezalel Academy of Art in Jerusalem. In 2015, she founded the Women in Academia Organization to protect and advance women's equality in the academy. Her project Return/Asylum: A New Community of Women, 1855–2019 is to be exhibited in Washington, D.C., and Los Angles during 2019–2020. Copyright © 2018 University of Pennsylvania Press

Social Impact Assessment of Rebuilding an Urban Neighborhood: A Case Study of a Demolition and Reconstruction Project in Petah Tikva, Israel

The rebuilding of deteriorating residential areas is being replicated rapidly throughout Israeli cities despite limited assessment of the social consequences. This paper presents the findings of a social impact assessment (SIA) applied to a demolition and reconstruction case study carried out in a low-income neighborhood in Petah Tikva. The project represents a typical example of developer-led removal of low-rise, mixed tenure housing replaced by privately owned high-rise housing. A mixed-methods approach was used to explore the actual and potential social implications from different points of view held by the various public and private actors in the project. The research was based on the analysis of official documents, field observations, and semi-structured interviews with key stakeholders involved in the rebuilding process, and with affected community representatives. The case study was analyzed with regard to three components: the public engagement process, financial well-being, and community cohesion and stability. The assessment revealed insufficient public and municipal involvement, the displacement of the majority of low-income households, disregard for the provision of community infrastructure, and the weakening of community stability. The paper suggests various ways to improve the outcomes of the project for all the affected parties, and argues that incorporating the SIA mechanism in this particular form of urban renewal might improve strategic decision-making and promote urban sustainability.

Petah Tikva, 1886: Gender, Anonymity, and the Making of Zionist Memory

The first significant clash between European Jewish agricultural colonists and Arab peasants in Palestine, a conflict over peasant grazing rights in Petah Tikva, took the life of one Jewish person, an older woman named Rachel Halevy. This article traces the commemoration history of the event in Zionist sources, particularly local Petah Tikva sources, between its occurrence in 1886 and the mid-1960s. It looks at both the evolving ghostly presence of the central Jewish female victim, who disappears, reappears, and lurks on the margins of the story, and Halevy’s son, Sender Hadad, who becomes increasingly prominent over the years as he is configured as an archetypal Zionist guardsman and hero. Through the commemoration history of these figures, the article traces shifting Zionist narratives about heroism and victimhood in Petah Tikva; the construction of Petah Tikva, founded before the Zionist movement, as a locus of foundational Zionist bravery; and the gendered notions by which men and women are remembered and forgotten.

Late-onset Uretero-vesical Junction Obstruction Following Endoscopic Injection of Bulking Material for the Treatment of Vesico-ureteral Reflux

To characterize patients who develop late obstruction after subureteral injection of bulking agent for the treatment of pediatric vesicoureteral reflux (VUR). We retrospectively evaluated the medical records of all patients who underwent endoscopic injection for the correction of VUR during 2008-2015 in 2 centers in Israel: Bnai-Zion Medical Center, Haifa, and Schneider Children's Medical Center, Petah Tikva. Nine patients who developed late-onset obstruction were included in the study, and their data were reviewed and analyzed. Three boys and 6 girls with mean age of 3 years were included in the study. All patients had moderate-to-high grade VUR. Following injection, all children had a radiographic evidence showing resolution of the reflux. During follow-up, patients were diagnosed with late obstruction in a mean time of 13.4 months. All patients underwent open re-implantation. Late-onset obstruction may develop in patients treated with subureteral injection for VUR. Patients with high grade reflux and dilated ureters are at risk of late obstruction. Long-term follow-up with ultrasound is mandatory following endoscopic treatment of VUR.

A Biallelic Mutation in the Homologous Recombination Repair Gene SPIDR Is Associated With Human Gonadal Dysgenesis.

Primary ovarian insufficiency (POI) is caused by ovarian follicle depletion or follicle dysfunction, characterized by amenorrhea with elevated gonadotropin levels. The disorder presents as absence of normal progression of puberty. To elucidate the cause of ovarian dysfunction in a family with POI. We performed whole-exome sequencing in 2 affected individuals. To evaluate whether DNA double-strand break (DSB) repair activities are altered in biallelic mutation carriers, we applied an enhanced green fluorescent protein-based assay for the detection of specific DSB repair pathways in blood-derived cells. Diagnoses were made at the Pediatric Endocrine Clinic, Clalit Health Services, Sharon-Shomron District, Israel. Genetic counseling and sample collection were performed at the Pediatric Genetics Unit, Schneider Children's Medical Center Israel, Petah Tikva, Israel. Two sisters born to consanguineous parents of Israeli Muslim Arab ancestry presented with a lack of normal progression of puberty, high gonadotropin levels, and hypoplastic or absent ovaries on ultrasound. Blood samples for DNA extraction were obtained from all family members. Exome analysis to elucidate the cause of POI in 2 affected sisters. Analysis revealed a stop-gain homozygous mutation in the SPIDR gene (KIAA0146) c.839G>A, p.W280*. This mutation altered SPIDR activity in homologous recombination, resulting in the accumulation of 53BP1-labeled DSBs postionizing radiation and γH2AX-labeled damage during unperturbed growth. SPIDR is important for ovarian function in humans. A biallelic mutation in this gene may be associated with ovarian dysgenesis in cases of autosomal recessive inheritance.