In this paper,we calculate the branching ratios and CP-violating asymmetries for $B^0 \to \rho^0 \eta^{(\prime)}$ and $B^+\to \rho^+ \etap$ decays in the perturbative QCD factorization approach. In this approach, we not only calculate the usual factorizable contributions, but also evaluate the non-factorizable and annihilation type contributions. Besides the current-current operators, the contributions from the QCD and electroweak penguin operators are also taken into account. The theoretical predictions for the branching ratios are $Br(B^+ \to \rho^+ \eta^{(\prime)}) \approx 9 \times 10^{-6}$ and $Br(B^0 \to \rho^0 \eta^{(\prime)}) \approx 5 \times 10^{-8}$, which agree well with the measured values and currently available experimental upper limits. We also predict large CP-violating asymmetries in these decays: $A_{CP}^{dir}(\rho^\pm \eta)\approx -13 %$, $A_{CP}^{dir}(\rho^\pm \eta^\prime)\approx -18 %$, $A_{CP}^{dir}(\rho^0 \eta)\approx -41%$, $A_{CP}^{dir}(\rho^0 \eta^\prime)\approx -27%$, $A_{CP}^{mix}(\rho^0 \eta)\approx +25%$, and $A_{CP}^{mix}(\rho^0 \eta^\prime) \approx +11%$, which can be tested by the current or future B factory experiments.
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