Tetrabromobisphenol A (TBBPA), a typical brominated flame retardant in industry, has been recognized as a toxic chemical and an endocrine disruptor. Hence, it’s urgently required to remove it from aquatic environment. In this work, the magnetic amorphous carbon@manganese ferrite (C@MnFe2O4) hybrid materials have been fabricated by hydrothermal method with high temperature annealing method to serve as catalyst for the activation of persulfate (PS) to degrade the TBBPA. The structure characterization results manifest that the synthesized MnFe2O4 particles are evenly distributed on the surface of amorphous carbon in the C@MnFe2O4 hybrid. The factors to affect the catalytic degradation of TBBPA by C@MnFe2O4 hybrid/PS system including type of C@MnFe2O4 hybrid materials, PS dosage, concentration of C@MnFe2O4 and reaction time are investigated systematically. The results show that the highest removal ratio of TBBPA could reach 91.9% after treatment of 90 min by C@MnFe2O4 hybrid/PS system. Furthermore, the C@MnFe2O4 hybrid demonstrates a high stability and recyclability. The electron paramagnetic resonance (EPR) verifies that the introduction of C@MnFe2O4 hybrid into PS system could facilitate the generation of ⋅OH and SO4⋅- radicals for degradation of TBBPA. The degradation intermediates are detected and two possible degradation pathways are proposed. This work provides a new insight for the design and development of novel catalyst for the activation of PS to degrade organic pollutants.