IntroductionPersonality disorders are rather widespread in oncology settings demanding special attention of clinician. Serious illness threatening person's life as well as severe treatment and side effects lead to specific self-regulatory emotional and cognitive efforts. Personality could both play an important role in this process predicting adjustment and survival and change in line with illness pathogenesis.ObjectivesThe personality patterns could be important predictors of operation success and further adjustment for patients with acute lymphoblastic leukemia (ALL) waiting for bone marrow transplantation.AimTo reveal personality patterns specific for patients with ALL.MethodsTwenty-five patients with ALL (11 males, 37.4 ± 9.5 years old) filled Millon Clinical Multiaxial Inventory–III and Big Five Questionnairie–2. Comparison group included 180 people of the same age and gender without history of mental or severe somatic disorders.ResultsMale patients comparing to healthy males were lower on emotional control and higher in negativistic personality pattern (P < .05). Female patients were higher on dynamism but lower in openness to culture and antisocial pattern (P < .05). They rarely expressed patterns of borderline disorder and drug dependence but reported more compulsive traits (P < .05).ConclusionsSevere illness could increase likelihood of emotion regulation difficulties and passive-aggressive coping in male patients while stimulate activity and compulsive behaviour in females. These patterns should be taken into account in psychological support of patents to bone marrow transplantation.Disclosure of interestThe authors have not supplied their declaration of competing interest.