ABSTRACT The US Supreme Court recently debated and upheld a significant piece of farmed animal welfare legislation, Proposition 12, which was broadly supported by Californian voters. The goal of this study was to determine how individual differences in personality are related to attitudes about this legislation. We examined how ten lower-order aspects of the Big Five personality traits were related to Proposition 12 in an American sample (n = 802). The Openness aspect of Openness to Experience, the Withdrawal aspect of Neuroticism, and trait domain Agreeableness were consistently related to support for Proposition 12. Effects were not moderated by political orientation, region, gender, or age. Our results show that personality traits are not only an important factor in general political attitudes about animal welfare, but that they can predict people’s attitudes about particular pieces of animal welfare legislation. Results also highlight the importance of considering lower-order aspects for predicting animal welfare attitudes.