Sample Of Persons Research Articles

88 Occupational Exposure to Metals Among Battery Recyclers in France: Biomonitoring and External Dose Measurements

Abstract In battery-recycling facilities, exposure to trace elements may occur through inhalation of contaminated dust or vapor emanating from the treatment processes. Thus, biomonitoring coupled with air measurements, appeared to be a relevant approach to assess exposure of battery recyclers. While lead exposure has been quite well covered in the literature, in contrast, data on exposure to other elements contained in batteries are lacking. The aim of this study was to characterize the exposure of French battery recyclers to multiple elements using biomonitoring and airborne measurements. Eighty-six workers participated in the study. Pre-shift and post-shift urine samples and personal airborne samples were collected during the working week. Inductively coupled plasma mass spectrometry was used to analyze 7 trace elements in both type of sample: Cd, Co, Cr, Li, Mn, Ni, Pb. Results showed battery recyclers to be mostly exposed to Cd, Co, Li, Mn and Ni. Urinary sample analysis indicated exposure to Cd and Co, with levels measured at up to 27.6 and 3.34 µg/g of creatinine, respectively. Cd, Co, Li, Mn, and Ni were detected at high levels in air samples, especially near the treatment facilities, with airborne cadmium levels of up to 79.4 µg/m3. Administrative and sorting workers were exposed at lower levels than maintenance, treatment, and dismantling workers. The data presented provide valuable information on exposure to trace elements for battery recyclers. They also highlight the need to improve both collective and individual protective measures, which were not sufficient in the participating companies.

129 A task-Based Approach to Nanomaterials Exposure Assessment in the Construction Trades

Abstract While the critical task of evaluating the hazards of nanomaterials continues, exposure assessments can provide additional information to safeguard workers. The frequent exposure of construction workers to inhalation hazards underscores a pressing need to characterize and quantify nanomaterials in aerosols generated during construction activities. Research was conducted in partnership with affected building trades unions and in collaboration with NIOSH toxicologists to obtain occupationally relevant exposure data. Initial studies took place in a test chamber, in which a skilled tradesperson sprayed or sanded paints and coatings containing ZnO, TiO2, or Ag nanoparticles. The current study, conducted outdoors, investigated exposure to graphene nanoplatelets during cutting, grinding, and tuckpointing of cementitious composites. Personal breathing zone samples were analyzed for elemental carbon (EC) respirable mass concentration and by transmission electron microscopy (TEM) with energy-dispersive x-ray spectroscopy. Wet methods and local exhaust ventilation effectively reduced exposure to graphene; respirable EC was non-detectable when using exposure controls versus up to 3 mg m-3 without. A high proportion of graphene particles observed by TEM were free and not bound to the cement matrix. Compared to the unincorporated graphene, the dimensions of graphene particles observed in air samples were smaller, suggesting a potential physical transformation prior to release from the matrix. Given the dustiness of construction environments, analysis of filter loading prior to collection of TEM samples proved methodologically valuable. These results provide actionable information about exposure risks and controls and support further investigation of the extent to which graphene may alter the toxicity of cement dust.

136 Occupational Exposure to Asbestos

Abstract Asbestos containing materials (ACMs) are still found in many buildings even though the use of asbestos in building materials has been prohibited in Norway since 1985. Employees that may be at risk of exposure to airborne fibers are workers within the construction industry. However, firefighters and workers investigating fires may also encounter asbestos fibers in their work. The aim of this study was to investigate the airborne fiber concentration during abatement of various ACMs. A comparison of counting results from scanning electron microscope (SEM) and phase-contrast microscope (PCM) were performed for these measurements. A separate part of the study focused on thermal transformation of fibers during fires. Parallel personal air samples were collected during asbestos abatement of different building materials and analyzed with SEM and PCM, respectively. Material samples from abatement sites and from fire scenes were investigated in SEM. The highest fiber concentrations were measured during interior wall removal (1.5-4.5 fibers/cm3 (f/cm3)). Thin fibers (<0.2 µm in width) constituted up to 50% of the total fiber concentration for some ACMs. Asbestos fibers observed in ACMs after fire may show a thermal transformation, however, in many cases the fibers are unchanged. For ACMs investigated in this study, there seem to be a good correlation between samples analyzed by SEM and PCM if the only dominant fiber type present is asbestos fibers. Thin fibers may constitute a large fraction of the total fiber concentration released and counting these fibers are therefore important for an adequate risk and exposure assessments.

128 Exposure to soot, Measured as Black Carbon and PAH, in Swedish Chimney Sweeps

Abstract The overall aim of our research is to study chimney sweeps exposure to soot to be able to give recommendations on how to effectively reduce the exposure. To do this a suitable method to study soot exposure is required. In this study we use a new method to study the personal airborne exposure to soot measured as black carbon (BC). BC is measured with a AethLabs MA200 micro aethalometer with a flow rate of 100 mL/min and sampling time of 1 min. By using a direct-reading instrument we aim to identify variability in exposure levels during the workday, and potential work tasks contributing to elevated exposure to soot. The study includes 20 chimney sweeps performing black sweeping in Sweden and BC is measured for eight workdays for each individual. During these days individuals also fill out a diary of work tasks performed. To assess the value of the BC levels, airborne polycyclic aromatic hydrocarbon (PAH) is also measured with personal sampler for particulate- and gas phase PAH. PAH is measured in parallel with BC during one workday. Preliminary results show variability of BC levels between different individuals as well as different workdays for the same individual. We are also able to link BC levels with work tasks from the diaries. Significantly elevated PAH levels and especially the particle-bound PAHs, including the carcinogenic benzo(a)pyrene, were observed in most samples.

122 A New Dichotomic Personal Sampler for Semi-Volatile Aerosols Named “Ppas” for a Better Exposure Assessment of the Workers

Abstract Semi-volatile organic compounds (SVOCs) are airborne pollutants present as a mixture of airborne particles and their vapour. Evaluating the exposure of workers to SVOCs represents a major challenge to occupational hygienists due to different toxicological effects regarding the particles and the vapour phases on human health. Therefore, the exposure assessment requires sampling these phases separately. In this regard, several methods were proposed to separate the two phases. However, all these methods have biased measurements of the concentration of the particulate and vapour phases. As an alternative, we propose a new personal SVOCs sampler named PPAS for “Préleveur Personnel d’Aérosols Semi-volatils”. The PPAS was built on the virtual impactor concept but with an inverted ratio between the major and minor flow. The development of the PPAS was first carried out using computational fluid dynamics (CFD) and then using experiments to estimate the actual performances. A great attention was paid to reduce at their minimum the pressure drops between the inlet and the two exits to allow 8 hours samplings using personal pumps classically used for assessing the exposure of the workers in workplaces. The transmission efficiency η of the PPAS was evaluated by CFD calculations for particles size ranging between 0.05 and 20 µm and measured experimentally with mono-dispersed aerosols consisted of a mixture of glycerol and fluorescein particles of 0.15, 2, 3 and 4.5 µm. The aim of the presentation is to focus on the CFD and experimental tests that permit to develop the PPAS.

12 A Review of Factors Influencing Passive Sampler Performance in Outdoor Workplaces with a Focus on Benzene

Abstract Passive or diffusion samplers have become standard tools for exposure and compliance testing despite their limited accuracy of 25-30%. Passive samplers have several advantages over active/pumped samplers, notably ease of use, low cost and inherent explosion safety. EN 838 advises their use for personal sampling at up to 4 m/s, but with a minimum of 0.1 m/s. Considerable underestimations were found in a set of passive sampler results compared to pumped samplers for BTEX. A literature review of laboratory and field studies was performed to investigate theoretical explanations for the discrepancies found. Based on results published in journals an underestimation of concentration by passive samplers is not uncommon, although usually the difference is within an acceptable range. Temperature and relative humidity have known, quantifiable effects, which are fairly small. High wind speed theoretically causes increased, not decreased, uptake due to smaller diffusion distances. This effect was confirmed experimentally, both in wind tunnels and in field studies, according to literature. Real-time monitoring in company operations shows that personal exposure in outdoor scenarios often fluctuates strongly with short peaks over periods of seconds rather than minutes. Theoretically this may influence uptake by diffusion samplers depending on their design and some researchers do report that passive samplers work less well under such conditions. Further research into passive sampler performance in fast fluctuating conditions as found in the field appears necessary.

49 Exposure Assessment and Health Surveys at Metal Additive Manufacturing Facilities

Abstract Additive manufacturing (AM) is the process of building parts from 3D model data by joining materials. AM includes different techniques, such as binder jetting and powder bed fusion which uses metal powder as feedstock. Knowledge regarding exposure-related health risks in metal AM environments is still limited. Herein, we report emission data from 8 different AM companies along with health examinations of 39 controls and 48 additive manufacturing machine users (AMMU). Exposure assessment of dust and metals was performed through stationary and personal sampling of total and inhalable dust followed by metal analysis by ICP-MS. Two handheld particle-counting instruments, Lighthouse 3016-IAQ (0.3-10 µm) and Philips Aerasense NanoTracer (10-300 nm), were used to identify dusty work tasks and thereby to help prioritize preventive measures. Health examinations consisted of questionnaires, spirometry, blood sampling after a workweek and collection of urine samples before and after a workweek. Clinical markers in urine (α1-microglobulin) and plasma (ASAT, ALAT, ALP, ApoA-1, ApoB, SAA1/PON1), and urinary metal levels were analyzed. Results: Daily averages of dust and metal exposure were in general low compared to Swedish occupational exposure limits. However, particle counting instruments identified specific work tasks with high exposure risk. Mann Whitney U-test indicated statistical differences between exposed and controls for three clinical markers; ASAT and ApoA-1 in plasma as well as α-1-microglobulin in urine. There were no significant increase in exposure markers Monday to Friday nor between AMMU and controls at a group level. Although high exposure levels were seen in some individuals.

96 Optimization of the Preparation of Cascade Impactors Collection Media for Airborne Metallic Ultrafine Particles Sampling

Abstract For some years, the characterization of workers' exposure to airborne metallic ultrafine particles (UFP) has been an increasing issue. Many industrial processes may generate UFP, which are characterized by constituent particle diameter less than 100 nm, and refer to nanosized particles not intentionally produced (welding, thermal spraying, 3D-printing ...). Thus, determining the size distribution of such an aerosol together with its chemical composition provide a real contribution to the understanding of UFP exposures and associated health effects. In the framework of proposing characterization methods adapted to occupational situations, the optimization of metallic aerosol sampling using cascade impactors is studied in order to improve the reproducibility of these samplings. Cascade impactors represent a valuable help since both the size distribution of an aerosol and its chemical characterization can be obtained from the samples collected. A welding fume bench was used to generate a highly reproducible test aerosol of metallic UFP (mass median aerodynamic diameter MMAD = 430 nm, ρeff = 0.55 g.cm-3). Four different cascade impactors were involved (DLPI+, MARPLE, SIOUTAS and Minimoudi 135-8). Our investigations allowed the lubrificating procedure of the collection supports (membranes, filters) to be optimized by determining the nature and the quantity of grease, which is of significative influence in the collection efficiency. Furthermore, under optimized conditions, the Minimoudi 135-8 (intended for personal sampling) leads to results very close to those stemming from the reference low pressure cascade impactor, DLPI+, thanks to its high resolution in terms of number of stages (8) and lowest cutoff diameter (180 nm).

83 Development of a New Xrd Method to Evaluate Exposure to Respirable TiO2 in Workplace Air

Abstract ECHA classified TiO2 particles with an aerodynamic diameter ≤10 μm as carcinogen. Although the OELV for TiO2 is still related to inhalable particles in many jurisdictions, NIOSH recommended a REL of 2.4 mg/m3 for fine TiO2, and 0.3 mg/m3 for ultrafine TiO2. The latter implies the development of a more robust method for measuring TiO2 in workplace air. X-ray diffraction (XRD) is a powerful laboratory method for quantifying crystalline matter and is frequently used to measure respirable crystalline silica in workplaces. Rutile and anatase powders were obtained from a commercial vendor and a size fraction smaller than 10 µm was separated from these powders and used to prepare a calibration series in a calm-air dust chamber. The methodology for quantifying the rutile or anatase is performed as described in ISO 16258-1:2015 for measuring respirable crystalline silica. The limit of detection and quantification (LOD/LOQ) were for rutile 0.8/1.4 µg and anatase 0.6/1.1 µg, respectively. From these measurements, we conclude that direct on filter XRD is a powerful method for analyzing respirable TiO2 samples. Further validation of the XRD method was performed by comparing the results of 177 respirable personal samples collected on 25 mm MCE filters using Casella-HD cyclone samplers at nine TiO2 production plants with ICP-MS data gained from the same samples. Excellent correlations were obtained between the XRD and ICP-MS data for each sampling site but observed consistent site-dependent deviations explained by differences in crystallinity of the TiO2 phases and the presence of titanium-containing minerals other than rutile and anatase.

Exposure of formal and informal nail technicians to organic solvents found in nail products.

Nail technicians are exposed to volatile organic compounds (VOCs) emitted from nail products used in their daily work, which may cause adverse health effects. This study aimed to assess VOC exposure of nail technicians in the South African formal and informal sectors and to provide a task-based exposure assessment of different nail applications. Personal passive sampling was conducted on 10 formal and 10 informal nail technicians located in the northern suburbs of Johannesburg and the Braamfontein area, over 3 days. Real-time measurements were taken to determine task-based peak exposures. The number of clients serviced, working hours, type of nail application, type of ventilation, room volume, and carbon dioxide (CO2) concentrations, were also recorded. There were differences in the nail products used, the types of nail applications performed, the number of clients serviced, and breathing zones VOC concentrations of the formal and informal nail technicians. Some formal nail salons were equipped with mechanical ventilation while the informal nail salons relied on natural ventilation. CO2 concentrations were higher in the informal than the formal nail salons and increased during the course of the working day. Formal nail technicians were exposed to higher total volatile organic compounds (TVOC) concentrations than informal nail technicians, which may be due to the different nail application procedures as well as 'background' emissions from their co-workers-the bystander effect. Acetone was the predominantly detected VOC: the formal nail technicians were exposed to significantly higher TWA (8 h) concentrations [geometric mean (GM) 43.8 ppm, geometric standard deviation (GSD) 2.49] than were the informal nail technicians (GM 9.87 ppm, GSD 5.13). Methyl methacrylate among the informal nail technicians was measured at 89.7% detection frequency, far higher than that among the formal nail technicians (3.4%). This may be attributed to the observed popularity of acrylic nail applications in this sector. Nail applications involving soak-off gave rise to high TVOC peaks at the start of the nail application process. This is the first study to compare organic solvent exposures among formal and informal nail technicians and determine task-based peak exposures. It also brings attention to the often-overlooked informal sector of this industry.

Impact of Health Workers' Choice of COVID-19 Vaccine Booster on Immunization Levels in Istanbul, Turkey.

There are limited data regarding short- and medium-term IgG antibody levels after the CoronaVac and BNT162b2 vaccines. This study aimed to investigate the antibody responses of health workers who initially received two doses of CoronaVac one month apart followed by a booster dose of either CoronaVac or BNT162b2, as well as determine whether either vaccine provided superior results. This research represents the second phase of a mixed-methods vaccine cohort study and was conducted between July 2021 and February 2022. The participants (n = 117) were interviewed in person and blood samples were collected before and at 1 and 6 months after the booster vaccination. BNT162b2 was found to have greater immunogenic potential than CoronaVac (p < 0.001). Health workers without chronic disease exhibited statistically significant increases in antibody levels after both vaccines (p < 0.001), whereas only BNT162b2 caused a significant increase in antibody levels in participants with chronic disease (p < 0.001). Samples obtained before and at 1 and 6 months after the booster vaccination revealed no age- or sex-based differences in IgG-inducing potential for either vaccine (p > 0.05). Antibody levels were comparable in both vaccine groups before the booster regardless of COVID-19 history (p > 0.05); however, antibody levels were significantly higher after the BNT162b2 booster at 1 month (<0.001) and at 6 months, except among participants who had a positive history of COVID-19 infection (p < 0.001). Our results suggest that even a single booster dose of BNT162b2 after initial vaccination with CoronaVac provides a protective advantage against COVID-19, especially for risk groups such as health workers and those with chronic diseases.

Physical function across the lifespan in adults with multiple sclerosis: An application of the Short Physical Performance Battery.

Multiple sclerosis (MS) typically has its onset in early and middle adulthood, but the population is steadily becoming more dominated by older adults. One of the primary consequences of both MS and aging involves declines of lower extremity physical function and mobility. This cross-sectional study compared physical function status based on Short Physical Performance Battery (SPPB) summary and component scores between persons with MS and healthy controls across 6 age groups. We further examined associations between SPPB summary scores and component scores as well as associations between summary scores and measures of physical and cognitive function for identifying the strongest correlates of SPPB summary scores. The study involved secondary analysis of cross-sectional data from multiple studies. Ambulatory adults with MS who were relapse-free for the last 30 days were recruited, and controls were recruited based on similar criteria to adults with MS except without the diagnosis of MS or relapses. The sample of 345 persons with MS and 174 controls completed questionnaires regarding demographic and clinical information and underwent assessments of physical and cognitive function including the SPPB, 6-Minute Walk, Timed 25-Foot Walk, Symbol Digit Modalities Test, California Verbal Learning Test-Second Edition, and Brief Visuospatial Memory Test-Revised. The two-way ANOVA indicated a main effect of MS status (F(5,500)=34.74, p<.01, η2=0.065), a main effect of age (F(1,500)=3.88, p<.01, η2=0.037), and no MS status by age interaction (F(5,500)=1.20, p=.31, η2=0.012) on SPPB scores. The bivariate correlation analysis indicated that summary SPPB scores were associated with component SPPB scores in the overall samples of persons with MS (rs=0.71 to 0.83) and controls (rs=0.42 to 0.91) as well as within most age groups of MS (rs=0.63 to 0.91) and controls (rs=0.34 to 1.00). The associations between SPPB scores and physical function outcomes were larger in the sample of persons with MS (rs=-0.72 to 0.76) than controls (rs=-0.47 to 0.48). SPPB scores were further significantly associated with scores on cognitive outcomes in persons with MS (rs=0.31 to 0.43), whereas these associations were weaker in controls (rs=0.09 to 0.32). Overall, the associations between SPPB scores and physical function outcomes were stronger than the associations between SPPB scores and cognitive function outcomes. Overall, MS status and aging have additive effects on physical function, and the summary SPPB score may be driven by a specific component within each age group. SPPB scores may be driven more by mobility rather than cognition, and are consistent with cognitive-motor coupling in MS. The novelty of this study provides evidence of worsening physical function based on the application of the SPPB and its scores across the lifespan in persons with MS and controls, and this has important implications particularly given the increasing prevalence of older adults with MS.

SARS-CoV2 in public spaces in West London, UK during COVID-19 pandemic

BackgroundSpread of SARS-CoV2 by aerosol is considered an important mode of transmission over distances >2 m, particularly indoors.ObjectivesWe determined whether SARS-CoV2 could be detected in the air of enclosed/semi-enclosed public...

Occupational health and safety, metal exposures and multi-exposures health risk in Canadian electronic waste recycling facilities

Electronic waste recycling (e-recycling) involves manual operations that expose workers to toxic metals. We aim to describe occupational health and safety practices and workers’ exposures to metals in the Canadian formal e-recycling industry, and to estimate the health risk associated with multiple exposures. This cross-sectional study documented practices through observations and questionnaires, and assessed metal exposures using personal air samples and biomarkers. Health risks were estimated relative to recognised occupational exposure guidelines, and using an additive approach for consideration of multiple exposures. Six e-recycling and one commercial recycling facilities were investigated, and the metal exposures of 99 workers (23 women) were measured. In most facilities, dust control was inadequate and personal protective equipment was improperly worn. In e-recycling, lead was detected in all air samples and in most blood samples, up to 48 µg/m3 and 136 µg/l, respectively. Other quantified metals included beryllium, mercury, arsenic, barium, cadmium, chrome, cobalt, copper, indium, manganese, nickel and yttrium. When handling cathode ray tube screens, workers were 4.9 times and 8.5 times more likely to be exposed to lead and yttrium, respectively, than workers who were not assigned to a specific type of electronics. Overall, exposures were largely associated with facility size and airborne dust concentration. The additive hazard indices for airborne exposures raised concerns for kidney disorders, for peripheral and central nervous systems, and for the male reproductive system. Minimizing airborne dust through collective control methods and adequately using personal protection should reduce metal exposures and associated health risks in this growing industry.

Occupational Bioaerosol Exposures Associated with Poultry Farming

ABSTRACT This study aimed to investigate occupational exposure to particulate dust, endotoxin, and (1–3)-β-D-glucan among workers involved in various poultry farming activities. A total of 298 personal samples were collected from randomly selected individuals from exposure groups based on distinct poultry farming activities comprising broiler farms, rearing, laying, hatchery, and catching activities. Aside from the inhalable particulate dust concentration that was determined, filter extracts were also analyzed for (1–3)-β-D-glucan and endotoxin using the endpoint Glucatell® and Limulus amoebocyte lysate (LAL) assays, respectively. Data were analyzed using STATA 12 and linear regression models developed. The mean (GM) dust particulate concentration was 11.04 mg/m3 (GSD = 3.87); 2298 endotoxin units (EU/m3) (GSD = 10.56) and 149 ng/m3 for (1–3)-β-D-glucan (GSD = 4.62). A modest positive correlation was observed between log-transformed endotoxin and (1–3)-β-D-glucan concentrations (Pearson r = 0.44, p < .001), whilst a moderate negative correlation was observed for inhalable dust particulate and (1–3)-β-D-glucan (Pearson r = −0.33, p < .001). However, there was a very poor correlation between inhalable dust and endotoxin (Pearson r = −0.02, p < .001). In the regression models, exposure group based on the nature of farming activity explained 50% of the variability in dust particulate and glucan levels. For dust particulate, rearing activities were significant predictors of higher dust levels compared to hatchery work, while rearing, laying, broiler and catching activities were significant predictors of higher endotoxin or glucan levels. Furthermore, working in a small broiler was a significant determinant of elevated glucan exposures. Farms using automated laying activities had significantly higher particulate levels compared to those using manual laying activities. This study revealed that workers engaged in poultry farming activities were exposed to significantly high levels of inhalable particulate dust, endotoxin, and (1–3)-β-D-glucan concentrations, posing an increased risk for adverse respiratory health effects in these farm workers.

Exposure to soluble platinum salts in precious metal refinery workers over a 17-year period.

Occupational exposure to soluble chlorinated platinum (Pt) salts, commonly called chloroplatinates, is a known cause of Pt salt sensitisation (PSS) and occupational asthma. We aimed to model inhalable soluble Pt salts exposure levels based on measurements in precious metal refineries for use in a retrospective cohort study on PSS. Five platinum refineries located in the United Kingdom (3 sites), United States, and South Africa provided time weighted average inhalable soluble Pt salts exposure data, measured in 2,982 personal air samples over a 17-year period (2000-2016). We used a Bayesian hierarchical model to estimate geometric mean (GM) exposure levels for each refinery and job title over time. The GM of measured exposure levels over all facilities was 92 ng/m3 with a geometric standard deviation (GSD) of 9.07. Facility-specific GMs ranged from 48 ng/m3 (GSD 15.3) to 242 ng/m3 (GSD 5.99). Exposure modelling showed that soluble Pt salts exposure levels declined approximately 10% per year in two of the five facilities, but there were no clear time trends in the other facilities. A priori specified exposure groups captured most of the between-jobs differences, which helps to accurately predict exposures for jobs with no measurement data available. We applied exposure modelling to estimate time, refinery, and job-specific soluble Pt salts exposures. A significant annual decline in exposure levels was observed in two of the five participating facilities. Modelled exposure levels can be linked to individual workers' job history for exposure-response analysis of PSS in an epidemiological study.

Non-adherence to mood stabilizers and antipsychotics among persons with bipolar disorder – A nationwide cohort study

BackgroundNon-adherence to medications is common in bipolar disorder but its prevalence estimations have varied significantly. In addition, non-adherence is known to increase the risk of poor clinical outcomes. Therefore, we studied how common primary non-adherence for mood stabilizers and antipsychotics is in Finland and which factors are associated with it. MethodsNationwide sample of persons diagnosed with bipolar disorder during 1987–2018 were identified from registers. Dispensings of their electronic prescriptions during 2015–2018 were followed up to define rates of primary non-adherence. Primary non-adherence was defined as having at least one non-dispensed mood stabilizer or antipsychotic prescription during 2015–2018. In a broader definition, non-adherence was defined as having ≥20 % of mood stabilizer and/or antipsychotic prescriptions non-dispensed. Adjusted logistic regression was used to assess risk factors for non-adherence. ResultsThe study cohort included 33,131 persons and 59.1 % had at least one non-dispensed mood stabilizer or antipsychotic prescription. 31.0 % of the cohort was non-adherent to ≥20 % of their mood stabilizer and/or antipsychotic prescriptions. Lithium and clozapine had the lowest proportions of non-dispensed prescriptions. Especially young age, recent bipolar disorder diagnosis, multiple hospitalizations due to bipolar disorder, and use of benzodiazepines or antidepressants were associated with an increased risk of non-adherence. LimitationsThis study was based on register data, and patient-reported reasons for medication non-adherence could not be included. ConclusionsThe majority of patients with bipolar disorder do not use their medications as prescribed. Patient-specific risk for non-adherence should be assessed and those at high risk for non-adherence should be followed closely.

Cancer risk assessment of exposure to asbestos during old building demolition.

Years ago, the use of asbestos in construction materials was common. Although asbestos has been recently banned in many countries, exposure to asbestos during old building demolition is not unexpected. The aim of this study is to assess the concentration of exposure to asbestos and estimate its cancer risk among old building demolition workers. In this study, personal air samples were collected during building demolition. The number of asbestos fibers in collected samples were determined according to the NIOSH-7400 standard method. Chemical compositions of fibers were assessed using scanning electron microscopy (SEM). The carcinogenic risk of exposure to asbestos was determined based on the recommended United State Environmental Protection Agency (USEPA) method and Monte-Carlo simulation used to estimate the probability of cancer. Chemical analysis confirmed the presence of asbestos in collected air samples, and 67% of counted fibers were asbestos. In a number of buildings, workers had exposed to asbestos that was higher than occupational exposure limit (0.10 f/ml). Results of cancer risk estimation showed that cancer risk were considerable among workers. Implementation of asbestos risk management program such as separation of asbestos containing material, personal protective equipment's and use of wet method in demolition could minimize asbestos exposure during old building demolition.

Environmental, bystander and resident exposure from orchard applications using an agricultural unmanned aerial spraying system

Unmanned aerial spraying systems (UASS), i.e., unmanned aerial vehicles designed for pesticide applications, are widely used in East Asia and increasingly prevalent in other regions of the world, including North America and Europe. However, according to a recent report of the Organization for Economic Co-operation and Development, spray drift and exposure caused by these systems are not yet fully understood. In particular, there are at present no peer-reviewed reports on direct exposure of residents and bystanders to spray drift following UASS applications. This lack of data results in regulatory concerns with respect to the environment and human safety. The objective of this study was to quantify environmental, resident and bystander exposure following the application of a plant protection product to an orchard using a commercial UASS under field conditions. Using a fluorescent tracer, horizontal and vertical downwind drift data were collected and direct exposure of residents and bystanders located downwind the sprayed area to spray drift was quantified using display mannequins equipped with personal air sampling pumps. Spray drift and exposure inversely correlated with sampling height and downwind distance. Furthermore, drift and exposure were strongly influenced by wind speed and direction, albeit hardly affected by the growth stage of the trees. In addition, substantially less tracer was extracted from the filters of the air sampling pumps than from the coveralls worn by mannequins, suggesting that direct resident/bystander exposure to spray drift may predominantly occur via the dermal route. This report provides essential data on UASS spray drift potential that are relevant for environmental and health risk assessments related to these systems. The results are compared to predicted values of current regulatory models and previously reported field data on drift and exposure caused by different spraying equipment.

The concept of pre-COPD: development and feasibility in primary health care

BACKGROUND: Chronic obstructive pulmonary disease is often not diagnosed as a preventable disease. The primary physician needs a diagnostic tool to detect chronic obstructive pulmonary disease at an early stage.&#x0D; AIM: To develop the concept of early detection of chronic obstructive pulmonary disease through a diagnostic tool that stratifies patients according to the risk of disease development.&#x0D; MATERIALS AND METHODS: Random sample of persons 3570 years from the lists provided by 15 polyclinics of Saint Petersburg and Arkhangelsk (cross-sectional study, n = 2388). Cohort prospective study (respondents with fixed or variable obstruction, n = 167). All respondents were asked about demographic data, smoking history, risk factors, and the presence of symptoms. Spirometry with a bronchodilator was performed for all participants.&#x0D; RESULTS: Fixed obstruction was found in 6.8% of the participants in the first phase; obstruction was associated with male sex, smoking status over 10 packs/years, age over 55 years, chronic cough and shortness of breath. Of the 65 members of the cohort with variable obstruction, 23.1% had a fixed obstruction after a year, the risk factors of which were a smoking status of more than 10 packs/years, a night cough and forced expiratory volume in 1 second less than lower limit of normal.&#x0D; CONCLUSIONS: Based on the results of the two phases of the study, a diagnostic tool was developed for the early detection of chronic obstructive pulmonary disease in the general population by identifying a group of people with preserved lung function and high-risk chronic obstructive pulmonary disease factors.