Personal Response Research Articles

A Review of Teachers and Teaching On Stage and On Screen

This piece is a review of Teachers and Teaching on Stage and on Screen: Dramatic Depictions, edited by Diane Conrad and Monica Prendergast (2019). Mortimer’s personal poetic response opens the review to honour her artistic ways of knowing and responding to the content. The book’s contributing authors, all educators, provide diverse cultural, social, and socio-economic perspectives and insights into how teachers and teaching are represented in film and on stage. Conrad and Prendergast’s book invites a range of audiences (from pre-service teachers to academics) to reflect on dramatic depictions of teachers and to use them to deepen understandings of the complexities of teaching, schooling, and students—and, if readers are teachers themselves, to examine their own practice.

Perceptions of dairy cow–handling situations: A comparison of public and industry samples

Inappropriate cattle handling poses a reputational threat to the dairy industry. To enhance social sustainability, handling practices must resonate with societal values about animal care. However, it has yet to be determined to what extent industry and public stakeholders differ in their perception of common cattle handling situations. We administered an online survey to samples of dairy industry (IND) and public (PUB) stakeholders to examine how they perceive a variety of cow-handling scenarios ranging from positive to negative in terms of effects on animal welfare. Participants were presented with 12 brief videos depicting a range of realistic cow-handling situations and responded to measures designed to assess their attitudes and beliefs about each scenario, their perception of the emotional response of the cows depicted in each scenario, as well as their own personal emotional response. Preexisting beliefs about cow treatment on US dairy farms and demographic data, including self-reported dairy consumption, were also collected and analyzed. Before viewing the videos, 52.9% of PUB (vs. 79.0% of IND) believed cows were treated well while 27.2% (vs. 9.0% of IND) believed cows were treated badly. Within IND, believing cows were treated badly was more common among nonwhites, those with greater formal education, more liberal politics, or from urban or suburban environments. In PUB, female and younger participants were more likely to believe cows were treated badly before viewing the videos. In both samples, participants with more positive preexisting beliefs about dairy cow treatment in the US reported consuming dairy products more frequently. In both PUB and IND, scenarios which were rated more positively for attitudes or for the cows' or respondents' emotional experiences were also perceived as more common. Within a given cow-handling scenario, qualitative attitudes (i.e., a positive, negative, or neutral valence) did not differ between the samples. In both samples, at the participant level, overall attitudes toward cow-handling scenarios were highly correlated with both their personal emotional response to the scenario and their perception of the cows' emotional responses. Although the participants' overall personal emotional responses did not differ between the samples, IND rated cows as experiencing more negative emotions overall. The consensus between industry and public stakeholders around dairy cow-handling practices observed in this study could provide a common starting point for addressing other, more contentious animal welfare issues.

Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment

Despite tremendous progress in deciphering breast cancer at the genomic level, the pronounced intra- and intertumoral heterogeneity remains a major obstacle to the advancement of novel and more effective treatment approaches. Frequent treatment failure and the development of treatment resistance highlight the need for patient-derived tumor models that reflect the individual tumors of breast cancer patients and allow a comprehensive analyses and parallel functional validation of individualized and therapeutically targetable vulnerabilities in protein signal transduction pathways. Here, we introduce the generation and application of breast cancer patient-derived 3D microtumors (BC-PDMs). Residual fresh tumor tissue specimens were collected from n = 102 patients diagnosed with breast cancer and subjected to BC-PDM isolation. BC-PDMs retained histopathological characteristics, and extracellular matrix (ECM) components together with key protein signaling pathway signatures of the corresponding primary tumor tissue. Accordingly, BC-PDMs reflect the inter- and intratumoral heterogeneity of breast cancer and its key signal transduction properties. DigiWest®-based protein expression profiling of identified treatment responder and non-responder BC-PDMs enabled the identification of potential resistance and sensitivity markers of individual drug treatments, including markers previously associated with treatment response and yet undescribed proteins. The combination of individualized drug testing with comprehensive protein profiling analyses of BC-PDMs may provide a valuable complement for personalized treatment stratification and response prediction for breast cancer.

‘I want to read this book again!’ decolonizing children’s literature to support indigenous children in reading and mathematics learning

ABSTRACT Although children’s literature is often viewed as a means to achieve educational goals and to strengthen children’s identities, existing or ongoing literature projects devalue Indigenous identity – or, more tragically, systematically obliterate it – to the point that every narrative within postcolonial education systems is inherently harmful to children. This study was intended to decolonise children’s literature to increase children’s reading and mathematics learning. We designed and implemented a decolonised picture storybook as a complementary resource for the third graders with integrating Indigenous West Papuan culture. This collaborative work involved an Indigenous elder and teacher, a homeroom teacher, and an expert. The results of the study showed that students were immersed in the narratives of the books they were reading during reading time. Due to our emphasis on social justice-oriented approaches – familiarizing Indigenous students’ experience in this book, students began sharing analytical, intertextual, personal, transparent, and performative responses. They expressed their genuine excitement by saying, ‘I want to read this book again!’ When brain-crossing pathways took place, students gained a more thorough understanding of the mathematical concept (i.e. multiplication). It occurred as they visualized, drew, estimated, and synthesized the narrative symbols in order to make sense of what they read.

Mālama i ke kai: Exploring psychosocial factors associated with personal and community coral reef conservation behavior on Maui, Hawai‘i

AbstractLocal and community conservation efforts can increase coral reefs' capacity to adapt to climate change. In this community‐engaged study, we examine affective dimensions and other psychosocial factors associated with coastal user conservation intentions and behaviors on Maui, Hawai‘i. In October and November 2019, we surveyed coastal users (n = 299). We found natural place attachment, sense of responsibility, and concern for coral reef ecosystems were positively associated with personal conservation intentions; civic place attachment was positively associated with community conservation intentions; and natural place attachment was positively associated with signing the Pono Pledge, a voluntary conservation commitment. We found personal and community response efficacy were positively associated with corresponding levels of conservation intentions. Our results provide insights into psychosocial factors that may underpin coral reef conservation behavior and inform partner communications and outreach.

The Impact of Artificial Intelligence on Chatbot Technology: A Study on the Current Advancements and Leading Innovations

Artificial intelligence (AI) has had a profound impact on various industries, and one prominent domain where its influence is evident is in chatbot technology. Chatbots, computer programs designed to simulate human conversation, have evolved significantly through the advancements in AI, becoming more sophisticated and intelligent. This research paper aims to explore the current state of AI-powered chatbot technology, focusing on the latest advancements and leading innovations. The study delves into the application of natural language processing (NLP) algorithms, machine learning models, and deep learning techniques in chatbot development to gain insights into their capabilities and limitations. The research also highlights leading innovations in AI-powered chatbot technology, such as virtual assistants and voice-enabled chatbots. These conversational agents have transformed various industries, providing innovative solutions to virtual reference services and customer-company interactions. The study delves into the contextual understanding and personalized responses that chatbots can provide, offering tailored interactions to meet users' specific needs and preferences. Furthermore, the integration of other technologies, including speech recognition and sentiment analysis, enhances chatbot capabilities, improving user satisfaction and engagement. However, while AI-powered chatbots have enhanced user experiences, customer satisfaction, and efficiency in industries like customer support and service, they also raise potential ethical and privacy concerns. Medical chatbots, in particular, pose legal and ethical challenges that require careful management and the development of appropriate ethical frameworks. Understanding the advancements, innovations, and impact of AI on chatbot technology is essential for recognizing the potential benefits and challenges these systems present. By addressing ethical and privacy concerns, chatbots can responsibly shape the future of human-computer interactions, further contributing to the broader understanding of AI's role in transforming industries and enhancing user experiences.

Imaging of cell death in malignancy: Targeting pathways or phenotypes?

Cell death is fundamental in health and disease and resisting cell death is a hallmark of cancer. Treatment of malignancy aims to cause cancer cell death, however current clinical imaging of treatment response does not specifically image cancer cell death but assesses this indirectly either by changes in tumor size (using x-ray computed tomography) or metabolic activity (using 2-[18F]fluoro-2-deoxy-glucose positron emission tomography). The ability to directly image tumor cell death soon after commencement of therapy would enable personalised response adapted approaches to cancer treatment that is presently not possible with current imaging, which is in many circumstances neither sufficiently accurate nor timely. Several cell death pathways have now been identified and characterised that present multiple potential targets for imaging cell death including externalisation of phosphatidylserine and phosphatidylethanolamine, caspase activation and La autoantigen redistribution. However, targeting one specific cell death pathway carries the risk of not detecting cell death by other pathways and it is now understood that cancer treatment induces cell death by different and sometimes multiple pathways. An alternative approach is targeting the cell death phenotype that is “agnostic” of the death pathway. Cell death phenotypes that have been targeted for cell death imaging include loss of plasma membrane integrity and dissipation of the mitochondrial membrane potential. Targeting the cell death phenotype may have the advantage of being a more sensitive and generalisable approach to cancer cell death imaging. This review describes and summarises the approaches and radiopharmaceuticals investigated for imaging cell death by targeting cell death pathways or cell death phenotype.

Microbial-host-isozyme: a new territory for understanding personalized responses towards drug therapy.

Microbial-host-isozyme: a new territory for understanding personalized responses towards drug therapy.

Post-Pandemic War Narratives: Case studies of Quo Vadis Aida? (2020), All Quiet on the Western Front (2022) and Top Gun: Maverick (2022)

War tends to polarise national and global conflicts as encapsulated by the phrase, ‘you are either with us or against us’. There is further danger of knee jerk reactions at such times, including the present, towards unconditionally funding long-term military security hardware and dedicating scarce resources that are badly needed for more benevolent projects, including equitable redistribution of resources, not to mention the challenge to move away from fossil fuels in our climate crisis. These tensions are evident on recognising European dependence on Russian oil and gas, which unfortunately is helping to fund the ongoing Ukrainian war. This paper will explore how a sample of more contemporary wars and national conflicts have been dramatised on film since the pandemic. Focusing specifically on three contrasting approaches to the tragedy of war and its effects on citizens and soldiers: from an insider’s personal response to the massacre in the Balkans during the 1990s in Quo Vadis, Aida? (2020), to the reworked conventional World War One classic All Quiet on the Western Front (2022), before finally coming full circle with the big budget Hollywood celebration of aerial war heroics in the sequel Top Gun: Maverick (2022). Sample textual and contextual analysis will be used to explore how such war narratives have become repurposed, both from an insider soldier’s perspective and also through a rejuvenated cinematic war framework, as contemporary audiences strive to cope with ever-increasing crises and conflicts facing the planet, having recently endured a global pandemic.

Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling

Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in 25 healthy participants over 14days. We develop a Bayesian inference framework to learn personal parameters that quantify circadian rhythms and physiological responses to external stressors. Modeling the effects of ingestion events on glucose levels reveals that slower glucose decay kinetics elicit larger postprandial glucose spikes, and we uncover a circadian baseline rhythm for glucose with high amplitudes in some individuals. Physical activity and circadian rhythms explain as much as 40%-65% of the HR variance, whereas the variance explained for HRV is more heterogeneous across individuals. A more complex model incorporating activity, HR, and HRV explains up to 15% of additional glucose variability, highlighting the relevance of integrating multiple biosensors to better predict glucose dynamics.

'Yourself in all your forms': A grounded theory exploration of identity safety in medical students.

Identity threats, such as stereotype threat and microaggressions, impair learning and erode well-being. In contrast to identity threat, less is known about how learners experience feelings of safety regarding their identity. This exploratory study aims to develop a theory of identity safety in the clinical learning environment. This multi-institutional, qualitative interview study was informed by constructivist grounded theory and critical pedagogy. Participants were clinical students at three public medical schools in the United States in 2022. Investigators purposively sampled participants for interviews based on their responses to an 11-item survey with an open-ended question soliciting students' personal identities and responses to both the racial/ethnic and gender Stereotype Vulnerability Scales. The investigators interviewed, coded, constantly compared and continued sampling until the codes could be developed into categories, then concepts and finally into a theory. The team engaged in critical reflexivity throughout the analytic process to enrich data interpretations. Sixteen diverse students were interviewed. We organised their identity-salient experiences into identity threat, threat mitigation and identity safety. Participants experienced identity threat through unwelcoming learning environments, feeling compelled to change their behaviour in inauthentic ways or sociopolitical threat. Threat mitigation occurred when a participant or supervisor intervened against an identity threat, dampening but not eliminating the threat impact. Participants characterised identity safety as the ability to exist as their authentic selves without feeling the need to monitor how others perceive their identities. Identity safety manifested when participants demonstrated agency to leverage their identities for patient care, when others upheld their personhood and saw them as unique individuals and when they felt they belonged in the learning environment. Attending to identity safety may lead to educational practices that sustain and leverage team members' diverse identities. Identity safety and threat mitigation may work together to combat identity threats in the learning environment.

The complexity of obesity-related health problems after bariatric surgery: The patient perspective

BackgroundBariatric surgery aims to improve quality of life by means of weight loss. Obesity-related physical and psychological health problems should improve, but long-term data are scarce. ObjectivesTo evaluate preoperative physical and mental health problems perceived by the patient and the association with weight loss and quality of life, 5 years after bariatric surgery. Methods101 persons (response rate 67%) who had had bariatric surgery an average of 4.6 years before this study completed a written survey on obesity-related physical and psychological health problems and three psychological questionnaires collecting information on eating behavior and quality of life. Over half of the participants (55%) had had a laparoscopic adjustable gastric banding. ResultsPreoperatively reported health problems improved but were not necessarily associated with weight loss. Minimal improvement in tiredness, shame and weight instability were associated with significantly less weight loss. Preoperative type 2 diabetes mellitus (T2D) improved but participants had significantly less weight loss and more dissatisfaction regarding the bariatric trajectory than participants without T2D. Eating concerns, emotional eating and external eating improved but not restrained eating. Compared to the Dutch population reference, most quality of life scores of the participants were lower. ConclusionIn this analysis, participants did report satisfaction although from a patients’ perspective, improvements of weight and health did not necessarily lead to satisfaction regarding the bariatric trajectory. Participants with postoperative reported fatigue and shame as well as participants with preoperative T2D showed significant less weight loss. More long-term research is necessary to close the current knowledge gap.

Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor

BackgroundOlder adults are more vulnerable to seasonal influenza than younger adults. The immune responses of older persons to the influenza vaccine are usually poorer than those of young individuals, which is hypothesized due to immunosenescence. We conducted a study to evaluate the immunogenicity and safety of a quadrivalent inactivated influenza vaccine (IIV4) in a total of 167 young (< 65 years, n = 79) and older (≥ 65 years, n = 88) adults from October 2021 to March 2022 in Tianjin, China. A single dose was administered to all participants. Blood samples were collected and strain-specific hemagglutination inhibition (HAI) antibody titers were measured before and 21 to 28 days after vaccination. Safety information was also collected for 28 days and 6 months after vaccination. Differences in immunogenicity and safety were compared between young and old age groups, and multivariate logistic regression was used to estimate the effect of age and other factors on HAI antibody responses.ResultsOverall, geometric mean titers (GMTs) against all four vaccine strains in older adults were lower than those in the young, whereas the seroconversion rates (SCRs) were similar. Multivariate logistic regression analysis showed that age, influenza vaccination history, and pre-vaccination HAI titers were independent factors affecting SCRs and seroprotection rates (SCRs). Older age had significant negative impact on SCRs against H1N1 (OR, 0.971; 95% CI: 0.944–0.999; P = 0.042) and B/Victoria (OR, 0.964; 95% CI: 0.937–0.992; P = 0.011). In addition, there was a significant negative correlation between chronological age (years) and post-vaccination HAI titers against H1N1 (rho = -0.2298, P < 0.0001), B/Victoria (rho = -0.2235, P = 0.0037), and B/Yamagata (rho = -0.3689, P < 0.0001). All adverse events were mild (grade 1 or grade 2) that occurred within 28 days after vaccination, and no serious adverse event was observed.ConclusionsIIV4 is immunogenic and well-tolerated in young and older adults living in Tianjin, China. Our findings also indicate that age is an independent factor associated with poorer humoral immune responses to IIV4.

Cisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform

Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived tumor organoids (PTOs) in elucidating personalized HIPEC responses to bypass rarity of disease in generating preclinical data. Specimens were obtained from PM patients undergoing cytoreductive surgery with HIPEC. PTOs were fabricated with tumor cells suspended in ECM-hydrogel and treated with HIPEC regimen parameters. Viability and characterization analyses were performed post-treatment. Treatment efficacy was defined as ≥ 50% viability reduction and p < 0.05 compared to controls. From October 2020 to November 2022, 17 tumors from 7 patients were biofabricated into organoids, with 16/17 (94.1%) sites undergoing comparative 37° and 42° treatments with cisplatin and mitomycin C (MMC). Hyperthermic cisplatin and MMC enhanced cytotoxicity which reduced treatment viability by 25% and 22%, respectively, compared to normothermia. Heated cisplatin displayed the greatest cytotoxicity, with efficacy in 12/16 (75%) tumors and an average viability of 38% (5–68%). Heated MMC demonstrated efficacy in 7/16 (43.8%) tumors with an average treatment viability of 51% (17–92.3%). PTOs fabricated from distinct anatomic sites exhibited site-specific variability in treatment responses. PM PTOs exhibit patient and anatomic location treatment responses suggestive of underlying disease clonality. In PM organoids cisplatin is superior to MMC in HIPEC.

PENGUKURAN DAN ANALISIS KECEPATAN REAKSI TERHADAP PERUBAHAN WARNA DAN BUNYI SEBAGAI DASAR DALAM PERANCANGAN ALAT PENGENDALI ERGONOMIS

Reaction time is the time span between receiving a stimulus and the initial appearance of a person's response. Many work equipment requires a quick reaction from the operator on the signal displayed. The quick reaction is turning off the engine, pressing the emergency button, braking etc. Quick action is needed, among others, to prevent work accidents, prevent damage to equipment. To find out the characteristics of the speed of reaction to several types of stimuli, a series of experiments was carried out. The study was conducted under normal conditions on 47 respondents in the ergonomics laboratory. Stimulation given changes in color and sound as well as visual cues in the form of moving needles. The calculation results show that the speed of reaction is influenced by the type of stimulus. The highest reaction speed occurs when the stimulus is in the form of a moving pointer, followed by the yellow, green, red buttons, the sound of the alarm and finally the whirring sound. The control board prototype designed using reaction speed characteristic data is equipped with 3 color push buttons that correspond to the color of the indicator light, 1 yellow push button to respond to a whirring sound indicator and an emergency stop button to respond to an alarm sound and a step on by foot switch to respond to indicators moving pointer emergency stop button to respond to the alarm sound as well as a step-by-foot switch to respond to indicators in the form of a moving pointer.

VOICE BASED VIRTUAL ASSISTANT

The goal of this project is to create a voice-based smart virtual assistant that makes use of cutting-edge machine learning, speech recognition, and other technologies. Through personalized responses and recommendations, the main goal is to improve user experience and streamline tasks. Aside from setting reminders and booking appointments, the virtual assistant will also be able to make calls, send messages, and operate smart home appliances. It will also retrieve current data on the weather, news, sports scores, and other topics. The assistant will offer a seamless and intuitive interface across several languages and maintain contextual information from past talks with the help of context awareness and multilingual assistance. The virtual assistant will gradually enhance its effectiveness and gain a deeper understanding of user preferences by continuously learning from user interactions. An intelligent, hands-free virtual assistant that revolutionizes user interaction and task management is the goal of this project. Keywords— AI, Voice Assistant,

Defining pharmacist activities in ambulatory heart failure clinics: North American survey and modified Delphi study

AbstractBackgroundPharmacists are key members of multidisciplinary heart failure (HF) clinics; however, there is variation in their roles and activities. This study aimed to: (1) define current roles of HF clinic pharmacists and (2) develop a consensus‐based list of key activities for HF clinic pharmacists.MethodsIn part 1, we invited Canadian and American HF clinic pharmacists to complete a survey on activities currently performed in the HF clinic. Part 2 consisted of a three‐round modified Delphi study including only Canadian participants to define key activities for ambulatory HF pharmacists among 44 candidates. In each round, participants rated a list of candidate activities based on importance and priority on a 9‐point Likert scale. Consensus was reached for inclusion when ≥75% of participants rated both criteria ≥7, or exclusion when both criteria ≤6. Participants received personal responses alongside aggregate ratings after each round to facilitate attainment of consensus.ResultsEighty‐four pharmacists participated in part 1, and 29 (of 55 invited) participated in part 2 (24 retained for all three rounds). Current pharmacist activities were similar between American and Canadian participants, with an emphasis on patient assessment and clinical activities including modification of HF‐specific pharmacotherapy. The final consensus‐based list included 32 activities, with high priority placed on activities involving optimization of medications for HF and common comorbidities, engaging in shared decision‐making, assessing adherence, reviewing lab tests, and assessing and modifying medications due to pharmacokinetic/pharmacodynamic parameters, which closely mirrored activities in current practice.ConclusionCurrent activities of ambulatory HF pharmacists are largely consistent within North America, focusing on patient assessment and HF‐specific pharmacotherapy modification. Our consensus‐based list defined 32 activities integral to the future role of pharmacists in HF clinics, which builds upon activities being currently performed. This provides a framework to standardize and expand the scope of practice for clinical pharmacy services in HF clinics.

Evaluating the long-term portrayal of antibiotic resistance in major U.S. newspapers

BackgroundPopular media play a critical role in informing the public about antibiotic resistance, which has remained a health concern for over seven decades. Media attention increases the notoriety of antibiotic resistance and shapes the public’s perception of its severity, causes, and solutions. Therefore, it is critical the media accurately portray scientific knowledge that may shape personal and policy responses to antibiotic resistance.MethodsWe analyzed articles from two major U.S. newspapers, The New York Times and Los Angeles Times, from 1940 to 2019 to assess trends in sentiment and lexicon surrounding antibiotic and antimicrobial resistance.ResultsWe observed a gradual increase in the number of relevant articles about resistance, although far fewer than other topics with comparable mortality rates. We found a consistently threatening portrayal of antibiotic resistance as a crisis, reflected in the usage of terms such as “superbug” to refer to some pathogens. Governmental agencies responsible for determining antibiotic usage policies were infrequently mentioned in articles. Blame for resistance was almost exclusively attributed to inappropriate antibiotic use, mainly in animals, rather than appropriate uses of antibiotics.ConclusionsCollectively, our results provide insights into how popular media can more accurately inform the public about antibiotic resistance. Potential changes include increasing news coverage, avoiding fear-mongering, and adequately conveying the multiple uses of antibiotics that can potentiate resistance.

TMS-induced inhibition of the left premotor cortex modulates illusory social perception

Communicative actions from one person are used to predict another person's response. However, in some cases, these predictions can outweigh the processing of sensory information and lead to illusory social perception such as seeing two people interact, although only one is present (i.e., seeing a Bayesian ghost). We applied either inhibitory brain stimulation over the left premotor cortex (i.e., real TMS) or sham TMS. Then, participants indicated the presence or absence of a masked agent that followed a communicative or individual gesture of another agent. As expected, participants had more false alarms in the communicative (i.e., Bayesian ghosts) than individual condition in the sham TMS session and this difference between conditions vanished after real TMS. In contrast to our hypothesis, the number of false alarms increased (rather than decreased) after real TMS. These pre-registered findings confirm the significance of the premotor cortex for social action predictions and illusory social perception.

Between Remembering and Forgetting: Reckoning with Racialized Transmissions

ABSTRACT The backdrop for this paper has been the ongoing COVID pandemic and the author’s personal response to the murder of George Floyd and the enduring destructiveness of racism and white supremacy that resides here in the US In writing this paper, the author argues that currently we are witnessing and living with the formidable trans-generationally transmitted return of inherited racial hatred that had been more repressed, denied, and refused. The challenge for the author, and for psychoanalysis in general, is to consider in what ways our theories and praxis keep in place whiteness as the unmarked category, a standard benefitting itself. As a result, the legacy of embedded racism continues to be reproduced. Transgenerational transmissions of racial trauma and the rupturing of attachments are examined within the author’s background and in a clinical case with a white patient.