Background: Tremors can result in negative consequences on physical, emotional, and cognitive status in patients with multiple sclerosis, which may affect patient satisfaction, clinical recovery, and hospital length of stay. Aim: This study aimed to assess multidimensional of tremors in patients with multiple sclerosis. Design: A descriptive exploratory design was utilized. Setting: Multiple Sclerosis Outpatient Clinic at Ain Shams University Hospitals/Egypt. Study subject: A purposive sample of one hundred and fifty patients checked in the previous mentioned setting. Tools of data collection: Two tools were used for data collection: An interviewing questionnaire, multidimensional assessment of tremors in patients with multiple sclerosis. Results: 54.66%of the studied patients had tremors in right upper extremities while, 40% had intentional tremors. In addition, there was positive correlations between tremors severity scale and age. There was correlation between tremors and self-care. There were positive correlations between self-care productivity activities. There was positive correlation between productivity activities, leisure activities and also there was positive correlation between leisure activities and other activities among the studied patients suffering from multiple sclerosis. Conclusion: Patients with multiple sclerosis experienced tremors related to the patient's related factors such as psychological factors, physical factors and personal habits related factors. Recommendations: Health education should be given to MS patients with tremors on how to improve their quality of life with more efforts to improve awareness of patients regarding the techniques that can relieve pain or stress.