Persistent Effects Research Articles

Fractional Poisson and Gamma Models for Rainfall: Implications Climate Change and Marine Ecosystems

This research explores the benefits of using fractional Poisson and fractional Gamma models in rainfall modeling, highlighting their advantages in handling zero-inflated data, reducing overdispersion, and providing greater flexibility and accuracy. The second part of this study delves into the dynamic interplay between oceanic ecosystems and global climate change. It focuses on the role of phytoplankton in oxygen production and the impact of warming waters on this delicate balance. By employing mathematical models integrating differential equations and Brownian motion, the study offers a comprehensive framework for understanding how varying rates of oxygen production influence the sustainability of oceanic ecosystems. Finally, the research incorporates fractional Brownian motion into modeling plankton-oxygen dynamics, addressing the limitations of traditional Brownian motion. This approach captures the long-range dependencies and persistent effects critical for predicting the response of marine ecosystems to climate change. The findings underscore the need for nuanced mitigation strategies to address the imminent risks posed by global warming on marine life and atmospheric oxygen levels.

Early social isolation disrupts adult personality expression in group-living mites.

Animal personalities are characterized by intra-individual consistency and consistent inter-individual variability in behaviour across time and contexts. Personalities abound in animals, ranging from sea anemones to insects, arachnids, birds, fish and primates, yet the pathways mediating personality formation and expression remain elusive. Social conditions during the early postnatal period are known determinants of mean behavioural trait expressions later in life, but their relevance in shaping personality trajectories is unknown. Here, we investigated the consequences of early social isolation on adult personality expression in plant-inhabiting predatory mites Phytoseiulus persimilis. These mites are adapted to live in groups. We hypothesized that transient experience of social isolation early in life, that is, deprivation of any social contact during a sensitive window in the post-hatching phase, has enduring adverse effects on adult personality expression. Newly hatched mites were transiently reared in isolation or in groups and tested as adults for repeatability of various within-group behaviours, such as movement patterns and mutual interactions including sociability, defined as the propensity to associate and interact benignly with conspecifics, and activity patterns when alone. Groups composed of individuals with the same or different early-life experiences were repeatedly videotaped and individual behaviours were automatically analysed using AnimalTA. Social experiences early in life had persistent effects on mean behavioural traits as well as adult personality expression, as measured by intraclass correlation coefficients (indicating repeatability). On average, isolation-reared females moved at higher speeds, meandered less, kept greater distances from others and had fewer immediate neighbours than group-reared females. Group-reared females were highly repeatable in inter-individual distance, moving speed, meandering and area explored, whereas isolation-reared females were repeatable only in the number of immediate neighbours. Activity, quantified as the proportion of time spent moving within groups, was only repeatable in group-reared females, whereas activity, quantified as the proportion of time spent moving when alone, was only repeatable in females reared in isolation. Strikingly, also the early-life experiences of male mates influenced personality expression of mated females, with isolation-reared males boosting the repeatability of behavioural traits of group-reared females. Overall, our study provides evidence that a transient phase of social isolation during a critical period early in life has lasting effects that extend into adulthood, impairing adult personality expression. These effects should cascade upward, changing the phenotypic composition and diversity within populations.

The Effect of Corporate Social Responsibility (CSR), Firm Size, Profitability, Leverage and Earning Persistence on Company Value

The study aims to test the effect of CSR, firm size, profitability, leverage and earning persistence on company value. The study was conducted primary consumer companies in food and beverage subsector listed in Indonesian Stock Exchange in the period 2019-2022. Sample selection in this study used the method of purposive sampling and obtained 25 samples. Data used in research is quantitative obtained from secondary data using unbalance data. Test results using the SPSS 26 analytical tool. This study shows that CSR variables, firm size, and earnings persistence have no effect on company value, while profitability and leverage variables have a positive effect on company value. This research contributes to corporate management on the importance of company value in the business.

The enduring trauma: How officials' childhood famine experiences affect year-end spending surge

This study investigates the impact of government officials’ childhood famine experiences on year-end spending surges (YESS), a phenomenon where organizations rush to spend unspent funds at fiscal year-end. We propose that early-life famine trauma fosters fiscal conservatism, leading to underutilized budgets, but the “use it or lose it” rule forces spending by the fiscal deadline. Analyzing data from Chinese cities (2008–2018), we find that officials who experienced famine in childhood significantly increased YESS, reducing fiscal efficiency and hindering local economic development. The effect is most pronounced among those who experienced famine in early childhood and is amplified in financially autonomous cities governed by officials with extensive local networks. Additionally, the observed correlation between mild depression and famine trauma suggests psychological mechanisms underlying the persistent effects of early trauma on fiscal behavior.

Subprime Crisis Revisited: Effect of Payment Shock on Foreclosure Rates

This study investigates how payment shock from interest rate resets affects subprime mortgage foreclosure rates. Using robust econometric techniques (OLS, 2SLS, GMM), it isolates the causal effect of payment shock while accounting for house prices and borrowers’ ability to pay. Our findings show a significant positive link (27%) between payment shock and foreclosure rates. It highlights economic stability’s importance, showing negative correlations between foreclosure rates and ability to pay, as well as foreclosure rates and house prices. Lagged foreclosure rates show a persistent effect. The GMM model provides the most reliable estimates by addressing endogeneity, heteroscedasticity, and serial correlation.

How do global value chains respond to climate change? A case study of Chinese manufacturing firms

This study investigates climate risk and its effects on global value chain (GVC) participation, with a focus on the impact of drought on the export value-added ratio (DVAR) of Chinese manufacturing firms. Using fixed effects (FE) and system GMM models, the main findings are: Drought significantly reduces manufacturing firms' DVAR, with the lagged dependent variable showing a strong persistence effect and an even greater impact in the second lag period. This impact varies based on the firm's location, the complexity of its value chain, and its ability to adapt to and mitigate climate change effects. Strategies such as improving operational efficiency, investing in sustainable technologies, and enhancing competitiveness in developed markets may help mitigate or reverse the adverse effects of climate change on these firms. Additionally, significant industry and regional differences are observed, with the Northeast, East, and South China regions being most severely affected by drought. Global innovation value chains and regional processing value chains are significantly negatively impacted, while labor-intensive value chains are affected only in the current period. These findings provide new insights into the economic impacts of climate change and offer a basis for policymakers to develop strategies that help firms adapt to and mitigate climate risks.

Assessment of the persisting effects of increased public funding for agriculture in Nigeria

Assessment of the persisting effects of increased public funding for agriculture in Nigeria

The Role of Charismatic Leadership Tactics and Inconsistent Messages in Processing and Evaluating Climate Change Information

Climate change poses an unprecedented challenge to humanity, and persuasive environmental communication is a crucial step for global leaders to counteract its consequences. Charismatic leaders are especially effective in communicating information. Interestingly, in recent years, there have been frequent incidences where charismatic leaders made inconsistent environmental statements. How people process such inconsistencies can provide key insights into understanding the processing of climate information. In two preregistered online studies (N = 668), we examined how people read and evaluate pro- and contra-environmentalism messages from an environmental, charismatic leader. We found persistent effects of message inconsistencies, leading to longer reading times and lower convincingness ratings for information. However, we failed to find an interaction effect of the experimental manipulations or a main effect of charisma on reading times for environmental messages. In Study 2, we detected an interaction effect of leader charisma and message inconsistency on how convincing participants rated text messages. Participants rated contra-environmental messages as more convincing when following displays of charismatic rather than neutral leader behavior. We discuss future research avenues to explore charismatic leader influences on processing climate change information.

Perioperative hypothermia and stress jeopardize anti-metastatic immunity and TLR-9 immune activation: potential mediating mechanisms (experimental studies).

The perioperative period often involves stress responses and surgery-induced hypothermia, which were suggested to hinder anti-metastatic immunity and promote cancer metastasis. During this critical period, immunotherapies are rarely used, given contraindications to surgery. However, recent pre-clinical studies support the feasibility of perioperative TLR-9 activation, using CpG-C. Herein, we employed hypothermic- and normothermic-stress paradigms to assess their impact on perioperative CpG-C immune-stimulation and resistance to experimental hepatic metastasis of CT26 colorectal cancer in BALB/C mice. Perioperative hypothermic wet-cage stress markedly abrogated CpG-C-induced increase in plasma IL-12 levels, a persistent deleterious effect across different CpG-C doses and administration routes. These effects were not attenuated by blocking glucocorticoids, adrenergic, or opioid signaling, nor by adrenalectomy, suggesting direct immunosuppressive impact of hypothermia on immunocytes. Indeed, normothermic wet-cage stress, which induced similar corticosterone response, caused significantly less deleterious effects on IL-12 levels, hepatic NK cell maturation and cytotoxicity, and CT26 metastasis. Additionally, in vitro exposure of PBMCs to 33°C markedly decreased CpG-C-induced IL-12 production. Last, two normothermic stress paradigms, tilt&light and restraint, did not jeopardize CpG-C-induced IL-12 response nor resistance to CT-26 metastases. Interestingly, attenuating glucocorticoid signaling under tilt&light conditions improved CpG-C efficacy. Overall, these findings suggest that perioperative hypothermic stress can jeopardize anti-metastatic immunity and resistance to metastasis, and prevent perioperative response to immune stimulation and its beneficial anti-metastatic impacts, effects that are not mediated through classical neuroendocrine stress responses, but potentially through direct hypothermic impact on leukocytes. These findings may have clinical implications in operated cancer patients, many of whom suffer hypothermic stress.

Acknowledging Loss: A Consultative Approach to Grief Support for Students with Intellectual Disabilities

ABSTRACT Students with intellectual and developmental disabilities (IDD) are at an elevated risk for exposure to bereavement, persistent negative mental health effects after loss, and layered and traumatic forms of grief. Despite this increased risk, students with IDD are too-frequently overlooked by school-based mental health professionals, leaving educators, community members, and family members without needed support. There are actionable steps that school-based mental health providers can take to adapt existing approaches to grief support and build consultee capacity to intervene with individuals with IDD. This paper reviews terminology surrounding the concept of grief, summarizes biases about IDD that have contributed to care disparities, and offers considerations for including grieving students with IDD in mental health consultation.

Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.

Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol (THC) influences development of circuits underlying these processes, especially in the prefrontal cortex, which matures during adolescence. We determined how 14 daily THC injections (5mg/kg) during adolescence persistently impacts medial prefrontal cortex (mPFC) dopamine-dependent cognition. In adult Long Evans rats treated as adolescents with THC (AdoTHC), we quantify performance on two mPFC dopamine-dependent reward-based tasks-strategy set shifting and probabilistic discounting. We also determined how acute dopamine augmentation with amphetamine (0, 0.25, 0.5 mg/kg), or specific chemogenetic stimulation of ventral tegmental area (VTA) dopamine neurons and their projections to mPFC impacts probabilistic discounting. AdoTHC sex-dependently impacts acquisition of cue-guided instrumental reward seeking, but has minimal effects on set-shifting or probabilistic discounting in either sex. When we challenged dopamine circuits acutely with amphetamine during probabilistic discounting, we found reduced discounting of improbable reward options, with AdoTHC rats being more sensitive to these effects than controls. In contrast, neither acute chemogenetic stimulation of VTA dopamine neurons nor pathway-specific chemogenetic stimulation of their projection to mPFC impacted probabilistic discounting in control rats, although stimulation of this cortical dopamine projection slightly disrupted choices in AdoTHC rats. These studies confirm a marked specificity in the cognitive processes impacted by AdoTHC exposure. They also suggest that some persistent AdoTHC effects may alter amphetamine-induced cognitive changes in a manner independent of VTA dopamine neurons or their projections to mPFC.

Harnessing the potential of acyl triazoles in bifunctional cobalt-catalyzed radical cross-coupling reactions

Persistent radicals facilitate numerous selective radical coupling reactions. Here, we have identified acyl triazole as a new and versatile moiety for generating persistent radical intermediates through single-electron transfer processes. The efficient generation of these persistent radicals is facilitated by the formation of substrate-coordinated cobalt complexes, which subsequently engage in radical cross-coupling reactions. Remarkably, triazole-coordinated cobalt complexes exhibit metal-hydride hydrogen atom transfer (MHAT) capabilities with alkenes, enabling the efficient synthesis of diverse ketone products without the need for external ligands. By leveraging the persistent radical effect, this catalytic approach also allows for the development of other radical cross-coupling reactions with two representative radical precursors. The discovery of acyl triazoles as effective substrates for generating persistent radicals and as ligands for cobalt catalysis, combined with the bifunctional nature of the cobalt catalytic system, opens up new avenues for the design and development of efficient and sustainable organic transformations.

Development of tungsten-modified iron oxides to decompose an over-the-counter painkiller, Acetaminophen by activating peroxymonosulfate

Acetaminophen (APAP) is a well-known type of over-the-counter painkillers and is frequently found in surface waterbodies, causing hepatotoxicity and skin irritation. Due to its persistence and chronic effects on the environment, innovative solutions must be provided to decompose APAP, effectively. Innovative catalysts of tungsten-modified iron oxides (TF) were successfully developed via a combustion method and thoroughly characterized using SEM, TEM, XRD, XPS, a porosimetry analysis, Mössbauer spectroscopy, VSM magnetometry, and EPR. With the synthesis method, tungsten was successfully incorporated into iron oxides to form ferrites and other magnetic iron oxides with a high porosity of 19.7 % and a large surface area of 29.5 m2/g. Also, their catalytic activities for APAP degradation by activating peroxymonosulfate (PMS) were evaluated under various conditions. Under optimal conditions, TF 2.0 showed the highest APAP degradation of 95 % removal with a catalyst loading of 2.0 g/L, initial APAP concentration of 5 mg/L, PMS of 6.5 mM, and pH 2.15 at room temperature. No inhibition by solution pHs, alkalinity, and humic acid was observed for APAP degradation in this study. The catalysts also showed chemical and mechanical stability, achieving 100 % degradation of 1 mg/L APAP during reusability tests with three consecutive experiments. These results show that TFs can effectively degrade persistent contaminants of emerging concern in water, offering an impactful contribution to wastewater treatment to protect human health and the ecosystem.

The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits

Exercise provides a range of cognitive benefits, including improved memory performance. Previously, we demonstrated that 14 days of continuous voluntary wheel-running exercise enables learning in a hippocampus-dependent Object Location Memory (OLM) task under insufficient, subthreshold training conditions in adult mice. Whether similar exercise benefits can be obtained from consistent intermittent exercise as continuous exercise is unknown. Here, we examine whether intermittent exercise (the weekend warrior effect: 2 days of exercise a week for 7 weeks) displays similar or distinct cognitive benefits as previously examined with 14 days of continuous exercise. We find that both continuous and intermittent exercise parameters similarly enable hippocampus-dependent OLM compared to the 2-day exercise control group. Mice receiving intermittent exercise maintained cognitive benefits following a 7-day sedentary delay, whereas mice that underwent 14 continuous days of exercise showed diminished cognitive benefits as previously reported. Further, compared to continuous exercise, intermittent exercise mice exhibited persistently elevated levels of the genes Acvr1c and Bdnf which we know to be critically involved in hippocampus-dependent long-term memory in the dorsal hippocampus. Together findings suggest that consistent intermittent exercise persistently enables hippocampal-dependent long-term memory. Understanding the optimal parameters for persistent cognitive function and the mechanisms mediating persistent effects will aid in therapeutic pursuits investigating the mitigation of cognitive ailments.

Efficient bioremediation of multiple steroid hormones by halotolerant 17β-hydroxysteroid dehydrogenase derived from moderately halophilic Pontibacillus chungwhensis HN14.

Steroid hormones exhibit potent endocrine disrupting activity and have been shown to disrupt the equilibrium of aquatic ecosystems and pose a threat to public health through their persistent and carcinogenic effects. Pontibacillus chungwhensis HN14, a moderately halophilic bacterium with the capacity to effectively degrade various polycyclic aromatic hydrocarbons and other organic pollutants, was previously isolated. Additionally, the strain HN14 showed strong environmental adaptability under various environmental stress conditions. In this study, the steroid degradation by strain HN14 was studied for the first time. We demonstrated that strain HN14 could degrade estradiol (E2) to maintain the growth of the strain and could convert E2 to estrone. Additionally, the efficient substrate degradation efficiency of P. chungwhensis HN14 under high salinity and high substrate concentration conditions was demonstrated. Furthermore, a 17β-hydroxysteroid dehydrogenase, 17β-HSD(HN14), was identified in strain HN14. Comparative analysis reveals that 17β-HSD(HN14) shares approximately 38% sequence identity with 17β-HSDx from Rhodococcus sp. P14. In addition, 100µg of purified 17β-HSD(HN14) could effectively convert about 40% of 0.25 mM of E2 within 1h period, with an enzyme activity of 17.5 U/mg, and catalyze the dehydrogenation of E2 and testosterone at the C-17 position. The characterization of purified enzyme properties reveals that 17β-HSD(HN14) exhibits exceptional structural robustness and enzymatic efficacy even under high salinity conditions of up to 20%. Overall, this study enhances our comprehension of steroid biodegradation in strain HN14 and contributes novel ideas and theoretical underpinnings for advancing bioremediation technologies targeting steroid pollution in high-saline environments.

An evidence based comprehensive review on thiacloprid, a pesticide residue, induced toxicity: Unveiling hazard to human health

Thiacloprid, a hazardous neonicotinoid insecticide, prevalent in daily agricultural practices, raises concerns due to the harmful effects of its residues on food items, and on unintended organisms poses a significant threat to human health. Introduced in 1990, Thiacloprid have gained popularity for its perceived effectiveness and reduced risks to non-target animals. However, emerging research in recent years reports significant toxic effects of Thiacloprid on non-target species, spanning neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive issues. Mammalian studies, particularly involving rodents, reveal cognitive impairment, hippocampal damage, and hepatic abnormalities upon Thiacloprid exposure. Reproductive toxicity and DNA damage are imminent concerns, disrupting gestational epigenetic reprogramming and suggesting persistent effects on future generations. Genotoxic effects, Embryotoxic, and observed reproductive toxicity accentuate the need for caution in the utilization of Thiacloprid. This review highlights reported toxic effects produced by Thiacloprid in recent years, challenging the initial belief in its lower toxicity for vertebrates.

Cultivating Therapeutic Presence: A Pilot Project.

Purpose: Cultivating therapeutic presence is a pilot project for addressing perceived stress in a group of holistic healthcare workers. Design and Methods: The project incorporated mindfulness-based interventions, self-care techniques, and the establishment of supportive relationships. It was presented during the COVID pandemic to integrative health care workers at a children's hospital. Findings: There was an overall improvement in perceived stress scores across the series, with an effect size estimated by Cohen's d = .963, consistent with a large effect. Participants reported persistent effects on a survey administered five months after completion of the project, which included feeling more confident, using the techniques, and more effectively caring for themselves. Conclusions: This project integrated mindfulness-based interventions with self-care techniques, as well as strengthening support networks. Upon completion, perceived stress decreased, a finding that persisted for several months.

A Comparison of Statistical Validity of In-Situ Hydraulic Conductivity Prediction Models of Rock Mass Inferred from Borehole Logs and Lugeon Test Data

In-situ hydraulic conductivity is a vital property in rock engineering for jointed rock mass. Understanding its correlation with rock mass parameters is crucial for water circulation. Therefore, a study was carried out to develop statistically significant empirical relationships between hydraulic conductivity and various rock mass parameters to estimate in-situ hydraulic conductivity from Lugeon test and various rock mass parameters obtained from borehole logs.The study initially aimed to establish a correlation between hydraulic conductivity and Rock Quality Designation (RQD). However, the outcomes were unsatisfactory, prompting further research. Later, two more robust models were developed, namely the HC-model and modified HC-model. The HC-model incorporated four rock mass parameters, including Rock Quality Designation Index, Depth Index, Gouge Content Designation Index, and Lithology Permeability Index, achieving a maximum coefficient of determination (R2) of 0.46. The modified HC-model included six parameters, encompassing fracture frequency and theoretical aperture, resulting in an improved R2 of 0.69. Both models significantly outperformed RQD-alone predictions (R2 < 0.10), highlighting the need for incorporating multiple rock mass parameters in predicting hydraulic conductivity due to a complex interplay of various factors. However, the effects of joint persistence and roughness are limiting in the present analysis.

Persistent Effects of the Paycheck Protection Program and the PPPLF on Small Business Lending

Persistent Effects of the Paycheck Protection Program and the PPPLF on Small Business Lending

Scars of the job market “ice-age”

Abstract Existing studies found that entering the labor market during a recession has persistent negative effects—the scarring effects—on employment and earnings for Japanese men. The cohorts who entered the labor market during the prolonged recession between 1993 and 2004 are called “the ice-age cohorts,” and the persistent gap between them and older cohorts who entered the labor market during the bubble economy is often interpreted as the scarring effect of business cycle conditions at entry. However, the existing studies in Japan use data covering cohorts who enter the labor market in the 1990s or earlier. Motivated by the lack of empirical evidence with updated data, this article revisits the scarring effects of a recession at labor market entry on employment and earnings using data covering graduation cohorts 1984–2013. Younger cohorts who enter the labor market during the recovery do not earn more or enjoy more stable employment than the cohorts who enter the bottom of the ice-age, and that the effects of unemployment rate at entry on employment and earnings are no longer statistically significant for cohorts who enter the labor market after the job market ice-age. I also discuss potential factors that may have weakened scarring effects.