Application Of Permethrin Research Articles

ブドウにおけるチャノキイロアザミウマとコウズケカブリダニの個体群密度に及ぼす薬剤散布の影響

The insecticide susceptibility of yellow tea thrips, Scirtothrips dorsalis and its natural enemy mite, Euseius sojaensis was evaluated at 25°C under 16L8D. Imidacloprid was highly effective against S. dorsalis second instar larvae. Permethrin was effective at 100–200 ppm and marginally effective at 25–50 ppm. Imidacloprid was not harmful to E. sojaensis female adults, while permethrin was seriously harmful. The effect of insecticide application on the population of S. dorsalis and E. sojaensis was investigated in a Delaware vineyard in Osaka Prefecture. With the application of imidacloprid, the density of S. dorsalis was effectively reduced, and E. sojaensis was found to survive on the grapes. In contrast, the density of S. dorsalis was slightly reduced, and E. sojaensis was not found on the grapes with the application of permethrin. Injury to fruit by S. dorsalis was significantly lower on grapes with imidacloprid application. The results suggest that imidacloprid did not seriously affect the population of E. sojaensis but shows good control against S. dorsalis on grapes.

Investigations of eugenol efficacy in treatment of mange in swine

The acaricide efficacy, tolerability and safety of the active ingredient of the etheric oil of cloves eugenol was investigated in the treatment of mange in swine, and the obtained results were compared with the results of acaricide efficacy of the synthetic acaricide permethrin, which has been in use for quite a some time. A single application of permethrin in the form of a 1% solution showed maximum efficacy of 62.5%, and after three applications of 75.0% in the treatment of sarcoptes in swine mange. A single application of eugenol in the form of a 10% solution had maximum efficacy of 75.0%, and applied three times an efficacy of 100% in curbing Sarcoptes scabiei var. suis. A single administration of 20% eugenol solution showed maximum efficacy of 87.5%, and applied three times it was 100% efficient in curbing Sarcoptes scabeiei var. suis. The best efficacy in the treatment of sarcoptes mange in swine was achieved with three applications of eugenol in a concentration of 20%. This maximum effect (100%) was obtained already after the second treatment. Eugenol in a concentration of 10% was safe for local application on skin because it does not cause any undesired reactions, while a 20% concentration caused irritation followed by a passing redness and disquiet in a smaller number of treated animals. The results of comparative investigations of acaricide efficacy of permethrin and eugenol demonstrate that there is resistence in Sarcoptes scabiei var. suis to permethrin. The biocide eugenol can safely be recommended for the treatment of sarcoptes mange in swine.

Effect of sub-lethal concentrations of permethrin on ovary activation in the predator Supputius cincticeps (Heteroptera: Pentatomidae)

Insecticides may cause mortality and deleterious effects on predatory stinkbugs. For this reason, the effect of five concentrations of permethrin applied on third instar nymphs of Supputius cincticeps (Stål) (Heteroptera: Pentatomidae) was investigated on ovary activation in this predator. The nymphs received topical application of permethrin in the following concentrations (mg a.i./ml): 10(-7), 10(-6), 10(-5), 10(-4), and 10(-3). Ovary lengths and oocyte numbers were quantified following first egg mass. Ovary length of S. cincticeps varied from 5.7 mm with 10(-4) mg a.i./ml, to 6.4 mm with 10(-7) mg a.i./ml, with similar values for the other permethrin concentrations and for the control. The number of oocytes per female varied from 13.5 with 10(-3) mg a.i./ml, to 29.2 for the control, with significant differences. The number of oocytes per female of nymphs exposed to a permethrin concentration of 10(-5) mg a.i./ml was similar to that of the control. However, the lower number of oocytes per female from nymphs exposed to other concentrations of permethrin suggests that this insecticide may affect the reproductive capacity of this predator. The results obtained are discussed in relation to tolerance of Heteroptera predators to insecticides and possible hormesis occurrence.

Probable Topical Permethrin-Induced Neck Dystonia

A 28-year-old Caucasian man who applied topical 5% permethrin cream once for the treatment of scabies infestation experienced a severe dystonic reaction on the left side of his neck. Assessment of causality using the Naranjo algorithm revealed a probable relationship between this adverse drug event and application of topical permethrin. Dystonic or musculoskeletal adverse reactions, including muscle spasms, have been reported with pyrethroid insecticides only after inappropriate occupational dermal exposure. These reported reactions occurred 4-48 hours after exposure and lasted from a few days to a few weeks. The mechanism behind these adverse effects may be related to permethrin's ability to delay sodium channel closure within nerve cells. This may result in a lowered threshold of nerve fibers to activation of further action potentials, leading to repetitive firing and hyperexcitation of the nervous system. Clinicians should be aware of this rare but potential adverse effect of permethrin.

Probable Topical Permethrin-Induced Neck Dystonia

A 28-year-old Caucasian man who applied topical 5% permethrin cream once for the treatment of scabies infestation experienced a severe dystonic reaction on the left side of his neck. Assessment of causality using the Naranjo algorithm revealed a probable relationship between this adverse drug event and application of topical permethrin. Dystonic or musculoskeletal adverse reactions, including muscle spasms, have been reported with pyrethroid insecticides only after inappropriate occupational dermal exposure. These reported reactions occurred 4–48 hours after exposure and lasted from a few days to a few weeks. The mechanism behind these adverse effects may be related to permethrin's ability to delay sodium channel closure within nerve cells. This may result in a lowered threshold of nerve fibers to activation of further action potentials, leading to repetitive firing and hyperexcitation of the nervous system. Clinicians should be aware of this rare but potential adverse effect of permethrin.

DAMPAK APLIKASI INSEKTISIDA PERMETRIN TERHADAP HAMA PENGISAP BIJAIJ HELOPELTIS SPP. (HEMIPTERA: MIRIDAE) DAN ARTROPODA NON-TARGET PADA PERTANAMAN KAKAO (THEOBROMA CACAO L.)

Impact of Permethrin-Insecticide Application on Mirid Pest of Cocoa Helopeltis spp. (Hemiptera: Miridae) and on Non-target Arthropods in Cocoa Plantations (Theobroma cacao L.). Cocoa mirid bugs, Helopeltis spp., (Hemiptera: Miridae) are the most important pest of cocoa in Indonesia. A field study was conducted to investigate the effect of permethrin on cocoa mirids and non-target arthropods at a cocoa plantation in specific place. A randomized complete block design was used in which each of four blocks consisted of 5 treatments (4 concentrations of permethrin; 50; 100; 200; and 250 ppm and control). The results indicated that the application of permethrin significantly increased the cocoa mirids mortaliiy throughout all sprayed cocoa trees (up to 100% 72 h after application). Even at 1 h after application, the percentage of Cocoa mirids mortality 29.2% - 53.9%) on cocoa trees sprayed with permethrin at concentrations of 50 - 250 ppm was significantly higher than that on control plant (3.6%). At 72 h after treatments, application of permethrin at concentrations of 200 and 250 ppm caused a complete kill (mortalty of 100%) in the test mirids. Meanwhile, ground cloths caught at least 22 fanilies of abore-ground arthropods that were found killed by permethrin applications. Moreover, the number of non-target arthropods killed by permethrin at concentrations of 100 - 250 ppm (27.3 - 85.3 individuals/ground cloth) were signifcantly higher than that on control trees. These results demonstrated that despite high efficacy of permethrin in controlling of cocoa mirids (Hetopeltis spp.), its application also had adverse effects on non-target arthropods incocoa plantations.

Emergence Suppression of Bark and Ambrosia Beetles in Infested Oaks

Logs were cut from each of eight coast live oaks (Quercus agrifolia) and one California black oak (Q. kelloggii) infested with bark and ambrosia beetles. For each tree, one log was collected from 1 m (3.3 ft) above the ground, a second from immediately below the crotch of the major limbs, and a third from a branch 8 cm (3 in.) in diameter. Permethrin significantly reduced emergence of both oak ambrosia beetles (Monothrum scutellare) and oak bark beetles (Pseudopityphthorus pubipennis) from the insecticide-treated logs (P = 0.001) compared to the control log sections. This result indicates the bark application of permethrin can lower the density of bark and ambrosia beetles in urban forests.

Demodex abscesses: clinical and therapeutic challenges

A 53-year-old man had a 6-week history of confluent erythematous papules, pustules, and abscesses of the face initially limited to the right nasolabial fold. Histologic investigation revealed a perifollicular infiltrate with lymphocytes, histiocytes, and many Demodex folliculorum mites. A large number of mites were seen in skin scrapings. The skin manifestations progressed and persisted for the following 5 years and were unresponsive to numerous antiparasitic treatments, including repeated oral administration of ivermectin and external application of lindane, permethrin, and benzoyl benzoate. Therapy with oral administration of 250 mg metronidazole 3 times a day for 2 weeks resulted in rapid and lasting recovery. Demodex folliculitis remains a diagnostic and therapeutic challenge. Antiparasitic therapies used against lice or scabies may fail in control of D folliculorum mites. In the presence of clinical and microscopic findings typical of Demodex folliculitis or abscesses, treatment failure with acaricidal agents does not exclude the diagnosis. Oral metronidazole seems to work in the management of this chronic mite infestation.

Development, reproduction, and control of the Indian meal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae), in stored seed garlic in Mexico

Developmental time, fecundity, and egg hatch rate were determined for the Indian meal moth, Plodia interpunctella (Hübner), reared on fresh garlic seed at room temperature in Mexico. Duration of the egg stage averaged 4.7±0.8 days with an egg hatch rate ranging from 82% to 95%. Five larval instars were determined based on head-capsule width. Total larval developmental time from egg hatch to adult emergence ranged from 42 to 47 days. Adult females began to oviposit within 12–48 h after mating with the maximum oviposition rate occurring during the first 24 h after mating. The mean (±SE) number of eggs laid by females was 212±34 with a range of 117–303. Application of pirimiphos-methyl, malathion, and permethrin to 30 kg lots of garlic seed failed to prevent infestation and bulb damage by the larvae. However, compared with controls, the percentage of damaged bulbs and the number of larvae detected during 12 weeks of storage was smaller on garlic treated with four doses of pirimiphos-methyl.

Dissipation and Mobility of Permethrin in the Field with Repeated Applications Under Tropical Conditions

Studies on persistence, mobility and the effect of repeated application of permethrin on its half‐life were carried out under field conditions. The half‐life of permethrin in the top 20 cm of the soil increased from 11.5 to 23.6 days as the application rates increased from 35 to 140 g ha− 1. Induced by heavier rainfall, more residues moved downward in trial 2 than in trial 1. Repeated applications enhanced degradation rates and mobility of permethrin in the soil. The residue level in the 0–5‐cm layer was reduced at day 28 after 17 consecutive applications to a level lower than after 5 applications. The half‐life of permethrin was reduced from 15.9 days to 11.2 days after 5 and 17 applications, respectively. The residue reached the 15–20 cm layer much earlier (approximately 3 days after treatment) in soil that received 17 applications as compared to those with two applications.

Combined Exposure to Deet (N,N-Diethyl-m-Toluamide) and Permethrin: Pharmacokinetics and Toxicological Effects

Permethrin and DEET are concurrently used for pests control inside homes, in public places, and in military shelters. Combined exposure to these compounds produced greater biochemical, behavioral, and metabolic alterations in animals compared to each individual compound. Concurrent application of DEET and permethrin induced urinary excretion of 3-nitrotyrosine and 8-hydroxy-2′-deoxyguanosine, markers of DNA damage and oxidative stress in rats, increased the release of rat brain mitochondrial cytochrome c, disrupted the blood–brain barrier (BBB) in rats, decreased m2 muscarinic acetylcholine receptor ligand binding density in rat brain, increased urinary excretion of 6β-hydroxycortisol, a marker CYP3A4 induction, altered sensorimotor and locomotor activities in rats, and changed in vivo and in vitro metabolism and pharmacokinetic profiles of the individual compound. These findings show that more research is needed to examine adverse effects of the combined use of DEET and permethrin on other biochemical/physiological system(s) and to predict mechanistic pathways for these effects, particularly mechanism of action at cellular and molecular levels and alterations of genes transcription.

Single-dose topical exposure to the pyrethroid insecticide, permethrin in C57BL/6N mice: effects on thymus and spleen

Immunomodulatory effects of single topical exposure to permethrin were evaluated in 5-week-old female C57BL/6N mice. Mice exposed to 5–25 μl permethrin (equivalent to 220–1100 mg/kg body weight) on shaved interscapular skin were evaluated for altered body weight; splenic and thymic organ weight and cellularity; thymocyte cell surface expression, cellular apoptosis; splenic macrophage phagocytosis and hydrogen peroxide production; splenic B cell antibody production and T cell cytolytic activity; and mitogen-induced proliferation of splenocytes and thymocytes after in vivo or in vitro permethrin exposure. Topical permethrin application (25 μl) caused 32% inhibition of splenic T cell proliferation; in vitro exposure to permethrin also diminished splenocyte proliferation by 72% at 25 μ m and 86% at 100 μ m. permethrin did not appear to affect other leukocyte functional assays. Dose-related decreases in thymic cellularity of 52 and 80% were seen in mice exposed to 15 and 25 μl permethrin, respectively. Apoptosis was significantly increased in CD4 −8 − and CD4 −8 + thymocytes, and the CD4 +CD8 + thymocyte subpopulation was most severely diminished, suggesting possible chemical-induced apoptotic mechanism of thymic atrophy. Permethrin also caused splenic hypocellularity by 31% at 15 μl, and by 50% at 25 μl, an effect that may relate to inhibited proliferation or reduced seeding from the hypocellular thymus.

Desenvolvimento e Reprodução do Predador Podisus distinctus (Stal) (Heteroptera: Pentatomidae) Frente a Doses Subletais de Permetrina

Desenvolvimento e reprodução foram estudados no predador Podisus distinctus (Stal) submetido a doses subletais do inseticida permetrina em condições de laboratório. Ninfas de 3º instar foram submetidas a aplicação tópica de permetrina nas doses de 0; 0,0172; 0,172; 1,72; 17,2 e 172 ppb. O único parâmetro significativamente afetado foi a viabilidade de ovos. Esse parâmetro teve um máximo de estímulo na dose 0,172 ppb provendo evidência do fenômeno de hormese.

DAMPAK APLIKASI INSEKTISIDA PERMETRIN TERHADAP SERANGGA HAMA (THOSEA SP.) DAN SERANGGA PENYERBUK (ELAEIDOBIUS KAMERUNICUS) DALAM AGROEKOSISTEM KELAPA SAWIT

Impact of Permethrin-Insecticide Application on Insect Pest (Thosea sp.) and Insect Pollinators (Elaeidobius kamerunicus) in Oil Palm Agroecosystem. Insecticide efficacy studies are usually determined from the target insect (pest) data without regard to the effect of that treatment on the non-target insects (such as pollinators). This study examined the effect of permethrin (one of widely used insecticides for agriculture) on defoliating insect pest (nettle caterpillar, Thosea sp.) and insect pollinator (weevil, Elaeidobius kamerunicus) which lives on pollen of male oil palm flowers. A complete block design was used in which each of four blocks consisted of 5 treatments (4 concentrations of permethrin; 50; 100; 200; and 250 ppm and control) . The results clearly demonstrated that the application of permethrin reduced significantly the number of nettle caterpillar throughout all sprayed plants (up to 100% 14 d after treatments). A significant difference in mean population of the caterpillar were detected between plots sprayed with permethrin (0.05; 0.25; 0.53; and 2.00 larvae/leaves at concentrations of 250; 200; 100; and 50 ppm respectively) and control plant (5.2 larvae/leaves) 3 d after treatments. This insecticide effects persisted for at least 14 d after treatments. On the other hand, permethrin application in oil palm agroecosystem had adverse effects on main pollinator (E. kamerunicus). The number of weevil pollinators on sprayed plants (12.5; 59.3; 77.5; and 209.5 weevil/male flower at concentrations of 50; 100; 200; and 250 ppm respectively) were significantly fewer compared to the control plants (976.0 weevil/male flower). The results indicate that, despite high efficacy of permethrin in reducing number of insect pests of oil palm (Thosea sp.), its application also cause a severe impact on important insect pollinators (E. kamerunicus).

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Background: Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. Methods: This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream^®), 20 patients metronidazole 0.75% gel (Roza gel^®) and 20 patients placebo cream (Basis cream^®), in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. All patients were also given SPF 20 cream for protection against sunlight. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. folliculorum were recorded at each visit. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were determined at baseline and on days 15, 30, 45 and 60. Side effects were also detected. Results: The effect of permethrin 5% cream on D. folliculorum was superior to that of metronidazole 0.75% gel. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. However, it had no effect on telangiectasia, rhinophyma and pustules. Conclusion: It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.

Development of Resistance in Field Housefly (Musca domestica): Comparison of Effect of Classic Spray Regimes versus Integrated Control Methods

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Subchronic Dermal Application of N,N-Diethyl m-Toluamide (DEET) and Permethrin to Adult Rats, Alone or in Combination, Causes Diffuse Neuronal Cell Death and Cytoskeletal Abnormalities in the Cerebral Cortex and the Hippocampus, and Purkinje Neuron Loss in the Cerebellum

N,N-Diethyl m-toluamide (DEET) and permethrin have been implicated as potential neurotoxic agents that may have played an important role in the development of illnesses in some veterans of the Persian Gulf War. To determine the effect of subchronic dermal application of these chemicals on the adult brain, we evaluated histopathological alterations in the brain of adult male rats following a daily dermal dose of DEET (40 mg/kg in 70% ethanol) or permethrin (0.13 mg/kg in 70% ethanol) or a combination of the two for 60 days. Control rats received a daily dermal dose of 70% ethanol for 60 days. Animals were perfused and brains were processed for morphological and histopathological analyses following the above regimen. Quantification of the density of healthy (or surviving) neurons in the motor cerebral cortex, the dentate gyrus, the CA1 and CA3 subfields of the hippocampus, and the cerebellum revealed significant reductions in all three treated groups compared with the control group. Further, animals receiving either DEET or permethrin exhibited a significant number of degenerating (eosinophilic) neurons in the above brain regions. However, degenerating neurons were infrequent in animals receiving both DEET and permethrin, suggesting that neuronal cell death occurs earlier in animals receiving combined DEET and permethrin than in animals receiving either DEET or permethrin alone. The extent of neuron loss in different brain regions was similar among the three treatment groups except the dentate gyrus, where neurodegeneration was significantly greater with exposure to DEET alone. The neuron loss in the motor cerebral cortex and the CA1 subfield of all treated groups was also corroborated by a significant decrease in microtubule associated protein 2-immunoreactive elements (15–52% reduction), with maximal reductions occurring in rats receiving DEET alone; further, the surviving neurons in animals receiving both DEET and permethrin exhibited wavy and beaded dendrites. Analysis of glial fibrillary acidic protein immunoreactivity revealed significant hypertrophy of astrocytes in the hippocampus and the cerebellum of all treated groups (24–106% increase). Thus, subchronic dermal application of DEET and permethrin to adult rats, alone or in combination, leads to a diffuse neuronal cell death in the cerebral cortex, the hippocampal formation, and the cerebellum. Collectively, the above alterations can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction.

Analysis of the effects of rotational larviciding on aquatic fauna of two Guinean rivers: the case of permethrin

Within the Onchocerciasis Control Programme about 50,000 km of west African rivers have been regularly sprayed with larvicides to control the vector of dermal filariasis caused by Onchocerca volvulus. Since the beginning of the programme invertebrates and fish data were collected to monitor adverse effects on non-target organisms. The regular series of biological and hydrological data collected in two Guinean rivers were analysed to evaluate the effects of rotational larviciding with particular attention to permethrin, as preliminary acute toxicology tests and semi-field experiments suggest it has stronger effects on non-target fauna in respect to other larvicides. Invertebrates and fish variations in biomass and species richness are seasonal and flow-related and the results presented here do not support any evidence of specific effects of permethrin application on the biological targets monitored. Larvicide applications influence community structures, putting pressure on some taxonomic groups, causing, for example, the rarefaction of some taxa. In spite of the above results, the scarcity of some invertebrate systematic units does not result in a significant reduction of total invertebrate density because of the corresponding increase in other systematic units. In nature the studied aquatic communities would rarely be in equilibrium because of frequent natural stresses, such as drought and spate events, the biological variations discussed are to be considered ecologically acceptable.

Pupation site selection of cat fleas (Siphonaptera: Pulicidae) in various carpet types and its influence on insecticide efficacy.

Pupation sites of cat flea, Ctenocephalides felis (Bouché), larvae were determined in three styles of nylon and one style of wool carpet. Nylon saxony carpet had 59.3% of pupae at the top of the pile and 40% at the base of the pile. In nylon contract carpet, 55.2% of pupae were found at the top, 42.6% in the middle, and only 2.2% at the base of the pile. Nylon loop carpet contained 59.2% of pupae at the base, 25.5% in the middle, and 15.3% in the top of the pile. Wool loop carpet had 92.4% at the base and 3.8% both in the middle and top of the pile. Bioassays comparing the control of pupae manually placed at the base of carpets to that in carpets with natural pupation showed that control of pupae in the latter was 39-68% higher. Pupal control after natural pupation was greatest in nylon saxony and nylon contract carpets and lowest in nylon loop and wool loop carpets. Additional studies demonstrated that vacuuming provided the same level of pupal control on nylon saxony carpet as a spray application of permethrin to the carpet surface. Therefore, pupae that survived chemical and mechanical control treatments in nylon saxony carpet probably pupated away from the surface of the pile. Application of permethrin to the base of nylon saxony carpet did not significantly increase control. Future bioassays with cat flea pupae in carpet should be performed after natural pupation and consider carpet make and style.

A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies

Background: The conventional antiscabietics have poor compliance. Ivermectin, an oral antiparasitic drug, has been shown to be an effective scabicide and could be a useful substitute. Objective: This study compares the efficacy of oral ivermectin with topical permethrin cream in the treatment of scabies. Methods: Eighty-five consecutive patients were randomized into 2 groups. Forty patients and their family contacts received 200 μg/kg body weight of ivermectin, and another 45 patients and their family contacts received a single overnight topical application of 5% permethrin cream. Patients were followed up at intervals of 1, 2, 4, and 8 weeks. Results: A single dose of ivermectin provided a cure rate of 70%, which increased to 95% with 2 doses at a 2-week interval. A single application of permethrin was effective in 97.8% of patients. One (2.2%) patient responded to 2 applications at a 2-week interval. Permethrin-treated patients recovered earlier. Conclusion: A single application of permethrin is superior to a single dose of ivermectin. Two doses of ivermectin is as effective as a single application of permethrin. The temporal dissociation in clinical response suggests that ivermectin may not be effective against all the stages in the life cycle of the parasite. (J Am Acad Dermatol 2000;42:236-40.)