Permeability Coefficient Research Articles

Permeability characteristics and mechanism of tungsten tailings treated by the acid solutions

<p>Most of the tungsten tailings (TTs) are filled in the open. As a result, the phenomenon that acid rain influences the engineering geological characteristics of tungsten tailings is impossible to avoid, especially in southern China, where acid rain occurs frequently. This work studied the permeability properties of TTs treated with different acid solutions. The HCl, H2SO4, and H3PO4 solutions were prepared as the permeate fluids with pH values of 7, 5, 4, and 3. The falling head permeability test studied the TTs’ permeability characteristics under different acid solutions action. The microscopic mechanism of the movement of the acid solutions and TTs was analyzed based on X-ray diffraction results and nuclear magnetic resonance. The experimental results show that the permeability coefficient of TTs decreases first and then increases with the pH value of HCl and H2SO4 solutions and first increases and then decreases and then increases with the pH value of H3PO4 solutions. When the pH value >3, the effect of acid on the permeability coefficient is satisfied with HCl >H2SO4> H3PO4; otherwise, it is satisfied with H2SO4> H3PO4> HCl. The development law of T2 spectrum distribution is consistent with the permeability coefficient of TTs treated with the same acid solution. The acid solutions react with chlorite and calcite in the tailings, which affects the permeability of TTs treated by the acid solution. Therefore, preventing the infiltration of acid solutions from entering the tailings is conducive to improving the stability of tungsten tailings dams.</p>

An Inversion Study of Reservoir Colluvial Landslide Permeability Coefficient by Combining Physical Model and Data-Driven Models

The saturated permeability coefficient (ks) is a key parameter for evaluating the seepage and stability of reservoir colluvial landslides. However, ks values obtained from traditional experimental methods are often characterized by large variations and low representativeness. As a result, there are significant deviations from actual observations when used in seepage field calculations for reservoir landslide analysis. This study proposes an intelligent inversion method that combines a physical model and a data-driven model for reservoir landslide ks based on actual groundwater level (GWL) monitoring data. This method combines Latin Hypercube Sampling (LHS), unsaturated flow finite element (FE) analysis, particle swarm optimization algorithm (PSO), and kernel extreme learning machine model (KELM). Taking the Hongyanzi landslide in Sichuan Province, China, as the research object, the GWL of the landslide under different ks was first obtained by LHS and transient seepage FE analysis. Then, a nonlinear functional relationship between ks and the landslide GWL was fitted based on the PSO-KELM model. Finally, the optimal landslide ks was obtained by minimizing the root-mean-squared error between the predicted and actual GWL using the PSO. A global sensitivity analysis was also conducted on the ks of different rock and soil layers to reveal their control rules on the calculation of landslide GWL. The research results demonstrate the feasibility of the proposed method and provide valuable information for similar landslides in practice.

Separation of acetochlor through polymeric membrane system

In this study, an acetochlor belonging to the herbicide group was transported using a synthesized polymer inclusion membrane (PIM). Tricapryl-methylammonium chloride (Aliquat 366) and cellulose triacetate (CTA) were used as carrier and support material, respectively, in the membrane structure. The acetochlor samples taken during the transport from the donor phase containing 0.1 M HCl to the acceptor phase containing pure water were determined by Liquid Chromatography Mass Spectrometry (LC-MS/MS). The permeability coefficient (P), rate constant (k), and material flow rate (J) values were calculated at the end of the transportation processes. The recovery factor (%) was determined to be 91.2 % at the end of 240 min of transportation time. The effects of relative amounts of the target analyte, carrier, and acid type on the donor phase were determined, as well as those of the acceptor phase pH and stirring effect. The results achieved in this study suggest that a stable and environmentally sustainable polymer inclusion membrane system might be used to effectively transport acetochlor.

Research on Spatial Distribution Pattern of Stability Inter-Controlled Factors of Fine-Grained Sediments in Debris Flow Gullies—A Case Study

Studies on the stability inter-controlled factors of fine-grained sediments in debris flow gullies play an important role in predicting the scale and danger of debris flows. However, up to the present, few studies have been carried out on the spatial distribution pattern and causes of stability inter-controlled factors of fine-grained sediments in debris flow gullies, leading to difficulty in finding the dangerous section of debris flow gullies to be monitored and controlled to reduce disaster losses. Therefore, the objective of this paper is to analyze the spatial distribution pattern and causes of stability inter-controlled factors (grain size, permeability coefficient, shear strength, and porosity), taking the Beichuan Debris Flow Gully, China, as a case. After collecting soil samples in the field, we carried out experiments to measure the stability inter-controlled factors and, from these, the results show that (1) fine-grained sediments in this case are mainly silty loams, which are stable under non-heavy rains; (2) the grain size of silty loams is mainly concentrated between 10 and 20 μm, with a spatial distribution pattern of fine in the middle and coarse at both ends; (3) the permeability coefficient of silty loams is concentrated between 1.15 and 2.17 m/d, with a spatial distribution pattern of high in the middle and low at both ends; (4) the average cohesion of silty loams is mainly concentrated between 20 and 30 kPa, with a spatial distribution pattern of low in the middle and high at both ends; and (5) the internal friction angle of silty loams is concentrated between 18.98 and 21.8°, with a spatial distribution pattern of high in the middle and low at both ends. The main reasons for these spatial distribution patterns are analyzed from three aspects of shear strength, water flow velocity, and terrain, which can provide a scientific basis for the prediction of debris flow disasters in such areas.

Sustainable solutions: Transforming waste shield tunnelling soil into geopolymer-based underwater backfills

Waste shield tunnelling soil is often utilized as backfill materials in engineering practice. However, traditional backfill materials exhibit poor backfilling performance in underwater condition, which is even more commonly encountered in backfilling projects. In response to this issue, this study introduces a geopolymer-based underwater controlled low-strength material (UWCLSM) that utilizes recycled waste shield tunnelling soil and granulated blast furnace slag (GBFS). The UWCLSM demonstrates promising underwater performance, making it a viable candidate as a new underwater construction material. Key characteristics include a flowability exceeding 280 mm, unconfined compressive strength ranging from 1 to 2 MPa, high resistance to water erosion with an anti-washout strength ratio consistently above 80%, and a permeability coefficient lower than 10−7 cm/s. The addition of anti-washout admixtures (AWA) plays a pivotal role in enhancing the UWCLSM's underwater performance. Polyacrylamide (PAM) effectively attracts soil particles, depolymerized GBFS monomers, and cement particles, reducing dispersion in water. An optimal amount of PAM forms cross-linked composites with GBFS and soil particles, resulting in slight improvements in UCS, shear strength, and impermeability. The combination of PAM and carboxymethyl cellulose enhances UWCLSM's cohesion and viscosity, optimizing its suitability for underwater applications. Moreover, the UWCLSM's cost, CO2 emissions, and energy consumption are only 55.6%, 16.7%, and 16.1% of those associated with traditional materials, contributing to sustainability and offering significant environmental benefits, respectively.

An update of skin permeability data based on a systematic review of recent research

The cutaneous absorption parameters of xenobiotics are crucial for the development of drugs and cosmetics, as well as for assessing environmental and occupational chemical risks. Despite the great variability in the design of experimental conditions due to uncertain international guidelines, datasets like HuskinDB have been created to report skin absorption endpoints. This review updates available skin permeability data by rigorously compiling research published between 2012 and 2021. Inclusion and exclusion criteria have been selected to build the most harmonized and reusable dataset possible. The Generative Topographic Mapping method was applied to the present dataset and compared to HuskinDB to monitor the progress in skin permeability research and locate chemotypes of particular concern. The open-source dataset (SkinPiX) includes steady-state flux, maximum flux, lag time and permeability coefficient results for the substances tested, as well as relevant information on experimental parameters that can impact the data. It can be used to extract subsets of data for comparisons and to build predictive models.

Calculation of and Key Influencing Factors Analysis on Equivalent Resilient Modulus of a Submerged Subgrade.

To calculate and analyze the equivalent resilient modulus of a submerged subgrade, a constitutive model considering the effect of saturation and matrix suction was introduced using ABAQUS's user-defined material (UMAT)subroutine. The pavement response under falling weight deflectometer (FWD) load was simulated at various water levels based on the derived distribution of the resilient modulus within the subgrade. The equivalent resilient modulus of the subgrade was then calculated using the equivalent iteration and weighted average methods. Based on this, the influence of the material and structural parameters of the subgrade was analyzed. The results indicate that the effect of water level rise on the tensile strain at the bottom of the asphalt layer and the compressive strain at the top of the subgrade is obvious, and its trend is similar to an exponential change. The equivalent resilient modulus of the subgrade basically decreases linearly with the rise in the water level, and there is high consistency between the equivalent iteration and weighted average methods. The saturated permeability coefficient and subgrade height have the most significant effect on the resilient modulus of the subgrade, which should be emphasized in the design of submerged subgrades, and the suggested values of the resilient modulus of the subgrade should be proposed according to the relevant construction conditions.

Influence of Mineral Admixtures on the Performance of Pervious Concrete and Microscopic Research

Pervious concrete is an innovative eco-friendly construction material. Through the application of mineral admixtures and microscopic analysis to optimize its performance and analyze its mechanisms, its traits as a sustainable building option may be further improved. This study primarily examines the impact of the optimal blend quantities of fly ash, silica fume, and reinforcing agent on the attributes, micro-morphology, and phase composition of porous concrete. The optimal admixture was chosen after analyzing the effects of various factors on the mix ratio and properties of permeable concrete. To understand the degree of impact, performance tests were conducted on the 28-day compressive strength, water permeability coefficient, and porosity. Furthermore, the micro-mechanisms of the admixtures and reinforcing agents on the properties of permeable concrete were analyzed from a microscopic point of view using scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. This research found that the advantageous properties of permeable concrete were enhanced by the simultaneous integration of appropriate quantities of fly ash, silica fume, and reinforcing agent. This resulted in a 28-day compressive strength of 18.33 MPa and a permeability coefficient of 8.27 mm/s. Compared with the unadulterated mineral admixture, the optimal admixture of fly ash, silica fume, and reinforcing agent at the same time increased the 28-day compressive strength by about double; the permeability coefficient was reduced by 36%, but it was still at a high level; and the measured porosity did not differ much from the designed porosity. Through thorough microanalysis, the hydration reaction was significantly improved, which could enhance the microstructure and pore structure of the concrete. This was supported by a substantial increase in the macroscopic compressive strength and a decrease in the water permeability coefficient, which were consistent with the aforementioned enhancement found in the microanalysis.

Assessment of stability of earth dams based on construction pace by fuzzy inference logic

This study aims to evaluate the earth dam stability fuzzy model based on the pace of construction by way of influential parameters, including the dam construction time (embankment consolidation time) in the stability analysis of earth dams. A fuzzy inference system based on the Sugeno inference engine was developed, and 620 if-then rules in plane strain and axial symmetry (Plaxis) were used to train the fuzzy system. The input parameters included the dam height, crest width, dam slope, cohesion, friction angle, elasticity modulus, Poisson’s ratio, unsaturated unit weight, consolidation (construction) time and permeability coefficient, with the factor of safety output. To develop the fuzzy inference system, a triangular membership function was employed, calculating the influential parameters over five periods in Matrix laboratory (Matlab) software. The fuzzy model results were compared with the results of numerical Plaxis and fast Lagrangian analysis of continua models. High coefficients of determination (R2) suggest good agreement between the fuzzy and numerical models, and it can be assumed that the proposed fuzzy model is efficient and effective for the stability analysis, and hence assessment of factors of safety, of earth dams.

Study on the use of CO2 to strengthen recycled aggregates and pervious concrete

Recycled aggregates (RA) are crushed materials derived from waste concrete or construction debris that play a crucial role in the recycling of construction waste resources. However, RA's irregular particle shape and surface cement paste adhesions limit its potential in pervious concrete applications. To overcome this limitation, the use of carbonation treatment methods to process RA and produce recycled aggregate pervious concrete (RAPC) was investigated. RA was subjected to a pre-carbonation treatment, followed by the production of RAPC mixtures using three slurry-to-aggregate ratios, carbonation curing, and two-step carbonation strengthening, which enhanced the physical and mechanical properties of the specimens. Then, the measurements including permeability coefficient, connected pore fraction, splitting tensile strength, and CT microstructure analysis were performed. A carbon footprint accounting system from "cradle to gate" was conducted to assess the specimens. Our results highlight that an increase in the slurry-to-aggregate ratio in RAPC mixtures results in enhanced mechanical properties but negatively affects permeability performance. By pre-carbonating RA, we significantly increase the pervious concrete's splitting tensile strength, up to 100%, and maintain the compactability while ensuring permeability performance (maximum 3.91% reduction for specimens with slurry-to-aggregate ratio of 0.3). The carbonation treatment method used in our study has ideal environmental effects, as it theoretically sequesters up to 58.12% of the total carbon emissions produced during the production process.

A Novel Calculation Model for the Permeability Coefficient of Soils Conditioned with Foam and Bentonite Slurry

A Novel Calculation Model for the Permeability Coefficient of Soils Conditioned with Foam and Bentonite Slurry

Innovative high-strength, high-permeability concrete for large-scale applications in permeable subgrade of highway tunnel

The durability of concrete roads in mountainous regions may be reduced due to underground water infiltration and surface water erosion within highway tunnels. A promising solution is the use of pervious concrete as a drainage subgrade layer to drain away the water, and then to prevent water-induced pavement damage of pavement. For pervious concrete to be an ideal drainage layer for high-traffic loads, it must have compressive strength and permeability coefficient exceeding 25 MPa and 15 mm/s, simultaneously. However, traditional pervious concrete tends to emphasize either in high-strength or high-permeability, depending on its porosity. This study introduces an innovative proportion design method of pervious concrete, which enables higher compressive strength and permeability coefficient by adjusting its skeleton structure, and thus catering to high-traffic load applications. In addition, the workability and setting time of pervious concrete were optimized according to the local environmental conditions, facilitating large-scale and efficient paving of the drainage subgrade. As a result, a drainage subgrade layer with a 28-day compressive strength of 26.43 MPa and permeability coefficient of 18.86 mm/s was successfully applied in a highway tunnel. This study provides a theoretical framework and technical support for widespread application of pervious concrete in drainage subgrade of high-traffic load road.

Effects of alkali activator on the chloride-ion permeability of one-part alkali-activated nickel slag concrete

Herein, the effects of the ionic types and content of alkali activator on the chloride-ion permeability of one-part alkali-activated nickel slag concrete were examined. The NT Build 492 method was adopted to measure the Cl− transport performance. In general, the total Cl− concentration in concrete decreases with the increase of penetration depth; however, the enrichment of Cl− concentration in the sample is not obvious. Anions have more effect on 28-d compressive strength, while cations have more effect on chlorine-ion permeability. For the same Na2O content, SiO32−-activator and Na+-activator perform better than other anions and cations, while OH– and K+ perform worse than other ions. The chloride-ion permeability coefficient (DRCM) of concrete with Na2SiO3 is the lowest and that with KOH is the highest. The DRCM of concrete prepared with KOH is 1.93 times higher than that of concrete prepared with Na2SiO3. When the activator is Na2SiO3, the DRCM of concrete decreases with the increase in Na2O content when the Na2O content is less than 7%. However, when the Na2O content exceeds 7%, the DRCM of concrete increases with the increase in Na2O content.

Hyaluronan/B12-chitosan polyelectrolyte complex for oral colistin administration

Polyelectrolyte complexes (PECs) based on polysaccharides, including hyaluronic acid (HA) and chitosan (CS), are promising delivery systems for antimicrobial agents, including oral administration of the peptide antibiotic colistin (CT). Modification of CS with different targeting ligands to improve intestinal permeability is a suitable way to improve the oral bioavailability of polyelectrolyte particles. This study describes the procedure for obtaining CT-containing PECs based on HA and CS modified with cyanocobalamin (vitamin B12). In this case, vitamin B12 is used as a targeting ligand because it is absorbed in the ileum via specific transporter proteins. The resulting PECs had a hydrodynamic size of about 284 nm and a positive ζ-potential of about 26 mV; the encapsulation efficiency was 88.2 % and the CT content was 42.2 μg/mg. The developed systems provided a two-phase drug release: about 50 % of the CT was released in 0.5–1 h, and about 60 % of the antibiotic was cumulatively released in 5 h. The antimicrobial activity of encapsulated CT was maintained at the same level as the pure drug for at least 24 h (minimum inhibitory concentration against Pseudomonas aeruginosa was 2 μg/mL for both). In addition, the apparent permeability coefficient of CT in the PEC formulation was 2.4 × 10−6 cm/s. Thus, the incorporation of CT into HA- and vitamin B12-modified CS-based PECs can be considered as a simple and convenient method to improve the oral delivery of CT.

Water inflow prediction and waterproof-drainage system optimization in undersea tunnel

This study focuses on the Shantou Bay Undersea Tunnel and engages in theoretical research to develop a water inflow prediction formula associated with pore water pressure, building upon Darcy’s law. The formula has stronger adaptability. Moreover, Grey Relational Analysis is conducted based on theoretical formulas considering various factors to identify the factors influencing the circumferential water inflow ranking in the tunnel. Subsequently, stability analysis of undersea tunnel waterproof and drainage systems is carried out, considering three forms of waterproof and drainage: full-encapsulation non-discharge, full-encapsulation controlled-discharge, and semi-encapsulation free-discharge. The results indicate that, in cases involving grouting, the water inflow prediction formula correlates with seven factors, including the grouting ring permeability coefficient and tunnel dimensions. Grey Relational Analysis reveals that the three most influential factors affecting water inflow in the undersea tunnel are, respectively, the far-field hydraulic head, tunnel outer diameter, and grouting ring permeability coefficient. Analyzing the seepage field distribution around the tunnel bore, it is observed that grouting has the most significant improvement in the seepage field for the full-encapsulation controlled-discharge form. Regarding water seepage, grouting has the most substantial impact on improving water seepage for the semi-encapsulation free-discharge form. Considering the displacement field, reductions are more pronounced in both the full-encapsulation controlled-discharge and semi-encapsulation free-discharge forms. Therefore, in conjunction with radial grouting, adopting a full-encapsulation controlled-discharge drainage system is more suitable for practical engineering applications. This approach reduces both economic costs and the risk of water inflow in the undersea tunnel.

Influence of Bile Acids on Clindamycin Hydrochloride Skin Permeability: InVitro and InSilico Preliminary Study.

Topical clindamycin formulations are widely used in clinical practice, but poor bioavailability and restricted skin penetration considerably limit their therapeutic efficacy. Penetration enhancement represents a promising and rational strategy to overcome the drawbacks of conventional topical pharmaceutical formulations. We aim to assess the influence of cholic acid (CA) and deoxycholic acid (DCA) on the permeability of clindamycin hydrochloride by performing the in vitro skin parallel artificial membrane permeability assay (skin-PAMPA) at two relevant pH values (5.5 and 6.5) and the interactions of tested substances with skin ATP-binding cassette (ABC) transporters in silico. After the incubation period, the clindamycin hydrochloride concentrations in both compartments were determined spectrophotometrically, and the apparent permeability coefficients (Papp) were calculated. Vienna LiverTox web service was used to predict the interactions of clindamycin and bile acids with potential drug transporters located in human skin. Both CA and DCA at the highest studied concentration of 100μM in the tested solutions increased the skin-PAMPA membrane permeability of clindamycin hydrochloride. This effect was more pronounced for CA and at a higher studied pH value of 6.5, which is characteristic of most dermatological indications treated with topical clindamycin preparations. Clindamycin transport may also be mediated by ABC transporters located in skin and facilitated in the presence of bile acids. The results of this study provide a solid foundation for further research directed at the improvement of topical formulations using bile acids as penetration-enhancing excipients, as well as the therapeutic efficacy of clindamycin hydrochloride.

Trophoblast stem cell-based organoid models of the human placental barrier

Human placental villi have essential roles in producing hormones, mediating nutrient and waste exchange, and protecting the fetus from exposure to xenobiotics. Human trophoblast organoids that recapitulate the structure of villi could provide an important in vitro tool to understand placental development and the transplacental passage of xenobiotics. However, such organoids do not currently exist. Here we describe the generation of trophoblast organoids using human trophoblast stem (TS) cells. Following treatment with three kinds of culture medium, TS cells form spherical organoids with a single outer layer of syncytiotrophoblast (ST) cells that display a barrier function. Furthermore, we develop a column-type ST barrier model based on the culture condition of the trophoblast organoids. The bottom membrane of the column is almost entirely covered with syndecan 1-positive ST cells. The barrier integrity and maturation levels of the model are confirmed by measuring transepithelial/transendothelial electrical resistance (TEER) and the amount of human chorionic gonadotropin. Further analysis reveals that the model can be used to derive the apparent permeability coefficients of model compounds. In addition to providing a suite of tools for the study of placental development, our trophoblast models allow the evaluation of compound transfer and toxicity, which will facilitate drug development.

Experimental investigation of pressure drop and heat transfer in porous media based on 3D printed triple periodic minimum surfaces

ABSTRACT Porous media are widely preferred for heat transfer applications because of complex structure and high porosity. It is relatively easy to produce complex structures with the additive manufacturing method. In this study, Gyroid-based triple periodic minimal surface is produced ABS (Acrylonitrile butadiene styrene) and PLA (polylactic acid) materials using 3D printers. The pressure drops and heat transfer in the porous structure with the gyroid model are investigated experimentally. Permeability and Forchheimer coefficients are determined for each gyroid porous channel. While the permeability and Forchheimer coefficient of the porous medium of PLA were calculated as 2.97 × 10−8 m2 and 0.07, respectively, the permeability and Forchheimer coefficient of the porous medium of ABS were calculated as 5.52 × 10−8 m2 and 0.09. The correlation between the Reynolds number and pressure drop per length is given. The gyroid structure-filled channel is heated by an asymmetric heat flux on the bottom side. The convection heat transfer in polymer-based porous media was investigated. Also, the correlation between the Nusselt number and the Reynolds number based on permeability is presented. While the Nusselt correlation of the PLA porous medium was obtained as N u K = 0.08 R e K 0.57 , the Nusselt correlation of the ABS porous medium was found to be N u K = 0.09 R e K 0.61 . There are improvements in heat transfer due to the flow mixing effect of the porous medium. The study aims to broaden the current knowledge of heat transfer in polymer porous structures. Especially, this study investigates heat transfer and flow in polymer-based porous structures with a low thermal conductivity coefficient produced by 3D printers.

Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae

Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major contributor to the declining efficacy of antibiotics through both acquired resistance and tolerance. In this study, a pan-drug resistant (PDR), NDM-1 and CTX-M-15 co-producing isolate of K. pneumoniae, CDC Nevada, (Kp Nevada) was exposed to the clinical combination of aztreonam + ceftazidime/avibactam (ATM/CAZ/AVI) to overcome metallo-β-lactamases. Unexpectedly, the β-lactam combination resulted in long filamentous cell formation induced by PBP3 inhibition over 168 h in the hollow fiber infection model experiments with eventual reversion of the total population upon drug removal. However, the addition of imipenem to the two drug β-lactam combination was highly synergistic with suppression of all drug resistant subpopulations over 5 days. Scanning electron microscopy and fluorescence microscopy for all imipenem combinations in time kill studies suggested a role for imipenem in suppression of long filamentous persisters, via the formation of metabolically active spheroplasts. To complement the imaging studies, salient transcriptomic changes were quantified using RT-PCR and novel cassette assay evaluated β-lactam permeability. This showed significant upregulation of both spheroplast protein Y (SPY), a periplasmic chaperone protein that has been shown to be related to spheroplast formation, and penicillin binding proteins (PBP1, PBP2, PBP3) for all combinations involving imipenem. However, with aztreonam alone, pbp1, pbp3 and spy remained unchanged while pbp2 levels were downregulated by > 25%. Imipenem displayed 207-fold higher permeability as compared with aztreonam (mean permeability coefficient of 17,200 nm/s). Although the clinical combination of aztreonam/avibactam and ceftazidime has been proposed as an important treatment of MBL Gram-negatives, we report the first occurrence of long filamentous persister formation. To our knowledge, this is the first study that defines novel β-lactam combinations involving imipenem via maximal suppression of filamentous persisters to combat PDR CDC Nevada K. pneumoniae.

Preparation and Performance Study of High-Strength and Corrosion-Resistant Cement-Based Materials Applied in Coastal Acid Rain Areas.

Investigations regarding the preparation and durability of cement-based materials applied in specific coastal acid rain environments are scarce, particularly those involving the addition of four auxiliary cementitious materials (ACMs) to cement for modification. To improve the durability of concrete structures in coastal acid rain areas, a systematic study was conducted regarding the preparation of high-strength and corrosion-resistant cement-based materials using ACM systems composed of fly ash (FA), granulated blast furnace slag (GBFS), silica fume (SF), and desulfurization gypsum (DG) instead of partial cement. Through an orthogonal experimental design, the effect of the water-binder ratio, cementitious ratio, and replacement cement ratio on the compressive strength, corrosion resistance coefficient, and chloride ion permeability coefficient of the materials were analyzed and the mix proportions of the materials were evaluated and optimized using the comprehensive scoring method. The results show that implementing a FA:GBFS:SF:DG ratio of 2:6:1:1 to replace 60% of cement allows the consumption of calcium hydroxide crystals generated through cement hydration, promotes the formation of ettringite, optimizes the pore structures of cementitious materials, and improves the compressive strength, acid corrosion resistance, and chloride ion permeability of the materials. This study provides a reference for selecting concrete materials for buildings in coastal acid rain environments.