In this study, the heat and mass transfer of the blood flow, particularly in a capillary tube having a porous lumen and permeable wall in the presence of external magnetic field are considered. The velocity, temperature and concentration of blood flow become unsteady due to the time dependence of the stretching velocity, surface temperature and surface concentration. The thermal and mass buoyancy effect on blood flow, heat transfer and mass transfer are taken into account in the presence of thermal radiation. This analysis is very much useful in the treatment of cardiovascular disorders. The equations governing the flow under some assumptions are complex in nature, but capable of presenting the realistic model of blood flow using the theory of boundary layer approximation and similarity transformation. First, the system of coupled partial differential equations (PDEs) is converted into a system of coupled ordinary differential equations (ODEs). Then the solutions are obtained by Runge-Kutta method of 4thorder with shooting technique. The effects of various parameters such as Hartman number, radiation parameter, unsteadiness parameter, permeable parameter, thermal buoyancy parameter, Prandtl number, mass buoyancy parameter, velocity slip parameter, thermal slip parameter, Schmidt number on velocity, temperature, concentration, skin friction, Nusselt number and Sherwood number are depicted through graphs. Local Sherwood number enhances because of increase in Schmidt number. Moreover, some of the important results, which are discussed in the present study and have an impact on diseases like hyperthermia, stoke and moyamoya in human body.