Impact-generated hydrothermal systems are a potential habitat for life on Earth and other planetary bodies. The ubiquity of impact craters on Mars makes them of particular interest for the search for life on this planet although their viability as a habitat is not well understood. To better understand such systems, two analogue impact structures on Earth were investigated, as their dominantly basaltic target rock makes them similar to impact structures in the Martian crust: the Vista Alegre and Vargeão Dome impact structures in Brazil.The goals of this paper are to 1) better understand the Vista Alegre and Vargeão Dome impact structures, and 2) understand how impact-generated hydrothermal systems on Earth can be compared with similar systems on Mars. To enable comparison, the software HYDROTHERM is used to reconstruct the hydrothermal evolution of both impact systems on Earth. Permeability, porosity, thermal conductivity, and initial temperature distributions are varied to simulate slow--, medium-, and fast-cooling models. The medium cooling rate models are then adapted to Martian conditions and scaled to 1×, 2×, 4×, and 8× the size on Earth, also adapting the impact energy and initial heat distribution, to check the comparability using similar target rocks. Finally, target rocks are changed to a basaltic composition only, to check how a lower-permeability Martian surface composition would affect the hydrothermal system.The models indicate between 150 and 650 thousand years (ka) of hydrothermal activity for both the Vista Alegre and Vargeão Dome impact structures. Due to the limited availability of water in the initial, high-temperature situation in the crater centre, water flux first increases and then decreases, although after 650 kyr the water flux towards the crater centre remains active in Vargeão Dome only. This sustained water flux is likely related to the low relative pressure in the crater centre due to the lack of overlying rock in comparison to outside the crater, as well as the direct connection of an underlying sandstone aquifer with high-permeability, fractured basalt in the centre of the structure.The Martian models with the same lithologies as on Earth show overall lower water flux and contain permafrost, which prevents the water flux within the aquifer from outside the crater towards the crater centre as seen in Vargeão Dome. The cooling times increase with scaling from 1× to 8× the size to ∼0.2 and 5 Myr, respectively. With only basalts in the target, cooling times reach ∼0.2 to 9 Myr. However, in that case, the water flow only remains active for up to the first Myr, and a minimum crater diameter of approximately 40 km is needed to achieve surface water fluxes close to those in Vargeão Dome and Vista Alegre.Below the Martian surface, hydrothermal system activity can persist for millions of years, providing potential for supporting life. Unfortunately, these parts of the system are currently unreachable for both sampling and spectroscopic techniques, and the short lifetime and low water fluxes at the surface related to the permafrost layers do not favour impact-generated hydrothermal systems on present-day Mars as targets for the search for life. However, these systems are highly dependent on the rock types and related permeabilities and could have provided habitats before 3.5 Ga, when the planet was warmer and liquid water was present at the surface.