City Of Perm Research Articles

The evolution of students’ digital skills as a source of transformation of the learning process in general and vocational education organizations

Mastering digital skills is one of the requirements of the modern world. Digital skills are usually divided into professional and user skills. Professional skills are formed in the systems of secondary, higher, and additional vocational education. User skills can be mastered in the system of general education. The boundaries between professional and user digital skills are increasingly blurred, and, therefore, it is necessary to rethink the requirements for the results of professional and general education in terms of the formation of digital skills.The material of the described study were the results of an independent assessment of digital skills of 8th grade students commissioned by the Department of Education of the Perm City Administration. The content of the independent assessment was designed considering modern international studies on the quality of education as well as primary idea that the digital literacy of each user promotes the building of a conscientious, fair, and secure digital community. The article has been prepared as an interdisciplinary publication that integrates aspects of general and professional pedagogy, methods of teaching mathematics and informatics, and the technical aspect of using software for processing large amounts of data.The study revealed new opportunities for the formation and assessment of digital skills of students of general educational organizations and, as a consequence, formulated recommendations for the training of teachers of mathematics and informatics both in terms of the disciplines content and teaching methods.

Zurov Alexander Alexandrovich (1863–1937), major-general retired, Jägermeister, acting manager of the office at the court of grand duchess Elizabeth Feodorovna: a found face

This article, as well as our previous ones («Vestnik of the Perm Federal Research Center» № 3, 2021, and № 3, 2022), is devoted to the 300th anniversary of the city of Perm (1723–2023), and continues our investigation on the identification of historical personalities who took the active part in the reception of Grand Duchess Elizabeth Feodorovna and her sister – Princess Victoria von Battenberg in Perm in July 1914. As a reminder, in the book, published by the Demidov Institute (Yekaterinburg, 2007), «I.F. Koshko, Memories of the Governor, 1911–1914» there were some mistakes revealed in the representation of personalities in the group photo taken in the garden of the governor's house in Perm. As it turned out, not only V.I. Europeus and A.P. Kornilov, but also many other persons were incorrectly indicated. Since there is no information concerning this photo found in Perm archives and in «Permskie vedomosti» of 1914, we hope our investigation will be interesting not only to local historians, but also to everyone who is interested in history. In the article, we give brief information about each person presented in the photo and, most importantly, provide additional photos confirming the identity of those persons.

Soil contamination by plastic particles in the floodplain of the small Danilikha River in an urbanized area

The aim of the study. To assess the content, morphology and surface degradation degree of plastic particles in the Danilikha river floodplain soils in an urbanized area. Location and time of the study. The study was conducted in a recreational area in the projected “Kamensky Square”, located on the left bank of the low floodplain of the small Danilikha River (a left-bank tributary of the Kama River) in the city of Perm. Urban-alluvial gray-humus gley soils were identified in the area. Soil samples were taken from surface horizons in July 2023. Methods. To extract plastic particles from soil we used visual selection, sieving, and flotation in a saturated NaCl solution. The shape and type of plastic particles were determined visually by external features. Natural organic matter was removed with Fenton's reagent. Surface morphology of the of plastic particles and their number were determined using a stereomicroscope. Information-logical analysis was used to determine the relationship between the shape of plastic particles and their sizes. Results. In the combined soil sample from the surface horizons, the number of plastic particles reached 177 pieces/kg (excluding fibers). The mass of plastic particles, including fibers, was 0.7 g/kg. Films prevailed quantitatively among the forms of plastic particles (62%), whereas foam and foam balls made up 34% and 4%, respectively. By mass, particles predominated in the following sequence: foam balls ˃ film ˃ fiber ˃ foam. The size range was dominated by large plastic particles from 1.1 to 15 mm. Specific sizes of plastic particles for different shapes were established. Conclusions. For the first time, the content of plastic particles in the surface soil horizons of the Danilikha river floodplain in an urbanized territory was studied using the case of a recreational zone in the projected Kamensky Square. Plastic particles had different sizes and shapes, which indicated a variety of contamination sources. Contamination of the studied soils with plastic particles can be regarded as moderate. The surface degradation degree of plastic particles indicated their active weathering, which occurs in soil under neutral reaction. The surface degradation of the plastic particles was also actively influenced by external factors that act before plastics enter alluvial soils. To detect soil contamination with plastic particles, we recommend Perm municipal authorities to organize monitoring of plastics content in areas with high anthropogenic pressure.

ЗАКОНОМЕРНОСТИ ПОКАЗАТЕЛЯ ТРАНСПОРТНОГО ЗАТОРА НА НЕКОТОРЫХ ПЕРЕСЕЧЕНИЯХ УЛИЧНО-ДОРОЖНОЙ СЕТИ

The average speed and density of road transport are used as indicators of the congestion situation, but do not allow tracking the evolution (stages of formatting, progressing, and vanishing) of traffic congestion. The authors proposed and justified a quantitative indicator of traffic congestion, which allows in an automated mode to identify the congestion situation on the urban road network using hardware and software video recording systems. The purpose of this study is due to the need to study the quantitative characteristics of the proposed indicator at characteristic intersections of urban roads, which will allow us to develop scientifically based recommendations for predicting congestion situations, substantiating, and making optimal decisions on measures to promptly eliminate traffic congestion. The object of study is the traffic flow at three types of intersections of the Perm city road network, equipped with a photo and video recording software and hardware complex. The subject of the study is the regularities of the evolution of the listed deterministic indicators of traffic flows, which can be used for operational forecasting of the formation, development, and elimination of traffic congestion. The theoretical and methodological approach is based on the methods of mathematical statistics used to process the results of observations of traffic flows at different types of intersections using a «sliding window», calculating the average daily value and standard deviation. The initial data were obtained with the help of hardware and software complexes for fixing violations of traffic rules installed on the street and road network of the Perm city. As a result of the study, the rational parameters of the «sliding window» were determined, ensuring the structuring of the traffic congestion indicator; the facts of the congestion situations formation were revealed; the features of the congestion evolution and the presence of problematic traffic directions for which it is advisable to change the traffic light regulation mode were determined. The theoretical and practical significance of the work consists in checking the operability of the proposed indicator and criterion of traffic congestion, which is of practical interest from the point of view of predicting anomalies in the movement of vehicles on the road network, adjusting the operating modes of traffic lights, etc. It is also possible to use the proposed traffic congestion indicator to assess the effectiveness of traffic light regulation on the Perm city road network. The direction of further research is to study the patterns of traffic congestion at intersections of the urban road network, of various types that are not included in this study.

Разработка стратегии озеленения г. Перми

This article presents the results of a study underpinning the Greening Strategy 2030 for the city of Perm. The research employed SWOT analysis — a technique that emerged within economics. In practice, SWOT analysis can be applied to objects of different scales outside profit-driven contexts to achieve social and socioeconomic purposes. In a broad understand­ing, SWOT analysis focuses on socioeconomic objects, an instance of which is urban green infrastructure. This study identifies and characterises Perm’s green infrastructure elements: conserva­tion areas, urban forests, public and limited access amenities and special-purpose objects. Strengths, weaknesses, opportunities, and threats of Perm’s current landscaping system are described, alongside potential development scenarios for the city’s green spaces up to 2030. A development strategy is outlined to achieve significant progress in landscaping and biodiver­sity conservation. Its other goals involve enhancing the urban environment by converting spontaneously growing vegetation into various landscaped areas, ranging from conservation zones to public amenities, and actively managing these areas. The study also defines the val­ues, vision and mission of green infrastructure, along with its purpose and long- and medi­um-term development plans.

Comparative assessment of COVID-19 incidence among healthcare workers and general population in the city of Perm

Objective. To compare the incidence of COVID-19 among healthcare workers and the general population.
 Materials and methods. A retrospective analysis of COVID-19 incidence among healthcare workers and the general population was conducted using official statistics from the Center of Hygiene and Epidemiology in Perm (Russia) for the period of 2020–2022. An epidemiological descriptive and analytical method was used.
 Results. During the pre-vaccination period, the disease incidence among healthcare workers exceeded that of the general population by 3.4 times. During the mass immunization period against the background of Delta strain circulation, there was a reduction in the severity of the epidemic process in both groups, while maintaining a trend towards an illness increase. When the Omicron strain appeared, there was revealed an explosive growth in the sickness rate among both healthcare workers and the general population, which was followed by a subsequent decline. Female healthcare workers had an illness rate 1.3 times higher than males. Among the afflicted healthcare workers, those aged 36–59 constituted the largest proportion. The share of infected in the group of 18–36 years and those of 60 and above was 24.7 % and 20.0 %, respectively. A similar gender and age structure of the disease was observed in the general population. The disease rate among doctors exceeded that of nurses and other medical personnel.
 Conclusions. It has been established that the severity of COVID-19 epidemic process among healthcare workers reliably exceeds that of the entire population with the similarity of qualitative manifestations of the epidemic process.

Variability of the SARS-CoV-2 Virus and the Susceptibility of the Population in the Dynamics of the Development of the Epidemic Process

Relevance. It is known that the main trigger for the development of the pandemic was the genomic diversity of viruses. Meanwhile, we did not find any studies on the influence of population susceptibility on the complex process of evolutionary transformations of the SARS-CoV-2 virus and their interdependent variability during the development of the pandemic. Aim. The study of the interdependent variability of two heterogeneous populations interacting in the dynamics of the development of the COVID-19 pandemic - the virus population and the population. Materials and methods. The study was conducted in the city of Perm from 03/01/2021. (Beginning of sequencing of the SARS-CoV-2 virus in the territory) until 01.01.2023. In weekly dynamics, the following were studied: SARS-CoV-2 genomic diversity (molecular genetic study of 2521 samples of biomaterial from patients), seroprevalence of the population (366,804 blood sera were examined for the presence of IgG), morbidity, disease prevalence rate and mortality (according to official statistics). The interpretation of the results was carried out in accordance with the provisions of the theory of self-regulation of parasitic systems by V.D. Belyakov. Results and discussion. An analysis of the genomic diversity of the virus during the pandemic made it possible to distinguish 5 periods. Three periods were characterized by the homogeneity of the pathogen population, when the variants Alpha, Delta and Omicron circulated. Two periods were characterized by the simultaneous circulation of two variants of viruses due to the adaptation of the virus to the changed habitat. Thus, the circulation of the Alpha variant in a population heterogeneous in terms of susceptibility (the proportion of seropositive ones increased to 52%) caused mutational changes in the virus genome with the formation of high transmission properties and high pathogenicity (according to the theory of V.D. Belyakov, the phase of formation of an epidemic variant). The formation of the epidemic variant of the pathogen (Delta genovariant) occurred within 12 weeks, it dominated for more than 6 months, increasing the incidence by 2.8 times, mortality by 17.3 times (epidemic spread phase). The increase in the incidence and large-scale vaccination increased the seroprevalence of the population to 70% or more. The Delta variant begins to adapt to a new habitat with a high proportion of immune organisms, the formation of the Omicron genovariant with high transmission and evasion of the immune response is underway (the phase of formation of the pathogen reservation variant). The pathogen population is heterogeneous; Delta and Omicron circulate simultaneously. Morbidity increases by 2.9 times, RT by 1.3 times, and mortality decreases by 5.1 times. Omicron replaces the Delta genovariant within 5 weeks, mortality decreases, while maintaining the distribution coefficient (reservation phase). Conclusions. Interdependent variability of the virus and the susceptibility of the population determined the phase development of the pandemic.

Types of city dwellers’attitudes towards service robots in the city of Perm

The effectiveness of robot implementation in various societal sectors depends not only on the robot’s technical characteristics but also on how different social groups perceive and interact with them. Social attitudes towards robots, in turn, are influenced by sociocultural and sociodemographic factors. In the context of the sociology of technology and actor-network theory, this research explores the social significance of technical devices, the processes of social adaptation, and communication with robots. However, empirical research on human-robot interaction (HRI), especially in the Russian context, remains limited. This article presents the results of a study that examines the perceptions of robots by actual and potential users in two aspects: the level of basic social attitudes towards new technologies and robots (social acceptability) and the evaluation of interactions with robots in specific situations (practical acceptability). The empirical basis of the study consists of survey data from customers at a multifunctional center providing state and municipal services in Perm. They received services from either a service anthropomorphic robot, Promobot V.4, or a human employee at the center. Using cluster analysis, three types (clusters) of attitudes towards innovations and robots were identified at the level of basic social attitudes: robo-skeptics, robo-phobes, and robo-philes. The social characteristics of these identified types were examined. The study introduces an original method for measuring satisfaction with actual interactions with service robots based on various parameters (evaluation of service convenience, communication quality, personal activity, willingness to recommend robot services, etc.). The study confirms the hypothesis of the connection between the type of attitude towards innovations and robots and the satisfaction with actual interactions with robots in specific situations. The lowest levels of satisfaction with robot interactions and the desire to avoid such interactions were observed among robo-phobes, who are more frequently represented by individuals of senior age group (age 55 and above). The research results allow determining the prospects for implementing service robots in the public space of a major Russian city based on understanding the social attitudes of users.

Analysis of the problems of the transport services market

The article provides a brief analysis of the problems of the transport services market in the Russian Federation on the example of the city of Perm and indicates directions for their solution.

The importance of vascular endothelial growth factor and polymorphism of the VEGF a gene (g634c) in the development of steatosis, fibrosis and cirrhosis of the liver patients in the city of Perm

Introduction. Chronic liver diseases are a significant medical problem all over the world. To date, there is a need to develop a set of laboratory tests, including genetic ones, to determine the risk of development and progression of steatosis, fibrosis and cirrhosis of the liver of various etiologies. Aim: To investigate the serum concentration of vasculoendothelial growth factor (VEGF) and the frequency of occurrence of VEGFA gene polymorphism genotypes in the region -634G/C (rs2010963) in patients with steatosis, fibrosis and cirrhosis of the liver in the Perm Region. Materials and methods: 258 people were examined, including 52 patients with non-alcoholic liver steatosis, 95 patients with chronic hepatitis C and liver fibrosis, 46 people with cirrhosis of the liver of viral (HCV) and alcoholic etiology and 65 practically healthy individuals. The serum concentration of VEGF was determined by enzyme immunoassay. Polymorphisms of the VEGFA gene in region -634G/C were analyzed by polymerase chain reaction. Result: The development of steatosis, fibrosis and cirrhosis of the liver is accompanied by endothelial damage with activation of neoangiogenesis due to hyperproduction of VEGF (p=0.001, p=0.0001 and p=0.001, respectively) in the blood serum. Elevated serum VEGF values in patients confirmed the presence of endothelial dysfunction in liver pathology. The study of the single nucleotide polymorphism of the VEGFA gene (G634C) showed a higher incidence of recessive allele C in patients with steatosis and cirrhosis in 54.81% (p=0.01) and 48.9% (p=0.04) of cases than in the control group -37.69%, which suggested the presence of an association of the carrier of allele C of this polymorphism in the form of genotypes CC or GC with a risk of developing steatosis and cirrhosis of the liver. Conclusion. Determination of the genetic marker VEGFA in the region -634G/C allows us to assess the increased risk of developing chronic liver diseases when exposed to various etiological factors.

Perm School of Lymphologysts: theory, experiment and clinic

The paper narrates the early research on the lymphatic system in the city of Perm (Russia) in 1951 and the systematic study of lymph nodes during the period from 1954 to 1963 under the guidance of Professor Ivan Ivanovich Kositsyn. The second period of experimental lymphology development in Perm is associated with the name of Professor Elizaveta Nikolaevna Oleneva. Her research on the lymphatic vessels of various organs when creating typological models of experimental venous congestion and lymphostasis became the basis for understanding pathological processes in organ interstices. The development of clinical lymphology owes much to Professor Nadezhda Alexandrovna Garyaeva. Close scientific cooperation between the Perm and St. Petersburg lymphological schools led to the development of structural foundations of modern lymphodynamics theory. The discovery of the lymphatic valve tensor muscle determined the role of valves in lymph flow in a historical discussion question. Reconstructive-restorative operations on the thoracic duct for surgical lymphology are significant for the prevention of lymphostasis and thrombosis. The study of mass transfer laws of medicinal substances through the interstitium provided a scientific rationale for lymphotropic therapy at a new level. The terms “intersticiology,” “somatic lymphedema,” and “visceral lymphedema” have been introduced into scientific circulation. Analysis of fundamental lymphostasis research allowed for the development of drug treatment methods for post-radiation fibrosis and lymphedema. The Department of Human Anatomy with a course in clinical lymphology under the leadership of Professor N.A. Garyaeva, developing treatment technologies in gynecology, phthisiopulmonology, surgery, traumatology, pediatrics, and therapy, became the scientific-methodological center in the city of Perm for building knowledge in the field of lymphology. The Lymphatech Clinic, opened in 2007, gave a new impetus to the development of clinical lymphology. The Lymphatech method, providing targeted pharmacological correction of the structures and functions of the lymphatic system, has stood the test of time and proved itself as an essential pathogenetic therapy for many pathologies. Scientific and clinical results are reported and published at international conferences, including the leading journal Lymphology.

Prevalence of bronchopulmonary dysplasia in infants with very low body weight and extremely low body weight in Perm Krai according to the data of catamnesis department of Perinatal center

Objective. To analyze the prevalence of bronchopulmonary dysplasia (BPD) in the city of Perm and Perm Krai, to state the prevalence dynamics for 3 years and BPD prevalence among infants with very low body weight (VLBW) and extremely low body weight (ELBW) from 2021 to 2021. Materials and methods. Examination of 271 patients aged 0 to 3 years and assessment of clinico-anamnestic, laboratory, instrumental, X-ray data according to diagnostic standards and protocols was carried out. Results. The number of infants diagnosed BPD in the group of preterm newborns was detected to decrease despite the fact that the quantity of preterm labors in Perm Krai is at the same level. Conclusions. In Perm Krai, for the recent 3 years there is a tendency to reduction in the frequency of BPD formation in infants with VLBW as well as decrease in the share of severe BPD forms among premature infants.

Dedicated to the 100th anniversary of the birth of professor Valentina Trofimovna Selezneva

The article is devoted to the 100th anniversary of the birth of Selezneva Valentina Trofimovna Doctor of Medical Sciences, professor, teacher, public health organizer, public figure, historian of medicine, Head of the Department of Social Hygiene and Organization of Public Healthcare of the Medicopreventive Faculty of Perm State Medical Academy. In 1947, she graduated with honors from the Sanitary-Hygienic Faculty of Molotov Medical Institute, in 1950 from the postgraduate courses. All her life was connected with Perm Medical Institute. Valentina Trofimovna paid a great attention to students' scientific society. Together with her colleagues, she founded the school "Young Organizer of Healthcare," where from 20 to 30 students were trained every year. Valentina Trofimovna was an active public figure four times she was elected the deputy of the city of Perm in Leninsky District Council; she was the Chairman of the permanent commission on health care and social security. Valentina Trofimovna was interested in the history of medicine in the region. Books on the history and development of Perm Medical University, "From the Medical Faculty to the Medical Academy" and "Essays on the History of Medicine in Perm Province" were published under the guidance of V.T. Selezneva. Under her supervision, nine Ph.D theses, including those on history of medicine were prepared. V.T. Selezneva was awarded the orders, medals and honorary diplomas for her truly selfless work. The article also presents an interview with colleagues, students and postgraduate students, reflecting the memories of Valentina Trofimovna Selezneva as a person and a teacher.

Interim results on concession agreements for the city of Perm and the Perm region

The article focuses on the ongoing economic processes associated with the conclusion of concession agreements in Perm and the Perm Territory. It is noted that two dozen such agreements have been concluded over the past year. Based on the study of information on concessions in Perm, it is shown that not all agreements are beneficial. The article notes the analysis relevance of concluded agreements. Despite the fact that all agreements are closely monitored by various structures, the economic or social effect does not always manifest. The work is based on the theoretical method of research. Several agreements concluded in 2022 have been analyzed and evaluated and the effect of which can be expected in 25–30 years. Replacement of electric transport in Perm is necessary, but not at the payment expense of the municipality residents. The article analyzes the expenditure part of the Perm budget and the expenditure part of the budget of the Perm Territory for 2023 as part of payment under concession agreements. Based on the generalization of the data obtained, the article draws conclusions that can be taken into account by local governments.

To memory of Daniil Sergeevich Aristov (1979–2022): biography and list of publications

On October 3, 2022, at the age of 43, the leading researcher of the Arthropod Laboratory of the Paleontological Institute of the Russian Academy of Sciences, Doctor of Biological Sciences Daniil Sergeevich Aristov (Figs 1, 2) died suddenly. He was born on January 27, 1979 in the city of Perm (former USSR) in a family of scientists. His father, Doctor of Physical and Mathematical Sciences Sergey Nikolayevich Aristov, worked as a chief researcher at the Ural Branch of the Russian Academy of Sciences, and his mother, Tatyana Aleksandrovna Aristova, was a linguist engineer and was engaged in scientific translation. As a child, Daniel was interested in biology, read a lot of popular science literature, and his favorite author was Gerald Malcolm Durrell. Daniil was a creative person: while studying at school, he went to the children’s painting studio and the creative workshop “Woodcarving” and participated with his works in exhibitions in Perm and other cities of Russia.

THE ABILITY TO CONTROL SPACE AND PROPERTY IN A MUNICIPALITY

The author's research is based on the need for control over the development of the public space of the municipality by its residents. The article is devoted to the study of the processes of formation of the public space of the city of Perm. The author shows that with today's approach to the processes of forming public space, a number of documents are mainly executed, but attention is not paid to the needs of city residents. Proposals have been formed for the development of urban public space and control over municipal property within the framework of the Strategy of Socio-economic Development o. In practice, the author presented a decision on the need to “digitize” municipal property, which was included in the draft Strategy for the socio-economic development of the municipality and in the plans (road maps) of subordinate institutions. The development of information systems, the growth of infrastructure services, an increase in the amount of processed and stored information in databases shows the need to increase the working capacity of service equipment and the volume of data storage systems, which in turn will lead to the need to determine a single method for assessing the result of using digital technologies, which in turn the queue will lead to the need to protect the results obtained f the city of Perm. It is presented in the analysis of materials characterizing the use of methods of analysis and systematization of theoretical fundamental research, applied developments and documentation. An analysis of the practice of project management and the specifics of the regulatory framework can make it possible to identify problematic points in the application of project management technologies at the municipal level: lack of synchronization of the processes of strategic socio-economic development, portfolio management and budget planning; lack of external expertise of the proposed results of government projects with justification of their effectiveness, sufficiency and necessity for local communities. The results of the study can be used in the development of public spaces of municipalities.

Preventive Efficacy of Domestic Vaccines against a New Coronavirus Infection in the Immunization of Employees of Medical Organizations

Relevance. Evaluation of the preventive effectiveness of domestic vaccines in immunization of employees of medical organizations, in the context of the ongoing pandemic caused by the SARS-CoV-2 virus, remains important. The aim. To evaluate the preventive effectiveness of domestic vaccines in the immunization of employees of medical organizations. Materials and methods. The preventive efficacy of domestic vaccines was studied in an epidemiological, analytical, retrospective (historical), cohort, parallel study involving 1115 healthcare workers from various outpatient and policlinic organizations in the city of Perm. Results. The high preventive efficacy of COVID-19 vaccination of health care workers was established in the conditions of analytical cohort study (the incidence of the unvaccinated was 3.3 times higher than the incidence of vaccinated). Among the vaccinated, a milder course of the disease was observed. The GamCovidVac Spuntic V and Sputnik Light vaccines were characterized by the highest prophylactic efficacy for which was 76.1 and 78.2 respectively, against 54.53 with Covivac immunization and 50.7 with EpiVacCorona. Conclusions. Vaccination is an effective measure against COVID-19 and can be recommended in the context of ongoing pandemic.

Features of the epidemiological situation with acute urogenital gonococcal infection in the Perm Region for the period from 2010 to 2021

BACKGROUND: According to WHO, more than 60 million people get sick with gonococcal infection every year. Recently, there has been a decrease in the incidence of gonorrhea in Russia. However, in addition to Neisseria gonorrhoeae, other microorganisms may also cause acute urethritis. However, there is no record of morbidity for them.
 AIM: This study analyzes the epidemiological situation of the incidence of аcute genital gonococcal infection and urethral nonspecific inflammatory diseases in the Perm Region for the period 20102021.
 MATERIALS AND METHODS: A comparative retrospective analysis of the incidence of аcute genital gonococcal infection and urogenital tract nonspecific inflammatory diseases among patients of the Perm Region was performed using the annually published data of official statistics. The data on the incidence of genital tract nonspecific inflammatory diseases were obtained from outpatient patient records of three clinics in the city of Perm. Epidemiological and statistical information processing methods were used in the work, and the Pearson coefficient was used for correlation analysis.
 RESULTS: The long-term dynamics of the incidence of аcute genital gonococcal infection among the population of the Perm Region was characterized by a pronounced downward trend. However, in recent years, the number of genital tract infections in women and men has increased. The decrease in the incidence of аcute genital gonococcal infection is most likely due to changes in the properties of N. gonorrhoeae, causing significantly more difficult laboratory diagnoses and often leading to false negative results. In addition, the high polymorphism of cultural, morphological, and biochemical properties of conditionally pathogenic microorganisms further complicates the identification stage of the isolated strains.
 CONCLUSION: As a result, against the background of a decrease in the incidence of аcute genital gonococcal infection, an increase in the incidence of genital tract nonspecific inflammatory diseases was revealed. The peculiarities of the epidemic process of аcute genital gonococcal infection and urogenital tract and the complexity of laboratory diagnostics of these conditions cause their untimely detection.

Молекулярно-генетический анализ генов ADRB2, NOS3 и PPARGC1A у единоборцев города Перми

The study of genetic predisposition to certain types of sports activities will make it possible to sci-entifically select the most promising athletes and adjust their training process, since these data influence the formation of the physical qualities of athletes. The purpose of this study is to identify the relationship between pol-ymorphic variants of the ADRB2 (Adrenoceptor Beta 2), NOS3 (Nitric Oxide Synthase 3) и PPARGC1A (Peroxi-some Proliferator-Activated Receptor Gamma Coactivator 1-Alpha) genes associated with endurance in judo and freestyle wrestling athletes with different sports qualifications. The sample for the study included 50 ath-letes, of which 27 were athletes involved in judo at the «Vityaz» sports school, and 23 athletes involved in free-style wrestling at the «Planeta» sports and health club in the city of Perm. Depending on their sporting success, the combatants were distributed into Group I with high qualifications and into Group II with low qualifications. In 50 martial artists aged 10 to 16 years, laboratory research was carried out using real-time polymerase chain reaction (PCR-RT) and polymorphisms of three genes were identified: G/T polymorphism of the NOS3 gene (rs1799983), G/A polymorphism of the PPARGC1A gene (rs8192678) and A/G polymorphism of the ADRB2 gene (rs1042713). An analysis of the relationship between allelic variants of genes in martial artists and their sports qualifications was carried out. An analysis of the relationship between allelic variants of genes in martial artists and their sports qualifications was carried out; significant differences were established between Group I and Group II for genotype A/A (Fexp 2.98>1.96 at p=0.05) and genotype G/G (Fexp 2.60>1.96 at p=0.05) of the ADRB2 gene, and also for the G/A genotype of the PPARGC1A gene (Fexp 2.43>1.96 at p=0.05). The frequency of occurrence of TGS, calculated for the physical quality “endurance”, based on the polymorphism of the ADRB2, NOS3 and PPARGC1A genes in 50 martial artists, ranged from 33 to 100. Combatants with the greatest TGS are highly qualified. The relationship between the two samples (Group I with high qualifications and Group II with low qualifications) and TGS, established based on the analysis of polymorphic positions of three genes (ADRB2, NOS3 and PPARGC1A) is statistically insignificant.

The role of university technology transfer centers in the development of the “green” potential of cities

A special role in creating a green economy of modern cities is assigned to service industries, which determine the conditions and quality of life of people. The aim of the study is to identify the contribution of Perm universities in the development of a city’s green economy through the creation and dissemination of green technologies. Using the comparative case study methodology, the methods of content qualitative analysis and bibliographic analysis, we study the contribution of Perm universities and university technology transfer centers to the creation of a green economy in the city of Perm and other cities in the region. It has been established that scientific research carried out in Perm universities is capable of providing the industry and service industries with modern scientific developments in the field of green technologies and green products. The study confirmed the research hypothesis that Russian Universities can influence upon the green development of urban and regional economies in the places of their location (presence). It is concluded that Perm universities are in line with the modern innovation ecosystem and there is an opportunity to expand the participation of universities in the Perm Territory in creating the city’s green economy.