Peripheral Odontogenic Fibroma Research Articles

TCVM Treatment of Oral Peripheral Odontogenic Fibromas in a Dog

A 6-year-old poodle was presented with a one-year history of multiple gingival masses causing visible swelling of the face. Complete surgical resection of the masses was not possible due to the large number of gingival masses involving incisors, canines, premolars, and molars of the maxilla and mandible. Histopathology yielded a diagnosis of peripheral odontogenic fibromas (formerly known as fibromatous or ossifying epulis). These are benign, slow-growing tumors located on the gingiva that originate from the periodontal ligament. Although this tumor type does not readily metastasize, it can be locally extensive, damaging normal oral architecture and can recur following incomplete excision. Due to the extensive number of masses in the oral cavity of the present case, conventional medicine (i.e. surgery) was considered unlikely to be curative. The dog was presented for traditional Chinese veterinary medicine (TCVM) treatment to augment surgery and attempt to slow recurrence of the large number of oral tumors. Two TCVM modalities (moxibustion, Chinese herbal medicine) were selected for adjunct treatment. The Zhong-wan acupuncture point (CV-12) was treated daily with moxibustion for 6 months along with the administration of a tumor-suppressing Chinese herbal medicine, Ai Zhong Ping (San Huang Shuang Ding tablets) for 30 days. At the 6-month clinic recheck, there was no evidence of recurrence, however, at the 1-year follow-up oral examination, there was a single gingival mass (6 mm) between the first (201) and second maxillary incisors (202). The owner did not pursue further treatment, as the dog was doing well.

Non-invasive and Locally Invasive Hypercellular Peripheral Odontogenic Fibroma in 20 Dogs.

Medical records of dogs with an initial histopathological diagnosis of odontogenic sarcoma were reviewed for information on signalment, body weight, medical history, clinical signs, physical examination and diagnostic imaging findings, surgical procedure performed, and histologic characteristics. Twenty dogs were deemed to fit the criteria following the rigorous histology review process. These tumors were characterized by hypercellularity of the spindle cell component with less intervening stroma, mitotic activity, and variable presence of odontogenic epithelium and hard substance (cementum/dentin/bone). Non-invasive or locally invasive hypercellular peripheral odontogenic fibroma is suggested by the authors to describe these tumors. There were no signs of recurrence of any of the masses following surgical excisions with varying margins.

LARGE PERIPHERAL ODONTOGENIC FIBROMA: CLINICAL AND HISTOLOGICAL ASPECTS: A CASE REPORT

Peripheral odontogenic fibroma (POdF) is an odontogenic neoplasm of connective tissue. Due to the rarity of POdF, the lesion is not commonly reported in the literature. POdF is a benign, slow-growing, asymptomatic, non-ulcerated gingival mass seen mainly in the anterior mandible. It is designated as the extraosseous counterpart of the central odontogenic fibroma (COF). POdF mainly consists of connective tissue with various amounts of epithelial nests. This entity should be added to armamentarium of the differential diagnosis of soft tissue tumors like peripheral ossifying fibroma, peripheral ameloblastoma, pyogenic granuloma, and giant cell granuloma. Surgical excision is the treatment of choice. Recurrence was reported in the literature. Thus, the patient should be followed up regularly after the surgery.

PERIPHERAL ODONTOGENIC FIBROMA IN THE GINGIVA

A 22-year-old Caucasian male was referred to evaluate an isolated lesion in the region of tooth 23. During anamnesis, a slow, progressive, and painless growth was perceived, not bleeding upon palpation and with no color change, with a one-year evolution. On clinical examination, a well-defined exophytic enlargement was noticed, with no color change in the distal papilla of tooth 23. Some gingival hyperplastic process was suspected. Imaging exams were requested, in which a possible fibro-osseous lesion was detected in the apical region of the same tooth. A biopsy was performed, targeting the intrasulcular region between teeth 22 and 25, from which a bone fragment and the entire soft tissue lesion were collected. The material was sent for histopathological analysis, and the report was conclusive for peripheral odontogenic fibroma over vital bone tissue. The patient is currently under follow-up, with no clinical signs of recurrence. A 22-year-old Caucasian male was referred to evaluate an isolated lesion in the region of tooth 23. During anamnesis, a slow, progressive, and painless growth was perceived, not bleeding upon palpation and with no color change, with a one-year evolution. On clinical examination, a well-defined exophytic enlargement was noticed, with no color change in the distal papilla of tooth 23. Some gingival hyperplastic process was suspected. Imaging exams were requested, in which a possible fibro-osseous lesion was detected in the apical region of the same tooth. A biopsy was performed, targeting the intrasulcular region between teeth 22 and 25, from which a bone fragment and the entire soft tissue lesion were collected. The material was sent for histopathological analysis, and the report was conclusive for peripheral odontogenic fibroma over vital bone tissue. The patient is currently under follow-up, with no clinical signs of recurrence.

Clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their laboratory diagnosis.

To explore clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their diagnosis. Data of cases with a histopathological diagnosis of peripheral odontogenic fibromas were obtained from a UK-based diagnostic laboratory and retrospectively reviewed. Prevalence amongst all biopsy submissions was assessed using binomial tests and Clopper-Pearson intervals. Age at diagnosis was assessed using t-test for independent samples. Lesion location, sex, and neuter status were assessed using χ2 and post hoc binomial tests. Breed odds ratios were calculated using univariable logistic regression modelling. The prevalence of peripheral odontogenic fibromas amongst all biopsy submissions was 2.8% (1001 of 35,328, 95% confidence interval [CI]: 2.7 to 3.0). The mean (sd) age was 8.1 (±2.7) years. The most affected quadrant was the rostral maxilla (40.1%). The ratio of maxillary to mandibular lesions was 1.3:1 (95% CI: 1.1 to 1.5), and for cases of multiple peripheral odontogenic fibromas the ratio of maxillary to mandibular lesions was 2.4:1 (95% CI: 1.1 to 5.6). Males had 1.2 times the odds of suffering of peripheral odontogenic fibromas compared to females (odds ratio [OR]: 1.2, 95% CI: 1.1 to 1.4). Neutering was associated with an increased risk of diagnosis (OR: 1.6, 95% CI: 1.3 to 1.9). Breeds with increased odds of peripheral odontogenic fibromas compared to crossbreed dogs included boxers (OR: 3.78, 95% CI: 2.80 to 5.09), border terriers (OR: 3.21, 95% CI: 2.10 to 4.91) and Basset Hounds (OR: 3.18, 95% CI: 1.58 to 6.44). Breeds with increased odds of multiple simultaneous peripheral odontogenic fibromas compared to crossbreed dogs included: Boxers (OR: 12.02, 95% CI: 7.13 to 20.24), border terriers (OR: 5.05, 95% CI: 2.32 to 11.43) and Staffordshire Bull terriers (OR: 2.42, 95% CI: 1.33 to 4.41). Knowledge of clinicopathological features and at-risk breeds for peripheral odontogenic fibroma development can assist clinicians with making a diagnosis. The identification of risk factors provides targets for future research investigating peripheral odontogenic fibroma pathogenesis.

Lesões da cavidade oral de cães: 720 casos

ABSTRACT: Seven hundred twenty cases of oral cavity lesions in dogs were diagnosed from 2015 to 2020 in Distrito Federal, Brazil. Four hundred thirty-two (60%) lesions were neoplastic, and 288 (40%) were non-neoplastic. Of the neoplasms, 229 (53%) were considered malignant and 203 (47%) benign, affecting mainly males, of 43 different breeds, with an average age of 9.4 years, mainly the gum and lip. Melanoma was the most (96/432, 22.2%) commonly diagnosed neoplasm, followed by peripheral odontogenic fibroma (68/432, 15.7%), papilloma (63/432, 14.5%) and squamous cell carcinoma (SCC) (56/432, 12.9%). Non-neoplastic lesions also affected males predominantly, from 41 different breeds, with an average age of 8.9 years, mainly in the gums, lip, and tongue. These lesions were diagnosed as inflammatory (230/288, 79.8%), hyperplastic (47/288, 16.3%) and other lesions (11/288, 3.8%).

Peripheral odontogenic fibroma of the mandible

Introduction: Odontogenic fibroma is a rare benign neoplasm of mature fibrous connective tissue, with variable amounts of inactive-looking odontogenic epithelium, with or without evidence of calcification. Two clinical variants are described: intraosseous or central odontogenic fibroma and extraosseous or peripheral odontogenic fibroma. The aim of the present article is to present and discuss a case … Continued

Central Odontogenic Fibroma of Mandible: A Rare Case Report with Review of Literature

Central Odontogenic fibroma is an extremely rare neoplasm that develops from mature fibrous connective tissue with varying amounts of odontogenic epithelium. Its incidence is 0.1% of all odontogenic tumors. It occurs with equal frequency in the maxilla and mandible with female predominance. Two clinical variants are known: intraosseous or central and extraosseous or peripheral odontogenic fibroma. It is radiolucent and may present as a well-defined unilocular or multilocular slow-growing mass. Here we reported a case of central odontogenic fibroma in 44-year-old male in the posterior region of left mandible. We present this case because of its rarity.

Random mucosal rotating flaps for rostral to mid maxillary defect reconstruction: 26 dogs (2000-2019).

To evaluate the feasibility and the complications following single or double random mucosal rotating (transposition or interpolation) flaps for the closure of rostral to mid maxillary defects in dogs. Medical records of dogs treated with single or double random mucosal rotating flaps after maxillectomy for oral lesions or traumatic loss of tissue, were evaluated. Clinical findings, surgery performed, outcome and postoperative complications (major and minor) were extracted. Twenty-six client-owned dogs were retrospectively included. Dogs underwent maxillectomy for canine acanthomatous ameloblastomas (9), oral squamous cell carcinomas (4), peripheral odontogenic fibromas (4), oral melanomas (3), oral fibrosarcomas (2), dentigerous cysts (2) and oral osteosarcoma (1) and trauma resulting in an oronasal fistula (1). Twenty-three dogs underwent a single transposition or interpolation flap and three dogs were treated with a double transposition flap. Postoperative complications, including dehiscence or flap necrosis, occurred in six dogs. Random mucosal rotating (transposition or interpolation) flaps are versatile when used to close rostral maxillary defects in dogs. Postoperative complications appear to be more likely when these flaps are used to close mid maxillary defects.

Rare Nodular Lesion on Gingiva - Peripheral Odontogenic Fibroma

Peripheral odontogenic fibroma (POF) is a rare lesion, the extraosseous counterpart of the odontogenic fibroma, an odontogenic tumor of ectomesenchymal origin. Clinically it resembles as the reactional processes and has slow growth. The purpose of the study is to present a clinical case of posterior maxillary POF mimicking inflammatory periodontal disease in a 42-year-old woman who, after complete surgical excision, is followed up every six months without recurrence of the lesion. POF is a lesion characterized by fibroblast proliferation containing portions of apparently inactive odontogenic epithelium. The surgical treatment, when well performed, presents a very favorable prognosis, with a rare chance of relapse. It is important to emphasize that all the gingival lesions should be submitted to the anatomopathological examination, and the radiographic examination of the region is fundamental to evaluate the extent of the lesion.

Peripheral odontogenic fibroma an uncommonly overviewed benign neoplasm: A case report and review of literature

Peripheral odontogenic tumors (POTs) are one of the rare neoplasms to occur on the gingiva. Peripheral odontogenic fibroma (POdF) is the most common POT constituting a prevalence of 1.2%. A plethora of lesions sharing similar clinical features makes the diagnosis difficult. Histopathological examination plays a key role in these types of cases. Here, we present a rare case of POdF in a 36-year-old female patient with a lobulated pebbled-like exophytic growth on the right gingiva. Histopathological investigation showed the presence of odontogenic epithelium and dystrophic calcification which are the pathognomonic features of POdF. After surgical removal, POdF is seen to recur, but the exact recurrence rate cannot be estimated due to the scarcity of reported cases. In this case, follow-up of the patient showed no recurrence at 6, 12, and 18 months post-surgery.

Large Peripheral Odontogenic Fibroma: Clinical and Histological Aspects: A Case Report

Large Peripheral Odontogenic Fibroma: Clinical and Histological Aspects: A Case Report

Peripheral Odontogenic Fibroma: Case Report and Literature Review

Odontogenic fibroma is a rare benign tumor of mature fibrous connective tissue, with varying amounts of inactive-appearing odontogenic epithelium, with or without evidence of calcification. There are two types ; central odontogenic fibroma and peripheral odontogenic fibroma. Peripheral odontogenic fibroma is a rare, non-encapsulated benign tumor of the oral mucosa often mistaken for a reactive lesion. Peripheral odontogenic fibroma is very often underdiagnosed or simply misdiagnosed, and therefore not much is known about this lesion. Through this work, we tried to bring out the sociodemographic, clinical, paraclinical and therapeutic characteristics of this lesion.

PERIPHERAL OSSIFYING FIBROMA - A CASE REPORT

Peripheral ossifying fibroma is a benign neoplasm that usually develops from gingiva, presenting as an exophytic smooth surfaced pink or red nodular mass that is sessile or is less frequently seen on a pedicle. From the Indian perspective, it is usually noticed in 5th–6th decades of life with female predilection. Microscopically, the tumour shows stratified squamous epithelium and highly cellular fibrous stroma, sparse endothelial proliferation with fibroblasts and dystrophic calcifications. It has to be differentiated histopathologically from pyogenic granuloma, fibroma, peripheral giant cell granuloma, peripheral odontogenic fibroma and fibrous hyperplasia. A case of peripheral ossifying fibroma of mandibular gingiva in a 70-year-old Indian woman is reported.

Peripheral Odontogenic Fibroma- Case Series of a Rare Benign Tumor

Peripheral odontogenic fibroma (POdF) is a rare benign odontogenic tumor of ectomesenchymal origin which is composed of fibrous connective tissue containing islands, strands or cords of odontogenic epithelium. The lesion is more common among females, commonly seen between the second to fourth decades of life, mostly affecting the anterior region of mandible. Clinically, it may present similar characteristics with other more common gingival lesions such as pyogenic granuloma, peripheral ossifying fibroma and peripheral giant cell granuloma. So, histopathological examination is required for accurate diagnosis. We present here three rare clinical cases of peripheral odontogenic fibroma and their management by complete excision of the lesion with good postoperative outcomes.

Giant Aggressive Odontogenic Fibroma in a 15-month-old Female: Case Report and Review of Literature

Introduction: Odontogenic fibroma (OF) is a rare benign tumor of mesenchymal odontogenic tissue with variable global incidence. Two variants comprising extraosseous /peripheral (POF) and intraosseous /central (COF) have been identified based on the anatomical origin of the tumor. OF isslow growing, and often asymptomatic with characteristic radiographic appearance of a unilocular or multilocular cyst frequently associated with unerupted or displaced teeth while histologically, varying amount of inactive odontogenic epithelium embedded in a mature relatively dense collagenous stroma is diagnostic. The absence of odontogenic epithelium does not exclude the diagnosis of odontogenic fibroma.
 Case report: A 15 months old female presented with 3 months history of left lower jaw swelling which showed aggressive growth following incisional biopsy. Parents said lesion was noticed for the first time as pinpoint on the submandibular area and was too small to warrant any worries. Initial radiograph revealed absence of bony involvement but the second showed evidence of bony involvement. An impression of soft tissue sarcoma was made and incisional biopsy was sent for pathological diagnosis which revealed peripheral odontogenic fibroma. The rapidity of growth following incisional biopsy bellied a benign lesion.
 Conclusion: An aggressive odontogenic fibroma with multifocal points in a 15months old girl.
 Keywords: Aggressive; Central; Odontogenic fibroma; Peripheral.

Peripheres odontogenes Fibrom im Oberkiefer bei einem 26-jährigen Patienten

Peripheral odontogenic fibroma (POF) is a rare and benign neoplasm consisting of a mature fibroblastic spindle cell proliferation and variable inclusions of odontogenic epithelium. It can occur in both the maxilla and mandible.

CT features of malignant and benign oral tumors in 28 dogs.

An improved understanding of the computed tomographic (CT) features for malignant versus benign oral tumors would be helpful for guiding prognosis and treatment planning decisions in dogs. This retrospective, multi-center, observational study compared the CT features of malignant and benign tumors in 28 dogs with 31 oral masses. Malignant tumors were present in 20 dogs, including malignant melanoma (n = 14), squamous cell carcinoma (SCC, n = 4), adenocarcinoma (n = 1), and fibrosarcoma (n = 1). Eight dogs had benign tumors, including giant cell granuloma (n = 2), peripheral odontogenic fibroma (n = 2), acanthomatous ameloblastoma (n = 2), plasmacytoma (n = 1), and oncocytoma (n = 1). Common CT features of malignant tumors included heterogeneous enhancement, tumor invasion into the adjacent bone, tooth loss, and ipsilateral mandibular lymphadenopathy. Malignant tumors were significantly larger than benign tumors. Bone lysis was found in benign tumors (n = 4) such as acanthomatous ameloblastoma, giant cell granuloma, and plasmacytoma. The bone lysis was a well-defined geographic area regardless of malignancy and tumor type. In periosteal reactions, amorphous patterns were seen in both malignant (n = 2) and benign tumors (n = 2); the latter subgroup also showed solid patterns. Bone expansion (n = 2) was identified in malignant melanoma and acanthomatous ameloblastoma. Findings supported a diagnosis of possible malignancy for dogs with oral tumors having the following CT characteristics: large size, heterogeneous contrast enhancement pattern, bone lysis, tooth loss, and ipsilateral lymphadenopathy. However, there was a considerable overlap of CT findings among the different types of oral tumors and between benign and malignant tumors. Histological evaluation therefore remains necessary for definitive diagnosis.

SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear clinically similar but of different histogenesis. The novel marker SATB2 is involved in regulation of osteoblastic differentiation and phenotype. However, SATB2 expression has not been previously explored in POFs and POdFs. Given the potential for mineralized tissue formation in POFs and POdFs, and to more clarify the phenotype of the lesional cells, this study was aimed to immunohistochemically investigate SATB2 expression in POFs and POdFs. Fourteen cases of POF and POdF (7 cases each) were selected, stained for SATB2 immunohistochemically, and scored according to the percentage of positive lesional cells (0, no staining; 1 +, < 5%; 2 +, 5-25%; 3 +, 26-50%; 4 +, 51-75%; and 5 +, 76-100%), and the intensity of staining was graded as weak, moderate, or strong. The control group included the inflammatory fibrous hyperplasia-like area present in two cases, 1 case fibroma, and 1 case giant cell fibroma. Moderate to strong, and diffuse SATB2 nuclear immunoreactivity was detected in the lesional cells of all cases of POFs and POdFs with variable scores; 3-5 + for the POFs and 3-4 + for the POdFs (P = 0.101). The distribution of staining was more prominent in those lesional cells associated with the osteoid/calcification in the cases of POFs. No staining was noted in the control group. The lesional cells in both POFs and POdFs express SATB2 and may exhibit the osteoblastic-like phenotype. SATB2 staining may be useful for diagnosis of subsets of POFs with minimal or absent calcification and some POdFs with unidentifiable odontogenic epithelium.

PERIPHERAL ODONTOGENIC FIBROMA: MIMICKING GINGIVAL SQUAMOUS CELL CARCINOMA: A RARE CASE REPORT AND REVIEW OF LITERATURE

In neoplasms Peripheral Odontogenic Tumors(POT) are one of the rare to occur on gingiva, among them, Peripheral Odontogenic Fibroma (POdF) is the most common. A plethora of lesions sharing similar clinical features, makes the diagnosis difcult. POdF is a benign, slow-growing, smooth, exophytic, painless lesion but it may show diverse clinical presentation as erythematous, lobulated, rapidly growing mass which might be tender on palpation overlapping the features with various inammatory gingival conditions to even a gingival squamous cell carcinoma.This results into diagnostic enigma. Histopathologoical examination plays a vital role in these type of cases. Discussed here is a case of POdF mimicking gingival squamous cell carcinoma. Histopathological investigation showed presence of odontogenic epithelium and dystrophic calcication which are the pathognomonic features of POdF. After surgical removal,POdF is seen to recur but, the exact recurrence rate cannot be estimated due to scarcity of reported cases.