Hereditary hemorrhagic telangiectasia, also known as Rendu-Osler-Weber syndrome, is an uncommon genetic disease characterized by arteriovenous malformations mainly in skin and mucous membranes, but also in visceral organs, lungs and even central nervous system, causing intermittent hemorrhagic episodes, some of them potentially severe. Their main consequence is iron deficiency anemia. Parvovirus b19 is a DNA virus with proerythroblast tropism whose infection is generally asymptomatic, but might cause cutaneous manifestations, such as infectious erythema, articular symptoms and medullary aplasia, rarely seen in immunocompetent individuals. The aim of this study is to demonstrate the association of these two diseases and their potential correlation. In this report we describe a 54 years old woman with a history of epistaxis since childhood, who presented worsening hemorrhagic episodes, melena, dyspnea at rest and pancytopenia. During investigation the diagnosis of Rendu-Osler-Weber syndrome was made, and posteriorly it was identified that her clinical worsening and pancytopenia was caused by medullary aplasia associated to parvovirus b19infection.