PurposeTo correlate the thickness of focal regions of the macula with those of the peripapillary nerve fiber layer using optical coherence tomography (OCT) in mild Alzheimer's disease (AD) patients and to compare them with age‐matched controls.MethodsOCT of the macula and of the optic nerve from 19 mild AD patients and 25 control patients were included in the study. The thickness of 36 macular voxels of the 6 × 6 grid considered for analysis was correlated with the thickness of the 7 temporal papillary wedges across subjects. Each macular voxel was labeled with the peripapillary wedge with the highest correlation using a color‐coded map.ResultsIn comparison with the controls, mild AD patients presented a significant: (i) thinning in the macular voxels 5, 6, 12, 15, 16, 18, 21, and 22 (p < 0.05) and; (ii) correlation between several macular voxels and some of the peripapillary wedges between groups (p < 0.05).ConclusionsThere were significant differences in the maculopapillary correlation map pattern between mild AD patients and control group. The OCT changes detected could be ascribed to the inflammation and neurodegeneration that occur in the early stages of AD and could serve as a basis for future research aimed to develop a quick, easy, and non‐invasive biomarker of AD.