IntroductionMassachusetts General Hospital (MGH) is a large academic medical center, where many proceduralists are using Hybrid Operating Rooms (OR) to perform cases, and these specialties often utilize supply inventory in the rooms and nearby spaces, but also transport supplies from other procedural areas outside of the OR. For these Hybrid ORs, we saw an increase in supply discrepancies for items used during procedures but that were not documented, and wanted to determine the root cause to minimize these events. MethodsA multidisciplinary team was assembled from across Perioperative Services, Cardiology, and Radiology to address this issue. Through a series of process improvement efforts, including relocation of Radiofrequency Identification cabinets, creation of new control processes, and education of key staff, we were able to address this problem. ResultsThrough the work of a multidisciplinary team, we achieved a nearly 90% decrease in the incidence of these missing supplies. This project served as one of the first initiatives of the MGH Procedural Services Committee—a group that is now working on a variety of initiatives across the procedural areas to improve patient care, increase efficiency, and reduce costs. ConclusionAs the procedural areas across hospitals continue to become more similar with respect to equipment, resources, staffing competencies, and supplies, there will need to be increased efforts to collaborate to solve shared problems. As many hospitals across the country continue to see margin pressures and declining reimbursement, it will be vitally important to standardize, share best practices, and create additional economies of scale where possible for these procedural areas.